Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Cardiovascular Endocrinology and Lipid Metabolism

ea0041ep195 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Liposomal prednisolone promotes macrophage necroptosis in experimental atherosclerosis: does this explain atherogenesis in Cushing’s disease?

Schulte Dominik M , van der Valk Fleur M , Meiler Svenja , Tang Jun , Zheng Kang He , van den Bossche Jan , Seijkens Tom , Laudes Matthias , de Winther Menno , Lutgens Esther , Alaarg Amr , Metselaar Josbert M , Dallinga-Thie Geesje M , Mulder Willem J M , Stroes Erik S G , Hamers Anouk A J

Introduction: Patients with a Cushing syndrome – a glucocorticoid driven disease–have a high risk for cardiovascular events, mainly due to atherosclerosis. Atherosclerosis is a lipid-driven inflammatory disease, for which novel anti-inflammatory strategies like glucocorticoids are under evaluation. Thus, the impact of glucocorticoids on atherosclerosis seems to be ambiguous: pro- or anti-inflammatory. To avoid systemic glucocorticoid side effects contributing to athe...

ea0041ep196 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

24-Hour blood pressure homeostasis and renal function in subjects with and without metabolic syndrome

Nedel Barbara Limberger , Tedesco Silva Leticia , Pazinato Tassia , Antoniolli Luciana , Piccoli Vanessa , Beer Mayara , Gerchman Fernando

Introduction: Metabolic syndrome (MS) is related with progressive decrease of renal function. Although hypertension has a major role on this relationship, it is not clear how its behavior is related to decreased renal function.Objective: To study how blood pressure (BP) measured by 24-hour ambulatory BP is related to renal function in patients with and without MS.Methods: We designed a cross-sectional study of consecutive individua...

ea0041ep197 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Effects of gender and menopausal status on serum apolipoprotein concentrations

Anagnostis Panagiotis , Stevenson John , Crook David , Johnston Desmond , Godsland Ian

Introduction: Inconsistent data exist as to whether menopause is associated with increased cardiovascular disease (CVD) risk. However, few studies have evaluated differences in apolipoprotein metabolism according to menopausal status and gender. The aim of this study was to investigate the effects of gender and menopause on serum apolipoprotein B (apoB), A-I (apoA-I) and A-II (apoA-II) concentrations.Methods/design: A cross-sectional analysis was underta...

ea0041ep198 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Urinary Albumin Excretion and Cardiovascular Risk in Nondiabetic Middle-Aged Adults: the 2011–2012 Korean National Health and Nutrition Examination Survey

Kim Jin Hwa , Ahn Hee Jung , Kim Sang Yong

Introduction: Microalbuminuria is known as a predictor of cardiovascular disease (CVD) in patients with and without diabetes, as well as the general population. The objective was to determine whether there was an association between the urinary albumin excretion and CVD risk by estimating the Framingham Risk Score (FRS) in nondiabetic middle-aged adults.Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey,...

ea0041ep199 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Hormonal treatment in a young and middle-aged population of transgender persons: impact on metabolic parameters

Levalle Oscar , Nagelberg Alberto , Gamez Juan , Perez Betiana , Ghiglioni Amalia , Mormandi Eduardo , Otero Patricia

The sex-specific sex steroid profile seems to be associated to the gender differences between males and females on metabolic and cardiovascular risk (CVR). Objetive: to examine the effects of cross-gender sex steroid exposure on metabolic and CVR parameters. We incorporated 152 women transgender (WT), age (Median) 31 yr old (16–62) and 76 male transgender (MT) age: 25 yr old (17–53), treated at least by 1 year. WT received transdermal 17ßEstradiol (E2) 50 μ...

ea0041ep200 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Free triiodothyronine is a predictor factor of left ventricular remodeling in patients after myocardial infarction and primary reperfusion assessed by means of two-dimensional speckle tracking echocardiography

Wierzbicka-Chmiel Joanna , Chmiel Artur , Koloczek Grzegorz , Pifczyk Grzegorz , Marek Bogdan , Kajdaniuk Dariusz

Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and...

ea0041ep201 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

The dual FXR/TGR5 agonist INT-767 counteracts nonalcoholic steatohepatitis in a rabbit model of high fat diet-induced metabolic syndrome

Vignozzi Linda , Cellai Ilaria , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Morelli Annamaria , Maneschi Elena , Vannelli Gabriella Barbara , Adorini Luciano , Maggi Mario

Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) are interesting pharmacological targets for the treatment of liver and metabolic diseases. FXR-deficient mice on a high-fat diet (HFD) exhibit massive hepatic steatosis, necro-inflammation and fibrogenesis. Moreover, pharmacological activation of TGR5 in mice promotes protective mechanisms in biliary epithelial cells and inhibits hepatic and systemic inflammation. Thus, we hypothesized that a FXR/TGR5 du...

ea0041ep202 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Adropin as a potential biomarker of nutrition status and cardiac function in hemodialyzed patients

Kaluzna Malgorzata , Schwermer Krzysztof , Hoppe Krzysztof , Czlapka-Matyasik Magdalena , Sawicka-Gutaj Nadia , Yusuf Ibrahim Aisha , Minczykowski Andrzej , Piatek Katarzyna , Pawlaczyk Krzysztof , Ziemnicka Katarzyna , Ruchala Marek

Introduction: Adropin, a newly discovered peptide hormone, seems to have broad implications in energy homeostasis and metabolism in humans. Its main role is in maintaining appropriate carbohydrate and lipid economy. However, the aim of this study was to look at the novel role of adropin as a potential marker for cardiac function and nutrition status in hemodialyzed (HD) patients. To the best of our knowledge, this was the first study to consider the relationship between serum ...

ea0041ep203 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Follicle stimulating hormone levels and subclinical atherosclerosis in older postmenopausal women

Bertone-Johnson Elizabeth , Virtanen Jyrki , Nurmi Tarja , Mursu Jaakko , Voutilainen Sari , Ronkainen Kimmo , Niskanen Leo , Kauhanen Jussi , Tuomainen Tomi-Pekka

Objective: Recent studies of perimenopausal women suggest that follicle stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of actions of estradiol (E2). Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown.Approach: We assessed the relation of FSH and E2 levels with carotid artery intima-media thickness (IMT) among 588...

ea0041ep204 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Testosterone supplementation and body composition: results from a meta-analysis of randomized controlled trials

Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Maggi Mario

Background: The role of testosterone (T) in regulating body composition is conflicting.Aim: To meta-analyze the effects of T supplementation (TS) on body composition and metabolic outcomes.Methods: All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.Results: Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control gr...

ea0041ep205 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Effects of sex steroids on cardiovascular risk profile in female to male transsexuals with cross-sex hormone treatment

Velazquez Gloria Aranda , Porta Mireia Mora , Hanzu Felicia Alexandra , Vera Josep , Ortega Emilio , Halperin Irene

Introduction: In transsexualism, cross-sex hormone treatment (CHT) both improves and impairs several surrogate cardiovascular risk markers in female to male (FtoM). Few randomized trials on CHT with long follow-up and control group are available, and present evidence is inconsistent. We here assess changes in metabolic and cardiovascular risk after 12 months CHT compared with biological sex in FtoM GID.Methods: Prospective observational study, including ...

ea0041ep206 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Circadian clock expression in hypothyroid male Wistar rats

Peliciari-Garcia Rodrigo A , Bargi-Souza Paula , Previde Rafael M , Young Martin E , Nunes Maria Tereza

Both metabolism and cardiac function fluctuate over the course of the day according to energy supply and demand. The triiodothyronine (T3) regulates several genes related to metabolism and function in cardiomyocytes. Our previous data have suggested that there is a potential interrelationship between the regulation of cardiac function by T3 and the intrinsic circadian clock in the heart. Considering that: i) the hypothyroidism is associated to a reduction...

ea0041ep207 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Moderate cross-sex hormone-induced prothrombotic changes of hemostatic variables in transgender subjects

