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18th European Congress of Endocrinology

Eposter Presentations

Endocrine tumours and neoplasia

ea0041ep589 | Endocrine tumours and neoplasia | ECE2016

Proposal of a two-step dynamic prognostic stratification for stage IV sporadic pancreatic neuroendocrine tumors

Marotta Vincenzo , Walter Thomas , Do Cao Christine , Tafuto Salvatore , Montesarchio Vincenzo , Arfi-Rouche Julia , Valette Pierre Jean , Lombard-Bohas Catherine , Leteurtre Emmanuelle , Borget Isabelle , Scoazec Jean Yves , Ducreux Michel , Faggiano Antongiulio , Colao Annamaria , Baudin Eric

Purpose: To validate a prognostic stratification system of overall survival (OS) in stage IV pancreatic neuroendocrine tumors (pNETs) naïve of therapy by analyzing 1) prognostic parameters at the time of stage IV diagnosis; 2) the role of spontaneous tumor slope.Patients and Methods: Multicenter retrospective study including consecutive patients diagnosed with stage IV pNET from January 1997 to March 2014. Inclusion criteria were: 1. pNET w...

ea0041ep590 | Endocrine tumours and neoplasia | ECE2016

Localization of benign insulinomas using glucagon-like peptide-1 receptor (GLP1-R) SPECT/CT and PET/CT in a prospective clinical study

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Purpose: The aim of our study is to compare the detection rate of GLP-1R PET/CT and GLP-1R SPECT/CT in patients with a biochemically proven endogenous hyperinsulinemic hypoglycemia. Preliminary results of an ongoing study are reported.Methods: Thirty-three patients (25 females, 8 males, age range 18–80 years, mean 49 years) with neuroglycopenic symptoms due to endogenous hyperinsulinemic hypoglycemia were enrolled (ClinicalTrials.gov, NCT02127541).<...

ea0041ep591 | Endocrine tumours and neoplasia | ECE2016

Mtor inhibitors responsiveness associates with Akt/Mtor pathway activation in pancreatic neuroendocrine tumors

Falletta Simona , Partelli Stefano , Rubini Corrado , Nann Dominik , Doria Andrea , Marinoni Ilaria , Polenta Vanessa , Di Paquale Carmelina , Uberti Ettore Degli , Perren Aurel , Falconi Massimo , Zatelli Maria Chiara

Introduction: Medical therapy of Pancreatic neuroendocrine tumors (P-NETs) may take advantage from mammalian target of rapamycin (mTOR) inhibitors. However, so far, the extent of therapeutic response cannot be predicted.Aim: To investigate the possible predictors of sensitivity to mTOR inhibitors in P-NETs.Materials and methods: P-NET primary cultures were treated with IGF1 and/or Everolimus. Cell viability and caspase activity wer...

ea0041ep592 | Endocrine tumours and neoplasia | ECE2016

Bone morphogenetic protein signaling as novel therapeutic target in pheochromocytoma

Richter Andrea , Leinhauser Ines , Pellegata Natalia

Introduction: Rats affected by the MENX syndrome develop bilateral pheochromocytoma (PCC) with complete penetrance. Transcriptome profiling of rat PCC identified Bmp7 (bone morphogenetic protein 7) as highly expressed in the tumors. Interestingly, 72% of human PCCs also showed elevated BMP7 expression. BMP7 plays pro- or anti-oncogenic roles in cancer in a cell type-dependent manner. To address the role of Bmp7 in PCC, its level was modulated in PCC cell line...

ea0041ep593 | Endocrine tumours and neoplasia | ECE2016

Prognostic factors of recurrence-free and overall survival in 52 patients with adrenocortical carcinoma

Nowak Karolina M. , Samsel Radoslaw , Cichocki Andrzej , Roszkowska-Purska Katarzyna , Kasperlik-Zaluska Anna , Papierska Lucyna

Adrenocortical carcinoma (ACC) is a rare and very aggressive tumor with poor prognosis. The aim of the study was to identify prognostic factors of recurrence-free (RFS) and overall survival (OS) in patients with ACC.We present a retrospective analysis in 52 patients diagnosed with ACC. A number of factors both histological and clinical were analyzed. Recurrent disease was defined as a new lesion confirmed in imaging. Kaplan-Meier method and multivariate ...

ea0041ep594 | Endocrine tumours and neoplasia | ECE2016

Sentinel lymph node biopsy in medullary thyroid microcarcinoma using methylene blue dye mapping – a pilot study

Dzodic Radan , Santrac Nada , Goran Merima , Buta Marko , Djurisic Igor , Pupic Gordana , Zivkovic Ognjen , Markovic Ivan

Introduction: Serum calcitonin level (sCT) is a precise marker for medullary thyroid carcinoma (MTC). However, lymph node (LN) metastases can be found in lower sCT, as well, and preoperative ultrasound may provide false negative findings on regional LNs. The aim was to present original technique of sentinel lymph node (SLN) biopsy of jugulo-carotid regions, after methylene blue dye mapping procedure, and its usefulness for selection of clinically N0 patients with MTC for modif...

ea0041ep595 | Endocrine tumours and neoplasia | ECE2016

Biochemical assessment of disease control in acromegaly: reappraisal of the glucose suppression test in somatostatin analogue (SA) treated patients

Arlien-Soborg Mai C. , Alvarson Elin , Dal Jakob , Jorgensen Jens Otto L.

Context: The nadir serum GH level during glucose suppression (OGTT) is recommended in patients treated by surgery, but not during SA treatment. We have shown that patients considered controlled by SA don’t suppress serum GH during OGTT and have impaired disease-specific QoL as compared to patients controlled by surgery. We hypothesize SA treated patients also don’t suppress GH in response to mixed meals.Aim: To compare GH levels during two mixe...

ea0041ep596 | Endocrine tumours and neoplasia | ECE2016

The role of insulin, IGFBP-3, folic acid, 25-OH-D, CA 19-9 and CA 72-4 as potential tumor’s predictors of the gastrointestinal tract in patients with acromegaly

Knyazeva Olga , Molitvoslovova Natalya , Rozhynskaya Lydmila

Introduction: Patients with acromegaly have increased risk of developing tumors of the gastrointestinal tract. There are some data that insulin, IGFBP-3, folic acid and 25-OH-D may influence the development of these tumors.Aim: To study the influence of insulin, IGFBP-3, folic acid and 25-OH-D, CA 19-9, CA 72-4 in the development of tumors of the gastrointestinal tract, and the frequency of neoplasms detection.Materials and Methods...

