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18th European Congress of Endocrinology

Eposter Presentations

Calcium and Vitamin D metabolism

ea0041ep135 | Calcium and Vitamin D metabolism | ECE2016

From pseudohypoparathyroidism to inactivating PTH/PTHrP signaling disorder (iPPSD), a novel classification proposed by the European EuroPHP-network

Thiele Susanne , Mantovani Giovanna , Barlier Anne , Boldrin Valentina , Bordogna Paolo , Elli Francesca , Freson Kathleen , Garin Intza , Hanna Patrick , Izzi Benedetta , Hiort Olaf , Lecumberri Beatriz , Pereda Arrate , De Sanctis Luisa , Saraff Vrinda , Turan Serap , Usardi Alessia , Werner Ralf , de Nanclares Guiomar Perez , Linglart Agnes

Background: Disorders caused by impairments in the parathyroid hormone (PTH) signaling pathway are historically classified under the term pseudohypoparathyroidism (PHP), that encompasses rare, related but highly heterogeneous diseases with demonstrated (epi)genetic causes. The actual classification is based on the presence or absence of specific clinical and biochemical signs together with an in vivo response to exogenous PTH and the results of an in vitro as...

ea0041ep136 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D deficiency in pregnancy associates with increased emotional and behavioral problems at preschool age: the Rhea pregnancy cohort, Crete, Greece

Daraki Vasiliki , Roumeliotaki Theano , Chalkiadaki Georgia , Margioris Andrew , Koutra Katerina , Katrinaki Marianna , Kyriklaki Andriani , Kampouri Mariza , Papavasiliou Stathis , Kogevinas Manolis , Chatzi Leda

Background and aims: Vitamin D deficiency during the perinatal period has been hypothesized to increase risk for several psychiatric disorders in humans. As newborn vitamin D levels are entirely dependent on maternal vitamin D status, vitamin D deficiency in utero may leave the infant vulnerable to cognitive defects and behavioral problems. Few human studies have examined these associations with inconclusive results. We aimed to investigate the associations of maternal 25-hydr...

ea0041ep137 | Calcium and Vitamin D metabolism | ECE2016

Mass Spectrometry coupled with liquid chromatography (HPLC-MS-MS) levels of 25-hydroxy vitamin D (25OHVitD) are associated with prognostic markers of Heart Failure

Saponaro Federica , Saba Alessandro , Frascarelli Sabina , Marcocci Claudio , Cetani Filomena , Passino Claudio , Zucchi Riccardo

Introduction and aims: Heart failure (HF) is a health problem with poor prognosis, despite many treatments available. Vitamin D is the pre-hormone of the active calcitriol (1,25(OH)2D3). It is involved in bone homeostasis, but recent studies suggest extraskeletal functions, including pleiotropic effects on cardiovascular system and a relationship between low levels of 25OHvitamin D and worse HF prognosis. The aims of the study were: 1) to define 25OH-D levels in the HF populat...

ea0041ep138 | Calcium and Vitamin D metabolism | ECE2016

Increasing incidence of parathyroid carcinoma – a nationwide study

Ryhanen Eeva M , Leijon Helena , Metso Saara , Eloranta Eija , Korsoff Pirkko , Niskanen Leo , Ahtiainen Petteri , Kekalainen Paivi , Tamminen Marjo , Ristamaki Raija , Knutar Otto , Loyttyniemi Eliisa , Heiskanen Ilkka , Valimaki Matti J. , Haglund Caj , Arola Johanna , Schalin-Jantti Camilla

Introduction and design: Parathyroid carcinoma (PC) is a rare endocrine malignancy and the diagnosis is difficult. As the incidence seems to be increasing, we examined all cases diagnosed in our country during years 2000–2011 and compared the results to those of atypical parathyroid (AA; n=28) and parathyroid adenomas (A; n=72). All tissue specimens were re-examined.Results: In 2000–2011, 32 patients were diagnosed with PC in ...

ea0041ep140 | Calcium and Vitamin D metabolism | ECE2016

Familial hypocalciuric hypercalcemia secondary to a novel mutation causing severe hypercalcemia

Shrikrishna Natasha , Mohamed Syuhada , Middleton Maeve , Wong Stephen

Introduction: Familial Hypocalciuric Hypercalcemia (FHH) is a benign autosomal dominant condition caused by an inactivating mutation on the gene coding for the Calcium Sensing Receptor (CASR). CASR plays a role in regulating parathyroid secretion and calcium metabolism. The majority of adults with FHH are asymptomatic. This is a case of three young brothers whose genetic tests shows two mutations in each of their CASR gene leading to hypercalcemia and varying symptoms.<p c...

ea0041ep141 | Calcium and Vitamin D metabolism | ECE2016

Idiopathic infantile hypercalcemia: presenting in childhood, diagnosed in adulthood – case report

Silvestre Catarina , Paixao Raquel , Aragues Jose Maria , Guerra Silvia , Mascarenhas Mario

Introduction: Hypercalcemia can be caused by a variety of pathologies/factors. Vitamin D plays a central role in calcium homeostasis, where a tight control of its metabolism is necessary. Inadequate 24-hydroxylase-enzime (CYP24A1) activity leads to failure of 25-hydroxyvitamin and 1,25-dihydroxy-vitamin D3 inactivation, resulting in hypercalcemia.Case report: An asymptomatic, 22-year-old woman was admitted in an Endocrinology appointment for evaluation o...

