Endocrine Abstracts

Introduction: Patients with a Cushing syndrome – a glucocorticoid driven disease–have a high risk for cardiovascular events, mainly due to atherosclerosis. Atherosclerosis is a lipid-driven inflammatory disease, for which novel anti-inflammatory strategies like glucocorticoids are under evaluation. Thus, the impact of glucocorticoids on atherosclerosis seems to be ambiguous: pro- or anti-inflammatory. To avoid systemic glucocorticoid side effects contributing to athe...

Introduction: Metabolic syndrome (MS) is related with progressive decrease of renal function. Although hypertension has a major role on this relationship, it is not clear how its behavior is related to decreased renal function.Objective: To study how blood pressure (BP) measured by 24-hour ambulatory BP is related to renal function in patients with and without MS.Methods: We designed a cross-sectional study of consecutive individua...

Introduction: Inconsistent data exist as to whether menopause is associated with increased cardiovascular disease (CVD) risk. However, few studies have evaluated differences in apolipoprotein metabolism according to menopausal status and gender. The aim of this study was to investigate the effects of gender and menopause on serum apolipoprotein B (apoB), A-I (apoA-I) and A-II (apoA-II) concentrations.Methods/design: A cross-sectional analysis was underta...

Introduction: Microalbuminuria is known as a predictor of cardiovascular disease (CVD) in patients with and without diabetes, as well as the general population. The objective was to determine whether there was an association between the urinary albumin excretion and CVD risk by estimating the Framingham Risk Score (FRS) in nondiabetic middle-aged adults.Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey,...

The sex-specific sex steroid profile seems to be associated to the gender differences between males and females on metabolic and cardiovascular risk (CVR). Objetive: to examine the effects of cross-gender sex steroid exposure on metabolic and CVR parameters. We incorporated 152 women transgender (WT), age (Median) 31 yr old (16–62) and 76 male transgender (MT) age: 25 yr old (17–53), treated at least by 1 year. WT received transdermal 17ßEstradiol (E2) 50 μ...

Introduction: Left ventricular remodeling (LVR) is the most important consequence of acute myocardial infarction (AMI). The aim of the study was to assess the value of free triiodothyronine (fT3) in the prediction of LVR after AMI and primary coronary angioplasty (PCI).Methods: Seventy patients (F/M=17/53, 61±11 years old) without recognized previous thyroid dysfunction and AMI were enrolled into the prospective observational study. Conventional and...

Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) are interesting pharmacological targets for the treatment of liver and metabolic diseases. FXR-deficient mice on a high-fat diet (HFD) exhibit massive hepatic steatosis, necro-inflammation and fibrogenesis. Moreover, pharmacological activation of TGR5 in mice promotes protective mechanisms in biliary epithelial cells and inhibits hepatic and systemic inflammation. Thus, we hypothesized that a FXR/TGR5 du...

Introduction: Adropin, a newly discovered peptide hormone, seems to have broad implications in energy homeostasis and metabolism in humans. Its main role is in maintaining appropriate carbohydrate and lipid economy. However, the aim of this study was to look at the novel role of adropin as a potential marker for cardiac function and nutrition status in hemodialyzed (HD) patients. To the best of our knowledge, this was the first study to consider the relationship between serum ...

Objective: Recent studies of perimenopausal women suggest that follicle stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of actions of estradiol (E2). Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown.Approach: We assessed the relation of FSH and E2 levels with carotid artery intima-media thickness (IMT) among 588...

Background: The role of testosterone (T) in regulating body composition is conflicting.Aim: To meta-analyze the effects of T supplementation (TS) on body composition and metabolic outcomes.Methods: All randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.Results: Overall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control gr...

Introduction: In transsexualism, cross-sex hormone treatment (CHT) both improves and impairs several surrogate cardiovascular risk markers in female to male (FtoM). Few randomized trials on CHT with long follow-up and control group are available, and present evidence is inconsistent. We here assess changes in metabolic and cardiovascular risk after 12 months CHT compared with biological sex in FtoM GID.Methods: Prospective observational study, including ...

