Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations

Female Reproduction

ea0041ep657 | Female Reproduction | ECE2016

Immunity to Haemophilus influenzae B and Peumococcal vaccination among adult women with Turner Syndrome

Bukowczan Jakub , Liew Aaron , Roberts Graham , Spickett Gavin , Quinton Richard

Introduction: Turner Syndrome (TS) is associated with a higher overall morbidity and mortality than the general population, with respiratory diseases as one of the major causes. Haemophilus influenza type B (HiB) and pneumococcal (PC) vaccination can reduce morbidity and mortality, by alleviating the risk of respiratory diseases. All patients in the Newcastle Adult Turner Syndrome clinic who lack immunity to either HiB or PC at baseline receive vaccination in our TS clinic. Ho...

ea0041ep658 | Female Reproduction | ECE2016

Sex hormone and steroid precursor measurement by simple and rapid liquid chromatography-tandem mass spectrometry (Lc-Ms/Ms) method: comparison with current routine immunoassays

Fanelli Flaminia , Mezzullo Marco , Fazzini Alessia , Baccini Margherita , Gambineri Alessandra , Vicennati Valentina , Pelusi Carla , Pasquali Renato , Pagotto Uberto

Though LC-MS/MS is replacing immunoassays for major glucocorticoids and androgens routine assessment, the measurement of other sex steroids and precursors is still challenging and available only in experienced research laboratories. Our aim was to develop a simple-prep and rapid 2D-LC-MS/MS method for the simultaneous measurement of estrone (E1), estradiol (E2), dihydrotestosterone (DHT) and 17OHpregnenolone.Serum volumes of 300ul were spiked with intern...

ea0041ep660 | Female Reproduction | ECE2016

Increased adipsin is associated with carotid intima media thickness and metabolic disturbances in polycystic ovary syndrome

Kocabas Gokcen Unal , Calan Ozlem Gursoy , Calan Mehmet , Senses Pinar Yesil , Ozden Ebru , Sari Kerime Rumeysa , Aktar Merve Kocar , Imamoglu Cetin , Senses Yasar Mehmet , Bozkaya Giray , Bilgir Oktay

Context: Adipsin, a protein secreted mainly from the adipose tissue, is a structural homologous of complement factor D, a rate-limiting enzyme of the alternative complement system. Growing evidence suggests that the alternative complement system plays a role both in the regulation of energy homeostasis and the atherosclerotic process. Polycystic ovary syndrome (PCOS) is an inflammatory based-metabolic disease.Objective: To ascertain whether circulating a...

ea0041ep661 | Female Reproduction | ECE2016

Follicular fluid Bisphenol A levels are higher and correlate negatively with the number of oocytes in women with tubal factor infertility compared to women with polycystic ovary syndrome

Boutzios Georgios , Mina Areti , Papoutsis Ioannis , Athanaselis Sotiris , Christopoulos Panagiotis , Mastrominas Minas , Kousta Eleni , Mastorakos George

Introduction: Bisphenol A (BPA) is a chemical compound found in a variety of everyday products. Exposure to BPA impacts negatively ovarian response, number of fertilized oocytes and implantation in women undergoing in vitro fertilization (IVF). The aim of the study was to determine BPA levels in women with polycystic ovary syndrome (PCOS) in comparison to women with tubal factor (TF) infertility who underwent IVF as well as to investigate their effect in critical endp...

ea0041ep662 | Female Reproduction | ECE2016

The relation of liver enzymes and insulin resistance in women with polycystic ovary syndrome (PCOS)

Macut Djuro , Bozic-Antic Ivana , Tziomalos Konstatinos , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Panidis Dimitrios

Introduction: A link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) has been recently demonstrated. The pathogenesis of NAFLD is multifactorial, but obesity and insulin resistance (IR) appear to be important contributing factors. The aim of this study was to analyze level of transaminazes in PCOS women, and its relation to the indices of IR.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria...

ea0041ep663 | Female Reproduction | ECE2016

Pre-pregnancy risk assessment and combined multidisciplinary care improves pregnancy outcomes in women with Turner’s syndrome