ea0041ep597 | Endocrine tumours and neoplasia | ECE2016

Phaeochromocytomas and paragangliomas: A comparative study between sporadic and familial cases in a reference care center in Spain

Luis Guillermo Ropero , Perez Jose Angel Diaz , Gracia Teresa Ruiz , Hernandez Martin Cuesta , Hoyos Emilia Gomez , Hernandez Irene Crespo , Novoa Paz de Miguel

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...

ea0041ep598 | Endocrine tumours and neoplasia | ECE2016

Norepinephrine transporter (NET) as a predictive marker of response to PI3K/mTOR inhibition in pheochromocytoma

Minaskan Ninelia , Lee Misu , Laitinen Iina , Braren Rickmer , Pellegata Natalia S

Phaeochromocytomas (PCs) are neuroendocrine tumors derived from neural crest-derived chromaffin cells of the adrenal medulla and sympathetic ganglia.About 10% of all PCs can be malignant.Currently, there is no effective therapy for malignant PCs.In many neuroendocrine tumors, including PCs, the PI3K/AKT/mTOR survival pathway is hyperactivated. Therefore, the inhibition of this signaling cascade may exert an a...

ea0041ep599 | Endocrine tumours and neoplasia | ECE2016

Dual targeting of PIK3/AKT/mTOR and IGF1/KRAS/BRAF pathways in an in vitro model of ovarian cancer: strategies for cell proliferation control

de Angelis Cristina , Galdiero Giacomo , Pivonello Claudia , Patalano Roberta , Bifulco Giuseppe , Di Spiezio Sardo Attilio , Alviggi Carlo , De Placido Giuseppe , Colao Annamaria , Pivonello Rosario

Ovarian cancer (OC) is the most lethal gynecological cancer. Debulking surgery and platinum-based chemotherapy are the cornerstone of OC management; however, after a partial initial response, tumors invariably relapse. Therapeutic approaches should account for interindividual heterogeneity since OC histiotypes show distinct genetic profile. A2780 cell line has been annotated as high grade serous ovarian cancer (HGSOC); nevertheless, recent research underlined that the genetic ...

ea0041ep600 | Endocrine tumours and neoplasia | ECE2016

Immunohistochemical study of AuroraB proves association with differentiation and expression of crucial progression markers in gastroenteropancreatic neuroendocrine neoplasms

Wang Yawen , Briest Franziska , Greshake Sonja , Lock Adrian , Horsch Dieter , Arnold Christian , Berg Erika , Hummel Michael , Siegmund Britta , Grabowski Patricia

Objective: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) are rare and heterogeneous in their tumor biology. Therapeutic options to prevent growth and dissemination are still not satisfactory. As shown previously, survivin and aurora kinases (members of the mitotic chromosomal passenger complex) play a role in cell cycle progression; FOXM1 is a transcription factor that regulates G2/M progression and is associated with grading and metastasis in GEP-NENs. Aurora kina...

ea0041ep601 | Endocrine tumours and neoplasia | ECE2016

Adrenal incidentalomas: functionality study

Rebollo-Roman Angel , Moreno-Moreno Paloma , Prior-Sanchez Maria-Inmaculada , Bahamondes-Opazo Rodrigo , Herrera-Martinez Aura-Dulcinea , Barrera-Martin Ana , Galvez-Moreno Maria-Angeles

Introduction: Due to the widespread use of imaging studies performed in hospitalised patients for other indications, adrenal incidentalomas (AI) are frequent findings in the everyday clinical practice. The objective of this research is to describe the prevalence of hormonally active and malignant AI.Patients and methods: Observational retrospective study of a cohort of patients who consulted in the Endocrinology service between 2005 and 2015 because of a...

ea0041ep602 | Endocrine tumours and neoplasia | ECE2016

Synergistic anti-tumour effects of 13-cis retinoic acid and lovastatin in pancreatic neuroendocrine tumour (BON1) cells through enhanced EGFR inhibition

Nolting Svenja , Prada Elke Tatjana Aristizabal , Lauseker Michael , Maurer Julian , Spottl Gerald , Goke Burkhard , Pacak Karel , Grossman Ashley

Introduction: In our previous studies we found that the combination of 13-cis retinoic acid (13cRA) and lovastatin significantly reduced tumour growth in a mouse phaeochromocytoma allograft model, with the lowest microvessel density in the combination-treated tumours. We have now investigated the effect of 13cRA plus lovastatin on neuroendocrine (BON1, H727) and non-endocrine tumour (HepG2, Huh7) cell viability and signalling pathways (EGFR, AKT, ERK, p70S6K) to eluci...

ea0041ep603 | Endocrine tumours and neoplasia | ECE2016

Medullary Thyroid Cancer: a comparative study between sporadic and familial cases in a reference care center in Spain

Luis Guillermo Ropero , Perez Jose Angel Diaz , Hoyos Emilia Gomez , Hernandez Martin Cuesta , Hernandez Irene Crespo , Gracia Teresa Ruiz , de Miguel Novoa Paz

Introduction: Hereditary Medullary Thyroid Cancer (MTC) accounts for 20–30% of cases and has some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients with MTC (n=48) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984–2013; 42% were germline mutation carriers (45% moderate risk (category MOD), 45% high risk (category H), 10% highest risk (ca...

ea0041ep604 | Endocrine tumours and neoplasia | ECE2016

Evaluation of differential genes expression of ARHI, FAM129A, KCNQ1, STT3A, CDH1, TIMP3, TFF3 and PTEN in thyroid tissue lesions and in biopsies obtained intraoperatively

Kusiński Michał , Czarnecka Karolina H , Soboska Kamila , Migdalska-Sęk Monika , Pastuszak-Lewandoska Dorota , Nawrot Ewa , Kuzdak Krzysztof , Brzeziańska-Lasota Ewa

Malignant transformation of the thyroid follicular cell in nodular goiter (NG) can lead to development of follicular adenoma (FA) or progression into: papillary thyroid carcinoma (PTC) or thyroid follicular cancer (FTC). Distinguishing follicular cell-derived thyroid tumors (FCDT) from NG on the molecular level can be especially helpful for underdetermined cytology (Bethesda III–IV) or FNAB with ‘follicular neoplasm’.Aim: Comparison of exp...