Both metabolism and cardiac function fluctuate over the course of the day according to energy supply and demand. The triiodothyronine (T3) regulates several genes related to metabolism and function in cardiomyocytes. Our previous data have suggested that there is a potential interrelationship between the regulation of cardiac function by T3 and the intrinsic circadian clock in the heart. Considering that: i) the hypothyroidism is associated to a reduction...

Context: Little research has been performed on hemostatic changes in transgender subjects receiving cross-sex hormone treatment (CSHT), despite the fact that several studies implicate an increased risk of venous thrombosis (VT) associated with hormones.Objective: Assessing whether coagulation is relevantly influenced by prolonged CSHT, stratified for the different treatment modalities, in transgenders.Design and main outcome: Prosp...

Primary human hepatocytes are considered the ‘gold standard’ to explore metabolic phenotype within the liver, however they come with limitations, such as donor variability, lack of proliferation and rapid phenotype loss. The human hepatoma cell line, HepG2, has been used extensively in cell-based metabolic studies but there are significant limitations including their malignant origin and inherent low rates of triglyceride secretion. The aim of this study was to inves...

Introduction: Elevated liver function tests (↑LFTs) are frequent in Turner’s syndrome (TS), with a prevalence between 20 and 80%, and increases with age. Their pathogenesis and clinical significance is unclear.Objectives: To study the prevalence of ↑LFTs and their relationship with karyotype, anthropometric, metabolic and TS-related conditions: 68 TS women, average age 39 years (range 18–61 years), were reviewed.<p class="abstex...

Background: Human fibroblast growth factor 21 (FGF21) is a new liver hormone that stimulate adipocyte glucose uptake and is involved in regulation of body fat.Objective: To define the natural history of FGF21 in peritoneal dialysis (PD) patients and analyze its relationship with glucose metabolism, peritoneal function, and residual renal function (RRF).Methods: We studied 48 uremic patients undergoing PD. Patients were evaluated at...

Introduction: In our setting, it is quite common that control of major risk factors of patients with type 2 diabetes (T2D) after myocardial infarction (MI) is not made by specific risk factors units (SRFU). Here, we conducted a preliminary study to investigate the effects of a SRFU intervention on metabolic and cardiovascular outcomes in T2D patients who suffered from MI.Methods/design: This retrospective and observational study was performed in one sing...

It has been generally assumed that partner’s erectile dysfunction (ED), premature (PE) and delayed ejaculation (DE) play a significant role in determining Female sexual dysfunction (FSD). The present study aimed to evaluate the role of perceived male partner’s sexual function and of the referred quality of relationship in determining FSD. A consecutive series of 156 heterosexual women consulting our outpatient clinic for FSD between January and December 2014 was retr...

Introduction: Both insulin resistance and oxidative stress are implicated in the pathophysiology of various diseases such as type 2 diabetes mellitus, atherosclerosis or liver disease. Furthermore, the uncoupling protein-1 (UCP1) is involved in induced thermogenesis, related to the pathogenesis of obesity and diabetes. The aim of this study was to assess the impact of aerobic exercise on the inflammatory profile in patients with chronic hepatitis C.Metho...

Introduction: Left ventricular diastolic dysfunction (LVDD) is a common cause of heart failure in obese patients. The aim of this study is to evaluate diastolic function and its relation to body mass index (BMI) in overweight and obese patients by using transthoracic echocardiography.Material and method: A total of 133 cases were enrolled in the study. All anthropometric and laboratory measures were recorded. After measuring two-dimensional and M-mode ec...

