Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Bone & Osteoporosis

ea0041ep97 | Bone & Osteoporosis | ECE2016

Abstract withdrawn....

ea0041ep98 | Bone & Osteoporosis | ECE2016

From EFOS to ExFOS, active treatment phase – similarities and differences of the Greek cohorts’ results

Aloumanis Kyriakos , Kokkoris Panagiotis , Kleisiounis Andreas , Kofini Evanthia , Karachalios Konstantinos , Drossinos Vangelis , Kapetanos Georgios

Introduction: Extended Forsteo® Observational Study (ExFOS), a multinational, non-interventional, prospective, observational study, designed to evaluate fractures, back pain (BP), adherence and health-related quality of life (QoL) in teriparatide (TPTD) treated patients, based on the extension of treatment duration (24 months) and the addition of new indications (glucocorticoid-induced and male osteoporosis) was compared with EFOS.Methods...

ea0041ep99 | Bone & Osteoporosis | ECE2016

Vertebral and non-vertebral low-traumatic fractures in patients with type 2 diabetes mellitus

Yalochkina Tatiana , Belaya Zhanna , Rozhinskaya Liudmila , Antciferov Michail , Dzeranova Larisa , Shestakova Marina , Melnichenko Galina

Introduction: Recent evidence suggests that the skeleton might be another affected organ in patients with type 2 diabetes mellitus (T2DM). This study evaluates the prevalence of low-traumatic vertebral and non-vertebral fractures and their risk factors in subjects with T2DM.Materials and methods: We invited outpatients with T2DM, who were under observation in a single outpatient clinic. The subjects were interviewed regarding the presence of low-traumati...

ea0041ep100 | Bone & Osteoporosis | ECE2016

Osteoporosis and osteopenia in older Emirati men with type 2 diabetes mellitus

Almazrouei Raya A , Alkaabi Fatima M , Gayar Heba El , Lessan Nader , Barakat Maha T

Introduction: Osteoporosis is an important cause of morbidity and mortality in older men, but the extent of the problem amongst Emiratis has not been previously reported. A screening programme has been in place for older men in a large diabetes centre in the UAE, allowing patients over age 70 to have DEXA scans; we have investigated the prevalence of osteoporosis and osteopenia in this population.Methods: Data on 179 consecutive patients with type 2 diab...

ea0041ep101 | Bone & Osteoporosis | ECE2016

Abstract withdrawn....

ea0041ep102 | Bone & Osteoporosis | ECE2016

A rare cause of hypocalcaemia: pseudohypoparathyroidism

Alp Gulay , Kutbay Nilufer Ozdemir , Yurekli Banu Sarer , Karaca Emin , Erdogan Mehmet , Cetinkalp Sevki , Ozgen Gokhan , Ozkinay Ferda , Saygili Fusun

Introduction: Pseudohypoparathyroidism (PHP) is a rare disease characterized by end-organ resistance to parathyroid hormone, causing hypocalcemia with hyperphosphatemia and elevated parathormone (PTH) levels. A prevalence of 3.4/million has been reported. Here, we present a rare case with PHP.Case report: A 28-year-old male patient with spasms in hands and feet was evaluated in the outpatient department of neurology and was referred to endocrinology clin...

ea0041ep104 | Bone & Osteoporosis | ECE2016

Association of vitamin D receptor gene with development of osteoporosis in patients with hypothyroidism

Pankiv Ivan

Polymorphism of the vitamin D receptor (VDR) gene has been reported to play a major role in variations for genetic regulation of bone mass. The current study is an attempt to examine the association of these variations with osteoporosis in patients with hypothyroidism. The purpose of this study was to determine distribution of genotypes and allelic frequencies of polymorphism of rs731236 (C+61968t; TaqI) VDR gene, and also risk of development and association with risk factors ...

ea0041ep105 | Bone & Osteoporosis | ECE2016

A rare differential diagnosis of Paget’s disease

Cetinarslan Berrin , Selek Alev , Canturk Zeynep , Tarkun Ilhan , Akyay Ozlem Zeynep , Akkas Nagihan

Hypertrophic osteoarthropathy (HOA) is a syndrome characterized with proliferation of bones at the distal parts of extremities. Clubbing, periostitis of tubular bones and non-inflammatory arthritis of lower extremities are commonly seen as a part of this syndrome.66 years old male patient was admitted to our hospital with painful swelling of his left lower extremity for 2 months. He denies any other systemic symptoms such as fever and weight loss. He had...