Selier Nienke , Cannegieter Suzanne , Venemans-Jellema Annemarie , Heijer Martin den

Context: Little research has been performed on hemostatic changes in transgender subjects receiving cross-sex hormone treatment (CSHT), despite the fact that several studies implicate an increased risk of venous thrombosis (VT) associated with hormones.Objective: Assessing whether coagulation is relevantly influenced by prolonged CSHT, stratified for the different treatment modalities, in transgenders.Design and main outcome: Prosp...

ea0041ep208 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Optimising human hepatocyte models for metabolic phenotype: effects of treatment with DMSO

Nikolaou Nikolaos , Green Charlotte , Gunn Pippa , Hodson Leanne , Tomlinson Jeremy

Primary human hepatocytes are considered the ‘gold standard’ to explore metabolic phenotype within the liver, however they come with limitations, such as donor variability, lack of proliferation and rapid phenotype loss. The human hepatoma cell line, HepG2, has been used extensively in cell-based metabolic studies but there are significant limitations including their malignant origin and inherent low rates of triglyceride secretion. The aim of this study was to inves...

ea0041ep209 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Turner’s syndrome and liver involvement: prevalence and characterization of a large population with Turner’s syndrome

Calanchini Matilde , Moolla Ahmad , Tomlinson Jeremy W , Cobbold Jeremy , Fabbri Andrea , Grossman Ashley , Turner Helen

Introduction: Elevated liver function tests (↑LFTs) are frequent in Turner’s syndrome (TS), with a prevalence between 20 and 80%, and increases with age. Their pathogenesis and clinical significance is unclear.Objectives: To study the prevalence of ↑LFTs and their relationship with karyotype, anthropometric, metabolic and TS-related conditions: 68 TS women, average age 39 years (range 18–61 years), were reviewed.<p class="abstex...

ea0041ep210 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Natural history and metabolic implications of the new hormone fibroblast growth factor 21 in uremic patients on peritoneal dialysis

Diez Juan J , Gonzalez Elena , Bajo Maria Auxiliadora , Peso Gloria Del , Grande Cristina , Rodriguez Olaia , Diaz-Almiron Mariana , Iglesiaas Pedro , Selgas Rafael

Background: Human fibroblast growth factor 21 (FGF21) is a new liver hormone that stimulate adipocyte glucose uptake and is involved in regulation of body fat.Objective: To define the natural history of FGF21 in peritoneal dialysis (PD) patients and analyze its relationship with glucose metabolism, peritoneal function, and residual renal function (RRF).Methods: We studied 48 uremic patients undergoing PD. Patients were evaluated at...

ea0041ep211 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Impact of a specific risk factors unit intervention on clinical outcomes in patients with type 2 diabetes after myocardial infarction

Blanco Manuel Cayon , Mateos Carolina Garcia-Figueras , Lechuga Ana del Rio

Introduction: In our setting, it is quite common that control of major risk factors of patients with type 2 diabetes (T2D) after myocardial infarction (MI) is not made by specific risk factors units (SRFU). Here, we conducted a preliminary study to investigate the effects of a SRFU intervention on metabolic and cardiovascular outcomes in T2D patients who suffered from MI.Methods/design: This retrospective and observational study was performed in one sing...

ea0041ep212 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Which are the male factors associated with female sexual dysfunction (FSD)?

Maseroli Elisa , Fanni Egidia , Mannucci Edoardo , Fambrini Massimiliano , Jannini Emmanuele A , Maggi Mario , Vignozzi Linda

It has been generally assumed that partner’s erectile dysfunction (ED), premature (PE) and delayed ejaculation (DE) play a significant role in determining Female sexual dysfunction (FSD). The present study aimed to evaluate the role of perceived male partner’s sexual function and of the referred quality of relationship in determining FSD. A consecutive series of 156 heterosexual women consulting our outpatient clinic for FSD between January and December 2014 was retr...

ea0041ep213 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Aerobic exercise increases catalase activity and decreased levels of leptin and TNFα in patients with liver disease