Introduction: Accumulating evidence suggests that one of the most significant contributors to endothelial dysfunction is increased oxidative stress. Excessive reactive oxygen species (ROS) generation can have injurious effects within the vasculature including elevated expression of adhesion molecules, stimulation of vascular smooth muscle cell proliferation, and promotion of endothelial cell apoptosis; events which culminate in the formation and progression of atherosclerotic ...

Introduction: Primary aldosteronism (PA) may present in younger age and it may so complicate pregnancy if not diagnosed early. Our aim was to identify patients in whom PA was diagnosed after pregnancy and to seek for possible complications during pregnancy.Design of methods: Retrospective analysis of patients with PA.Results: We found nine patients with PA (age at diagnosis 31.9±5 years, hypertension duration 5.9±2.6 year...

Introduction: Secondary high blood pressure is commonly diagnosed in young patients. In recent years, hypertension is increasing as well as the other components of metabolic syndrome such as obesity. The aim of this study was to determine the etiology of hypertension in patients aged <40 years old admitted in an endocrinology department.Materials and methods: It was a retrospective study including 55 patients <40 years old hospitalized at the end...

Introduction: LDL cholesterol (LDL-C) is usualy estimated using the Friedewald equation. This equation assumes a fixed factor of 5 for the ratio of triglycerides to very LPL cholesterol (TG:VLDL-C); however, the actual TG:VLDL-C ratio varies significantly across the range of triglyceride and cholesterol levels. A new method was proposed by Martin, S and co-workers using NHANES data. We aimed to evaluate the concordance Friedewald formula with the new method for LDL-C estimatio...

Introduction: Correction of Insulin resistance (IR) and dyslipidemic conditions of obese patients is important for the prevention of cardiovascular disease (CVD). The aim of our study is to determine the relationship between IR and non-high-density lipoprotein cholesterol (non-HDL-C) in obese patients.Material and methods: 248 patients over the age of eighteen, non-pregnant, followed with a diagnosis of obesity but did not receive the treatment of metfor...

Objective: The present study aimed to evaluate thyroid stimulating hormone (TSH) levels and anti-thyroid peroxidase antibodies (anti-TPOab) in euthyroid subjects with metabolic syndrome (MetS) and to compare them with healthy subjects without MetS.Design: Study included 173 subjects consisted of 96 subjects with MetS and 77 healthy controls. Gender, age, body mass index (BMI), waist circumfrence (WC), and detailed medical history of all participants were...

Sex steroid hormones effect on the early embryo-development and regulate the calcium signaling in cardiac muscle. Progesterone (P4) has been reported to affect both blood pressure and other aspects of the cardiovascular system. To confirm the effect of P4 on early differentiation of mouse embryonic stem (mES) cells into cardiomyocytes, the hanging-drop method was performed to form embryoid bodies (EB). The mouse EBs (mEB) were suspended, attached onto six well plates and cultu...

Aim: Recent studies have shown that immune responses contribute to atherosclerosis. The aim of this study was to investigate the relationship between carotid imt and the levels of anti-tpo in type 2 diabetic subjects with subclinical hypothyroidism (sch).Subjects and methods: A total of 109 non-smoking diabetic subjects with sch were recruited for this study from June 2013 to May 2015. We used the analysis of variance to compare the differences of imt am...

Background: The aim of this study was to explore if evaluation of lipid risk factors like lipoprotein(a) (Lp(a)) and conventional lipid profile parameters can be a efficient predictor of the cardiovascular risk in the patients of diabetes.Methods: Sixty individuals with angiographically proven premature CAD and 30 healthy individuals matched for age and sex were studied a tertiary health care center, New Delhi, India, over a period of 18 months. CAD pati...

Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.Materials and methods: A prospective study of 40 non-diabetics patients were perf...

Introduction and objectives: A possible increase in blood pressure (BP) and other cardiovascular risk factors has been associated with testosterone treatment (TT) in female-to-male transsexuals (FMT). Nonetheless, the available evidence does not support an increase in CV morbidity or mortality. We set out to analyze the impact of TT on BP and lipid profile in a cohort of FMT patients.Methodology: Retrospective observational study with no control group in...