Kumarasinghe Gayathri , Calanchini Matilde , Mackillop Lucy , Ormerod Oliver , Manning Nicky , Orchard Elizabeth , Turner Helen

Aims: Women with Turner’s syndrome (TS) are increasingly undertaking pregnancies, either via natural conception (mosaic TS) or assisted conception (AC). Increased TS pregnancies have led to reports suggesting high risk of pregnancy associated aortic dissection (AOD) 2%, and maternal mortality 2% due to underlying aortic valve abnormalities and aortopathies. However, the literature is limited to small case series. We report our practice providing risk-assessment and combin...

ea0041ep664 | Female Reproduction | ECE2016

The first hungarian preimplantational karyomapping In men2a syndrome – case report

Csajbok Eva , Csenki Marianna , Nanassy Laszlo , Fazekas Anita , Vereczkey Attila

The case: The multiplex endocrine neoplasia 2A (MEN2A) syndrome is a monogenic disease caused by mutation of the RET protooncogene leading to medullary thyroid cancer (MTC), pheochromocytoma and primary hyperparathyroidism. The specific mutations determine the timing of the preventive thyroidectomy. In 2007, in a 26 year old female patient, after detailed endocrine investigation, total thyroidectomy with both sided lateral neck lymph node dissection was performed because of su...

ea0041ep665 | Female Reproduction | ECE2016

PCOS in women with type 1 diabetes mellitus is not related to diabetes duration or insulin dose

Kogoj Tina Krokter , Sever Mojca Jensterle , Goričar Katja , Tomažič Marjeta , Skvarča Aleš , Šalamun Vesna , Jančar Nina , Janež Andrej

Introduction: Polycystic ovary syndrome (PCOS) is highly prevalent in women with type 1 diabetes mellitus (T1DM), possibly due to premenarchal exogenous hyperinsulinism (supraphysiological doses and nonphysiologic route of insulin administration). Our aim was to determine if PCOS was related to daily or basal insulin dose or T1DM duration.Methods: We examined 47 women with T1DM (mean age 36.02 years, ±6.03) treated with continuous subcutaneous insul...

ea0041ep667 | Female Reproduction | ECE2016

Glucose level after standard oral glucose tolerance test as a potential marker for the development of type 2 diabetes in women with polycystic ovary syndrome (PCOS)

Bozic-Antic Ivana , Bjekic-Macut Jelica , Ilic Dusan , Vojnovic-Milutinovic Danijela , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Stanojlovic Olivera , Damjanovic Svetozar , Macut Djuro

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...

ea0041ep668 | Female Reproduction | ECE2016

Serum alanine aminotransferase level as an early indicator of metabolic disturbancies in women with polycystic ovary syndrome (PCOS)

Bjekic-Macut Jelica , Bozic-Antic Ivana , Tziomalos Konstatinos , Ilic Dusan , Vojnovic-Milutinovic Danijela , Stanojlovic Olivera , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Macut Djuro , Panidis Dimitrios

Introduction: Serum alanine aminotransferase (ALT) level is used to screen patients for unsuspected liver disease. The entire histologic spectrum of nonalcoholic fatty liver disease (NAFLD) can be seen in individuals with normal ALT values. Accordingly, it has been suggested that by using ALT>19 U/l, early stages of NAFLD could be detected. As it was established a relation of NAFLD and PCOS, the aim of our study was to compare metabolic characteristics of women with polycy...

ea0041ep669 | Female Reproduction | ECE2016

The association between polycystic ovary syndrome and lipid accumalation product index

Kılıc Halime , Cadırcı Kenan , Durmaz Şenay , Utlu Mustafa , Sevimli Hakan , Carlıoğlu Ayşe

Aim: The lipid accumulation product (LAP) index which is associated with abnormal glucose regulation can be easily calculated. Women with polycystic ovary syndrome have more than one risk factor for the development of cardiovascular diseases such as glucose intolerance, insulin resistance and abdominal lipoidosis. In this study, we intend the evaluation of LAP index in women with PCOS.Method: This study included 35 women patients with PCOS (mean age 22.4...

