Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 41 | ECE2016 | Next issue

18th European Congress of Endocrinology

Guided Posters

Thyroid Cancer (1)

ea0041gp229 | Thyroid Cancer (1) | ECE2016

ALK alterations in thyroid cancer

Kleinlein Irene , Furst Heinrich , Keller Gisela , Seehaus Tanja , Weichert Wilko , Kremer Markus

Background: Thyroid cancer is the most frequent endocrine malignancy, with >7000 cases diagnosed in central Europe every year. Recently, ALK/EML4 translocations have been reported in single cases in anaplastic thyroid cancer (ATC). Little is known about the frequency of ALK alterations in poorly differentiated thyroid cancer (PTC). Our aim was to investigate the frequency of ALK alterations in patients with advanced thyroid carcinomas.Material and me...

ea0041gp230 | Thyroid Cancer (1) | ECE2016

Analysis of germline VEGF-A SNPs allows the identification of a subgroup of ATA low-intermediate risk DTC (differentiated thyroid cancer) patients with poor probability to develop recurrences

Marotta Vincenzo , Sciammarella Concetta , Capasso Mario , Testori Alessandro , Gambardella Claudio , Grasso Marica , Rubino Manila , De Palma Maurizio , Grazia Chiofalo Maria , Pivonello Claudia , Pivonello Rosario , Santini Luigi , Pezzullo Luciano , Colao Annamaria , Faggiano Antongiulio

Introduction: Constitution of new blood vessels is crucial for cancer self-maintenance and progression. Neo-angiogenesis may be affected from hereditary traits, namely the presence of SNPs (single nucleotide polymorphisms) of genes involved in its regulation. VEGF-A represents the main regulator of angiogenesis. Germline SNPs of the VEGF-A gene have been associated to outcome of several cancers, but no data exist about differentiated thyroid cancer (DTC).<p class="abstext"...

ea0041gp231 | Thyroid Cancer (1) | ECE2016

Antiproliferative actions of 1,25(OH)2D3 in differentiated thyroid carcinoma are dependent on Sirtuin1 activity

Rohlen Natascha , Doring Claudia , Hansmann Martin-Leo , Badenhoop Klaus , Penna-Martinez Marissa

Antiproliferative actions of 1,25(OH)2D3 (1,25D), the active form of Vitamin D, are reported in various types of cancer, whereas little is known about the underlying molecular mechanism. Interestingly, in non thyroid-cancer cells, stimulation with 1,25D has been shown to affect cell proliferation in a Sirtuin 1 (Sirt1) dependent manner. Sirtuin histon deacetylases are key factors in cell metabolism recently found to be overexpressed in different carcinoma...

ea0041gp232 | Thyroid Cancer (1) | ECE2016

Does serum Galectin-3 add value in thyroid cancer diagnosis?

Dobrescu Ruxandra , Schipor Sorina , Manda Dana , Picu Catalina , Giulea Cosmin , Niculescu Ana-Maria , Badiu Corin , Caragheorgheopol Andra

Background: The role of circulating Galectin-3 as a potential biomarker of malignancy in thyroid disease remains inconclusive. In a previous pilot study we reported a significant difference between serum Gal-3 levels in papillary thyroid carcinoma (PTC) patients and those with benign pathology, but no association with tumor aggressiveness.Aim: We measured serum Gal-3 levels in a larger series of patients submitted to thyroidectomy, in order to assess its...

ea0041gp233 | Thyroid Cancer (1) | ECE2016

Malignancy risk and false negative rate of fine needle aspiration cytology in thyroid nodules equal or greater than 4 cm

Bestepe Nagihan , Ozdemir Didem , Ali Tam Abbas , Dellal Fatma Dilek , Kilicarslan Aydan , Parlak Omer , Ersoy Reyhan , Cakir Bekir

Background: We aimed to evaluate malignancy rate in thyroid nodules ≥4 cm and determine false negativity of fine needle aspiration biopsy (FNAB) in these nodules.Methods: Patients who underwent thyroidectomy between January 2007 and December 2014 in our institution were reviewed. Demographical and clinical data and preoperative ultrasonography (US) findings were obtained from the medical records. The nodules in these patients were grouped as &#8805...

