Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Adrenal medulla

ea0041ep84 | Adrenal medulla | ECE2016

Pheochromocytoma/paraganglioma: Histopathological features as clue to the underlying germline mutation in these genetically heterogeneous tumors

Roy Maitrayee , Agarwal Shipra , Sharma Mehar Chand , Gupta Poonam , Khurana M L , Khagawat Rajesh , Tandon Nikhil

Introduction: Pheochromocytomas (PHEOs) and paragangliomas (PGLs) are rare neuroendocrine tumors arising from chromaffin cells within adrenal medulla and autonomic paragranglia respectively. Recent evidences show that nearly one-third patients harbour germline mutation, namely in von Hippel-Lindau (VHL), REarranged during Transfection (RET), neurofibromatosis type 1 (NF 1) and succinate dehydrogenase (SDH) complex genes. However, the tumor morphology arising in various syndrom...

ea0041ep85 | Adrenal medulla | ECE2016

Clinical review of patients with pheochromocytoma diagnosed between 2011 and 2015

Kurowska Maria , Oszywa-Chabros Anna , Malicka Joanna , Tarach Jerzy S

Introduction: WHO classification of endocrine tumors defines pheochromocytoma as a tumor arising from chromaffin cells in the adrenal medulla. Almost all pheochromocytomas produce catecholamines. An annual incidence of this tumor in the general population is estimated at 3–8 cases/million/year. 40–50% of patients with pheochromocytoma are characterized by sustained hypertension, a similar percentage – only by paroxysmal hypertension and up to 10% are normotensiv...

ea0041ep86 | Adrenal medulla | ECE2016

Diagnostic tools for incidental pheochromocytoma and paraganglioma

Kawashima Akiyuki , Okamoto Kentaro , Amano Aya , Murabe Hiroyuki , Yokota Toshihiko

Introduction: Pheochromocytoma and paraganglioma are the cause of secondary hypertension, glucose intolerance, arteriosclerosis and associated with increase of mortality. In addition, 10–17% of them are reported to be malignant. Therefore, diagnosis at the early stage is important.Methods: We retrospectively analyzed the medical records of Japanese patients who were admitted to our hospital from January 2001 to December 2015. They were confirmed phe...

ea0041ep87 | Adrenal medulla | ECE2016

Importance of long term follow up in pheochromocytoma

Bellarbi Dhiya eddine , Azzoug Said , Rabehi Leyla , Chentli Farida

Pheochromocytomas and paragangliomas are rare but life threatening tumors secreting catecholamines. They could be either sporadic or inherited. Either isolated or integrated in genetic syndromes such as Von Hippel Lindau (VHL) (OMIM193300) which is an autosomal dominant disorder resulting from germline mutations in the VHL gene.Observation: We report a 42-year-old man operated at 8 years old for bilateral pheochromocytoma revealed by adrenergic symptoms ...

ea0041ep88 | Adrenal medulla | ECE2016

High prevalence of germinal mutations in pheochromocytomas with normal urinary metanephrines results

Silva Joao , Prazeres Susana , Domingues Rita , Font Ana , Leite Valeriano

Introduction: Pheochromocytomas are tumors derived from the adrenal-medullary chromaffin cells that normally produce catecholamines. Rarely these tumors are non-secreting. In the assessment of a suspected pheochromocytoma, guidelines recommend dosing urinary or plasma metanephrines.Objective: To evaluate the prevalence of pheochromocytomas biochemically non-secreting and their differences.Methods: We searched all patients with meas...

ea0041ep90 | Adrenal medulla | ECE2016

A case of ectopic Cushing syndrome due to pheocromositoma

Gungunes Askin , Durmaz Senay Arikan , Cifci Aydin , Erden Esra , Tas Merve , Yalcin Selim

Background and aim: Pheochromocytoma, is a catecholamine-producing tumor, may rarely secrete other hormones such as adrenocorticotropic hormone (ACTH). We aimed to report a rare case of ectopic cushing syndrome due to malignant pheochromocytoma.Case report: A 42-year-old man admitted to outpatient clinic with headache, irritability, vomiting, nausea, and palpitation. He had paroxysmal hypertension and urinary fractionated metanephrines were measured appr...