ea0041ep142 | Calcium and Vitamin D metabolism | ECE2016

Atypical cases of familial hypocalciuric hypercalcemia: utility of genetic testing in the diagnosis

Garcia Fernando , de Pinillos Guillermo Martinez , Tome Mariana , Fernandez Ignacio , Fernandez Ignacio , Cuellar Eyvee Arturo , Romero Jose Alvaro , de Quiros Juan Manuel Garcia , Cozar Maria Victoria

Introduction: Familial hypocalciuric hypercalcemia (FHH) has been classically characterized as an asymptomatic disease with mild hypercalcemia, hypocalciuria and inappropriately normal or high serum PTH concentration. The aim of our study is to assess the utility of genetic testing in patients with suspected FHH with atypical clinical manifestations, and the validity of classical biochemical parameters for the diagnosis.Description of methods: A retrospe...

ea0041ep143 | Calcium and Vitamin D metabolism | ECE2016

Sensitivity of localization studies performed by various radiologists whom are not precisely experienced in the evaluation parathyroid lesions

Sisman Pinar , Gul Ozen Oz , Demirtas Coskun , Muti Aybuke , Elbasan Onur , Saraydaroglu Ozlem , Cander Soner , Ersoy Canan , Erturk Erdinc

Objectives: Preoperative imaging studies are being commonly used in primary hyperparathyroid patients to increase cure rate and to decrease complication rate of surgery. In this study we correlated the surgical outcomes with localization studies performed by various radiologists.Method: A total of 174 patients with primary hyperparathyroidism in which healing of hypercalcemia achieved by parathyroidectomy were evaluated retrospectively. Since our hospita...

ea0041ep144 | Calcium and Vitamin D metabolism | ECE2016

Bone mineral density is associated with hypercalciuria in primary hyperparathyroidism

Yavuz Dilek Gogas , Tekin Bahar , Buket Bayram F. , Melin Uygur M.

Aim: The most common clinical presentation of primary hyperparathyroidism (PHPT) is asymptomatıc and it is diagnosed incidentally without developing complications.In our study, we aimed to examine the characteristics of participants with primary hyperparathyroidism and the relationship between bone mineral density (BMD) and hypercalciuria.Methods: Consecutive 191 normocalciuric (24-h urinary calcium<400 mg/day) patients with PHPT (51±13 yea...

ea0041ep145 | Calcium and Vitamin D metabolism | ECE2016

Bone mineral density measurement in newly diagnosed primary hyperparathyroidism patients

Tekin Bahar , Melin Uygur M. , Buket Bayram F. , Yavuz Dilek Gogas

Aim: Clinical presentation of primary hyperparathyroidism (PHPT) differs between populations. In this study, we aimed to examine bone mineral density (BMD) and bone metabolism parameters in newly diagnosed and untreated PHPT patients in a single endocrine center in İstanbul, Turkey.Methods: Consecutive 256 PHPT patients (50.7±14 years, F/M:205/51) and 89 healthy controls (38.8±10 years, F/M:67/22) were included in the study. Serum calcium...

ea0041ep146 | Calcium and Vitamin D metabolism | ECE2016

Serum calcium to phosphorous ratio (Ca/P) as a simple, inexpensive screening tool in the diagnosis of primary hyperparathyroidism (PHPT)

Madeo Bruno , Kara Elda , Cioni Katia , Vezzani Silvia , Simoni Manuela , Rochira Vincenzo

Background: PHPT is often overlooked/underdiagnosed. Several strategies (biochemical markers alone or combined in complex algorithms) have been investigated to easily diagnose/screen PHPT, but PHPT diagnosis remains challenging at present, especially in asymptomatic patients. As serum calcium (Ca) and phosphorous (P) are inversely related in PHPT, the Ca/P ratio could be a good candidate tool for PHPT diagnosis. Surprisingly, no literature data on Ca/P ratio are available, des...

ea0041ep147 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D status in infants during the first 9 months of age and its effect on growth and other biochemical markers: a prospective cohort study

Gutch Manish , Mandal Uday , Kumar Sukriti

Background: We planned this prospective cohort study in term newborn babies, with the objective to determine the incidence of vitamin D deficiency in infancy and to determine the level of vitamin D which triggers the physiological PTH axis of the body so as to differentiate truly deficient from sufficient vitamin D status.Methods: 96 participants at birth were enrolled and followed up till 9 months of age. Serum 25OHD was estimated in cord blood at birth...

ea0041ep148 | Calcium and Vitamin D metabolism | ECE2016

New onset of epileptic seizures induced by Fahr’s syndrome secondary to idiopatic hypoparathyroidism

Silaghi Cristina Alina , Georgescu Carmen Emanuela , Ghervan Cristina , Valea Ana , Irimia Ramona , Cosma Daniel Tudor , Petrus Sanda , Filip Alina , Silaghi Horatiu , Tibre Vasile