ea0041ep670 | Female Reproduction | ECE2016

Androgen distribution in different phenotypes of women with polycystic ovary syndrome (PCOS)

Ilic Dusan , Bozic-Antic Ivana , Bjekic-Macut Jelica , Vojnovic-Milutinovic Danijela , Bogavac Tamara , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Stanojlovic Olivera , Damjanovic Svetozar , Macut Djuro

Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women...

ea0041ep671 | Female Reproduction | ECE2016

Effect of methomyl on the biochemical and reproductive parameters in pregnancy rats: the protective role of Pistacia Lentiscus oil

Mosbah Rachid , Mokrani Nadia , Mosbahi Imane , Rouabhi Sara , Mantovani Alberto

Methomyl (MET) is a carbamate insecticide used worldwide to protect a wide variety of crops from insect nuisances. Besides this beneficial role, it is classified as highly toxic compound for humans and animals by the EPA. Pistacia Lentiscus (PL) is a shrub that grows in the Mediterranean region; plant parts and oil have a long history in folk medicine in healing several diseases by their antioxidant, anti-inflammatory, antimicrobial, antifungal, antiatherogenic and anticancer ...

ea0041ep672 | Female Reproduction | ECE2016

The association between increased circulating irisin levels and inflammatory markers in polycystic ovary syndrome

Yildiz Nurdan , Calan Mehmet , Cobanoglu Minegul , Sengul Hatice İsik , Kocabas Gokcen Unal , Guclu Serkan

Purpose: Irisin is a secreted protein implicated in the regulation of insulin sensitivity and energy metabolism. Polycystic ovary syndrome (PCOS) is an inflammatory-based metabolic disease associated with insulin resistance, dyslipidemia, glucose metabolism dysfunction and obesity. There is also some evidence of a link between irisin and inflammation. Our aim of the study to ascertain whether the association of circulating irisin levels with inflammatory markers in PCOS.<p...

ea0041ep673 | Female Reproduction | ECE2016

Improvement of beta-cell function with DPP-4 inhibitor alogliptin vs alogliptin in combination with pioglitazone as a potential treatment target in metformin treated PCOS with persistent high metabolic risk: randomized pilot study

Jensterle Mojca , Goricar Katja , Janez Andrej

Introduction: High conversion rates to impaired glucose tolerance (IGT) and diabetes in PCOS indicate that current treatment strategy with lifestyle modification and metformin is insufficient. Preservation of β-cell function remains unaddressed although it is declined by 80% long before IGT is identified. Alogliptin is selective dipeptidyl peptidase-4 inhibitor improving insulin sensitivity (IS) and β-cell function. Pioglitazone predominantly improv...

ea0041ep674 | Female Reproduction | ECE2016

Pregnancy by Treatment for Graves Disease in a Patient with Primary Ovarian Failure

Evranos Berna , Polat Sefika Burcak , Baser Husniye , Bestepe Nagihan , Cakir Bekir

Introduction: Premature ovarian failure (POF) is a disorder associated with female infertility, and it affects approximately 1% of women under the age of 40 year. It is considered a multifactorial, heterogeneous condition, for which the exact underlying cause remains unclear. Associations with autoimmune diseases, environmental factors and genetic causes have been described. Herein we presented a case with POF who regained fertility after the treatment of Graves disease.<p...

ea0041ep675 | Female Reproduction | ECE2016

Baseline and metoclopramide induced plasma prolactin level in lean PCOS women according to their FAI phenotype

Mrozinska Sandra , Gorztyla Katarzyna , Przywara Agnieszka , Guzik Justyna , Kialka Marta , Milewicz Tomasz

Aim: Aim of our study was to compare: the baseline and metoclopramide induced prolactin plasma level between PCOS women with FAI <5 phenotype (group A)(FAI, total testosterone divided by sex hormone biding globulin, whole multiply by 100) and PCOS women with FAI>5 phenotype (group B).Patients and methods: The study population consisted of 354 lean women with PCOS. In all the patients the prolactin level at 02:00 h, 08:00 h and during the metoclop...