ea0041ep106 | Bone & Osteoporosis | ECE2016

An uncommon reason of osteoporosis: spondyloepiphyseal dysplasia congenita

Elbasan Onur , Sisman Pinar , Muti Aybuke , Oz Gul Ozen , Cander Soner , Erturk Erdinc , Ersoy Canan

Introduction: Spondyloepiphyseal dysplasia congenita (SEDC) is a rare congenital disease of skeletal system,which is characterized by short stature, shortage of trunk and mostly affect vertebral column and epiphysis of long bones. In this case report, we aimed to represent a patient complaining of short stature and referred to our hospital,who was detected to have an early onset osteoporosis accompanied by proximal femoral aplasia; in the light of literature.<p class="abst...

ea0041ep107 | Bone &amp; Osteoporosis | ECE2016

Bone microarchitecture assessed by trabecular bone score in liver transplants with New-Onset Diabetes after transplantation

Librizzi Maria Soledad , Allo Gonzalo , Sierra Milagros , Aramendi Mercedes , Guadalix Sonsoles , Jimenez Carlos , Diaz-Guerra Guillermo Martinez , Hawkins Federico

Background: The increased risk for fractures in type 2 diabetes mellitus despite higher bone density is unexplained. Trabecular bone score (TBS) is a novel texture index related to bone microarchitecture and it is independent of bone mineral density (BMD). The aim of this study was to investigate the relationship between TBS, BMD and body composition in patients with New-Onset Diabetes after transplantation (NODAT).Methods: In a cross-sectional study, TB...

ea0041ep108 | Bone &amp; Osteoporosis | ECE2016

Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: is there an association with bone mineral density?

Mpalaris Vasilios , Anagnostis Panagiotis , Anastasilakis Athanasios , Goulis Dimitrios , Doumas Argyrios , Iakovou Ioannis

Introduction: Adipokines and ghrelin exert well-documented effects on energy expenditure and glucose metabolism. Experimental data also support a role in bone metabolism, although data from clinical studies are conflicting. The purpose of this cross-sectional study was to investigate the association of serum concentrations of leptin, adiponectin and ghrelin with bone mineral density (BMD) in post-menopausal women.Methods/design: BMD in lumbar spine and f...

ea0041ep109 | Bone &amp; Osteoporosis | ECE2016

Bone turnover markers in women with postmenopausal osteoporosis depending on the level of vitamin D

Novakovic-Paro Jovanka , Icin Tijana , Mitrovic Milena , Tomic-Naglic Dragana , Pejin Radoslav , Popovic Djordje , Bajkin Ivana , Vukovic Bojan , Benc Damir , Medic-Stojanoska Milica , Kovacev-Zavisic Branka

Introduction: It is indisputable importance of vitamin D for the preserved integrity of the skeleton and bone metabolism.The aim of the study was to analyse bone turnover parameters in relation to the vitamin D status in women with postmenopausal osteoporosis.Materials and methods: This study included a total of 195 postmenopausal women with osteoporosis. Osteoporosis is diagnosed by DXA scan of the spine and hip. Bone turnover mar...

ea0041ep110 | Bone &amp; Osteoporosis | ECE2016

Clinical characteristics of Paget disease of bone from Turkey

Yavuz Dilek Gogas , Ayturk Semra , Bayraktar Firat , Cetinkalp Sevki , PD Study Group

Prevalence of Paget’s disease (PD) of bone as well as clinical and demographical presentation may differ between the populations.Aim: In this study we evaluate clinical and demographical parameters of Paget’s disease patients followed from endocrinology clinics in Turkey.Method: An invitation was sent to all tertiary endocrinology clinics to complete a survey on demographic clinical, laboratory parameters, treatment modal...

ea0041ep111 | Bone &amp; Osteoporosis | ECE2016

Association of bone mineral density with DXA-determined adipose tissue volume and concentrations of selected hormones in young adult women

Sowinska-Przepiera Elzbieta , Andrysiak-Mamos Elzbieta , Syrenicz Justyna , Syrenicz Anhelli