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

Introduction: Aortic dilation (AD) is the life threating complication of Turner syndrome (TS). The reported prevalence of AD in TS various between 12 and 39%. Factors predicting enlargement of diameter of aorta (DA) are still under investigation.Aim: To assess the prevalence of AD in TS in Lithuanian population, to evaluate the possible predictors of AD development.Methods: Forty-three patients with TS aged ≥18 year were enro...

Hypertension or elevated arterial blood pressure (BP) is the most common cause of cardiovascular diseases (CVDs). The arterial BP is regulated by renin-angiotensin-aldosterone system (RAAS), whereas dysfunctional RAAS may lead to development of hypertension and associated CVDs. Parathyroid hormone (PTH) secreted by parathyroid glands regulates RAAS by directly stimulating aldosterone synthesis in zona glomerulosa cells, which leads to development of hypertension. Conversely, R...

Late identification and inadequate assessment of cardiovascular risk factors are being considered as the main cause of high mortality in men with type 2 diabetes mellitus (T2DM).Aim: To analyze the carbohydrate metabolism, levels of testosterone, proinflammatory cytokines in patients with T2DM and obesity.Methods: We examined 123 men with T2DM and obesity (mean age – 53.8±6.8). Parameters of carbohydrate metabolism, total...

Objectives: International and national guidelines on the treatment of chronic non-hypovolaemic hypotonic hyponatraemia differ widely. Using methods embodied in the Cochrane Handbook, a systematic review and meta-analysis was conducted to investigate the efficacy and safety of interventions for this condition.Methods: Following registration of the review protocol with PROSPERO (CRD42015016670), systematic literature searches were conducted to identify ran...

Introduction: The metabolic syndrome (MS) is a frequent complication of the obstructive sleep apnea hypopnea syndrome (OSAHS). Its predictive factors have to be known by the doctors setting in charge patients with OSAHS. The aim of this study was to determine the prevalence of the MS and its predictive factors in Tunisian patients with OSAHS.Methods: A retrospective study including 181 patients with OSAHS from the respiratory D department at the Abderrah...

Pathophysiological calcification in the vasculature favours cardio- and cerebrovascular diseases. In patients with chronic kidney disease vitamin K metabolites are associated with decreased vascular calcification.We investigated the expression of the vitamin K dependent proteins PRRG1-4 in vessels and bone to identify differences in expression pattern during atherosclerosis (AS) stages and compare the two tissue profiles.Gene expre...

Introduction: Apelin is one of the cardiovascular factors, adipokin, which plays an important role not only in the pathogenesis of hypertension, but also of type 2 diabetes (T2D). The aim of the study was to assess apelin levels in blood serum and investigate its relationship with duration of diabetes in hypertension patients with T2D.Methods: The study involved 63 hypertension patients grades 2–3 with T2D (32 men and 31 women) aged 43 to 70. Depend...

Background: Kidney diseases and cardiac diseases can affect each other. Patient with renal failure have many cardiac problems specially heart failure, anemia of CRF is resistant to treatment with iron or even blood transfusion and erythropoietin therapy gives good results as the failing kidney can not synthesize itThe previous published data showed that EPO treatment in patients with cardiorenal syndrome (CRS) anemia led to reverse ventricular remodeling...

Postural orthostatic tachycardia syndrome (PoTS) occurs as a consequence of the abnormal functioning of the autonomic nervous system (dysautonomia). Despite the many associated conditions, the assessment and relationship to reactive hypoglycaemia has not been explored in the clinical literature.The purpose of this retrospective observational-cohort study was to identify relationships between the physical and biochemical characteristics in potential carbo...