ea0041ep605 | Endocrine tumours and neoplasia | ECE2016

Real life data on Lanreotide Autogel in the treatment of patients with neuroendocrine tumors (NET) – an interim analysis from SOPRANo study

Rinke Anja , Muller Lothar , Maintz Christoph , Bolling Claus , Raderer Markus , Christ-Crain Mirjam , Hoffmanns Philipp , Chevts Vitali , Houchard Aude , Petersenn Stephan

Introduction: This non-interventional study assesses real-life use and potential predictive parameters for lanreotide (LAN) in pts with either acromegaly (ACRO) or NET over a period of 24 months. We present a pre-specified interim analysis after first 6 months of therapy.Methods: The primary objective is to evaluate the long term treatment response under LAN and to correlate it with early changes of biochemical markers. The planned sample size is 152 (76...

ea0041ep606 | Endocrine tumours and neoplasia | ECE2016

Novel mutations p.V220E and c.30G>T in menin gene are associated with hereditary predisposition to multiple endocrine neoplasia type 1

Ziemnicka Katarzyna , Budny Bartlomiej , Gut Pawel , Hernik Aleksandra , Leitgeber-Dominiczak Olena , Siudzinski Marcin , Gryczynska Maria , Janicki Adam , Ruchala Marek

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant condition characterized by varying combinations of endocrine tumors and commonly accompanying hyperplasia within the parathyroid gland, anterior pituitary and gastrointestinal tract. Heterozygous germline mutation of the tumor suppressor gene MEN1 is the most common cause of the disease. Molecular genetic testing of menin gene, in which mutation is known to cause MEN1 syndrome, detects pathogenic...

ea0041ep607 | Endocrine tumours and neoplasia | ECE2016

Glucagon-like-1 Receptor imaging specifically localizes insulinomas in patients with Multiple Endocrine Neoplasia Type 1 (MEN-1)

Antwi Kwadwo , Fani Melpomeni , Heye Tobias , Nicolas Guillaume , Merkle Elmar , Pattou Francois , Grossmann Ashley , Chanson Philippe , Reubi Jean Claude , Gloor Beat , Wild Damian , Christ Emanuel

Introduction: Surgery is often the only treatment option that can effectively treat patients with insulinoma in MEN-1. However, the surgical intervention should be limited as surgery can not cure patients with MEN-1. It is, therefore, mandatory to correctly localize insulin secreting tumors from other neuroendocrine tumors.Materials and Methods: In this report we include 6 patients with proven endogenous hyperinsulinemic hypoglycemia and neuroglycopenia ...

ea0041ep608 | Endocrine tumours and neoplasia | ECE2016

Pituitary magnetic resonance imaging in pituitary apoplexy

eddine Bellarbi Dhiya , Azzoug Said , Rabehi Leyla , Terki Brahim , Chentli Farida

Introduction: Pituitary apoplexy is a rare endocrine emergency characterized by the sudden onset of severe headaches, vomiting, visual abnormalities and pituitary dysfunction secondary to an acute hemorrhage or infarction within a pituitary adenoma.Subjects and methods: We report a retrospective study from 2000 to 2014 of 23 cases with pituitary apoplexy. Their mean age was 38.7 years ±10 years, with a male to female ratio of 2:1. All patients benef...

ea0041ep609 | Endocrine tumours and neoplasia | ECE2016

Craniopharyngioma registry for adult patients, an initiative of the pituitary workgroup of the DGE

Mende Klaus Christian , Kopczak Anna , Deutschbein Timo , Droste Michael , Honegger Jurgen , Stalla Gunther , Muller Herrmann , Petersenn Stephan , Flitsch Jorg

Introduction and Objective: Adult craniopharyngioma as a rare neoplasm of the central nervous system is still very poorly understood. The clinical implications for affected patients are numerous, ranging from endocrine dysfunction to visual loss and neurological impairment. Although the progress of this tumor entity is slow by nature, affected patients often suffer from multiple symptoms even after successful treatment with a strong impact on their individual quality of life. ...

ea0041ep610 | Endocrine tumours and neoplasia | ECE2016

Effect of 17β-estradiol on the expression of cytochrome P450 1A1 gene via an estrogen receptor dependent pathway in cellular and xenografted ovarian cancer models

Go Ryeo-Eun , Choi Kyung-Chul

Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and CYP1A1 genes was investigated for BG-1 ovarian cancer expressing ER. In reverse transc...

ea0041ep611 | Endocrine tumours and neoplasia | ECE2016

Obstructive sleep apnea syndrome in patients with Cushing’s syndrome

Gokosmanoglu Feyzi , Guzel Aygul , Kan Elif Kılıc , Atmaca Hulusi

Aim: Obstructive sleep apnea syndrome (OSAS) has been studied rarely in patients with Cushing’s syndrome. We investigated the possible association between Cushıng’s syndrome and OSAS in this study.Method: Thirty female patients with newly diagnosed Cushing’s syndrome and 30 female obese control subjects were included in this study. All the participants were evaluated by polysomnography. OSAS was defined as apneahypopnea index (AHI) of...

ea0041ep612 | Endocrine tumours and neoplasia | ECE2016

Human endometrial adenocarcinoma: growth hormone involvement in cancer chemoresistance

Gentilin Erica , Di Pasquale Carmelina , Benfini Katiuscia , Falletta Simona , Riva Eleonora , degli Uberti Ettore , Zatelli Maria Chiara

Introduction: It is known that growth hormone (GH) may influence neoplastic development of endometrial epithelium. GH is produced by normal and neoplastic endometrial cells and elevated levels have been observed in endometrial epithelium of patients with endometriosis and endometrial adenocarcinoma (EA). Moreover, endometrium cancer is one of the most occurring tumors in acromegalic patients. Furthermore, autocrine GH increases the oncogenicity of EA cells and is considered fu...

ea0041ep613 | Endocrine tumours and neoplasia | ECE2016

Silent incidental adrenal pheochromocytoma

Bettaibi Asma , Jemel Manel , Ktari Kamel , Marmouch Hela , Sayedi Hanen , Graja Sameh , Saad Hammadi , Khochtali Ines

Introduction: The widespread use of abdominal ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) has led to a predictable rise in the discovery of incidental adrenal lesions, some of which will be silent pheochromocytoma. Thus, about ten en percent of pheochromocytoma cases were diagnosed incidentally.Methods: We studied retrospectively the notes of 23 patients with histologically confirmed pheochromocytom. Demographic information,...