ea0041ep91 | Adrenal medulla | ECE2016

Neurofibromatosis type 1 associated with pheochromocytoma

Slim Tensim , Jemel Manel , Sayadi Hanen , Marmouch Hela , Graja Sameh , Khochtali Ines

Introduction: Neurofibromatosis 1 (NF1) or von Recklighausen disease is an autosomal condition caused by heterozygous mutations of the NF1 gene. Patients with NF-1 are at an approximately fourfold higher risk of developing tumors than the general population. Pheochromocytoma may occur in about 1% of these patients.Case report: A 24-year-old woman was admitted to our hospital for further examinations of a 6-cm right adrenal mass, that was incidentally dis...

ea0041ep92 | Adrenal medulla | ECE2016

Clinical case of giant pheochromocytoma with low hormonal activity

Volkova Natalya , Beltsevitch Dmitriy , Porksheyan Mariya , Kanaeva Saida , Davidenko Ilya

Background: Pheochromocytoma (Ph) is the tumor that is fatal if do not suspect and treat it on time. It is supposed that size of tumor is correlated with its synthetic activity. Here we present a clinical case of giant Ph with low synthetic activity that could have been recognized as adrenal cancer, which, in turn, may have led to wrong treatment.Clinical case: Young woman, 28 years old, presented with the adrenal incidentaloma. She had not any complaint...

ea0041ep93 | Adrenal medulla | ECE2016

Hypertension and hypokalemia in a 56-year-old male

Quintana-Arroyo Sara , Acosta-Calero Carmen , Arnas-Leon Claudia , Santana-Suarez Ana-Delia , Martinez-Martin Francisco-Javier

A 56-year-old Swedish male was diagnosed with hypertension, initially attributed to continued use of NSAIDs. These were withdrawn and treatment with 80 mg valsartan was started, but BP remained uncontrolled. A fixed combination (valsartan/hydrochlorothiazide, 80/12.5 mg) was introduced, but blood pressure remained high and hypokalemia (K+3.3 mEq/l) developed. The patient was referred to our Endocrinology Clinic for study. Treatment was switched to manidipine 10 mg/1...

ea0041ep94 | Adrenal medulla | ECE2016

Asymptomatic ‘giant’ pheochromocytoma discovered as adrenal incidentaloma

Radojkovic Danijela , Radojkovic Milan , Pesic Milica , Kostic Sonja , Curkovic Sanja , Radenkovic Sasa , Antic Slobodan , Ilic Ivan

Introduction: Adrenal incidentalomas are defined as adrenal lesions incidentally discovered during radiological imaging of the abdomen without prior suspicion of adrenal disease. Approximately 70% of adrenal incidentalomas are non-functional adenomas. Pheochromocytoma presents only 5–7% of the remaining functional incidentalomas. Asymptomatic pheochromocytoma-incidentaloma is usually smaller than 1 cm. Large pheochromocytoma, incidentally found, without any clinical signs...

ea0041ep95 | Adrenal medulla | ECE2016

Abstract unavailable....

ea0041ep96 | Adrenal medulla | ECE2016

Usefulness of assessment of urinal metoxycatecholamines secretion in everyday clinical practice – pheochromocytoma as diagnostic challenge

Przybylik-Mazurek Elwira , Rzepka Ewelina , Buziak-Bereza Monika , Hubalewska-Dydejczyk Alicja

Introduction: Adrenal incidentaloma is an adrenal mass found on imaging studies done for other reason than suspected adrenal disease. The majority of them are non-functioning adenomas, however pheochromocytomas could be also observed. Currently, in diagnosis of incidentalomas, the assessment of hormones of adrenal cortex and medulla is performed. The aim of the study was to assess the incidence of pheochromocytoma in patients with incidentaloma.Methods: ...