Hypocalcemia due to hypoparathyroidism leads to a large spectrum of clinical manifestations but a rare and unusual presentation is onset or aggravation of epilepsy.We report a 77-year-old man who was found to have profound hypocalcaemia and idiopatic hypoparathyroidism when investigated for epileptic seizures. He had affective disturbances and only mild neurocognitive disorders. Cataract was present. The neurological examination showed an extrapyramidal ...

ea0041ep149 | Calcium and Vitamin D metabolism | ECE2016

Investigation of vitamin D deficiency in autoimmune endocrine disease in terms of frequency and causal or consequential relationship

Kocaeli Aysen Akkurt , Sisman Pinar , Cander Soner , Gul Ozen Oz , Ersoy Canan , Erturk Erdinc

Introduction: Vitamin D Deficiency has been widely regarded as contributing to autoimmune disease, but low levels of vitamin D in patients with autoimmune disease may be a result rather than a cause like from malabsorbtion due to celiac disease, gastrointestinal disorders related to diabetes or thyroid disease, corticosteroid therapy complications etc\..In this study, we aimed to investigate vitamin d levels in autoimmune endocrine disorders and relationship with silent celiac...

ea0041ep150 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D status in a HIV-infected cohort from south of Spain: descriptive analysis

Mateos Carolina Garcia-Figueras , Blanco Manuel Cayon , Herrera Patricia Bancalero , Pernia Alberto Terron

Introduction: Vitamin D deficiency is common among people living with HIV worldwide. There is a lack of studies focusing on prevalence and consequences of low levels of vitamin D in our health care area (south of Spain). The main aim of this study is to know the status of vitamin D and its consequences on parameters related to calcium metabolism in a cohort of patients with HIV infection in our area.Methods/Design: Cross-sectional study encompassing HIV-...

ea0041ep151 | Calcium and Vitamin D metabolism | ECE2016

Metabolic changes in vitamin D deficiency

Rozhinskaya Ludmila , Petrushkina Alexandra , Pigarova Ekaterina , Tarasova Tatyana , Ilyin Alexander

Introduction: The improvement of vitamin D status is necessary to overcome an impaired calcium-phosphorus metabolism and disturbances in other tissues functioning; safety of medical intervention should include analysis of metabolic changes.Material and methods: Twenty four apparently healthy volunteers 24.9±2 year were included in the study: Group 1 (11/24) with blood serum levels of 25(OH)D <10 ng/ml and Group 2 (13/24) with 25(OH)D levels 10&#...

ea0041ep152 | Calcium and Vitamin D metabolism | ECE2016

Calcium as a marker of metabolic decompensation in glycogen storage disease type-1a

Sendur Suleyman Nahit , Unluturk Ugur , Dagdelen Selcuk

Introduction: Glycogen storage disease type 1a (GSD1a) is an inborn error of metabolism with several metabolic decompensations including anaerobic glycolysis and lactic acidosis but few known about GSD1a-related hypercalcemia. Here we aimed to present a putative relationship between serum Ca and the affected metabolic parameters during metabolic decompensation of GSD1a.Case report: Two patients with GSD1a and hypercalcemia were retrospectively analyzed. ...

ea0041ep153 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D3 deficiency and secondary hyperparathyroidism development in patients with different stages of chronic kidney disease

Karlovich Natalia

The aim was to estimate Vitamin D3 (25OHD) level and it’s relation to secondary hyperparathyroidism (SHPT) development in patients with different stages of chronic kidney disease (CKD).We examined 114 patients, 71 f, 43 m; age 44.6±14.3 years. CKD stage was defined by estimated glomerular filtration rate (eGFR) calculated by MDRD formula. 48 patients have CKD stage 1–2, 26 pts – CKD3, 27 pts – CKD4, 13 pts – CKD5 (not on dia...

ea0041ep155 | Calcium and Vitamin D metabolism | ECE2016

Biochemical and hormonal alterations in women who underwent total thyroidectomy

Kakava Kassiani , Tournis Symeon , Papadakis Georgios , Karelas Ioannis , Stampouloglou Pavlos , Kassi Evanthia , Triantafillopoulos Ioannis , Karatzas Theodoros , Villiotou Vassiliki , Dogkas Nikolaos , Sarov Pavlos , Tassopoulos Georgios , Petridis Nikolaos

Introduction: Postsurgical hypoparathyroidism, (postHypoP), is a common complication of total thyroidectomy. We studied the variation of biochemical and hormonal parameters in patients who underwent total thyroidectomy.Design: The study included 106 females of a mean age (±S.D.) 51.03 (±13.42) years who underwent total thyroidectomy for multinodular goiter. We estimated the value of 25(OH)vitD, PTH, CT, adjusted Ca, P, and alkali...

ea0041ep156 | Calcium and Vitamin D metabolism | ECE2016

Association of serum calcium concentrations with fibrinogen and homocysteine in non-diabetic Korean subjects

Kim Eun Sook , Moon Sung Dae , Han Je Ho

Objectives: Considerable evidence shows that increased serum calcium levels are associated with metabolic disorders, cardiovascular disease and increased mortality. This study investigated whether serum calcium, within a normal range, is significantly associated with serum fibrinogen and homocysteine, markers of increased cardiovascular disease risk in non-diabetic Korean subjects.Methods: A cross-sectional analysis was performed on 1096 subjects (mean a...