Javier Vilchez-Lopez Francisco , Rivas-Rivas Marta , Mateo-Gavira Isabel , Rodriguez-Ramos Claudio , Romero-Gomez Manuel

Introduction: Both insulin resistance and oxidative stress are implicated in the pathophysiology of various diseases such as type 2 diabetes mellitus, atherosclerosis or liver disease. Furthermore, the uncoupling protein-1 (UCP1) is involved in induced thermogenesis, related to the pathogenesis of obesity and diabetes. The aim of this study was to assess the impact of aerobic exercise on the inflammatory profile in patients with chronic hepatitis C.Metho...

ea0041ep214 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Impact of overweight and obesity on cardiac diastolic function

Soysal Atile Neslihan , Baykiz Derya , Ekiz Bilir Betul , Bilir Bulent

Introduction: Left ventricular diastolic dysfunction (LVDD) is a common cause of heart failure in obese patients. The aim of this study is to evaluate diastolic function and its relation to body mass index (BMI) in overweight and obese patients by using transthoracic echocardiography.Material and method: A total of 133 cases were enrolled in the study. All anthropometric and laboratory measures were recorded. After measuring two-dimensional and M-mode ec...

ea0041ep215 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

TNF related apoptosis inducing ligand (TRAIL) reduces reactive oxygen species production by human aortic endothelial cells exposed to inflammatory stimuli

Forde Hannah , Davenport Colin , Rochfort Keith , Cummins Philip , Smith Diarmuid

Introduction: Accumulating evidence suggests that one of the most significant contributors to endothelial dysfunction is increased oxidative stress. Excessive reactive oxygen species (ROS) generation can have injurious effects within the vasculature including elevated expression of adhesion molecules, stimulation of vascular smooth muscle cell proliferation, and promotion of endothelial cell apoptosis; events which culminate in the formation and progression of atherosclerotic ...

ea0041ep216 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Primary aldosteronism and pregnancy

Zelinka Tomas , Widimsky Jiri

Introduction: Primary aldosteronism (PA) may present in younger age and it may so complicate pregnancy if not diagnosed early. Our aim was to identify patients in whom PA was diagnosed after pregnancy and to seek for possible complications during pregnancy.Design of methods: Retrospective analysis of patients with PA.Results: We found nine patients with PA (age at diagnosis 31.9±5 years, hypertension duration 5.9±2.6 year...

ea0041ep217 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Hypertension in young patients: at what age should we explore?

Tougorti Molka , Chaker Fatma , Yazidi Mariem , Cherif Ines , Chihaoui Malika , Rejeb Ons , Slimane Hedia

Introduction: Secondary high blood pressure is commonly diagnosed in young patients. In recent years, hypertension is increasing as well as the other components of metabolic syndrome such as obesity. The aim of this study was to determine the etiology of hypertension in patients aged <40 years old admitted in an endocrinology department.Materials and methods: It was a retrospective study including 55 patients <40 years old hospitalized at the end...

ea0041ep218 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Comparison low-density lipoprotein cholesterol levels calcutation using the novel method by Martin vs the Friedewald equation in type 2 diabetic patients

Duarte Sequeira , Azinheira Jorge

Introduction: LDL cholesterol (LDL-C) is usualy estimated using the Friedewald equation. This equation assumes a fixed factor of 5 for the ratio of triglycerides to very LPL cholesterol (TG:VLDL-C); however, the actual TG:VLDL-C ratio varies significantly across the range of triglyceride and cholesterol levels. A new method was proposed by Martin, S and co-workers using NHANES data. We aimed to evaluate the concordance Friedewald formula with the new method for LDL-C estimatio...

ea0041ep219 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

The relationship between non-high density lipoprotein cholesterol and insuline resistance in obese patients