Introduction: The question if obesity may protect against osteoporosis is still a matter of discussion. A breakthrough in this debate may be the introduction of a state-of-the-art densitometric software (CoreScan) suitable for fast and accurate volumetry of total body fat (BF), including android (A), female-type (F) and visceral fat (VAT) volumes.Aim: The aim of the study was to analyze an association between bone mineral density (BMD]), concentrations o...

ea0041ep112 | Bone &amp; Osteoporosis | ECE2016

Relationships between body composition components in women with anorexia nervosa

Aleknaite Inga , Baks Brigita , Tamulaitiene Marija , Alekna Vidmantas , Sapoka Virginijus

Objective: The aim of this study was to assess the relationships between the body composition elements in women with anorexia nervosa (AN).Description of methods: In this study women with AN and healthy women aged 19–33 years were investigated. Anthropometry for height, weight and body mass index (BMI) was performed. Body composition including lean mass, fat mass, fractional contribution of fat, bone mineral content (BMC), and bone mineral density (...

ea0041ep113 | Bone &amp; Osteoporosis | ECE2016

Is carbonhydrate intake a risk factor for postmenopausal spinal osteoporosis?

Kurtulus Duygu , Humeyra Bicer Ayse , Selcen Bicer Hatice , Ilhan Muzaffer

Introduction: Osteoporosis is a disease that is characterized by bone mass loss and deterioration in bone micro-architecture. One of the most important risk factors is dietary habits. The effects of the amount of calcium intake via eating, and low calcium consumption on the development of osteoporosis is still an active research area. The intestinal absorption of calcium and its renal excretion are still not understood very well. Even though the effects of carbohydrates on cal...

ea0041ep114 | Bone &amp; Osteoporosis | ECE2016

Bone density in the HIP and the lumbar spine in healthy male population

Kokkoris Panagiotis , Hatzidakis Ioannis , Hatzelis Eleftherios , Makras Polyzois , Toloumis Georgios

Introduction: Low bone density is a frequent finding in both women and men of older age. There is not enough data about bone density in younger adults and especially men. In this study we measured bone density in healthy males per decade of age.Method: We measured bone density (BMD), T-score, Z-score and body mass index (BMI) in 1902 healthy men, age 20–59 years old. The study population was divided into four groups according to th...

ea0041ep115 | Bone &amp; Osteoporosis | ECE2016

The effect of anorexia nervosa on bone

Vicente Nuno , Rodrigues Dircea , Barros Luisa , Guelho Daniela , Cardoso Luis , Oliveira Diana , Martins Diana , Ventura Mara , Lages Adriana , Carrilho Francisco

Introduction: One of the most common endocrine complications of anorexia nervosa (AN) is the decrease in bone mineral density. The authors evaluated the predictive factors of osteopenia and osteoporosis in AN patients admitted with low weight.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology department, corresponding to 63 admissions. Bone mineral density was classified according to WH...

ea0041ep116 | Bone &amp; Osteoporosis | ECE2016

The influence of osteoporosis and cardiometabolic syndrome risk factors on bone mineral density in females with thyroid dysfunction

Gluvic Zoran , Samardzic Vladimir , Lackovic Milena , Tica Jevtic Jelena , Vujovic Marina , Popovic-Radinovic Vesna , Mitrovic Bojan , Popin-Taric Marija , Vasic-Vlaisavljevic Anita , Isenovic Esma R

Introduction: The effects of TSH and thyroid hormones on bone turnover are well-known. The aim of this study is to examine the influence of osteoporosis (Op) and cardiometabolic syndrome risk factors on bone mineral density (BMD) in the population of age-matched, normotensive and nondiabetic females.Material and methods: Cross-sectional study involved 76 females (average age 53±10 years), divided into three groups: hypo-, hyper-, and euthyroid. Pres...

ea0041ep117 | Bone &amp; Osteoporosis | ECE2016

Use of Denosumab for treatment of steoporosis at a Tertiary Referral Centre: an evaluation according to the UK National Institute of Health and Care Excellence (NICE) Guidelines

Yahia Seifeldin , Roji A M , Ledda Roberto , Chilaka Chioma , Chokkalingam Kamal , Prinsloo P J , Divyateja H

Aim: To evaluate the use of Denosumab in accordance to the UK National Institute of Health and Care Excellence (NICE) technology appraisal guidelines TA204 – Denosumab indicated for the prevention of osteoporotic fractures in post-menopausal women.Methods: A retrospective audit involving 129 patients prescribed Denosumab for osteoporosis between October 2011 and March 2015 at Nottingham University Hospitals, UK. Denosumab prescription data was obtai...

