Endocrine Abstracts

Animal models are valuable tools in fertility research. Worldwide, there are more than 1000 transgenic or knockout mouse models available showing a reproductive phenotype; almost all of them exhibit an infertile or at least subfertile phenotype. By contrast, animal models revealing an improved fertility phenotype are barely described. We developed two outbred mouse models exhibiting a ‘high-fertility’ phenotype. These mouse lines were generated via selection over a t...

Intratesticular testosterone levels in Klinefelter syndrome (KS) are comparable to controls and Leydig cell function was proven to be normal at least in vitro, testicular vascularization changes came into focus as a potential factor contributing to hypogonadism. We performed enhanced ultrasound based analysis of the testicular blood support in our 41,XXY* mice. Adult male 41,XXY* (n=5) and control mice (n=6) underwent ultrasound...

Dopamine has been found in both semen and oviductal fluid and dopamine receptors (DRs) have been detected in male genital tract and spermatozoa, suggesting that dopamine system may control important reproductive functions in humans. Dopamine improves sperm motility and viability in animal models, although the underlying molecular mechanisms have not been fully elucidated. The aims of this study were to investigate DRs expression in human spermatozoa and to evaluate the in ...

Introduction: The current Endocrine Society guidelines (2010) recommend biochemical and radiological evaluation of men with HH to ascertain underlying hypothalamic and/or pituitary aetiology although the cost-effectiveness of this strategy is yet to be established. We did a retrospective audit to ascertain epidemiology, management and diagnostic outcomes for men with HH in our hospital practice against the current Endocrine society guidelines.Methods: A ...

Follicle-stimulating hormone (FSH) therapy is a potential treatment option in idiopathic infertile men with normal FSH levels. In fact, a recent Cochrane meta-analysis showed that FSH treatment of men affected by idiopathic oligozoospermia significantly improves pregnancy rate. Hyaluronic acid (HA) binding capacity of spermatozoa is considered a marker of functional competency, consequently the evaluation of the percentage of HA bound spermatozoa in the ejaculate can serve as ...

Introduction: An inverse relation was found between testosterone and vasculopathy of the allograft in heart-transplanted men. We evaluated the correlation between serum testosterone levels and graft function early after heart transplantation.Methods: In a cross-sectional study serum total testosterone levels prior to hospital discharge (19±3 postoperative day) was determined in 49 consecutive male patients who underwent heart transplantation between...

Introduction: Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. The pathogenesis of increased cardio-metabolic risk in hypogonadal patients is not clear. Oxidative stress plays an important role in the pathogenesis of cardio-metabolic diseases. The aim of this study was to search for any difference of the oxidative stress parameters between in patients with hypogonadism and healthy controls.Materials and Methods: Thirty ...

The reawakening of hypothalamo-pituitary-gonadal axis at puberty is influenced by a number of hormonal and genetic factors along with certain environmental cues. In boys, puberty is initiated at around 9 years of age as plasma concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH) and testosterone (T) begin to rise leading to development of secondary sex characteristics. The absence of signs of sexual maturation at the age of 14/15 years is regarded as ...

Background: Prevalence of hypogonadism is high (30%) in men with HIV. In these patients T treatment (TT) is currently used mainly to counteract wasting syndrome and/or HIV-related lipodystrophy, irrespective of patients’ serum T. However, its effect and safety in HIV-infected men is still not completely known.Aim: To investigate both beneficial and adverse effects related to TT in HIV-infected men using a meta-analytic approach.<p class="abstext...

There is a rising use of Aluminium oxide nanoparticles (Al2O3NPs) in many branches of industry and personal care products. Because of these uses, their impact on the environment must be considered and investigated. Almost nothing is known about the effects of Al2O3NPs on semen quality and reproductive hormones. Possible mechanisms for the cytotoxicity of Al2O3NPs are still being discussed, but oxidative stress m...

Introduction: In our practice we’ve been following some oncologic survivors patients with low-low/normal levels of testosterone who are asymptomatic. Aims: to determine the levels of total (TT) and free testosterones (FT) and dihydrotestosterone (DHT) in healthy men, in order to find the reference intervals (RI) adjusted to our population and compare them with those provided by the kit-producers (KP).Methods: We collected blood samples from 125 heal...

There have been many discussions about testosterone role in inflammation and autoimmunity. Inflammatory bowel disease (IBD) is a chronic autoimmune disease in younger age groups. The aim ouf our study was to evaluate testosterone concentration and it’s influence on disease acitivity and the quality of life.In our cross-sectional study we measured total testosterone levels in males with IBD (Crohn’s Disease, Ulcerative colitis). Age, BMI, main c...

Introduction: Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder. It can be sporadic or familiar and is divided into anosmic hypogonadotropic hypogonadism (Kallmann syndrome - KS) and congenital normosmic isolated hypogonadotropic hypogonadism (idiopathic hypogonadotropic hypogonadism &hyphen; IHH). A growing number of genes are involved in its etiology, suggesting the heterogeneity and complexity of this condition.Cases Reports: Six cases...

Introduction: Garcinia cambogia is a plant with reported spermatogenic properties. ciprofloxcin is an antibiotic used in the treatment of of various bacterial infection but with reported toxic effects on the testes. The modulatory effects of Garcinia cambogia on ciprofloxacin-induced testicular toxicity was evaluated in this study.Method: Twenty one (21) male Wistar rats were randomly divided into four (4) groups. Group A was given ciprofloxacin...

Background and Objective: Although several epidemiological studies have been conducted, the impact of Follicle Stimulating Hormone Receptor (FSHR) polymorphisms on male infertility remains unclear. The aim of this study was to investigate the prevalence of specific FSHR Single Nucleotide Polymorphisms (SNPs) in the Greek population and associate the latter with the clinical phenotype.Patients and Methods: We enrolled 96 subjects: men with idiopathic non-...

Introduction: The effect of self-prescribed cross-sex hormone therapy on Male-to-Female (MtF) transgenders do not appear to have been well investigated and can be associated with potential serious longterm complications. The main purpose of this study is to look at the clinical and metabolic profile, and cardiovascular outcomes of MtF transgenders in Zamboanga Peninsula.Methodology: This is a cross-sectional study, done to determine the clinical and meta...

Introduction: Hypogonadotropic hypogonadism(HH) is mandatory treated with testosterone (T). However, gonadotropin(hCG/FSH) administration might be the challenging optimal therapy.Case 1: Male, 23-y-old, hypophisectomy pp. adenoma hromophobum, one month later- FSH 1.5 U/L, LH 0.55 U/L. Primogonyl(hCG) test; testosteronemia: 0 day 0.069, 3 day 19.01 nmol/l. After 5 m in ejaculate no sperm. 5 m after introduction of hCG twice weekly 1,500 i.u. and FSH+LH 15...

Introduction: Azoospermia is identified in approximately 1% of all men and in 10 to 15% of infertile males. A precise diagnosis of azoospermia and systematic evaluation of the patient to establish the disease etiology are needed to guide appropriate management options. The development of intracytoplasmic sperm injection (ICSI) as an efficient therapy for severe male factor infertility has become an appropriate treatment for the majority of male reproductive tract deficiencies....