Macit Melih , Mert Meral , Ates Ramazan , Polat Ozlem , Hatipoglu Sadik Sami

Introduction: Correction of Insulin resistance (IR) and dyslipidemic conditions of obese patients is important for the prevention of cardiovascular disease (CVD). The aim of our study is to determine the relationship between IR and non-high-density lipoprotein cholesterol (non-HDL-C) in obese patients.Material and methods: 248 patients over the age of eighteen, non-pregnant, followed with a diagnosis of obesity but did not receive the treatment of metfor...

ea0041ep220 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Comparison of serum thyroid stimulating hormone and anti-thyroid peroxidase antibody levels in euthyroid subjects with and without metabolic syndrome

Serin Sibel Ocak , Kocoglu Hakan , Okuturlar Yildiz , Dogan Hakan , Gedikbasi Asuman , Utku Irem Kirac , Demir Esra , Yesil Ezgi Ersoy , Koc Guven , Eyupgiller Tulay , Ucak Sema , Harmankaya Ozlem

Objective: The present study aimed to evaluate thyroid stimulating hormone (TSH) levels and anti-thyroid peroxidase antibodies (anti-TPOab) in euthyroid subjects with metabolic syndrome (MetS) and to compare them with healthy subjects without MetS.Design: Study included 173 subjects consisted of 96 subjects with MetS and 77 healthy controls. Gender, age, body mass index (BMI), waist circumfrence (WC), and detailed medical history of all participants were...

ea0041ep221 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Effect of progesterone on intracellular calcium in mESC-derived cardiomyocytes

Hwang Jeong Ung , Choi Young-Kwon , Kang Hee Young , An Jin Yong , Jeung Eui-Bae

Sex steroid hormones effect on the early embryo-development and regulate the calcium signaling in cardiac muscle. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the effect of P4 on early differentiation of mouse embryonic stem (mES) cells into cardiomyocytes, the hanging-drop method was performed to form embryoid bodies (EB). The mouse EBs (mEB) were suspended, attached onto six well plates and cultu...

ea0041ep222 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Anti-thyroid antibodies as an additional risk factor for endothelial dysfunction in type 2 diabetic patients with subclinical hypothyroidism

Petrosyan Lilit

Aim: Recent studies have shown that immune responses contribute to atherosclerosis. The aim of this study was to investigate the relationship between carotid imt and the levels of anti-tpo in type 2 diabetic subjects with subclinical hypothyroidism (sch).Subjects and methods: A total of 109 non-smoking diabetic subjects with sch were recruited for this study from June 2013 to May 2015. We used the analysis of variance to compare the differences of imt am...

ea0041ep223 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

A novel lipid tetrad index as predictor of premature coronary artery disease in diabetic patients

Das Saswati , Gupta SK , Girish MP

Background: The aim of this study was to explore if evaluation of lipid risk factors like lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care center, New Delhi, India, over a period of 18 months. CAD pati...

ea0041ep224 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Metabolic effects by H. pylori infection and eradication

Cornejo-Pareja Isabel M , Mar Roca-Rodriguez M , Coin-Aranguez Leticia , Molina-Vega Maria , Diaz-Perdigones Cristina , Hernandez-Garcia Carmen , Munoz-Garach Araceli , Alcaide-Torres Juan , Clu-Fernandez Carlos , Vinuela-Gonzalez Laura , Mora-Navas Laura , Mancha-Doblas Isabel , Tinahones-Madueno Francisco J

Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and methods: A prospective study of 40 non-diabetics patients were perf...

ea0041ep225 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Testosterone therapy in female-to-male transsexuals: effects on body weight, blood pressure and lipid profile

Acosta-Calero Carmen , Arnas-Leon Claudia , Dellia Santana-Suarez Ana , Quintana-Arroyo Sara , Javier Martinez-Martin Fco

Introduction and objectives: A possible increase in blood pressure (BP) and other cardiovascular risk factors has been associated with testosterone treatment (TT) in female-to-male transsexuals (FMT). Nonetheless, the available evidence does not support an increase in CV morbidity or mortality. We set out to analyze the impact of TT on BP and lipid profile in a cohort of FMT patients.Methodology: Retrospective observational study with no control group in...