ea0041ep118 | Bone &amp; Osteoporosis | ECE2016

Incident fragility fractures under antiresorbtive therapy in a 76 year old lady: never too late to discover new causes

Ioana Arhire Amalia , Tudose Cornelia , Florea Suzana , Gabriela Barbu Carmen

Introduction: We report a case of severe osteoporosis with incident fragility fractures during antiresorbtive therapy in the presence of amiodarone induced hypothyroidism.Case report: A 76 year old female was admitted in our department for the evaluation of antiresorbtive therapy in the context of a recent rib fracture after coughing. Severe osteoporosis (lumbar T-score: −2.8DS, femoral neck T-score: −2.9DS with multiple fra...

ea0041ep119 | Bone &amp; Osteoporosis | ECE2016

Thyroid and parathyroid secretion disorders in senile osteoporosis

Arsenovic Branka , Vuksanovic Miljanka , Beljic-Zivkovic Teodora

Introduction: Osteoporosis is a metabolic disease characterised by reduction of the bone mass density and deterioration of architecture of the bone and its strength. Continuous process of modeling and remodeling of bones is regulated by action of numerous circulating hormones. Fracture risk makes osteoporosis clinically important disease.Goal of this study was to examine thyroid dysbalance, parathormone secretion disorder as risk factors for osteoporosis...

ea0041ep120 | Bone &amp; Osteoporosis | ECE2016

Hypophosphatasia: a novel mutation

Lopez Gallardo Gema , Roa Llamazares Carlos

Introduction: Hypophosphatasia (HPP) is a rare genetic disease of very variable severity (from letal to mild). HPP results from APL gene mutations, which lead to a deficiency of tissue-nonspecifc alcaline phosphatase (TNAP), and accumulation of inorganic pyrophosphate, a potent inhibitor of mineralization that is also a natural substrate of TNAP in the extracelular space. HPP causes mineralization disorders including soft bones (rickets, osteomalacia, fractures) and defects in...

ea0041ep121 | Bone &amp; Osteoporosis | ECE2016

Anorexia nervosa: beyond psychiatry

Vicente Nuno , Rodrigues Dirceaj , Barros Luisa , Guelho Daniela , Cardoso Luis , Martins Diana , Oliveira Diana , Lages Adriana , Ventura Mara , Fonseca Ligia , Figueiredo Julia , Carrilho Francisco

Introduction: Despite being a psychiatric disorder, anorexia nervosa (AN) is associated to severe systemic complications. The endocrine complications of AN are an opportunity for the diagnosis and treatment of this condition. The authors report the experience of the Endocrinology Department in the treatment of AN in inpatient setting.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology de...

ea0041ep122 | Bone &amp; Osteoporosis | ECE2016

Osteoporosis therapy with denosumab in patients after solid organ transplantation

Brunova Jana , Kratochvilova Simona , Bruna Josef

Introduction: The transplantation- associated osteoporosis became an increasingly important problem with the better survival of patients after the solid organ transplantation (Tx). Adequate vitamin D intake, calcium supplementation and bisphosphonates therapy are currently recommended for osteoporosis treatment. However bisphosphonates may be limited with patients’ impaired renal function. Denosumab use is the possible option but till now only a little data exist in solid...

ea0041ep123 | Bone &amp; Osteoporosis | ECE2016

Osteoporosis as a side effect of antineoplazic therapy

Sleiman Joan El Hajj , Jinga Dan , Nitipir Cornelia , Barbu Carmen Gabriela

Objective: The aim of this retrospective study is to evaluate the bone status in patients receiving oncological treatment, like radiation, chemotherapy, adjunctive therapies, and surgery.Material and methods: Medical records of 102 womens (mean age 59.12 yrs) with breast cancer history reffered for endocrine evaluation were retrospectivelly analysed. Demographic data, bone densitometry parameters, prevalent fractures and antineoplastic treatments history...

ea0041ep124 | Bone &amp; Osteoporosis | ECE2016

Bone mineralization and hormonal status in Turner syndrome patients: cross sectional one population study

