Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Guided Posters


ea0041gp70 | Diabetes | ECE2016

The association between vitamin D metabolites and the DHCR7 rs12785878 polymorphism in German T2D patients

Nejatian Nojan , Penna-Artinez Marissa , Moran-Auth Yasmin , Badenhoop Klaus

Introduction: Hypercholesterolemia is frequently found in patients with type 2 diabetes (T2D). Cholesterol is metabolized from 7-dehydrocholesterol by 7-dehydrocholesterol reductase (DHCR7) from 7-dehydrocholesterol, a precursor of pre-vitamin D3. Therefore single nucleotide polymorphisms (SNP) in the DHCR7 gene could regulate cholesterol levels and concentrations of vitamin D metabolites (25(OH)D3 or 1,25(OH)2D3). For this purpose we investiga...

ea0041gp71 | Diabetes | ECE2016

A critical evaluation of the metabolic syndrome definition: why we should be more cautious

Slagter Sandra , van Waateringe Robert , van Beek Andre , van der Klauw Melanie , van Vliet-Ostaptchouk Jana , Wolffenbuttel Bruce

Aim: We assessed in both men and women within different BMI- and age classes the prevalence of MetS and its individual components, since these specific estimates obtained simultaneously in a large western European population are lacking. Secondly, we measured as well how age-specific blood pressure (BP) cut-offs affect the prevalence of elevated BP and MetS.Methods: Data of 74 531 western European participants, aged 18–79 years, were obtained from t...

ea0041gp72 | Diabetes | ECE2016

Olfactory and gustatory functions in patients with non-complicated type 1 diabetes mellitus

Baskoy Kamil , Ay Seyid Ahmet , Hira Serdar , Salihoglu Murat , Deniz Ferhat , Yıldırım Aynur , Altundag Aytug , Yonem Arif , Tekeli Hakan , Hummel Thomas

Introduction: Olfactory and gustatory dysfunction in patient with diabetes mellitus (DM) and its pathophysiology were studied in many previous studies. Some studies reported that there was a relationship between type 1 DM (T1DM) and olfactory and gustatory functions the presence of diabetic complications. However findings are limited and controversial. The aim of this study was to determine the relationship between olfactory and gustatory scores and patients with non-complicat...

ea0041gp74 | Diabetes | ECE2016

A novel gene mutation in Berardinelli Seip Syndrome: Three case reports

Gungor Adem , Gokkaya Naile , Karadeniz Yusuf , Bilen Arzu , Bilen Habib

Introduction: Berardinelli Seip Congenital Lypodystrophy (BSCL) is a rare otosomal recessive disease characterized by major criteria which are lypoatrophy, acromegaloid features, hepatomegaly, hypertriglyceridemia, insulin resistance and minor citeria which are hypertrophic cardiomyopathy, psycomotor retardation, hirsutism, precocious puberty, long bone cysts, phlebomegaly. The presence of three major criteria or two major plus two minor criteria required for diagnosis of BSCL...

ea0041gp75 | Diabetes | ECE2016

Intact proinsulin level is associated with insulin resistance but not insulin secretory capacity in subjects with abnormal glucose tolerance

Hwang You-Cheol , Cho In-Jin , Jeong In-Kyung , Jeung Ahn Kyu , Chung Ho Yeon

Introduction: Proinsulin is a propeptide of insulin and C-peptide during physiological insulin production and is increased in patients with type 2 diabetes. Increased proinsulin in peripheral blood indicates impairment of cleavage capacity to process insulin within the beta cell. Recently, chemiluminescence assays have been developed that are able to specifically measure uncleaved intact proinsulin in peripheral blood. In this cross-sectional study, we investigated the relatio...

ea0041gp76 | Diabetes | ECE2016

Oxidative stress in the gestational diabetes mellitus mother and placenta

Lopez-Tinoco Cristina , Visiedo Francisco , Roca-Rodriguez Mar , Rosendo Celeste , Mateos Rosa , Segundo Carmen , Aguilar-Diosdado Manuel

Background and aims: The mechanisms underlying placenta oxidative stress co-existing with alterations in maternal-placenta interactions during gestational diabetes mellitus (GDM) are not well understood. We sought to evaluate the levels of oxidative stress markers and antioxidants in women with GDM, and to assess the impact on placenta.Material and methods: Pregnant women (63 with GDM, 63 controls) were enrolled, together with 41 cases and 21 controls fo...

ea0041gp77 | Diabetes | ECE2016

Pancreatic damage induced by cigarette smoke: How does smoking affect the pancreatic functions?

Topsakal Senay , Ozmen Ozlem , Aslankoc Rahime , Aydemir Demet Hancer

Background: Studies have shown that smoking may increase the risk of pancreatic disorders. This study aimed to evaluate the oxidative stress status, biochemical, pathological and immunohistochemical findings of rats exposed to the cigarette smoke, pathogenesis of smoking related pancreatic damage and usability of Alpha Lipoic Acid (ALA) for amelioration of cigarette’ harmful effects on rat pancreas.Methods: Twenty eight female, Sprague Dawley rats w...

ea0041gp78 | Diabetes | ECE2016

Effect of alpha lipoic acid on high fructose corn syrup induced hepatic pathology

Topsakal Senay , Ozmen Ozlem , Ozgocmen Meltem

Objectives: High-fructose corn syrup (HFSC) is used as an artificial sweetener. However, there is limited information about the metabolic effects. Fructose is implicated in the etiology of nonalcoholic fatty liver disease(NAFLD). Unfortunately, no therapy for NAFLD currently exists. The aim of this study was to investigate the hepatic lesion induced by chronic HFCS consumption and the protective effects of alpha-lipoic acid (ALA) on hepatic pathology.Met...

ea0041gp79 | Diabetes | ECE2016

Metagenomic analysis of saliva and biofilm microbiome of type 1 diabetics under continuous subcutaneous insulin infusion

Carrilho Eunice , Coelho Ana , Paula Anabela , Caramelo Francisco , Silva Mario , Carrilho Francisco , Melo Miguel , Barros Luisa , Batista Carla , Botelho Filomena , Ferreira Marques

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...