Endocrine Abstracts

Objectives: To evaluate the use of antidepressant drugs in patients with type 2 diabetes mellitus (T2DM) and to analyse if these drugs are associated with a more deteriorated metabolic control.

Methods: Cross-sectional study which included patients with T2DM followed in a primary care setting. Data about age, sex, T2DM evolution, body mass index (BMI), HbA1c and associated antidepressant treatment was collected. Statistical analysis was performed with SPSS v 15.0 for Windows.

Results: 79 patients were included, with a mean age of 70.1±11.8 years (63.3% men) and a mean duration of T2DM of 5.9±5 years. 47% of patients were under treatment with antidepressant drugs (men 30%, women 65%, p=0.018). Metabolic control was more deteriorated in patients with associated antidepressant treatment (HbA1c 7.1% vs 6.6%, p=0.037), even after adjustment by sex, age and body mass index.

Conclusions: A high rate of prescription of antidepressant drugs is frequently found in individuals with T2DM, especially in women. T2DM patients under antidepressant treatment show a worse metabolic control.