Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Guided Posters

Thyroid - Translational & Clinical (1)

ea0041gp209 | Thyroid - Translational & Clinical (1) | ECE2016

Higher thyrotropin can be used as an additional risk factor in prediction of malignancy in euthyroid thyroid nodules evaluated by cytology based on Bethesda system

Baser Husniye , Topaloglu Oya , Ali Tam Abbas , Evranos Berna , Alkan Afra , Sungu Nuran , Gurkan Dumlu Ersin , Ersoy Reyhan , Cakir Bekir

Introduction: Recently, it has been suggested that thyrotropin (TSH) concentration can be used as a marker for prediction of thyroid malignancy. However, the association between the cytology results and TSH levels is not clear. In this study, we aimed to investigate the relationship between TSH levels and Bethesda categories and determine the role of TSH levels in prediction of malignancy in patients with different Bethesda categories.Methods: The data o...

ea0041gp210 | Thyroid - Translational & Clinical (1) | ECE2016

The expression of co-stimulatory receptor SLAMF-1 in lymphocytes from patients with autoimmune thyroiditis

Sampedro-Nunez Miguel , Vitales-Noyola Marlen , Serrano-Somavilla Ana , Di Pasquale Carmelina , Hernandez-Martinez Rebeca , Ramos-Levi Ana , Gonzalez-Amaro Roberto , Marazuela Monica

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

ea0041gp211 | Thyroid - Translational & Clinical (1) | ECE2016

Long-term outcome in levothyroxine treated individuals with Subclinical Hypothyroidism and concomitant Heart Disease

Andersen Mette Nygaard , Olsen Anne-Marie Schjerning , Madsen Jesper Clausager , Kristensen Soren Lund , Faber Jens , Torp-Pedersen Christian , Gislason Gunnar Hilmar , Selmer Christian

Introduction: Subclinical hypothyroidism (SCH) is a common condition and can lead to impaired systolic and diastolic cardiac function. However, controversy remains over the potential benefits of levothyroxine substitution in patients with SCH and concomitant heart disease. We aimed to examine the effects of levothyroxine treatment on all-cause mortality in patients diagnosed with SCH and heart disease.Methods: Primary care patients aged 18 years and olde...

ea0041gp212 | Thyroid - Translational & Clinical (1) | ECE2016

Acute icteric hepatitis as a presentation of Graves’ thyrotoxicosis

Doraiswamy Amudha , Henry Adelyn , Kamaruddin Nor Azmi

Introduction: Graves’ thyrotoxicosis has been known to affect other organ systems in the body including the liver. However, severe hepatitis in this clinical context is quite rare.Case report: We report a 55-year-old man who presented with marked weight loss and jaundice. In addition, he had a diffuse goitre with fine tremors in the hands. Laboratory work-up revealed thyrotoxicosis with FT4 of 87.9 pmol/l and TSH of <0.01 mIU/l. He ha...

ea0041gp213 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Autoimmune thyroid disease related to Helicobacter pylori contamination

Voloshyna Iryna , Krivenko Vitaliy , Voloshyn Mykola , Deynega Vladimir , Ponomarenko Vladislav

Introduction: Strong association between pathogenesis of autoimmunity and bacterial infection particularly Helicobacter pylori (H.pylori) had been observed in numerous studies. Nevertheless the possible role of H.pylori in progression of autoimmune thyroid disease is still discussed.The aim of the study was to reveal the relation between Hashimoto thyroiditis (HT) and presence of H.pylori as well as to analyze the impact of eradication therapy on level o...

ea0041gp214 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Evaluation of quality of life in euthyroid patients with high autoantibody titers

Kurt Funda , Atmaca Aysegul

Introduction: Thyroid dysfunction affects quality of life (QoL) in untreated patients. However, patients with high thyroid autoantibodies complain about symptoms that resemble thyroid dysfunction even if they are euthyroid. The aim of this study was to evaluate QoL in euthyroid patients with elevated thyroid autoantibodies.Methods: Patients who admitted to Endocrinology clinic with symptoms of thyroid dysfunction and no other disease were included in the...

ea0041gp215 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Assessing thyroid function and immunogenicity in patients undergoing chronic treatment with methadone

Petrov Sava , Orbetzova Maria , Iliev Yanko , Deneva Tanya , Boyadjiev Doychin

Introduction: The aim of the study was to assess the function and immunogenicity of thyroid gland of patients undergoing chronic treatment with the opiate agonist Methadone.Material and methods: Cross-sectional, observational study included patients from 18 to 40 years of age undergoing chronic treatment with Methadone for at least 6 months. A total of 176 participants took part in the study. 140 patients were from five clinical programs in Bulgaria and ...

ea0041gp216 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Endocrine toxicities of immune checkpoint inhibitors: a single centre experience

Gonzalez-Rodriguez Elisa , Rodriguez-Abreu Delvys

Introduction: Immune checkpoint inhibitors (ICI) are a new drug generation used for advanced neoplasias. They are monoclonal antibodies which enhance the immune system to combat cancer cells. As a result, immunologic tolerance can be altered and autoimmunity triggered. Toxicities associated to ICIs have been named immune-related adverse events (irAE). ‘Time to resolution’ of endocrine irAEs have not been well described as this term has not been defined in clinical tr...

ea0041gp217 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Evaluation of the interrelations between thyroid function, insulin resistance, lipid profile, C-reactive protein and homocysteine in patients with autoimmune thyroiditis

Neves Celestino , Neves Joao Sergio , Oliveira Sofia Castro , Esteves Cesar , Sokhatska Oksana , Dias Camila , Delgado Luis , Medina Jose Luis , Carvalho Davide

Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistanc...

ea0041gp218 | Thyroid - Translational &amp; Clinical (1) | ECE2016

Relationship between immunoexpression of IL17A, CD68 positivity and lymphocyte infiltration degree in Hashimoto’s thyroiditis patients

Konrade Ilze , Zake Tatjana , Skuja Sandra , Kalere Ieva , Groma Valerie

Introduction: Th17 cells and their hallmark cytokine IL-17A were reported to be involved in the development of autoimmune orchitis and encephalomyelitis by impairing the integrity of the blood–testis and blood–brain barrier integrity and by inducing local inflammation. However, the role of IL17A in autoimmune thyroid disease is still debatable.The aim of our study was to estimate immunoexpression of IL-17A in the thyroid tissue of patients with...