ea0041ep226 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) associated with free androgen index but not with serum testosterone and androstendione in women with PCOS

Kuliczkowska-Plaksej Justyna , Milewicz Andrzej , Laczmanski Lukasz , Jedrzejuk Diana , Lwow Felicja , Bolanowski Marek

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

ea0041ep227 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Higher than expected prevalence of the aortic dilation in Turner syndrome in Lithuanian population

Kriksciuniene Ruta , Zilaitiene Birute , Ereminiene Egle , Verkauskiene Rasa

Introduction: Aortic dilation (AD) is the life threating complication of Turner syndrome (TS). The reported prevalence of AD in TS various between 12 and 39%. Factors predicting enlargement of diameter of aorta (DA) are still under investigation.Aim: To assess the prevalence of AD in TS in Lithuanian population, to evaluate the possible predictors of AD development.Methods: Forty-three patients with TS aged ≥18 year were enro...

ea0041ep228 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Hypertension and related cardiovascular diseases: a new role for low levels of parathyroid hormone

Afzal Nadia , Ali Raza Kazmi Syed , Akram Maleeha , Jahan Sarwat , Raza Abida , Kokab Raja Ghazala , Nazir Saba , Nazir Sidrah , Ahmed Naseem Afzaal , Qayyum Mazhar , Shakeel Raza Rizvi Syed

Hypertension or elevated arterial blood pressure (BP) is the most common cause of cardiovascular diseases (CVDs). The arterial BP is regulated by renin-angiotensin-aldosterone system (RAAS), whereas dysfunctional RAAS may lead to development of hypertension and associated CVDs. Parathyroid hormone (PTH) secreted by parathyroid glands regulates RAAS by directly stimulating aldosterone synthesis in zona glomerulosa cells, which leads to development of hypertension. Conversely, R...

ea0041ep229 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Role of additional risk factors of cardiovascular disease in men with type 2 diabetes and obesity

Dzantieva Elizaveta , Khripun Irina , Vorobyev Sergey , Gusova Zalina , Bova Elena , Kogan Michail

Late identification and inadequate assessment of cardiovascular risk factors are being considered as the main cause of high mortality in men with type 2 diabetes mellitus (T2DM).Aim: To analyze the carbohydrate metabolism, levels of testosterone, proinflammatory cytokines in patients with T2DM and obesity.Methods: We examined 123 men with T2DM and obesity (mean age – 53.8±6.8). Parameters of carbohydrate metabolism, total...

ea0041ep230 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

A systematic review and meta-analysis of interventions for the treatment of chronic non-hypovolaemic hypotonic hyponatraemia

McCool Rachael , Glanville Julie , Quinn Jennifer , O'Reilly Karl , Petrakova Larisa , Jamookeeah Clare

Objectives: International and national guidelines on the treatment of chronic non-hypovolaemic hypotonic hyponatraemia differ widely. Using methods embodied in the Cochrane Handbook, a systematic review and meta-analysis was conducted to investigate the efficacy and safety of interventions for this condition.Methods: Following registration of the review protocol with PROSPERO (CRD42015016670), systematic literature searches were conducted to identify ran...

ea0041ep231 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Predictive factors of the metabolic syndrome in the obstructive sleep apnea hypopnea syndrome

Houda Ennaifer , Sonia Maalej , Ines Kamoun , Samira Aouadi , Leila Gharbi

Introduction: The metabolic syndrome (MS) is a frequent complication of the obstructive sleep apnea hypopnea syndrome (OSAHS). Its predictive factors have to be known by the doctors setting in charge patients with OSAHS. The aim of this study was to determine the prevalence of the MS and its predictive factors in Tunisian patients with OSAHS.Methods: A retrospective study including 181 patients with OSAHS from the respiratory D department at the Abderrah...

ea0041ep232 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Vascular calcification – Impact of PRRG1-4

Schweighofer Natascha , Aigelsreiter Ariane , Trummer Olivia , Kniepeiss Daniela , Wagner Doris , Stiegler Philipp , Pieber Thomas , Muller Helmut , Obermayer-Pietsch Barbara