ea0041ep614 | Endocrine tumours and neoplasia | ECE2016

Nestin and Klotho protein expression in neuroendocrine tumors of the lung

Bromińska Barbara , Gabryel Piotr , Jarmołowska-Jurczyszyn Donata , Kluk Andrzej , Woliński Kosma , Trojanowski Maciej , Czepczyński Rafał , Dyszkiewicz Wojciech , Ruchała Marek

Introduction: Neuroendocrine tumors of the lungs comprise 20% of primary lung tumors. Nestin is an intermediate filament protein, expressed in stem cells during fetal development. It is also described as a potential cancer stem cell marker, angiogenesis marker and indicator of poorer survival probability for patients with some types of malignancies. Adversely, Klotho gene is a potential tumor suppressor. Aberrant expression of Klotho have been recently noticed in a number of c...

ea0041ep615 | Endocrine tumours and neoplasia | ECE2016

Genetic predisposition to breast cancer occurring in a male-to-female transsexual patient

Potorac Iulia , Corman Vinciane , Manto Florence , Dassy Sarah , Segers Karin , Thiry Albert , Bours Vincent , Daly Adrian F , Beckers Albert

Introduction: Breast cancer affects less than 1% of all male cancer patients. In 5–20% of cases, genetic predisposition is involved, mostly due to mutations of the BRCA2 gene. Hormonal imbalance between oestrogens and androgens is another predisposing factor. Male-to-female (MtF) transsexual patients usually undergo long-term cross-sex hormone therapy, which could expose them to higher risks of developing hormonally-dependent cancers.We rep...

ea0041ep616 | Endocrine tumours and neoplasia | ECE2016

Clinical benefit of patients with advanced adrenocortical carcinoma (Acc) treated in phase I clinical trials: the royal marsden hospital (Rmh) experience

Custodio Ana , Lopez Juanita , de Bono Johann S

Introduction: After progression on conventional treatment options, some patients with advanced ACC are offered experimental Phase I therapies. The outcomes of these patients have not yet been formally evaluated. This study aims to describe the experience of refractory ACC patients treated on Phase I clinical trials at the RMH.Methods: We retrospectively reviewed the records of metastatic ACC patients consecutively treated in our Drug Development Unit bet...

ea0041ep617 | Endocrine tumours and neoplasia | ECE2016

Dual inhibition of PI3K and mTORC1/C2 by PKI-587 (PF-05212384) as a promising therapeutic option for pulmonary neuroendocrine tumor disease

Broker Vanessa , Freitag Helma , Christen Friederike , Briest Franziska , Siegmund Britta , Grabowski Patricia

Background: Pulmonary neuroendocrine neoplasms are heterogeneous in their clinical behavior and therapeutic options are still not satisfactory. The ‘crosstalk’ of different signaling pathways in NEN cells appears to be more complex as known already. PKI-587 is a highly potent novel dual inhibitor of PI3K and mTORC1/C2.Aim: Therefore, we assessed the effects of PKI-587 in different pulmonary NEN cell lines compared to the established mTORC1 inhi...

ea0041ep618 | Endocrine tumours and neoplasia | ECE2016

The prevalence of pancreatic neuroendocrine neoplasms with dedifferentiation during their natural history

Alexandraki Krystallenia , Kaltsatou Maria , Chrysochoou Maria , Nikolopoulos Georgios , Moschouris Panagiotis , Angelousi Anna , Mavroeidi Vasiliki , Tsoli Marina , Chatzellis Eleftherios , Boutzios Georgios , Kaltsas Gregory

Introduction: Neuroendocrine neoplasms (NENs) are neoplasms with a slow progression and a 5-year survival 77–95%. It is well known that secondary deposits of NENs may dedifferentiate during the natural history of the disease, presenting a more aggressive biological behaviour.Aim of the study: The prevalence of secondary foci dedifferentiation of pancreatic NENs (p-NENs).Methods: From the NENs database of 414 patients, 160 (38....

ea0041ep619 | Endocrine tumours and neoplasia | ECE2016

Referral of patients from Lithuania to determination of dehydroepiandrosterone sulphate and no clinical consequences of results

Mazeikaite Julija , Uzkurnys Mazvydas , Banisauskaite Ilona , Galkine Aiste , Kurakovas Tomas , Venclovas Zilvinas , Steponaviciute Rasa , Urbanavicius Vaidotas , Verkauskiene Rasa , Matulevicius Valentinas

The 1772 patients were referred for the dehydroepiandrosterone sulphate (DHEA-S) concentration assessment in Lithuania during 2014. We investigated 309 clinical history cases of which 162 presented with normal DHEA-S concentration and 147 with elevated one.One hundred twenty-three women with increased DHEA-S were examined. The following symptoms were found: hirsutism −39%, menstruation disorders −23%, weight gain −8%, and the rest &#872...

ea0041ep620 | Endocrine tumours and neoplasia | ECE2016

Potential role of the adrenolitic drug mitotane in the treatment of hepatocarcinoma (HCC): effect on cell proliferation in HCC cell lines

Pivonello Claudia , Provvisiero Donatella Paola , Negri Mariarosaria , Di Gennaro Gilda , De Angelis Cristina , Simeoli Chiara , Patalano Roberta , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

HCC is one of the most common malignancies worldwide. Local approaches are generally preferred for patients whose disease is restricted to the liver. In patients with extrahepatic disease systemic therapy can be considered. Chemotherapy did not demonstrate convincing survival advantages in several trails for HCC patients. Presently, the kinase inhibitor sorafenib is the only approved systemic target therapy for the treatment of advanced HCC. Mitotane (dichlorodiphenildichloroe...

ea0041ep621 | Endocrine tumours and neoplasia | ECE2016

Body image perception in acromegaly is not associated with objective acromegalic changes, but depends on depressive symptoms

Dimopoulou Christina , Leistner Sarah , Ising Marcus , Schneider Harald , Schopohl Jochen , Rutz Sandra , Kosilek Robert , Frohner Richard , Stalla Guenter , Sievers Caroline

Objective: Diagnosis of acromegaly is often delayed up to 10 years after disease onset despite obvious visual changes, bone and soft-tissue deformities. We hypothesized that a reduced sense of body perception in acromegaly, possibly mediated by psychiatric or cognitive alterations, might contribute to the delayed initiation of a diagnostic work-up.Design: Cross-sectional study.Methods: We investigated perceived body image ...