ea0041ep157 | Calcium and Vitamin D metabolism | ECE2016

Bone mineral density in postmenopausal women with high levels of parathyroid hormone

Esen Irfan , Esen Selin Akturk , Cander Soner , Gul Ozen Oz , Erturk Erdinc

One of the main problems encountered with increased levels of serum PTH is decrease in bone mineral density in the long term. Secondary hyperparathyroidism due to vitamin D deficiency leads to mineralization disorders of the bones, low bone mineral density, osteoporosis and ultimately an increased risk of bone fracture in adults. In this study, we aimed to determine the reasons of secondary hyperparathyroidism for bone mineral density.One hundred and thi...

ea0041ep158 | Calcium and Vitamin D metabolism | ECE2016

Investigation of interference with binding proteins in two commonly used 25-hydroxyvitamin D assays

Toldy Erzsebet , Viragh Eva , Horvath Dora Eszter , Kovacs Laszlo , Kovacs Eniko Andrea , Lakatos Peter , Locsei Zoltan

Background: Adequate vitamin D supply is necessary for bone metabolism and also for the general maintenance of health. 25OHD is transported primarily bound to vitamin-D binding protein (DBP), but also to albumin. Lower concentration of plasma proteins may cause difficulties in immunoanalytics. Our aim was to investigate the protein dependence of the two most often used 25OHD immuno- (CLIA) and protein binding- (ECLPBA) assays.Methods: levels were measure...

ea0041ep160 | Calcium and Vitamin D metabolism | ECE2016

The relationship between serum vitamin D levels and metabolic syndrome in obese children and adolescents

Aydogan Seda , Onder Asan , Aycan Zehra

Objective: Obesity and vitamin D deficiency are become most important public health problems independently. We aimed to investigate the relationship between vitamin D levels and metabolic sydrome (MetS) in obese children and adolescents.Patients and methods: 51 obese children/adolescents at the age of 12.4±2.73 (7.0–18.0) years and 48 age–sex matched healthy controls were enrolled. Serum 25 OHD, 1,25 (OH)2 D, calcium, phosphorus, alkal...

ea0041ep161 | Calcium and Vitamin D metabolism | ECE2016

Evaluation the relationship between subclinical hypothyroidism and vitamin D level

Gungormez Nergis , Ahbab Suleyman , Ataoglu Esra , Turker Betul Cavusoglu , Cakir Evrim , Yenigun Mustafa

Background: Subclinical hypothyroidism is a thyroid disease which encountered in practice, commonly. Thyroid hormones affect metabolic syndrome parameters including HDL cholesterol, triglycerides, plasma glucose levels, blood pressure and abdominal obesity. Furthermore; there have been growing evidences about the relationship between vitamin D deficiency and autoimmune thyroid diseases. Therefore; we aimed to evaluate the association between the metabolic parameters and 25-OH-...

ea0041ep162 | Calcium and Vitamin D metabolism | ECE2016

Correlation of serum vitamin D level with mortality in patients with sepsis

Kumar Sukriti , Gutch Manish

Background: Sepsis is the leading cause of mortality in the critically ill. Recent studies emphasize early classification and treatment is paramount to improving mortality rates. Recently it has been found in many studies that many trace elements and nutrients do have effect on human body and if supplemented can improve the prognosis in patients with sepsis.Aim and objectives: primary objective: Whether low vitamin D is associated with mortality.<p c...

ea0041ep163 | Calcium and Vitamin D metabolism | ECE2016

The relationship of Beck depression inventory with vitamin D levels and visceral fat mass in cancer patients

Tuna Savas , Mert Meral , Soyluk Ozlem , Okuturlar Yildiz , Tastekin Didem , Kocoglu Hakan

Introduction: The aim of this study is to determine the relationship of Beck Depression Inventory (BDI) with vitamin D levels and total and visceral fat mass in cancer patients.Methods: A total of 219 patients were included in the study. All patients underwent blood tests including prealbumin, vitamin D. Also patients’ BMI values were calculated and total and visceral fat masses of all patients were measured by bio-impedance analyzer. All subjects c...

ea0041ep164 | Calcium and Vitamin D metabolism | ECE2016

4D-CT parathyroid increases the likelihood of localising parathyroid adenoma in patients with primary hyperparathyroidism and indeterminate Tc99m-Sestamibi+I-123 subtraction scan

Lee Brian , Pandit Manish , Basu Ansu

Introduction: Tc99m-Sestamibi+I-123 subtraction using planar and SPECT-CT is commonly used to investigate PHPT. Our centre previously published sensitivity and specificity of 92 and 86% respectively for Tc99m-Sestamibi+I-123 subtraction. Five false-negative studies required neck exploratory surgery. One false-positive study incorrectly localised a PA which was not found in surgery (n=67). In recent years 4D-CT parathyroid has emerged as a useful technique to detect an...

ea0041ep165 | Calcium and Vitamin D metabolism | ECE2016

BMI but not visceral adiposity index is related to vitamin D levels in overweight HIV-patients

Blanco Manuel Cayon , Mateos Carolina Garcia-Figueras , Herrera Patricia Bancalero , Pernia Alberto Terron