Patients with diabetes mellitus (DM) type 2 is a group of high cardiovascular risk. The incidence of coronary heart disease in their 2–4 times higher than in the population without diabetes, 80% of cases of diabetes combined with hypertension. At the same time any change in lipid metabolism leads to increased cardiovascular risk in patients with type 2 diabetes. Statins is first-line drugs in patients with dyslipidemia.Materials and methods: The stu...

Objective: A subclinical hypothyroidism (SH) is the independent factor of the risk of cardiovascular diseases. The aim is to learn the possibility of optimization of the standard treatment of lipid and carbohydrate disoders, antihypertensive treatment of the levothyroxine replacement therapy (LRT) for women with metabolic syndrome (MS) and SH.Methods: 137 women: 1gr.-68pts with MS, SH and with the LRT use; 2gr.-69pts with MS and without LRT use. Body mas...

Introduction and aims: Polycystic ovary syndrome (PCOS) is a frequent endocrinopathy among with young women. It is known that insulin resistance is encountered in the vast majority of the women with PCOS and hence the risk of type 2 diabetes mellitus and coronary artery disease are increased. These cardiac and metabolic risk increments may also associated with hyperandrogenemia and dyslipidemia. The metabolic changes of lipid profiles in young women with PCOS are not completel...

The purpose: To investigate the prevalence and the relationship between cardiovascular complications (CVC) and risk factors (RF) in patients with essential hypertension (EH) and coronary heart disease (CHD) in combination with diabetes mellitus type 2 (DM-2).Materials and methods: A retrospective analysis of case histories of 79 patients with cardiac profile (37 of them women, with an average patient age – 59.6±6.2 years) with hypertension stag...

Background: The pathophysiological base of metabolic syndrome is insulin resistance. According to Scott E.M., Grant P.J., insulin resistance is supposed to be formed during the evolution and connected by circadian rhythms. Melatonin is synchronizer of circadian rhythms. The modern lifestyle leads to the breach of melatonin synthesis because of absence of season changes in the length of a light day due to the using of artificial lighting.Aim: The aim was ...

Background: Diabetic autonomic neuropathy (DAN) is among the least recognized and understood complication of diabetes despite its significant negative impact on survival and quality of life in people with diabetes. Diabetic neuropathies including cardiac autonomic neuropathy (CAN), are a common chronic complication of type 1 and Type 2 diabetes and confer a high morbidity and mortality to diabetic pateints. The reported prevalence of CAN varies greatly depending on the criteri...

Demonstrating a relationship between diet and atherosclerosis should provide an opportunity for potential risk reduction at an early stage of the known long disease process instead of the need to intervene at the symptomatic disease stage. Thus, we aimed to evaluate the relationship between levels of nutrients intake as determined by food frequency questionnaire (FFQ) with the degree of atherosclerotic lesions as measured by carotid intima-medial ratio (CIMT).<p class="abs...

Methods: This study, was a cross-sectional survey. Sampling design was based upon multistage probability sampling. Patient with diabetes, hypertension, cardiovascular diseases and any other diseases were excluded from the study. Age and gender were noted. Heights, weights and waist circumference (WC) were measured. BMI was calculated. Blood pressure (BP) was measured. Fasting thyrigliseride levels were evaluated. Patients were divided into two groups according to their triglyc...

Three eagerly awaited large, randomised, controlled cardiovascular safety trials with new antidiabetic drugs have recently been completed. The results of these studies are of wide interest to the diabetes and cardiology clinical scientific communities, and the results have been presented at diabetes and cardiology scientific meetings. These have studied drugs in each of the new classes of antidiabetic drugs: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor; lixisenatide...

In a large sample of elderly patients with acute myocardial infarction, higher glucose levels were associated with a greater risk of 30-day mortality in patients with diabetes compared to patients without diabetes. In addition to previous hypothesis for mechanism of harm, recent studies have concluded that stress hyperglycaemia is an independent predictor of left ventricular remodelling after anterior myocardial infarction and may also contribute to arrhythmias.<p class="a...