ea0041ep622 | Endocrine tumours and neoplasia | ECE2016

The role of immunohistochemical assessment of somatostatin receptor expression in case of patients with well differentiated neuroendocrine neoplasms with symptoms of carcinoid syndrome and negative somatostatin receptor imaging

Stefanska Agnieszka , Sowa-Staszczak Anna , Hubalewska-Dydejczyk Alicja

Introduction: Over expression of somatostatin receptors (SSTR) is the characteristic feature of well differentiated neuroendocrine neoplasms (NENs). We present two patients with well differentiated NENs of the large intestine with negative SRS and without SSTR expression confirmed with immunohistochemical (IHCH) examination and symptoms of carcinoid syndrome with good clinical response to the therapy with long acting somatostatin analogs.Case reports: 53...

ea0041ep623 | Endocrine tumours and neoplasia | ECE2016

Dual face of sex-steroid hormones, estrogen and progesterone, on ovarian cancer metastasis via the regulation of epithelial-mesenchymal transition

Heo Jae-Rim , Jeon So-Ye , Choi Kyung-Chul

Ovarian carcinoma is the most deadly and leading cause of cancer death occurring in the female reproductive tracts. 17β-estradiol (E2) has long been considered as one of the effective causes of ovarian cancer through its actions via estrogen receptors (ERs). In contrast, progesterone (P4) offers protective effect against ovarian carcinogenesis. We predicted that P4 would inhibit the metastasis of BG-1 human epithelial ovarian cancer cells, which was induced by E2. In the ...

ea0041ep624 | Endocrine tumours and neoplasia | ECE2016

Inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing’s syndrome

Sanchez Beatriz Lardies , Aznar Pablo Trincado , Fernandez Leticia Perez , Monreal Isabel Azcona , Garcia Maria Martinez , Sanz Guayente Verdes , Paris Alejandro Sanz , Perez Javier Acha

Introduction: Bilateral sampling of the inferior petrosal sinuses is an accurate test to diagnose Cushing’s disease and distinguish it with the ectopic ACTH syndrome. The aim of the study was to review the petrosal sinus samplings carried out during last 10 years in our hospital.Methods and material: The medical histories of patients admitted for suspected Cushing’s disease in the last 10 years (from 2005 till 2015) were reviewed. There were se...

ea0041ep625 | Endocrine tumours and neoplasia | ECE2016

Four cases of hyperparathyroidism-jaw tumor syndrome in young patients with primary hyperparathyroidism in Russia

Mamedova Elizaveta , Mokrysheva Natalya , Pigarova Ekaterina , Voronkova Iya , Vasilyev Evgeny , Petrov Vasily , Rozhinskaya Liudmila , Tiulpakov Anatoly

Introduction: Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a rare autosomal-dominant disorder caused by mutations in CDC73 tumor suppressor gene. To date about 80 mutations in CDC73 have been described.Case reports: Four patients among a cohort of young patients (<40 y.o.) with primary hyperparathyroidism (PHPT) underwent next-generation sequencing (NGS) (Ion TorrentTM PGMTM, Thermo Fisher Scientific&#150...

ea0041ep626 | Endocrine tumours and neoplasia | ECE2016

Efficiency of cabergoline suppressive therapy in young patients with prolactinoma

Khyzhnyak Oksana , Karachentsev Iurii , Mykytyuk Myroslava , Gogitidze Teona

Aim: The aim is to study the clinical and hormonal peculiarities of PROL (prolactinoma), manifesting in people under the age of 18 and monitoring the effectiveness of suppressive CAB (Cabergoline, Dostinex) therapy during 12 months period.Materials and methods: The total study included 11 patients with PROL, manifesting in childhood. There were also examined 54 healthy volunteers (25 males and 29 females) aged 15–19 to determine the range of normal ...

ea0041ep627 | Endocrine tumours and neoplasia | ECE2016

RSUME regulates tumorigenesis and metastasis in pancreatic neuroendocrine tumors

Wu Yonghe , Tedesco Lucas , Lucia Kristin , Schlitter Anna M , Esposito Irene , Auernhammer Christoph J , Theodoropoulou Marily , Arzt Eduardo , Stalla Gunter K , Renner Ulrich

The factors triggering pancreatic neuroendocrine tumor (PanNET) progression are largely unknown. Here we investigated the role and mechanisms of the sumoylation enhancing protein RSUME in PanNET tumorigenesis. Immunohistochemical studies showed that RSUME is strongly expressed in normal human pancreas, in particular in β-cells. RSUME expression is reduced in insulinomas and is nearly absent in other types of PanNETs suggesting a role in PanNET tumorigenesis. In human panc...

ea0041ep628 | Endocrine tumours and neoplasia | ECE2016

Potential role of vitamin D in restoring sensitivity to mTOR inhibitors in hepatocellular carcinoma (HCC): 1,25(OH)vitamin D (VITD) reverts everolimus (EVE) resistance in a HCC cell line

Pivonello Claudia , Provvisiero Donatella Paola , Negri Mariarosaria , Di Gennaro Gilda , De Angelis Cristina , Galdiero Giacomo , Simeoli Chiara , De Martino Maria Cristina , Colao Annamaria , Pivonello Rosario

HCC is a difficult-to-treat- cancer with poor prognosis. The recent EVOLVE-1 trial demonstrated that EVE did not improve overall survival in molecularly and clinically unselected patients with advanced HCC resistant to sorafenib treatment. In selected patients, the well-established antitumor effect of EVE could make this drug a potential adjuvant therapy. Unfortunately, the acquired resistance to this molecule due to the tumor adaptation to chronic drug use is a current challe...

ea0041ep629 | Endocrine tumours and neoplasia | ECE2016

Circulating levels of survivin in acromegaly

Ademoglu Esra , Candan Zehra , Gorar Suheyla , Niyazoglu Mutlu , Carlioglu Ayse , Yildiz Faruk , Baydar Idris , Sevimli Hakan , Arslan Abdulmuttalib

Introduction: Acromegaly is a chronic disorder characterized by chronic growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in different benign and malignant human tumors. A number of studies showed overexpression of survivin in pituitary adenomas. This study is intended to determine circulating levels of survivin in patients with acr...

ea0041ep630 | Endocrine tumours and neoplasia | ECE2016

A thymic carcinoid tumor causing Cushing syndrome in the setting of a multiple endocrine neoplasia syndrome type 1

Gligic Ana , Sumarac-Dumanovic Mirjana , Kendereski Aleksandra , Stamenkovic-Pejkovic Danica , Cvijovic Goran , Zoric Svetlana , Jeremic Danka , Micic Dragan