Introduction: Several studies have shown that BMI and visceral adiposity index (VAI) are inversely related to serum 25-hydroxy vitamin D (25OHD) in general population. There is a lack of studies performed in HIV population, whose body fat distribution is altered by lipodystrophy or liver disease. We aimed to analyze the cross-sectional associations of VAI and BMI with the 25OHD concentration and parameters related to calcium-phosphorus metabolism in HIV-infected patients.<...

ea0041ep166 | Calcium and Vitamin D metabolism | ECE2016

Hypoparathyroidism and difficult to control hypocalcemia

Alkaabi Fatima M , Almazrouei Raya A , Aldahmani Khaled M , Gayar Heba El

Introduction: Autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive disorder characterized by autoimmune multiorgan attack. Clinical manifestations are widely variable. Treatment is based on supplementation of the various deficiencies and the prognosis is variable.Case: An 18-year-old female presented with nail dystrophy and candida infection at age 7. Then, she was diagnosed with primary hyporparathyroidism and Addison’s di...

ea0041ep167 | Calcium and Vitamin D metabolism | ECE2016

Adult iatrogenic hypoparathyroidism therapy: between less and more

Terec Adina , Morar Andra , Carsote Mara , Pop Dan Dumitru , Georgescu Carmen Emanuela , Valea Ana

Introduction: The hypoparathyroidism (HypoPT) represents a rare condition characterized by low calcium (Ca) and parathyroid hormone (PTH) levels, frequently due to thyroid surgery by direct trauma of the parathyroid glands, devascularization, or their accidental removal. Postoperative hypoparathyroidism-related hypocalcemia may be permanent or transient.Case report: We report the case of a 64-year-old man presenting with severe symptoms of hypocalcemia (...

ea0041ep168 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D deficiency is highly prevalent in obesity and is related with BMI and inflammation

Fernandez-Garcia Jose Carlos , Cardona-Diaz Fernando , Cortes-Salazar Carmen Maria , Asenjo-Plaza Maite , Ruiz Maria Concepcion Garcia , Varea-Marineto Enrique , Banderas-Donaire Maria Jose , Alcaide-Torres Juan , Queipo-Ortuno Maria Isabel , Moreno-Indias Isabel , Clemente-Postigo Mercedes , Castellano-Castillo Daniel , Tinahones Francisco

Objectives: To study vitamin D deficiency in a cohort of obese males and to evaluate associated clinical and biochemical characteristics.Methods: Case-control study which included obese (defined by a BMI ≥30 kg/m2) males. Vitamin D deficiency was defined as vitamin D levels <20 ng/ml. Estimation of vitamin D status was determined in serum using a commercially available enzyme- immuno-assay designed to measure 25-OH Vitamin D concentr...

ea0041ep169 | Calcium and Vitamin D metabolism | ECE2016

25-hydroxy vitamin D levels in patients with newly diagnosed of cancer

Boj-Carceller Diana , Llorente-Barrio Monica , Perez-Fernandez Leticia , Azcona-Monreal Isabel , Lardies-Sanchez Beatriz , Sanz-Paris Alejandro

Introduction: Recent studies have pointed out a possible role of vitamin D in carcinogenesis. Vitamin D deficiency may be related to a major cancer incidence and mortality. This association would be more relevant for breast and colorectal cancer. Obesity acts as a risk factor for these type of neoplasms on which vitamin D could influence.Subjects and methods: A cross-sectional study of consecutive out-patients with newly diagnosed cancer: urological, col...

ea0041ep170 | Calcium and Vitamin D metabolism | ECE2016

Correlations among calf circumference index, selected anthropometric and biochemical parameters among patients over 60 years

Nowak Justyna , Kulik-Kupka Karolina , Bronczyk-Puzon Anna , Koszowska Aneta , Jagielski Pawel , Korzonek-Szlacheta Ilona , Zubelewicz-Szkodzinska Barbara

Introduction: Anthropometric parameters are easy and quickly methods of assess risks of many diseases.Aim: The purpose of this study was to assess the correlation between calf circumference index, selected anthropometric (such as BMI, BAI, WHR, WHtR index) and biochemical parameters (such as concentration of 25(OH)D3, lipid profile, fasting glucose) among patients over 60 years.Materials and methods: Cross-sectional study was done ...

ea0041ep171 | Calcium and Vitamin D metabolism | ECE2016

The association between vitamin D deficiency and urinary tract infection in postmenopausal women

Cosic Vesna , Miskic Blazenka , Miskic Karla

Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D3] and silent urinary tract infection (UTI) among postmenopausal women.Methods: Age, postmenopausal period, BMI, white blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, serum 25(OH)D3 levels and native urin speicemens were measured in 124 postmenopausal women without signs of UTI, on regular gyne...

ea0041ep172 | Calcium and Vitamin D metabolism | ECE2016

Roux-en-Y Gastric Bypass reversal due to recalcitrant hypocalcaemia after total thyroidectomy

Silva Joao , Ivo Catarina , Simoes Helder , Lopes Luis , Passos Dolores , Marcelino Mafalda , de Castro Joao Jacome