Pathophysiological calcification in the vasculature favours cardio- and cerebrovascular diseases. In patients with chronic kidney disease vitamin K metabolites are associated with decreased vascular calcification.We investigated the expression of the vitamin K dependent proteins PRRG1-4 in vessels and bone to identify differences in expression pattern during atherosclerosis (AS) stages and compare the two tissue profiles.Gene expre...

ea0041ep233 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Relation of apelin with duration of diabetes in hypertension patients with type 2 diabetes

Koval Sergiy , Iushko Kostiantyn , Starchenko Tatiana

Introduction: Apelin is one of the cardiovascular factors, adipokin, which plays an important role not only in the pathogenesis of hypertension, but also of type 2 diabetes (T2D). The aim of the study was to assess apelin levels in blood serum and investigate its relationship with duration of diabetes in hypertension patients with T2D.Methods: The study involved 63 hypertension patients grades 2–3 with T2D (32 men and 31 women) aged 43 to 70. Depend...

ea0041ep234 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Erythropoietin therapy and the cardiovascular outcome in cardio-renal syndrome patients

Mashahit Mohamed

Background: Kidney diseases and cardiac diseases can affect each other. Patient with renal failure have many cardiac problems specially heart failure, anemia of CRF is resistant to treatment with iron or even blood transfusion and erythropoietin therapy gives good results as the failing kidney can not synthesize itThe previous published data showed that EPO treatment in patients with cardiorenal syndrome (CRS) anemia led to reverse ventricular remodeling...

ea0041ep235 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

A retrospective observational-cohort study of the relationship between reactive hypoglycaemia to postural orthostatic tachycardia syndrome (PoTS)

Goedhart Claire , Gall Nick , Lulsegged Abbi

Postural orthostatic tachycardia syndrome (PoTS) occurs as a consequence of the abnormal functioning of the autonomic nervous system (dysautonomia). Despite the many associated conditions, the assessment and relationship to reactive hypoglycaemia has not been explored in the clinical literature.The purpose of this retrospective observational-cohort study was to identify relationships between the physical and biochemical characteristics in potential carbo...

ea0041ep236 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Effects of statins on lipid and carbohydrate metabolism in patient with type 2 diabetes and cardiovascular diseases

Mankovsky Boris , Kondratska Iryna , Briukhova Aleksandra

Patients with diabetes mellitus (DM) type 2 is a group of high cardiovascular risk. The incidence of coronary heart disease in their 2–4 times higher than in the population without diabetes, 80% of cases of diabetes combined with hypertension. At the same time any change in lipid metabolism leads to increased cardiovascular risk in patients with type 2 diabetes. Statins is first-line drugs in patients with dyslipidemia.Materials and methods: The stu...

ea0041ep237 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Fixed combination features in management of Hypertensive patients with diabetes, dyslipidemia and subclinical hypothyroidism

Alla Logvinenko

Objective: A subclinical hypothyroidism (SH) is the independent factor of the risk of cardiovascular diseases. The aim is to learn the possibility of optimization of the standard treatment of lipid and carbohydrate disoders, antihypertensive treatment of the levothyroxine replacement therapy (LRT) for women with metabolic syndrome (MS) and SH.Methods: 137 women: 1gr.-68pts with MS, SH and with the LRT use; 2gr.-69pts with MS and without LRT use. Body mas...

ea0041ep238 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Dyslipidemia in young women with polycystic ovary syndrome

Ayhan Mehmet Emin , Durmaz Senay Arikan , Carlioglu Ayse , Demirelli Selami

Introduction and aims: Polycystic ovary syndrome (PCOS) is a frequent endocrinopathy among with young women. It is known that insulin resistance is encountered in the vast majority of the women with PCOS and hence the risk of type 2 diabetes mellitus and coronary artery disease are increased. These cardiac and metabolic risk increments may also associated with hyperandrogenemia and dyslipidemia. The metabolic changes of lipid profiles in young women with PCOS are not completel...