Introduction: Multiple endocrine neoplasia syndrome type 1 (MEN1) associated thymic carcinoids (Th-NETs) are rare and have poor prognosis. Cushing syndrome (CS) caused by Th-NET in MEN1 syndrome is extremely rare.Case report: We report a case of a 55-year-old man with CS at presentation due to ectopic ACTH production in MEN1 syndrome. Thirty years ago, this patient had total gastric resection due to Zollinger-Ellison’s syndrome and extirpation of tw...

ea0041ep631 | Endocrine tumours and neoplasia | ECE2016

Clinical characteristics, survival and prognostic factors of patients with adrenocortical carcinoma: a tertiary centre experience

Elezovic Valentina , Macut Djuro , Ognjanovic Sanja , Isailovic Tatjana , Popovic Bojana , Bozic Antic Ivana , Bogavac Tamara , Ilic Dusan , Damjanovic Svetozar

Adrenocortical carcinoma (ACC) is rare malignancy associated with poor prognosis. The aim of this study was to present clinical characteristics and survival of patients with ACC and to analyse the effect of prognostic factors on survival.We retrospectively analysed 69 patients (46 female and 23 males) with pathologically confirmed ACC who were treated in our hospital between January 2005 and December 2015. The median age at diagnosis was 51,0 years (rang...

ea0041ep632 | Endocrine tumours and neoplasia | ECE2016

Evaluation of the incidence and clinical characteristics of glucose metabolism alterations during the follow-up of surgically treated insulinomas

Sergio Neves Joao , Lau Eva , Oliveira Joana , Isabel Oliveira Ana , Freitas Paula , Carvalho Davide

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

ea0041ep633 | Endocrine tumours and neoplasia | ECE2016

Mechano growth factor (MGF) expression increased in secondary compared to primary foci in well neuroendocrine neoplasms

Alexandraki Krystallenia , Philippou Anastasios , Boutzios Georgios , Moschouris Panagiotis , Karnezis James , Theohari Irini , Koutsilieris Michael , Delladetsima Ioanna , Kaltsas Gregory

Introduction: Insulin-like growth factor-I (IGF-I) has a role in cell proliferation, differentiation, migration, and survival. By alternative splicing different IGF-I mRNA transcripts as IGF-IEc (mechano growth factor, MGF) or IGF-IEa variants are produced. MGF induces muscle hypertrophy and implicated in the pathophysiology of various types of cancer. Aim of the study was to investigate the role of MGF in the pathophysiology of neuroendocrine neoplasms (NENs).<p class="ab...

ea0041ep634 | Endocrine tumours and neoplasia | ECE2016

Hypoglycaemia unawareness – a challenge in the management of a Von Hippel-Lindau patient

Bettencourt-Silva Rita , Souteiro Pedro , Magalhaes Daniela , Oliveira Joana , Bessa de Melo Renato , Costa Maia Jose , Carvalho Davide , Queiros Joana

Background: The key physiologic defences against hypoglycaemia are the decrease in insulin and the increased secretion of glucose counterregulatory hormones, namely glucagon and epinephrine. The absence of warning signs of impending neuroglycopenia is known as hypoglycaemic unawareness.Case report: Male, 26 year-old, without relevant medical history and with normal body mass index, presented with hypertension, palpitations and diaphoresis. Clinical suspi...

ea0041ep635 | Endocrine tumours and neoplasia | ECE2016

Thyrotoxicosis leading to adrenal crises reveals primary bilateral adrenal lymphoma – case report

Roque Catarina , Fonseca Ricardo , Bello Carlos , Capitao Ricardo , Sousa Santos Francisco , Vasconcelos Carlos

Introduction: Amiodarone use may be associated with secondary severe organ dysfunction. Thyrotoxicosis develops in 15% cases. Primary bilateral adrenal lymphoma is a rare malignancy. If frequently presents bilaterally and with symptoms of adrenal insufficiency. Symptomatology for both conditions is nonspecific, especially in the elderly, and a high suspicion index is necessary for appropriate diagnosis.Case report: A 78 year old female presented to the e...

ea0041ep636 | Endocrine tumours and neoplasia | ECE2016

Hyperparathyroidism-jaw tumour syndrome in Adolescence

Hafeez Saba , Kalk John , Saqib Aaisha , Izzat Louise

Introduction: The hyperparathyroidism-jaw tumour syndrome is a rare autosomal, dominantly inherited disorder characterized by neoplastic or cystic lesions in parathyroid gland, jaws and the kidneys. With approximately 200 reported cases in literature this condition remains a challenge both diagnostically and in guiding further management.Case report: Seventeen year old scholar was seen by the maxillofacial department at Medway Hospital with 2 painless sw...

ea0041ep637 | Endocrine tumours and neoplasia | ECE2016

Analogues of somatostatin in preoperative treatment of rare NET

Papierska Lucyna , Nowak Karolina , Rabijewski Michał , Ćwikła Jarosław

Analogues of somatostatin are widely used in management of neuroendocrine tumors. The “classic” indications for this treatment are: acromegaly and NETs of midgut to diminish symptoms caused by hormonal overproduction and slow down the tumors’ growth. However we consider the use of this medication also in the other cases in which we confirm the presence of somatostatin receptors in tumor by somatostatin receptor scintigraphy.We would like t...

ea0041ep638 | Endocrine tumours and neoplasia | ECE2016

A case of tumor-induced osteomalacia in which recurrence and bilateral lung metastases occurred following tumor resection

Tanaka Toshiaki , Itagaki Eiji , Moriya Rie , Ishitobi Minori , Ishimoto Mai , Kondo Ken , Sumitani Yoshikazu , Nishida Susumu , Kondo Takuma , Hosaka Toshio , Morii Kenji , Ishii Jun , Kanma Hiroshi , Ishida Hitoshi

A 32-year-old woman with a nine-year history of right hip pain was admitted after she became unable to walk. Based on marked hypophosphatemia as indicated by serum phosphate of 1.4 mg/dl, intactPTH;29 pg/ml, TmP/GFR;1.14 mg/dl, and fibroblast growth factor 23 (FGF23) increased to 713 pg/ml, tumor-induced osteomalacia (TIO) was diagnosed. Systemic venous sampling of FGF23 performed for locating the tumor revealed an elevated level of 1600 pg/ml in the right femoral vein, and MR...

