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18th European Congress of Endocrinology

Oral Communications

Diabetes prediction & complications

ea0041oc3.1 | Diabetes prediction & complications | ECE2016

Identification of a spliceosome-associated fingerprint with potential to predict development of type 2 diabetes in high-risk patients

Luque Raul M. , Gahete Manuel D. , Rio-Moreno Mercedes del , Pedraza-Arevalo Sergio , Camargo Antonio , Delgado-Lista Javier , Gracia-Navarro Francisco , Perez-Jimenez Francisco , Lopez-Miranda Jose , Castano Justo P.

Prevalence of metabolic syndrome (MetS) and type-2 Diabetes (T2D) is growing dramatically worldwide. Loss of phenotypic flexibility, i.e. the difficulty to cope with different stressors to maintain metabolic homeostasis, contributes critically to the development of MetS/T2DM. Thus, it is essential to identify the key modifiers of phenotypic plasticity that define an individual’s susceptibility to develop T2DM. In this scenario, emerging evidence indicates that, under adve...

ea0041oc3.2 | Diabetes prediction & complications | ECE2016

Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6

Timper Katharina , Dalmas Elise , Dror Erez , Rutti Sabine , Thienel Constanze , Sauter Nadine S. , Bouzakri Karim , Bedat Benoit , Pattou Francois , Kerr-Conte Julie , Boni-Schnetzler Marianne , Donath Marc Y.

Introduction: Glucose-dependent insulinotropic peptide (GIP) induces the cytokine interleukin (IL)-6 in adipocytes. IL-6 enhances insulin secretion from β-cells via L- and α-cell-derived GLP-1.Therefore we hypothesized that GIP regulates Glucagon-like peptide (GLP)-1 as well as glucose control via IL-6.Methods/Design: Basic research study on isolated human and mouse pancreatic islets and FACS-sorted human α-and β-cells that were treat...

ea0041oc3.3 | Diabetes prediction & complications | ECE2016

Reproducibility of fasting and oral glucose tolerance test derived parameters of glucose metabolism in non-diabetic postmenopausal women.

Van de Velde Frederique , Dierickx Anneloor , Depypere Herman , Delanghe Joris , Kaufman Jean-Marc , Lapauw Bruno

Introduction: Given the importance of establishing a reliable diagnosis of impaired glucose metabolism and diabetes mellitus (DM), knowledge on accurate and reproducible parameters is needed. However, little is known on the reproducibility of fasting and oral glucose tolerance test (OGTT) derived parameters, especially with respect to the 2-hour derived parameters.Objectives: To determine reproducibility of parameters of glucose metabolism in a non-diabe...

ea0041oc3.4 | Diabetes prediction & complications | ECE2016

Association of neutrophil to lymphocyte ratio with vitamin D levels in type 2 diabetes mellitus

Atile Neslihan Soysal , Yavaş Rıfat , Bilir Betul Ekiz , Bilir Bulent

Introduction: Increased neutrophil to lymphocyte ratio (NLR) is an inflammatory marker and an indicator of cardiovascular risk. Recent studies demonstrated that the NLR values of the diabetic patients were significantly higher than the healthy controls. Vitamin D (25OHD) deficiency has been associated with diabetes mellitus and cardiovascular diseases. Studies established a significant negative correlation between 25(OH)D and HbA1c levels. Aim of this study is to evaluate the ...

ea0041oc3.5 | Diabetes prediction & complications | ECE2016

Improvement in diabetic neuropathy after metabolic surgery a comprehensive electrophysiological follow up study

Cagiltay Eylem , Celik Alper , Uzun Nurten Adatepe , Sonkaya Riza , Ugale Surendra , Kayadibi Ayca , Zengin Gulsum , Buyukbozkirli Deniz , Adatepe Turgut , Ertas Mustafa

Aim: In the present study, we aimed to analyze the incidence of diabetic neuropathy (DN) via electrophysiological testing of type 2 diabetes mellitus (T2DM) patients scheduled for laparoscopic diverted sleeve gastrectomy with ileal transposition (DSIT). At a mean of 8 months after surgery, the electrophysiological tests were repeated and differences in electrophysiological parameters were evaluated to investigate the effects of the operation on outcomes related to diabetic neu...