ea0041ep676 | Female Reproduction | ECE2016

Determinants of the reliable contraceptive use: a nationwide cross-sectional survey in Hungary

Vanya Melinda , Devosa Ivan , Pasztor Norbert , Kozinszky Zoltan

Objective: The purpose of this study was to investigate the contraceptive practice and sociodemographic determinants of employment of contraceptive methods among sexually active women.Design and methods: A randomly selected representative sample of 4542 women aged 15–49 years from the Hungarian population participated in a prospective web-based and postal questionnaire survey. Women completed self-report questionnaires on sociodemographic characteri...

ea0041ep677 | Female Reproduction | ECE2016

The influence of the body fat distribution on the selected biochemical parameters in a group of women with Polycystic Ovary Syndrome – preliminary report

Bronczyk-Puzon Anna , Nowak Justyna , Kulik-Kupka Karolina , Koszowska Aneta , Zubelewicz-Szkodzinska Barbara

Introduction: Polycystic Ovary Syndrome is usually accompanied by metabolic changes such as carbohydrate and lipid metabolism disorders and obesity.Aim: The aim of the study is to determine the impact of the deployment of body fat on selected biochemical parameters in women with Polycystic Ovarian Syndrome.Materials and methods: The study included a group of 45 women with diagnosed Polycystic Ovarian Syndrome based on the 2003 Rott...

ea0041ep678 | Female Reproduction | ECE2016

The influence of insulin resistance on selected anthropometric and biochemical parameters in women with Polycystic Ovary Syndrome- preliminary report

Bronczyk-Puzon Anna , Kulik-Kupka Karolina , Nowak Justyna , Koszowska Aneta , Zubelewicz-Szkodzinska Barbara

Introduction: Polycystic Ovary Syndrome is the most common recognized endocrinopathy in women. The syndrome is often accompanied by obesity and insulin resistance.Aim: The aim of the study was to assess the differences between the selected anthropometric and biochemical parameters in a group of women with insulin resistance and without insulin resistance.Materials and methods: The study included a group of 45 women diagnosed with P...

ea0041ep679 | Female Reproduction | ECE2016

Evaluation of serum osteoprotegerin and soluble receptor activator of nuclear factor κB ligand in obese and non-obese patients with polycystic ovary syndrome

Tutal Esra , Arslan Muyesser Sayki , Karakose Melia , Demirci Taner , Cakal Erman , Ozbek Mustafa , Erden Gonul , Delibasi Tuncay

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with increased cardiovascular risk in reproductive aged women. Circulating osteoprotegerin (OPG) and soluble receptor activator of nuclear factor κB ligand (sRANKL) are associated with subclinical atherosclerosis. Our aim is to evalutate serum OPG and sRANKL levels and their relations with cardiovascular and metabolic markers in paients with obese and non-obese PCOS.<p class="abstext"...

ea0041ep680 | Female Reproduction | ECE2016

Validation of the Estradiol III assay (Roche) in the ovulatory phase

Laskewitz Anke , Homminga Irene , Wagenmakers Lucie , Kobold Anneke Muller

Introduction: Estradiol is an important parameter in the evaluation of female fertility. Moreover, the measurement estradiol is essential in determining the right moment for oocyte retrieval in modified natural cycle IVF (MNC-IVF). Estradiol is measured by an immunochemical method and a change between immunoassays usually comes with a change in reference values due to differences in antibodies used and the lack of harmonization. In our hospital we changed in 2014 from the Auto...

ea0041ep681 | Female Reproduction | ECE2016

The influence of hormonal disorders on quality of life of women with acne

Naumova Liudmyla , Prystupiuk Lev , Prystupiuk Maksym , Naumova Marianna , Prystupiuk Oleksandr

Introduction: About 80% of people had acne of some form. This dermatosis manifests at age 12–14, when there is a physiological increase in the level of hormones, and in most cases it regresses at 18–22. However today, the number of women with acne at age 25 and older has significantly increased.Methodology: Conducted was prospective observational study involving 126 women aged 19 to 37 years with inflammatory form of acne of different severity....