ea0041ep639 | Endocrine tumours and neoplasia | ECE2016

Effects of genetically engineered human neural stem cells expressing cytosine deaminase and interferon-beta on the growth of lymph node metastatic colorectal adenocarcinoma

Park Geon-Tae , Choi Kyung-Chul

Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, we employed human neural stem cells (HB1.F3; hNSCs) transduced with genes expressing Escherichia coli cytosine deaminase (HB1.F3.CD) and human interferon-beta (HB1.F3.CD.IFN-β) as a treatment strategy for human lymph node metastatic colorectal cancer. CD can convert the prodrug 5-fluorocytosine (5-FC) to its act...

ea0041ep640 | Endocrine tumours and neoplasia | ECE2016

gp91-phox in differential diagnosis of hyperplastic lesions in parathyroid gland

Segiet Oliwia , Deska Mariusz , Mielańczyk Łukasz , Brzozowa-Zasada Marlena , Buła Grzegorz , Helewski Krzysztof , Wojnicz Romuald

Introduction: Glycoprotein gp91-phox is an essential component of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox. gp91-phox is a significant element of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain th...

ea0041ep641 | Endocrine tumours and neoplasia | ECE2016

Myelolipoma in a rheumatoid arthritis patient – report of a case

Tzanavari Aikaterini , Kostoglou-Athanassiou Ifigenia , Banti Theodota , Katsavouni Charoula , Xanthakou Eleni , Athanassiou Panagiotis

Introduction: Adrenal myelolipoma is an extremely rare benign adrenal tumor. Adrenal myelolipoma is characterized by the presence within the adrenal gland of mature adipose tissue and active bone marrow elements. Owing to their non-functional nature most cases are incidental, either at autopsy or through computer tomography scan. Occasionally the lesions attain a large size to become clinically apparent. Seropositive rheumatoid arthritis is a disorder affecting approximately 1...

ea0041ep642 | Endocrine tumours and neoplasia | ECE2016

A case of multiple endocrine neoplasia type 2A with a C634A mutation and a L769L polymorphism in RET proto-oncogene

Jeong Kwon Min , Kim Taekyoon , Hee Lee Soon , Hyun Park Jeong

Introduction: Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominant condition characterized by the presence of a medullary thyroid carcinoma, pheochromocytoma and hyperparathyroidism. The germ-line mutations of the RET proto-oncogene cause MEN2A. Specific RET mutations correlate with the onset of age and the aggressiveness of the disease. It has been reported that polymorphisms of RET may have a modifier effect on the presentation.Case re...

ea0041ep643 | Endocrine tumours and neoplasia | ECE2016

Multiple endocrine neoplasia type 1: an underdiagnosed disorder

Espirito Santo Raquel , Sabino Teresa , Filipe Edite , Mario Coutinho Jose , Vasiljevic Alexandre , Agapito Ana

Introduction: Multiple Endocrine Neoplasia type 1 is an underdiagnosed autosomal dominant disorder, with inter and intrafamilial variability without a genotype-phenotype correlation.Case report: A young female (born in 1986) presented with galactorrhea and secondary amenorrhea in 2002, and investigation revealed a prolactinoma. Her brother (born in 1982) presenting gynecomastia and erectile dysfunction at age 21, was also diagnosed with prolactinoma. The...

ea0041ep644 | Endocrine tumours and neoplasia | ECE2016

A case of recurred parathyroid carcinoma with multiple lymph node metastasis: concurrent with papillary thyroid cancer

Woo Lee Hyoung , Jin Kim Ho , Sung Moon Jun , Sung Yoon Ji , Chang Won Kyu , Eun Lee Ji

Parathyroid carcinoma, a rare endocrine malignancy, accounting for only 1–2% of patients with primary hyperparathyroidism (HPT). In addition, a few case have been reported coexistence of parathyroid carcinoma and papillary thyroid cancer. Here, we present a case of recurred parathyroid cancer with multiple lymph node metastasis. A 57-year-old women was presented with high serum calcium level (14.4 mg/dl) in medical check-up. Hyperparathyroidism was considered to be the re...

ea0041ep645 | Endocrine tumours and neoplasia | ECE2016

Postprandial hypoglycemia in the presence of insulinoma – case report

Gungunes Askin , Arikan Durmaz Senay , Oguz Dilek , Rendeci Serkan

Background and aim: Although insulinoma typically causes fasting hypoglycemia, postprandial hypoglycemia occasionally reported in these patients. We aimed to report a rare case of insulinoma who atmitted to outpatient clinic with postprandial hypoglycemia.Case report: A 31-year-old woman was admitted to outpatient clinic with postprandial hypoglycemia. Capillary blood glucose levels were found 25 and 27 mg /dl during typical hypoglycemic symptoms such as...

ea0041ep646 | Endocrine tumours and neoplasia | ECE2016

A novel mutation of the menin gene in a family with multiple endocrine neoplasia type 1

Nahit Sendur Suleyman , Dogrul Ahmet , Kabacam Serkan , Abbasoglu Osman , Onder Sevgen , Sokmensuer Cenk , Erbas Belkis , Dagdelen Selcuk , Alikasifoglu Mehmet , Erbas Tomris

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant genetic disorder characterized by parathyroid adenomas, enteropancreatic endocrine tumors and anterior pituitary adenomas. It is caused by inactivating mutations of the MEN1 tumor suppressor gene, encoding menin (chromosome 11q13). A large family with several members affected were evaluated for clinical and genetic characteristic of MEN1.The index male patient (42 yr) presented ...

ea0041ep647 | Endocrine tumours and neoplasia | ECE2016

Multiple liver-directed therapy including theraspheres for recurrent metastatic jejeunal carcinoid tumor

Al Emadi Budoor , Ahmed Mohammed , Alsuhaibani Hamad , Amin Tarek , Al Hindi Hindi , Tuli Mahmoud

Introduction: Majority of patients with neuroendocrine tumors (NET) harbor hepatic metastases at presentation, posing therapeutic challenge. Multiple liver-directed treatment modalities have been employed with variable success. Herein is presented successful outcome in a patient whose recurrent metastatic liver metastases from NET was managed using multidisciplinary approach.Case report: We present long-term18-years course of a patient with liver metasta...

ea0041ep648 | Endocrine tumours and neoplasia | ECE2016

Clinical case of rare adrenal tumor – schwannoma

Volkova Natalya , Porksheyan Mariya , Kyt Oleg , Kanaeva Saida , Dimitriadi Sergey