Introduction: Hypocalcaemia is a potential post-thyroidectomy complication. Patients with previous Roux-en-Y Gastric Bypass (RYGBP) are at increased risk of symptomatic hypocalcaemia refractory to treatment. This complication is rare and there is not consensus on how to act.Clinic case: Female with 34 years old, with a history of Obesity (BMI 45.7 kg/m2), submitted to RYGBP in 2013, with a total loss of 47 kg (current BMI 27.3 kg/m2...

ea0041ep173 | Calcium and Vitamin D metabolism | ECE2016

Evaluation of renin-angiotensin-aldosterone system in patients with asymptomatic primary hyperparathyroidism

Arslan Emre , Altinova Alev Eroglu , Yilmaz Banu Aktas , Akturk Mujde , Yetkin Ilhan , Arslan Metin , Toruner Fusun

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

ea0041ep174 | Calcium and Vitamin D metabolism | ECE2016

Vitamin D status among women living in a sunny region: Marrakesh study

Baki Salwa , Harkati Imane , Tali Abdelali , El Mghari Ghizlane , chabaa Leila , El Ansari Nawal

Background: Hypovitaminosis D is associated with poor dietary intake and inadequate sunshine exposure. It is common worldwide. However, recent studies has shown a high prevalence of hypovitaminosis D in Moroccan population.Objective: We undertook this study to determine the specific prevalence of hypovitaminosis and its relationship to metabolic parameters in pre-menopausal women living in a sunny region.Methods: The group studied ...

ea0041ep175 | Calcium and Vitamin D metabolism | ECE2016

Severe hungry bone syndrome after incidental parathyroidectomy in hypophosphatemic rickets

Cardoso Luis , Paiva Isabel , Rodrigues Dircea , Guelho Daniela , Vicente Nuno , Balsa Margarida , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Carrilho Francisco

Introduction: Hypophostemic rickets is characterized by phosphate renal loss associated with a primary defect of osteoblasts and metabolism of vitamin D. Marked bone turnover caused by high levels of parathyroid hormone attribute to these patients an elevated risk for hungry bone syndrome after parathyroidectomy.Case report: A 34-years old woman with a past history of Lynch syndrome and hypophostemic rickets associated with hyperparathyroidism and brown ...

ea0041ep176 | Calcium and Vitamin D metabolism | ECE2016

Primary hyperparathyroidism detected in a patient undergoing two prior thyroidectomies for follicular thyroid carcinoma: a case report

Elbuken Gulsah , Gulciftci-Dagci Zehra , Ozcaglayan Omer , Tonbul Ayse Tuba , Atile Neslihan Soysal , Zuhur Sayid

Introduction: Primary hyperparathyroidism (PHPT) is usually characterized by overproduction of parathormone (PTH) due to a solitary parathyroid adenoma. Its treatment involves surgical removal of the solitary adenoma or hyperplastic parathyroid glands that secrete PTH. Medical treatment options are used for patients with conditions that preclude surgical operation.Case presentation: A 57-year-old female patient underwent left total and right subtotal thy...

ea0041ep177 | Calcium and Vitamin D metabolism | ECE2016

Calcium and vitamin D metabolism among patients with excess of weight of a docent clinic in Salvador-Ba

de Lourdes Souza E Silva Maria , Rodrigues Jamille , Carvalho Minna

Introduction: Hypovitaminosis D is a biochemical change with high prevalence among the population, especially in obese patients. Its function more known relates to bones metabolism, although recently, many functions have been described.Methods: A descriptive cross-sectional study, which included women over 18 years old with BMI equal or superior of 25 kg/m2. Anthropometric measurements were obtained: weight, height, BMI, waist circumference, h...

ea0041ep178 | Calcium and Vitamin D metabolism | ECE2016

A Rare Case of Intracranial Calcification: Fahr Disease

Yilmaz Merve , Tanrivermis Asli , Kehribar Demet Yalcin , Akdemir Neslihan Unal , Karadas Adnan , Akyol Ozkan

Introduction: Fahr disease, is a rare pathology characterized by neuropsychiatric symptoms and bilateral symmetrical intracranial, especially basal ganglial calcifications. Although the exact etiology is not known, it is often associated with calcium and phosphorus metabolism disorders. We aim to present two brothers who presented with Fahr’s disease which is a rare condition.Case: Sixty-year-old male patient without a medical history of ilness was ...

ea0041ep179 | Calcium and Vitamin D metabolism | ECE2016

Giant-cell tumor: hyperparathyroidisme is not always involved – a case report

Saad Ghada , Dendana Emna , Hasni Yosra , Kacem Maha , Maaroufi Amel , Chadli Molka , Ach Kousay

Giant-cell tumor is a skeletal disorder that occurs secondarily to hyperparathyroidism and is caused by long-term stimulation of parathyroid hormone (PTH) excess. The overactivity and proliferation of osteoclasts stimulated by PTH breaks down bone and leads to replacement of bone matrix and thinning of the cortex. True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.We report the case of a 47 yea...

ea0041ep180 | Calcium and Vitamin D metabolism | ECE2016

Which social factors that may be associated with high parathyroid hormon levels in postmenapausal women?

