Introduction: PCOS women appear to have an adverse body composition (BC). The aim of this study was to compare BC in lean PCOS in comparison to controls and to assess possible metabolic consequences.
Methods: We evaluated 150 lean PCOS women (BMI: 20.96±2.06 kg/m2; age: 25.50±4.52 years) diagnosed using ESHRE/ASRM criteria, and 39 lean BMI-matched healthy women (BMI: 20.33±2.16 kg/m2; age: 27.67±5.39 years). BC was evaluated using bioelectrical impedance (Tanita) and waist circumference (WC) was measured. In follicular phase of menstrual cycle lipids, glucose, and insulin were determined. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) and lipid ratios were calculated. All analyzes were age adjusted.
Results: There were no difference between groups in WC (P=0.066), whole body (WB) fat mass (FM, P=0.063), and WB fat free mass (FFM, P=0.763), abdominal FM (AFM, P=0.079) and abdominal FFM (AFM, P=0.520), HDL (P=0.777), LDL (P=0.065), LDL/HDL (P=0.059), triglycerides/HDL (P=0.086) and HOMA-IR (P=0.115). PCOS women in comparison to controls had higher FM/FFM ratio (0.35±0.01 vs. 0.31±0.02, respectively, P=0.044), total cholesterol (TC) (5.05±0.09 vs. 4.65±0.17, respectively, P=0.037), triglycerides (0.92±0.03 vs. 0.78±0.06, respectively, P=0.048), non-HDL (3.57±1.08 vs. 3.27±0.80 mmol/l, respectively, P=0.037), TC/HDL (3.51±0.07 vs. 3.18±0.13, respectively, P=0.029). In PCOS group FM/FFM correlated with WC (ρ=0.561, P<0.001), non-HDL (ρ=0.176, P=0.032), TC/HDL (ρ=0.228, P=0.005) and LDL/HDL ratio (ρ=0.196, P=0.016).
Conclusion: Our lean PCOS women had the same BC as lean controls although with disproportional FM to FFM, and that suggested its possible involvement in the pathogenesis of dyslipidemia in PCOS. As HOMA-IR index predominantly assess hepatic insulin resistance, it could possibly explain lack of correlation between FM/FFM and HOMA-IR.
28 - 31 May 2016
European Society of Endocrinology