ea0041gp234 | Thyroid Cancer (1) | ECE2016

TROP-2 is a novel reliable marker for immunohistochemical diagnosis of papillary thyroid carcinoma

Bychkov Andrey , Sampatanukul Pichet , Shuangshoti Shanop , Keelawat Somboon

Introduction: Immunohistochemistry (ihc) in thyroid pathology is often recruited for differentiating between challenging benign and malignant tumors. There is no single antibody that can render definitive diagnosis. Most of the recently identified ihc markers have never been assimilated into daily clinical practice due to their low reproducibility and other associated limitations. Trop-2 ihc was recently reported as a useful tool for identifying papillary thyroid carcinoma (pt...

ea0041gp235 | Thyroid Cancer (1) | ECE2016

Thyroid nodules: a highly specific molecular and cytological combined predictor of malignancy

Lasolle Helene , Riche Benjamin , Decaussin Myriam , Dantony Emmanuelle , Cornu Catherine , Lifante Jean-Christophe , Capraru Oana-Maria , Rousset Bernard , Borson-Chazot Francoise , Roy Pascal

Thyroid nodules are very common and benign in most cases. Thus, malignancy detection avoiding overtreatment is a challenge. Nodule evaluation mainly supports on US and fine needle aspiration cytology (FNAC). The Bethesda classification (BC) for reporting thyroid cytopathology is now currently used for the interpretation of results but it does not enable classifying 30% of samples.The objective was to identify, by transcriptome analysis, a molecular signa...

ea0041gp236 | Thyroid Cancer (1) | ECE2016

Utility of ultrasound shear wave elastography for diagnosis of malignant thyroid nodules: evaluation of maximum and standard deviation elasticity values

Kim Hye Jeong , Kwak Mi Kyung , Park Hyeong Kyu , Byun Dong Won , Suh Kyoil , Yoo Myung Hi

Background: Shear wave elastography (SWE) is an emerging technique that can be used to evaluate malignancy in many organs. The aim of this study was to address the role of elasticity indices as a possible predictive marker for detecting papillary thyroid carcinoma (PTC) and quantitative assessment of SWE for differential diagnosis of benign and malignant thyroid nodules.Methods: One hundred and nineteen patients with thyroid nodules undergoing SWE before...

ea0041gp237 | Thyroid Cancer (1) | ECE2016

The origin of patients with inherited medullary thyroid cancer, who are carriers of the rare exon 8 mutation (G533C) of the RET gene in Greece

Saltiki Katerina , Anagnostou Elli , Angelopoulou Anastasia , Kouki Sofia , Apostolakis Michail , Sarika Lida , Papathoma Alexandra , Alevizaki Maria

Introduction: Mutations in the ret gene are responsible for the transmission of inherited medullary thyroid cancer (MTC). In recent years a high prevalence of the ‘rare’ exon 8 mutation (G533C) has been found in patients with inherited MTC in Greece. The aim of this study was to record with more detail the place of origin of these families in the country.Design: We analysed the details of 44 patients belonging to 22 families who were c...

ea0041gp238 | Thyroid Cancer (1) | ECE2016

Correlation between basal and stimulated thyroglobulin in differentiated thyroid carcinoma of intermediate and high risk

Senes Paola , De Rosa Annapina , Paragliola Rosa Maria , Papi Giampaolo , Locantore Pietro , Pontecorvi Alfredo , Corsello Salvatore Maria

Thyroglobulin (Tg) is a highly sensitive tumor marker of differentiated thyroid cancer (DTC). To optimize the sensitivity, guidelines recommend Tg measurement after stimulation with recombinant TSH (rh-TSH) 6–12 months after radio remnant ablation (RRA). Based on recent evidence in Literature, it is possible to avoid the measurement of Tg after stimulation with rh-TSH (S-Tg) in presence of undetectable values of basal Tg (B-Tg) if high functional sensitivity (0.1 ng/ml) m...