Esen Irfan , Esen Selin Akturk , Cander Soner , Gul Ozen Oz , Erturk Erdinc

In this study, we aimed to investigate the causes of elevated PTH levels in postmenopausal women without the use of drugs that may affect of PTH levels and without concomitant diseases.A total of 156 postmenopausal women, aged ≥ 50 years, had no menstruation for at least 2 years and had no disease known to affect calcium metabolism were considered. Education, occupation, average duration of exposure to sunlight per day in summer and winter, consump...

ea0041ep181 | Calcium and Vitamin D metabolism | ECE2016

Mean platelet volume in a patient with hypoparathyroidism: the relationship between metabolic syndrome, impaired fasting glucose and cardiovascular risk

Cipil Handan , Timur Ozge , Sevimli Hakan , Yildiz Faruk , Utlu Mustafa , Arslan Abdulmuttalip , Ademoglu Esra Nur , Budak Mehmet Emin , Baydar Idris , Kadi Melek , Carlioglu Ayse

Background: Parathyroid hormone (PTH) is a key regulator of mineral metabolism, the homeostasis of calcium, phospate, vitamin D and bone turnover. Hypoparathyroidism is a rare disease characterized by hypocalceamia with inappropriately low plasma levels of PTH. Mean platelet volume (MPV) is the measure of platelet size. Increased MPV has been associated with cardiovascular risk.Objective: In our preliminary study, we aim to show that untreated hypoparath...

ea0041ep182 | Calcium and Vitamin D metabolism | ECE2016

Clinical case of chronic calcific pancreatitis in a patient with parathyroid carcinoma caused primary hyperparathyroidism

Britvin Timur , Ignatyuk Vyacheslav , Kazarian Armine

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism (PHPT) and is usually presented with severe hypercalcaemia and parathyroid hormone (PTH) elevation. Hypercalcaemia can lead to calcification of parenchymatous organs, including pancreas, and acute or chronic pancreatitis.Case report: A 46-year-old woman was admitted to the endocrine surgery department of our institution with severe weakness, appetite and weight loss (25 kg in a year), a...

ea0041ep183 | Calcium and Vitamin D metabolism | ECE2016

The relationship between obesity and serum Vitamin B12, folic acid, vitamin D concentrations in obes adults: a retrospective study

Yagan Fidan Canan Celik , Olcum Gulcin Gungor , Kurtulus Duygu , Tugtekin Haci Bayram

Background: Obesity is associated with many diseases. e.g. cardiovascular diseases. The most common deficiency associated with obesity seems to be low concentrations of vitamin D that is associated with an increased risk of diabetes and other cardiovascular diseases. Low concentrations of vitamins are linked to accelerated atherosclerosis through increased oxidative stress. The purpose of this research was to investigate the association between obesity and vitamin B12(VB12), f...

ea0041ep184 | Calcium and Vitamin D metabolism | ECE2016

Our cases of familial hypocalciuric hypercalcemia

Bayrak Muharrem , Cadirci Kenan , Carlioglu Ayse , Sevimli Hakan , Durmaz Senay

Familial hypocalciuric hypercalcemia is an inherited disease caused by inactivating heterozygous mutations in the gene encoding calcium-sensitive receptors, that affects calcium metabolism and generally follows a benign course. It must be also considered in the differential diagnosis of hyperparathyroidism. Six patients presenting to our internal diseases clinic between January, 2010, and June, 2015, were evaluated in terms of clinical and biochemical parameters. The youngest ...

ea0041ep185 | Calcium and Vitamin D metabolism | ECE2016

‘Hyngry bone syndrome’: after tertiary hypeparathyroïdism treatment

Mezoued Mouna , Stiti Meriem , Meskine Djamila

Post parthyroïdectomy hypocalcemia is a frequent situation, generally due to a definitive or transient hypoparathyroïdism.The ‘Hungry bone syndrome’, is a rare severe hypocalcemia etiology, assigned to an excessive osseous avidity, occurring in intense bone remodeling situations like fibrous osteitis or renal osteodystrophy.We report a case of a 41 years old woman, presenting a chronic renal failure, at hemodial...

ea0041ep186 | Calcium and Vitamin D metabolism | ECE2016

Calcium intake in Tunisian postmenopausal women: evaluation and impact on diabetes

Grira Wafa , Kandara Hajer , Zoubeidi Hana , Enneifer Houda , Salem Leila Ben , Slama Claude Ben

Introduction: Calcium intake is important to prevent osteoporosis in postmenopausal women. The objectives of our study were to evaluate the daily dietary calcium intake in postmenopausal Tunisian women, to compare diabetic and non-diabetic postmenopausal women in their calcium intake and finally to propose corrective interventions to promote calcium intake and minimize the complications of menopause.Subjects and methods: The study involved 73 postmenopau...

ea0041ep187 | Calcium and Vitamin D metabolism | ECE2016

The role of cinacalcet in a patient with persistent hypercalcaemia despite parathyroidectomy

Mlawa Gideon , Affam Dora , Silveira Maria

Introduction: Parathyroid adenoma is the commonest cause of primary hyperparathyroidism, but 10% of these adenomas can be ectopic, leading to persistent and recurrent hypercalcaemia.Case: We present a case of 82 years old man was admitted in June 2011 with increasesd confusion, slurred speech, poor balance (ataxia). He had no features of sepsis and no other focal neurology. His past medical history included constipation, dry eyes. He was on Aspirin, hypr...

