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Endocrine Abstracts (2016) 41 EP171 | DOI: 10.1530/endoabs.41.EP171

Calcium and Vitamin D metabolism

The association between vitamin D deficiency and urinary tract infection in postmenopausal women

Vesna Cosic1, Blazenka Miskic2,3 & Karla Miskic4

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1Policlinic Cosic, Slavonski Brod, Croatia; 2Medical Faculty Osijek, University of Josip Juraj Strossmajer Osijek, Slavonski Brod, Osijek, Croatia; 3Endocrinology Department of General Hospital Dr J.Bencevic, Slavonski Brod, Osijek, Croatia; 4Medical Faculty Rijeka, Study of Dental Medicine Rijeka, Rijeka, Croatia.


Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and silent urinary tract infection (UTI) among postmenopausal women.

Methods: Age, postmenopausal period, BMI, white blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, serum 25(OH)D3 levels and native urin speicemens were measured in 124 postmenopausal women without signs of UTI, on regular gynecological checking.

Results: A total of 124 women average age of 53.4, with period of 3.5 year after last menstruation were included, 66 had UTI and they were symptom free, other 58 had normal urine. The mean serum levels of 25(OH)D3 among woman with UTI were significantly lower than those of controls (26.7±3.1 vs 36.59±4.2 nmol/l; P<0.001). The serum levels of 25(OH)D3 were significantly lower in patients with UTI compared to patients without (21.4±2.6 vs 31.9±2.9 nmol/l; P<0.001). Within the study group, mean serum levels of 25(OH)D3 among women with greater BMI >30.0 kg/m2 were lower than those of under it (21.8±3.7 nmol/l vs 32.7±4.8 nmol/l; P<0.001). Multivariate analysis showed that the BMI did not correlate with UTI.

Conclusions: Our results suggest that vitamin D deficiency may be a risk factor for UTI in postmenopausal women.

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