Klimaite Raimonda , Kriksciuniene Ruta , Zilaitiene Birute , Verkauskiene Rasa

Introduction: Women with Turner syndrome (TS) are known to be at risk of decreased BMD (dBMD). Sex hormone replacement therapy is crucial to ensure the proper BMD formation, although the dBMD remains a problem in TS.Aim: To investigate the prevalence of decreased bone mineralization and it’s association with hormone levels in TS.Subjects: Women with geneticaly confirmed TS aged ≥ 18 year.Methods: T...

ea0041ep125 | Bone &amp; Osteoporosis | ECE2016

Osteoporosis in a cohort of 1062 postmenopausal women

Bouzid Aicha , Meskine Djamila

Osteoporosis is a worldwide public health problem, particularly in ageing subjectsThe objectives of this study were to screen a sample of postmenopausal women aged >45 years for osteoporosis and to identify its risk factors.Methods: This cross-sectional survey was conducted at the endocrinology department of the Bologhine hospital in Algiers, Algeria. A total of 1062 postmenopausal women participated in this study. Each subject...

ea0041ep126 | Bone &amp; Osteoporosis | ECE2016

Osteoporosis and type 2 diabetes

Meskine Djamila , Bouzid Aicha

Diabetes mellitus and osteoporosis are important comorbidities commonly seen in postmenopausal women. Diabetes can cause bone alterations that increases the risk of fractures. However, in patients with type 2 diabetes, bone mineral density (BMD) often appears not to be decreased, due to diabetes-induced increased weight and body fat mass, which can hamper densitometric assessment of osteoporosis and of fracture risks. The aim of the present study was to compare bone mineral de...

ea0041ep127 | Bone &amp; Osteoporosis | ECE2016

State of bone mineral density in children with Turner Syndrome in Ukraine

Zelinska Nataliya , Shevchenko Iryna , Globa Evgenia

Background: Low bone mineral density (BMD) and osteoporosis are the frequent consequences of Turner Syndrome (TS).Objective and hypotheses: We examined the BMD in TS girls with different age and karyotype.Methods: Measurements of BMD (g/cm2), Z-score (S.D.) were conducted in 26 girls using X-ray absorptiometry (DEXA) at the lumbar spine L2–L4 depending on the child’s age.<p class="ab...

ea0041ep128 | Bone &amp; Osteoporosis | ECE2016

Osteocalcin as a marker of bone metabolism disorders in girl with Turner syndrome

Zelinska Nataliya , Shevchenko Iryna , Globa Evgenia

Background: One of the markers of bone metabolism is osteocalcin (OC) and Its elevated level indicates osteoporosis.Objective and hypotheses: We investigated the OC level in 14 girls with TS (45,X (n=8), 45,X/46,XX (n=3), structural abnormalities of chromosome X (n=3): seven patients at 4–11 year and 7 – at 12–18 year.Method: DEXA (Z-score, S.D.), serum levels of OC,...

ea0041ep129 | Bone &amp; Osteoporosis | ECE2016

Adrenal tumors in menopause: bone assessment

Ghemigian Adina , Carsote Mara , Dumitrascu Anda , Dumitru Nicoleta , Valea Ana , Voicu Gabriela , Dumitrache Constantin

Introduction: Menopause correlates endocrine dysfunctions; whether an adrenal incidentaloma represents one of these it is difficult to establish since an age-dependent pattern of incidence has been described. Bone assays are necessary according to years since last menstruation but also if persistent hypercortisolemia is confirmed.Aim: This is a series of cases incidentally found with an adrenal tumor (AT) and osteopenia while evaluation of their menopaus...

ea0041ep129b | Bone &amp; Osteoporosis | ECE2016

Similarities in postsurgical vs nonsurgical patients with hypoparathyroidism: post hoc analysis from recombinant human parathyroid hormone (rhPTH[1-84], parathyroid hormone rDNA) REPLACE study

Brandi Maria Luisa , Bilezikian John P , Clarke Bart L , Fraser William , Krasner Alan , Lagast Hjalmar , Li Benjamin , Mannstadt Michael , Rejnmark Lars , Shoback Dolores M , Vokes Tamara J

Hypoparathyroidism, a rare disorder characterized by absent or low levels of parathyroid hormone (PTH), often results from thyroid surgery. However, nonsurgical etiologies are present in >10% of patients. Data about this group of patients are limited.In this post hoc REPLACE (NCT00732615, EudraCT2008-005063-34) analysis, baseline characteristics and response to 50–100 μg/day rhPTH(1-84) in patients with postsurgical or nonsurgical ...