ea0041ep188 | Calcium and Vitamin D metabolism | ECE2016

Use of recombinant parathyroid hormone with significant improvement of debilitating hypocalcaemia and hypomagnesaemia

Panteliou Eleftheria , James Ajith , Hawkins Anna , Jones Stuart , Kwong Pandina , Gupta Dinesh , Razzak Yousaf , Casey Edel , Nikookam Khash

Primary hypoparathyroidism is a rare condition. Contrary to other endocrine deficiencies treated with hormone replacement, recombinant parathyroid hormone (PTH) is not currently licensed for its treatment in Europe. Emerging evidence of efficacy and safety of recombinant PTH in treating resistant hypoparathyroidism will hopefully provide a new tool in managing this challenging condition.This is the case of a 45 year-old woman presenting with gradually wo...

ea0041ep189 | Calcium and Vitamin D metabolism | ECE2016

Severe hypercalcemia due to the vitamin D intoxication presenting with acute renal failure

Peynirci Hande , Sisman Pinar , Aydin Fethullah , Ersoy Canan , Erturk Erdinc

Introduction: Hypervitaminosis D is a rarely reported condition. It may be observed more frequently because of the recent increase in supplement use of vitamin D. Herein, we report a case of vitamin D intoxication which was the first case with this high level of calcium as we searched the literature.Case report: A 57-year old hypertensive woman admitted to our emergency room with symptoms of constipation, loss of appetite and confusion. Blood pressure, h...

ea0041ep190 | Calcium and Vitamin D metabolism | ECE2016

Case report of osteitis fibrosa cystica

AbdelWahab Engy , Farrag Wael , Qoutb Nesreen , AbdelRaof Yaser

Female patient named M.F., aged 37 years was complaining of Dull aching pain in her left shoulder, difficulty on lifting the left arm into right angle.The patient had past history of generalised body aches.The patient sought orthopaedic consultation because the pain in her left shoulder became severe.X Ray on her left shoulder revealed an intamedullary infiltrative lesion in the humerus of ground glass (Mouth...

ea0041ep191 | Calcium and Vitamin D metabolism | ECE2016

Influence of hypercalcemia in the type 2 diabetes

Brutskaya-Stempkovskaya Elena , Shepelkevich Alla

Status of carbohydrate metabolism in patients with hypercalcaemia and the influence of hypercalcemia on the risk of type 2 diabetes continue to be studied.Objective: To study the prevalence of type 2 diabetes in patients with hypercalcemia and in patients without hypercalcemia.Materials and methods: Continuous survey of 1000 people, average age 54.68±16.96 (727 women, 273 men) from 18 to 96 years. Examination: total calcium, t...

ea0041ep192 | Calcium and Vitamin D metabolism | ECE2016

Dysarthria: a subject of neurology? What about endocrinology?

Bahadir Cigdem Tura , Bahadir Sinan

Objective: Dysarthria is a motor speech disorder resulting from impairment in strength, speed and coordination of neural and/or muscular structures that are related to respiration, voice and speech. They may be classified as motor neuron dysarthria, cerebellar dysarthria and extrapyramidal dysarthria (subdivided as hypokinetic and hyperkinetic). Patients with dysarthria are evaluated primarily by neurology specialists. Though, we present our case to emphasize that dysarthria m...

ea0041ep193 | Calcium and Vitamin D metabolism | ECE2016

Pregnancy with Fahr’s disease: a rare case report

Gokay Ferhat , Simsek Yasin , Yesiltepe Ali , Dizdar Oguzhan Sitki

Introduction: Fahr’s disease is a rare, neurological disorder characterized by abnormal calcified deposits in basal ganglia. The clinical characteristics are various and usually appears such as disfunction of the affected areas. According to our knowledge, no case of Fahr’s disease together with pregnancy has been described in the literature until now. The objective of this case report was to describe the clinical course of this rare condition in pregnancy.<p cla...

ea0041ep194 | Calcium and Vitamin D metabolism | ECE2016

Pseudohypoparathyroidism with seizure: a rare case report

Gokay Ferhat , Simsek Yasin , Dizdar Oguzhan Sitki , Ozer Ozerhan

Introduction: Pseudohypoparathyroidism is characterised by hypocalcaemia, hyperphosphataemia, increased serum parathyroid hormone values and insensitivity to the biological activity of parathyroid hormone. Pseudohypoparathyroidism is often associated with a characteristic phenotype known as Albright’s hereditary osteodystrophy. This case was reported in order to remind pseudohypoparathyroidism in patients with hypocalcemic seizures.Case report: We d...

ea0041ep194b | Calcium and Vitamin D metabolism | ECE2016

Surgical treatment the patients with tertiary hyperparathyroidism

Makarov Igor , Sidorov Aleksandr , Koposov Ivan , Kletter Viktoria

Introduction: Tertiary hyperparathyroidism (THPT) develops for the patients with chronic kidney diseases undergoes program hemodialysis. THPT is seen in patients with long-term secondary hyperparathyroidism which eventually leads to hyperplasia of the parathyroid glands (PTG) then it leads to adenomatous transformation and autonomization of the PTG.The purpose of the study is the choice of rational diagnostic and treatment algorithm for...