ECE2016 Eposter Presentations Male Reproduction (18 abstracts)
Adjustment of testosterone and dihydrotestosterone reference intervals to the male Portuguese population
Joana Simões-Pereira , Susana Prazeres , Daniel Macedo , Margarida Silva-Vieira , Pedro Marques & Maria Conceição Pereira
Instituto Português de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.
Introduction: In our practice we’ve been following some oncologic survivors patients with low-low/normal levels of testosterone who are asymptomatic. Aims: to determine the levels of total (TT) and free testosterones (FT) and dihydrotestosterone (DHT) in healthy men, in order to find the reference intervals (RI) adjusted to our population and compare them with those provided by the kit-producers (KP).
Methods: We collected blood samples from 125 healthy male blood-donors and determined, for each man, the levels of TT, FT and DHT. Age groups: A-21–30-years: 20 men; B-31–40-years 34 men; C-41–50-years: 34 men; D-51–60-years: 25 men; E-61–70-years: 12 men. In these assays we used Immulite2000, Free TESTO-RIA-CT and Dihydrotestosterone RIA for TT, FT and DHT, respectively. RIs were calculated through mean±2 S.D., being the RI described as −2 S.D.–+2 S.D.
Results:
Conclusion: The RI that we determined are inferior and narrower than those provided by the KP. We highlight the need to verify if the RI provided are adjusted to our population’s reality. It would also be important to include the paediatric population in next studies.
| TT (ng/dl) | FT (pg/ml) | DHT (pg/ml) | ||||
| RI | RI | RI | ||||
| Age group | Calculated | KP | Calculated | KP | Calculated | KP |
| A | 247–635 | 160–726 | 4.9–14.9 | 8.9–42.5 | 149–395 | 169–692 |
| B | 137–562 | 4.0–13.3 | 120–386 | 163–597 | ||
| C | 120–482 | 3.9–11.3 | 6.6–30 | 109–349 | 77–−440 | |
| D | 104–478 | 129–767 | 2.8–9.3 | 64–306 | 93–413 | |
| E | 2.8–8.6 | 4.9–21.6 | 61–281 | |||
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