ea0041ep682 | Female Reproduction | ECE2016

Polycystic ovary syndrome (Pcos) in female-to-male (Ftm) transsexual persons

Calvar Cecilia , Fernandez Mirta , Duran Yanina , Ballester Gustavo Perez , Landini Samanta

This study was conducted to evaluate the frequency of PCOS in a group of FTM transsexual persons and its relationship between clinical, hormonal and metabolic characteristics.Subjects and Methods: We studied 21 FTM cases, aged 17–37 years, BMI 24.6±5.2. No patient reported previous hormonal treatment or sex re-assignment surgery. PCOS was diagnosed according to the Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group, 2004. World Health...

ea0041ep683 | Female Reproduction | ECE2016

Increased level of serum irisin concentration and its regulation by hyperinsulinemia in women with polycystic ovary syndrome

Adamska Agnieszka , Karczewska-Kupczewska Monika , Lebkowska Adamska , Milewski Robert , Gorska Maria , Otziomek Elzbieta , Nikolajuk Agnieszka , Wolczynski Slawomir , Straczkowski Marek , Kowalska Irina

Background: Irisin is an adipokine/myokine which could be connected with insulin sensitivity. Polycystic ovary syndrome (PCOS) is characterized by oligo- or anovulation, polycystic ovary, hyperandrogenism and insulin resistance.Objective: The aim of the present study was to determine the relationship between serum irisin concentration and insulin sensitivity (Mffm) as well as the effect of insulin infusion on circulating irisin levels in PCOS ...

ea0041ep684 | Female Reproduction | ECE2016

Usefulness of dynamic Tsh evaluation for diagnosis of subclinical hypothyroidism in luteal deficiency

Mancini Antonio , Giacchi Elena , Saporosi Aurora , Olivieri Giulio , Di Segni Chantal , Marana Riccardo , Pontecorvi Alfredo

Introduction: It is known that thyroid disorders can influence menstrual cycle, but subclinical hypothyroidism (SH), as cause of ovulation disorders and luteal deficiency (LD) in particular,is underestimated. Monitoring women’s cycles, according to the Billings Ovulation Method (BOM), can allow a precise timing for hormonal evaluation and diagnose LD. Usually, a basal TSH value of 2.5 mg/ml is considered as cut-off for a good luteal function, but alone cannot identify all...

ea0041ep685 | Female Reproduction | ECE2016

Subclinical hypothyroidism and polycystic ovary syndrome

Velija-Asimi Zelija , Burekovic Azra , Dizdarevic-Bostandzic Amela

Introduction: The correlation of subclinical hypothyroidism (SH) and polycystic ovary syndrome (PCOS) is a still insufficiently explored entity. It is known that the patients with PCOS are at the greatest risk of infertility as well as cardiovascular morbidity and mortality. The aim of this study was to determine the existence of correlation between SH and PCOS. We also aimed to investigate the impact of SH on the metabolic and endocrine parameters in women with PCOS.<p cl...

ea0041ep686 | Female Reproduction | ECE2016

Cigarette smoke exposure disturbed maturation of ovarian follicle and induced abnormal growth of uterus inner wall of female rats

Lee Hae-Miru , Choi Kyung-Chul

Cigarette smoke (CS) is well known to be very harmful to human body functions such as fertility, reproduction, and development. To elucidate the effect of CS on women’s fertility more definitely, we examined the histophaological characteristics of the uterus and ovary samples received from Korean Conformity Laboratories (KCL), which were obtained from the female rats exposed to the different amounts (low, medium, and high concentrations) of smoke of the standard cigarette...

ea0041ep687 | Female Reproduction | ECE2016

Would thyroid binding globulin compensate for albumin loss during pregnancy?