ea0041ep130 | Bone &amp; Osteoporosis | ECE2016

Long-term use of steroid and secondary ostoporosis to multiple displaced metatarsal stress fracture: with rheumatoid arthritis a case report

Demirel Esra , Cadirci Kenan , Yiliz Kadri

Introduction: In rheumatological diseases have been observed in a rate of 0.8% of non-traumatic insufficiency fractures. The most common sites of insufficiency fractures are pelvis, sacrum, tibia, the sections near to the insertion of the fibula, calcaneus and buttocks. Generally, bone – joint involvement in rheumatic diseases and osteoporosis connected with prolonged use of corticosteroids prepares the ground for these insuffiency fractures. In this case, We aimed to pre...

ea0041ep131 | Bone &amp; Osteoporosis | ECE2016

Barrett’s esophagus and osteopenia: Report of a case

Athanassiou Panagiotis , Tzanavari Aikaterini , Spyridis Anestis , Kostopoulos Markos , Xanthakou Eleni , Kostoglou-Athanassiou Ifigenia

Introduction: Barrett’s esophagus is metaplasia in the cells of the lower end of the esophagus. It is characterized by the replacement of the normal stratified squamous epithelium lining of the esophagus by simple columnar epithelium with goblet cells. The disease is often related to gastroesophageal reflux and patients have pain necessitating chronic usage of proton pump inhibitors. Proton pump inhibitors have been associated with the development of low bone mineral dens...

ea0041ep132 | Bone &amp; Osteoporosis | ECE2016

Osteoporosis and recurrent pathological fractures associated with intense cannabinoid use: a case report

Yorulmaz Goknur , Gonullu Eskisehir Emel , Karakus Nazim

Introduction: Cannabis/marijuana/cannabinoids are the most commonly used illicit drug in the world which can be originated from plants or can be in synthetic forms. Here, an intensive marijuana smoker, 33 years old patient, who has osteoporosis with recurrent pathologic fractures will be presented.Case: Thirty-three-years-old male patient was referred to the our clinics in order to investigate the causes that may lead a pathologic fracture because the pa...

ea0041ep133 | Bone &amp; Osteoporosis | ECE2016

Paget’s disease of bone - case report and a review of epidemiology, pathophysiology and management

Corina Pop Radu Cristina

Introduction: Paget’s disease of bone (PDB) is the second-most-common metabolic bone disease, after osteoporosis, affecting about 3% of the population at age over 40 years. This disease is characterized by excessive and abnormal bone remodeling due to increased bone resorption followed by disorganized bone formation.This paper will include a case report and a review of PDB epidemiology and pathophysiology, complications and clinical findings, indica...

ea0041ep134a | Bone &amp; Osteoporosis | ECE2016

Depression, Obesity, and Elbow Fracture: a Pathogenic Triangle?

Carsote Mara , Radoi Valentin , Valea Ana , Albu Simona Elena , Vasiliu Cristina , Ghemigian Adina

Introduction: Depression and associated medication, especially Selective Serotonin Reuptake Inhibitors, may associate high fracture risk through serotonin (but not only). Obesity has been recently proved to be correlated with a higher fracture risk for a few sites as ankle, elbow, shoulder, etc. Moreover, depression and some anti-depressants may increase the calories intake and consecutive increased of Body Mass Index (BMI) is registered.Aim: We present ...

ea0041ep134b | Bone &amp; Osteoporosis | ECE2016

Negative correlation of osteocalcin with insulin resistance, but not with body fat, in lamin-mutated lipodystrophies

Leclerc Marion , Benomar Kanza , Lion George , Douillard Claire , Vigouroux Corinne , Pigny Pascal , Vantyghem Marie-Christine

Bone is involved in both phosphate-calcium and energetic metabolism. Osteocalcin, secreted by the osteoblasts, stimulates insulin secretion and improves insulin sensitivity. FGF-23, secreted by the osteoclasts, increases phosphate urinary excretion and is a marker of insulin resistance. Relationship between insulin-resistance, body fat and bone metabolism remains unclear. Therefore, the aim of this study was to evaluate osteocalcin and FGF-23 levels in diseases differing by bo...