Endocrine Abstracts

Introduction: Recently, it has been suggested that thyrotropin (TSH) concentration can be used as a marker for prediction of thyroid malignancy. However, the association between the cytology results and TSH levels is not clear. In this study, we aimed to investigate the relationship between TSH levels and Bethesda categories and determine the role of TSH levels in prediction of malignancy in patients with different Bethesda categories.Methods: The data o...

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

Introduction: Subclinical hypothyroidism (SCH) is a common condition and can lead to impaired systolic and diastolic cardiac function. However, controversy remains over the potential benefits of levothyroxine substitution in patients with SCH and concomitant heart disease. We aimed to examine the effects of levothyroxine treatment on all-cause mortality in patients diagnosed with SCH and heart disease.Methods: Primary care patients aged 18 years and olde...

Introduction: Graves’ thyrotoxicosis has been known to affect other organ systems in the body including the liver. However, severe hepatitis in this clinical context is quite rare.Case report: We report a 55-year-old man who presented with marked weight loss and jaundice. In addition, he had a diffuse goitre with fine tremors in the hands. Laboratory work-up revealed thyrotoxicosis with FT4 of 87.9 pmol/l and TSH of <0.01 mIU/l. He ha...

Introduction: Strong association between pathogenesis of autoimmunity and bacterial infection particularly Helicobacter pylori (H.pylori) had been observed in numerous studies. Nevertheless the possible role of H.pylori in progression of autoimmune thyroid disease is still discussed.The aim of the study was to reveal the relation between Hashimoto thyroiditis (HT) and presence of H.pylori as well as to analyze the impact of eradication therapy on level o...

Introduction: Thyroid dysfunction affects quality of life (QoL) in untreated patients. However, patients with high thyroid autoantibodies complain about symptoms that resemble thyroid dysfunction even if they are euthyroid. The aim of this study was to evaluate QoL in euthyroid patients with elevated thyroid autoantibodies.Methods: Patients who admitted to Endocrinology clinic with symptoms of thyroid dysfunction and no other disease were included in the...

Introduction: The aim of the study was to assess the function and immunogenicity of thyroid gland of patients undergoing chronic treatment with the opiate agonist Methadone.Material and methods: Cross-sectional, observational study included patients from 18 to 40 years of age undergoing chronic treatment with Methadone for at least 6 months. A total of 176 participants took part in the study. 140 patients were from five clinical programs in Bulgaria and ...

Introduction: Immune checkpoint inhibitors (ICI) are a new drug generation used for advanced neoplasias. They are monoclonal antibodies which enhance the immune system to combat cancer cells. As a result, immunologic tolerance can be altered and autoimmunity triggered. Toxicities associated to ICIs have been named immune-related adverse events (irAE). ‘Time to resolution’ of endocrine irAEs have not been well described as this term has not been defined in clinical tr...

Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistanc...

Introduction: Th17 cells and their hallmark cytokine IL-17A were reported to be involved in the development of autoimmune orchitis and encephalomyelitis by impairing the integrity of the blood–testis and blood–brain barrier integrity and by inducing local inflammation. However, the role of IL17A in autoimmune thyroid disease is still debatable.The aim of our study was to estimate immunoexpression of IL-17A in the thyroid tissue of patients with...