Yatama Fatima Al , Mohammed Fawziah , Thani Hess , Masoud Fatima Al

Introduction: Normal thyroid function is necessary for normal body function. During pregnancy if the thyroid hormone deficiency, it will induce maternal and fetal hypothyroxinemia. And the vulnerable fetuses and neonates will suffer from irreversible deficit in the neuro-psycointellectual development including mental retardation. It is being established that albumin level decreases during pregnancy with recorded increase in urine microalbumin, An elevation in both thyroid stim...

ea0041ep688 | Female Reproduction | ECE2016

Endocan as a novel biomarker to evaluate cardiovascular risks in Polycystic Ovary Syndrome

Apaydin Mahmut , Beysel Selvihan , Caliskan Mustafa , Kizilgul Muhammed , Ozcelik Ozgur , Kan Seyfullah , Ozbek Mustafa , Cakal Erman , Delibasi Tuncay

İntroduction: Polycystic ovary syndrome (PCOS) is associated with risk of cardiovascular disease (CVD). Endocan is potential immunoinflammatory and endothelial dysfunction marker that may be linked to CVD. This study aimed to evaluate the risk of CVD in PCOS patients and to identify the novel biomarker for CVD risk.Material and methods: We analyzed 52 premenopausal women with PCOS and 59 healthy controls. Clinical, biochemical parameters and endoca...

ea0041ep689 | Female Reproduction | ECE2016

Body composition in lean women with polycystic ovary syndrome (PCOS) in relation to lipids and insulin resistance

Bogavac Tamara , Bozic-Antic Ivana , Ilic Dusan , Bjekić-Macut Jelica , Vojnovic-Milutinovic Danijela , Popovic Bojana , Isailovic Tatjana , Elezovic Valentina , Ognjanovic Sanja , Stanojlovic Olivera , Damjanovic Svetozar , Macut Djuro

Introduction: PCOS women appear to have an adverse body composition (BC). The aim of this study was to compare BC in lean PCOS in comparison to controls and to assess possible metabolic consequences.Methods: We evaluated 150 lean PCOS women (BMI: 20.96±2.06 kg/m2; age: 25.50±4.52 years) diagnosed using ESHRE/ASRM criteria, and 39 lean BMI-matched healthy women (BMI: 20.33±2.16 kg/m2; age: 27.67±5.39 years). BC wa...

ea0041ep690 | Female Reproduction | ECE2016

Turner syndrome and reproductive counseling

Vicente Nuno , Lopes Helena , Couto Daniela , Cortesao Paulo , Sousa Paula , Barros Luisa , Bastos Margarida , Carrilho Francisco , Santos Teresa Almeida

Introduction: Spontaneous fertility in Turner syndrome (TS) is rare, due to low or absent ovarian reserve. A greater number of ovarian follicules is present in the cases of gonadal mosaicism, although the accelerated pace of apoptosis remains. Thus, the early referral to reproductive counseling is advisable, ideally soon after diagnosis. The criopreservation of oocytes is one of the options for fertility preservation. The authors present a series of 7 patients with TS admitted...

ea0041ep691 | Female Reproduction | ECE2016

Flutamide treatment in severe acne in women-still controversial

Chiriac Anca , Foia Liliana , Urma Alina , Pinteala Tudor , Chiriac Anca E

Guidelines recommend hormonal treatment in severe acne, in forms of acne with no response to standard therapeutical options, in women with proved hyperandrogenism. Hormonal therapy for acne includes oral contraceptives; anti-androgens, such as cyproterone acetate, spironolactone and flutamide; low-dose glucocorticoids and gonadotropin-releasing hormone agonists.In daily practice there are many cases with moderate to severe forms of acne, in young women w...

ea0041ep692 | Female Reproduction | ECE2016

Resistant macroprolactinoma and infertility: a difficult challenge

Cheikhrouhou Nesrine , Kammoun Ines , Khatib Maria , Fennira Emna , Salem Leila Ben , Slama Claude Ben

Introduction: Dopamine agonist resistance is rare in prolactinoma (10%). Doses of cabergoline of up to 2.0 mg/week are usually effective in controlling prolactin (PRL) secretion and reducing tumor size. Surgical treatment is rarely indicated.Case report: An 18-year-old female presented in 2002 with a 2-year history of amenorrhea and galactorrhea. Hormonal investigation showed a hyperprolactinemia (4800 mUI/l) with integrity of the other pituitary axis. T...