ea0041ep239 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

The cardiovascular complications and risk factors in cardiac patients with type 2 diabetes

Bilovol Olexander , Bobronnikova Lesya , Ilchenko Irina

The purpose: To investigate the prevalence and the relationship between cardiovascular complications (CVC) and risk factors (RF) in patients with essential hypertension (EH) and coronary heart disease (CHD) in combination with diabetes mellitus type 2 (DM-2).Materials and methods: A retrospective analysis of case histories of 79 patients with cardiac profile (37 of them women, with an average patient age – 59.6±6.2 years) with hypertension stag...

ea0041ep240 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Metabolic syndrome as the result of the inversion of the cycle ‘day/night’

Dzherieva Irina , Volkova Natalia

Background: The pathophysiological base of metabolic syndrome is insulin resistance. According to Scott E.M., Grant P.J., insulin resistance is supposed to be formed during the evolution and connected by circadian rhythms. Melatonin is synchronizer of circadian rhythms. The modern lifestyle leads to the breach of melatonin synthesis because of absence of season changes in the length of a light day due to the using of artificial lighting.Aim: The aim was ...

ea0041ep241 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Detection of subclinical diabetic autonomic neuropathy by reflex cardiovascular testing

Mahdy Maram , Gadalla Fadila , Khorshid Hazem

Background: Diabetic autonomic neuropathy (DAN) is among the least recognized and understood complication of diabetes despite its significant negative impact on survival and quality of life in people with diabetes. Diabetic neuropathies including cardiac autonomic neuropathy (CAN), are a common chronic complication of type 1 and Type 2 diabetes and confer a high morbidity and mortality to diabetic pateints. The reported prevalence of CAN varies greatly depending on the criteri...

ea0041ep242 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Dietary intakes in relation to carotid intima-media thickness in subjects with subclinical atherosclerosis

Alissa Eman , Alsalmi Maisa'a , Helmi Sara

Demonstrating a relationship between diet and atherosclerosis should provide an opportunity for potential risk reduction at an early stage of the known long disease process instead of the need to intervene at the symptomatic disease stage. Thus, we aimed to evaluate the relationship between levels of nutrients intake as determined by food frequency questionnaire (FFQ) with the degree of atherosclerotic lesions as measured by carotid intima-medial ratio (CIMT).<p class="abs...

ea0041ep243 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Comparison of hypertriglyceridemic and normotriglyceridemic patients in Konya and in the surrounding area in Turkey

Kaya Ahmet , Turan Elif , Kulaksizoglu Mustafa , Bayram Fahri

Methods: This study, was a cross-sectional survey. Sampling design was based upon multistage probability sampling. Patient with diabetes, hypertension, cardiovascular diseases and any other diseases were excluded from the study. Age and gender were noted. Heights, weights and waist circumference (WC) were measured. BMI was calculated. Blood pressure (BP) was measured. Fasting thyrigliseride levels were evaluated. Patients were divided into two groups according to their triglyc...

ea0041ep244 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Cardiovascular safety; which antidiabetic agent will be your choice in patients, who have coexisting cardiovascular disease?

Qasim Bayar

Three eagerly awaited large, randomised, controlled cardiovascular safety trials with new antidiabetic drugs have recently been completed. The results of these studies are of wide interest to the diabetes and cardiology clinical scientific communities, and the results have been presented at diabetes and cardiology scientific meetings. These have studied drugs in each of the new classes of antidiabetic drugs: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor; lixisenatide...

ea0041ep245 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2016

Stress hyperglycemia in acute coronary syndrome and pulmonary disease

Qasim Bayar

In a large sample of elderly patients with acute myocardial infarction, higher glucose levels were associated with a greater risk of 30-day mortality in patients with diabetes compared to patients without diabetes. In addition to previous hypothesis for mechanism of harm, recent studies have concluded that stress hyperglycaemia is an independent predictor of left ventricular remodelling after anterior myocardial infarction and may also contribute to arrhythmias.<p class="a...