Background: Schwannoma (Sch) is a rare peripheral nerve sheath tumor comprised entirely of neoplastic Schwann cells. Adrenal Sch are extremely rare. Most adrenal Sch are incidental, and patients with Sch may not have any complaints. Here we present the clinical case of giant adrenal Sch, which caused hematuria and had indiscriminating organ origin on MRI.Clinical case: Woman, 58 y.o., was consulted by urologist because of painless macrohematuria. Abdomen...

ea0041ep649 | Endocrine tumours and neoplasia | ECE2016

The contribution of fast test in the diagnostic approach of hypoglycemia in non-diabetic patients

Gharbi Radhouen , Chaker Fatma , Chihaoui Melika , Danguir Syrine , Yazidi Mariem , Rejeb Ons , Slimane Hedia

Introduction: Hypoglycemia is an uncommon complaint among non diabetic patients. The aim of this study was to determine the role of fast test in the diagnostic approach to hypoglycemia.Patients and methods: It was a retrospective study, including 40 patients admitted in the endocrinology department from 2001 to 2015 for hypoglycemia signs. We collected clinical and biologic data, fast test results and final diagnosis of hypoglycemia.<p class="abstext...

ea0041ep650 | Endocrine tumours and neoplasia | ECE2016

Evaluation of postmenopausal hyperandrogenism – case report

Fernandez-Ladreda Mariana Tome , De Pinillos Guillermo Martinez , Cuellar Eyvee Arturo

Introduction: Evaluation of postmenopausal hyperandrogenism may be a challenge for physicians as it is necessary to exclude the presence of the relatively rare but potentially life-threatening underlying tumorous causes. We report the case of a postmenopausal woman who presented with clinical and biochemical hyperandrogenism.Case Report: We present the case of a 65 year-old woman being followed at our clinic because of mild hypothyroidism. At inspection ...

ea0041ep651 | Endocrine tumours and neoplasia | ECE2016

Hirsutism with rapid onset presenting in a 62-year-old postmenopausal woman

Tzaves Ioannis , Papadakis Georgios , Moustakas Konstantinos , Keramidas Ioannis , Kaltzidou Victoria , Veniou Eirini , Kalinoglou Nikolaos , Tertipi Athanasia

Introduction: Virilizing tumors are rare, but frequent cause of virilization in postmenopausal women.Case report: A 62-year-old postmenopausal woman presented with a rapid onset of hirsutism with increased terminal hair growth, particular on chin and abdomen, frontal male pattern balding in the last 5 months. Physical examination revealed a low-pitched, deepened voice and clitoromegaly. The Ferriman–Gallwey score was 18. Laboratory evaluation: Testo...

ea0041ep652 | Endocrine tumours and neoplasia | ECE2016

Clinical presentations and genetic analyses of patients with multiple endocrine neoplasia type 2A: a single thai tertiary center experience

Laichuthai Nitchakarn , Houngngam Natnicha , Sunthornyothin Sarat , Snabboon Thiti

Introduction: Multiple endocrine neoplasia type 2A (MEN 2A) is an autosomal dominant disorder from a RET proto-oncogene mutation, characterized by the presence of medullary thyroid carcinoma (MTC), pheochromocytoma and/or primary hyperparathyroidism.Materials and Methods: A retrospective study of 5 probands (3 males and 2 females, age range 31–46 years) and 6 family members (2 males and 4 females, age range 2–50 years) diagnosed as MEN 2A at Ki...

ea0041ep653 | Endocrine tumours and neoplasia | ECE2016

Multiple complications of severe hyperandrogenism in a postmenopausal woman

Capatina Cristina , Scafa-Udriste Alexandru , Ghinea Adela , Dumitrascu Anda , Poiana Catalina

Introduction: Severe hyperandrogenism is not only associated with cosmetic concerns but it also increases the risk of neoplastic (endometrial, breast cancer), cardiovascular, respiratory and metabolic complications.Case report: A 68 years-old woman with a recent history of severe arterial hypertension, cardiogenic pulmonary edema, diabetes mellitus, severe respiratory failure, marked obesity was referred to our department due to the markedly androgenic p...

ea0041ep654 | Endocrine tumours and neoplasia | ECE2016

Incidentaloma. Myxoid adrenal adenoma

Porcel Jose Alvaro Romero , De Pinillos Gordillo Guillermo Martinez , Lloclla Eyvee Arturo Cuellar , Perez Fernando Garcia , Muros Mariola Mendez , Fernandez-Ladreda Mariana Tome , Pena Jose Ignacio Fernandez , De Quiros Juan Manuel Garcia , Lopez Jose Ignacio Fernandez , Leon Maria Victoria Cozar

Introduction: Myxoid tumors of the adrenal glands constitute an unusual entity and should be part of the differential diagnosis of atypical adenomas in the study of adrenal incidentaloma.Description of methods: We report the finding of myxoid adrenal adenoma in left adrenal gland in a 38-year-old woman.Case: PMH: Active smoker. Non hypertension, type 2 diabetes or dyslipidemia. No constitutional symptoms.Phys...

ea0041ep655 | Endocrine tumours and neoplasia | ECE2016

Von Hippel-Lindau syndrome with musculoskeletal manifestations. report of a case

Athanassiou Panagiotis , Tzanavari Aikaterini , Pantazi Eleni , Spyridis Anestis , Kostoglou-Athanassiou Ifigenia

Introduction: Von Hippel-Lindau (VHL) syndrome is an inherited disorder characterized by the formation of tumors and cysts in diverse organ systems. Tumors may be malignant or benign and they tend to appear during young adulthood. Hemangioblastomas are characteristic of VHL syndrome.Aim: The aim was to describe the case of a patient with VHL syndrome presenting with musculoskeletal manifestations and multiple tumors.Case report: A ...

ea0041ep656 | Endocrine tumours and neoplasia | ECE2016

Insulinoma misdiagnosed as neurologic disease

Salavessa Judite , Gomes Vania , Alcantara Cristina , Ferreira Florbela

Introduction: Insulinoma is a rare pancreatic endocrine tumor derived from ß cells that secret insulin, which results in hypoglycemia. Most are benign and solitary. The median age at diagnosis is about 47 years. The age range for peak incidence is between 30 and 60 years and it is more prevalent in women. Diagnosis relies on clinical features along with laboratory tests and imaging. However, the nonspecific symptoms and small size of these tumors can lead to difficulties ...