ea0041ep693 | Female Reproduction | ECE2016

A 12-year-old virilized girl

Pacheco Lucia Vera , Del Peso Gilsanz Cristina , Redondo Lorena Rentero , Aviles Amparo Meoro , Garcia Maria Teresa Gallego , Blaya Flora Navarro , Lopez Eugenio Lopez

Introduction: Hyperthecosis ovarian is a type of hyperandrogenism and severe insulin resistance, usually found in postmenopausal women.Case Report: This case is about a 12 year-old girl who came to our hospital because of a rapidly progressive virilization. She had no medical history. For the previous 10 months, she had felt progressive growth of terminal hair in androgen-dependent areas, abundant hair loss, facial acne and voice changes. Axilarche and p...

ea0041ep694 | Female Reproduction | ECE2016

Correlation between dehydroepiandrosterone-sulfate levels and markers of bone turnover in hypothalamic amenorrhea

Mancini Antonio , Romualdi Daniela , Raimondo Sebastiano , Di Florio Christian , Di Segni Chantal , Bruno Carmine , Apa Rosanna , Lanzone Antonio

It is known that functional hypothalamic amenorrhea is associated with low bone turnover due to low gonadal homone levels. Estrogens are critical for activation of bone remodelling units, suppression of bone reabsorption, increase of 1-25(OH)Vitamin D receptors expression. Other mechanisms could be operative, including improper diet and unbalanced exercise; however the physiopathology of such a condition is not entirely known. In order to evaluate the correlation between pitui...

ea0041ep695 | Female Reproduction | ECE2016

High testosterone level in Chronic Liver Disease

Ibraheem Nawal , Shahbuddin Ibrahim , Gouni Ravi , Mudenha Emily

A 26 year old lady under investigation for infertility was referred to our endocrine clinic for raised testosterone levels at 6.6 nmol/l (0.5–2.8).she had regular period with no features of hirsutism. Her past medical history included common acute lymphoblastic leukaemia on chemotherapy, liver cirrhosis with portal hypertension secondary to chemotherapy, Trans jugular intrahepatic portosystemic shunt (TIPS) insertion for bleeding gastric varices.Cli...

ea0041ep696 | Female Reproduction | ECE2016

Increased uric acid levels and clinical relationship in polycystic ovary syndrome

Keskin Havva , Timur Ozge , Kaya Yasemin , Utlu Mustafa , Yildiz Faruk , Ademoglu Esra Nur , Kadi Melek , Budak Mehmet Emin , Gozcu Hakan , Sevimli Hakan , Durmaz Senay , Carlioglu Ayse , Kamalak Zeynep

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder that affects women of reproductive age. Clinical and biochemical characteristics are similar to metabolic syndrome. Insulin resistance in patients with metabolic syndrome, is associated with serum uric acid levels. In our study, we aimed to investigate the relationship between serum uric acid levels and clinical and laboratory in PCOS patients.Materials and Method: PCOS ...

ea0041ep697 | Female Reproduction | ECE2016

Kablia Samia Ould , Iabassen Malek , Cheikh Assya

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting 6–10% of reproductive aged women. This syndrome is associated with obesity, menstrual irregularity, infertility, hirsutism and insulin resistance. It has been reported that PCOS is frequently associated with hyperprolactinemia with ranges from 17 to 50%. So for many researchers the difficulty is to differentiate between real PCOS associated with hyperprolactinemia or hyperprolactinemia wit...

ea0041ep698 | Female Reproduction | ECE2016

Can weight loss reverse polycystic ovary syndrome?

Grira Wafa , Kammoun Ines , Zoubeidi Hana , Sfar Hayfa , Salem Leila Ben , Slama Claude Ben

Introduction: Weight loss is a mainstay in the treatment of polycystic ovary syndrome (PCOS). While the cause of this complex endocrine disorder remains unknown, it’s approved that weight loss improves symptoms of PCOS. We report a case of a patient with PCOS. Her symptoms disappeared totally after losing 50kgCase report: In 2005, a 16-year-old girl presented for evaluation of spaniomenorrhoea and obesity. Physical examination showed a weight of 88 ...