Searchable abstracts of presentations at key conferences in endocrinology
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18th European Congress of Endocrinology

Eposter Presentations


ea0041ep728 | Neuroendocrinology | ECE2016

Women with idiopathic intracranial hypertension have a distinct andro-metabolic signature compared to polycystic ovary syndrome and simple obesity

Kempegowda Punith , O'Reilly Michael , Hornby Catherine , Botfield Hannah , Taylor Angela , Hughes Beverley , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Context: Idiopathic intracranial hypertension (IIH) is characterised by elevated intracranial pressure and occurs predominantly in obese premenopausal women. Signs and symptoms of polycystic ovary syndrome (PCOS) often coexist in IIH. Here we compared the androgenic and metabolic phenotypes in IIH, PCOS and simple obesity.Patients and Methods: We studied 25 patients with IIH (mean age 34.4±9.2 years; mean BMI 37.8±5.2 kg/m2), in comp...

ea0041ep729 | Neuroendocrinology | ECE2016

The cyclin-dependent kinase 4/6 inhibitor LEE001 (ribuciclib) demonstrates antiproliferative effects in neuroendocrine tumor cells in vitro

Prada Elke Tatjana Aristizabal , Nolting Svenja , Spottl Gerald , Maurer Julian , Auernhammer Christoph

Cyclin-dependent kinases (CDKs) are crucial for the cell cycle regulation and alterations of the cell cycle and its regulators are often observed in human malignancies. CDK4/6 in particular orchestrates the G1 phase progression and the G1/S transition. Here we investigated the in vitro effects of the CDK4/6 inhibitor LEE001(Novartis, Basel) on the human neuroendocrine tumor (NET) cell lines BON1, QGP1 and NCI-H727. The cells were treated with different concentrations ...

ea0041ep730 | Neuroendocrinology | ECE2016

The oxytocin regulates kidney function through V2 receptor

Gutkowska Jolanta , Plante Eric , Menouar Ahmed , Danalache Bogdan , Jankowski Marek

During maturation of oxytocin (OT) prohormone, several bioactive intermediate molecules are formed. The plasma concentrations of these forms (OT-G; OT-GK and OT-GKR) increase markedly in rat circulation at the end of gestation. At low concentration in the circulation OT stimulates while OT-GKR inhibits diuresis. Since OT and OT-GKR show different effects on the urine flow, we hypothesized that OT-GKR modulates renal action by targeting the V2 receptor.<p class="...

ea0041ep731 | Neuroendocrinology | ECE2016

Abstract withdrawn....

ea0041ep732 | Neuroendocrinology | ECE2016

Growth hormone increases ALAS2, the rate-limiting enzyme of Hbb in male rat hippocampus

Walser Marion , Oscarsson Jan , Wickelgren Ruth , Isgaard Jorgen , AEberg David

Objective: Growth hormone (GH) has long been known to have neuroprotective properties. Hypophysectomy (Hx) completely abolishes circulating endocrine GH. Also neuronal (non-erythrocyte) haemoglobin beta chain (Hbb) in the hippocampus decreases following Hx while GH infusions and injections robustly increase the levels approximately 2-4-fold in male rat hippocampus. Recently it has been revealed that Hbb protein is present in mitochondria in the mammalian brain. Current investi...

ea0041ep733 | Neuroendocrinology | ECE2016

Impaired innate immunity in Cushing’s syndrome: increase CD14+CD16++ monocytes

Velazquez Gloria Aranda , Lopez Cristina , Esteban Yaiza , Mora Mireia , Halperin Irene , Casals Gregori , Ensenat Joaquim , Hanzu Felicia Alexandra

Introduction: Chronic hypercortisolism is marked by an increased cardiovascular risk pattern. Atherosclerosis is a chronic inflammation that involves both innate and adaptive immunity. Glucocorticoids (GC) are immune-suppressors and adrenocorticotrophic hormone (ACTH) possesses immune-modulatory activities. GC and ACTH may act in atherothrombotic inflammatory pathways.Aim: To analyze the immune cells pattern in endogenous Cushing syndrome (CS) in order t...

ea0041ep734 | Neuroendocrinology | ECE2016

Serum concentrations of glucose, cholesterol and triglyceride in men with prolactinoma treated with cabergoline

Dawid Maria del rocio , Arcano Karina , Diez Juan Jose , Villabona Carles , Bernal Carmen , Iglesias Pedro

Introduction: Hyperprolactinemia has been associated with several metabolic abnormalities both in glucose homeostasis, insulin sensitivity, and in lipid profile. Moreover, it has also been reported that many of them seem to improve after normalizing serum prolactin (PRL) concentrations.Objective: To study serum glucose, cholesterol and triglyceride in men with prolactinoma before and after chronic treatment with cabergoline.Patient...

ea0041ep735 | Neuroendocrinology | ECE2016

Phenotype-genotype analysis in patients with GnRH deficiency in a single center

Djurdjevic Sandra Pekic , Xu Cheng , Dwyer Andrew , Cassatella Daniele , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Pitteloud Nelly , Popovic Vera

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

ea0041ep736 | Neuroendocrinology | ECE2016

The medical treatment with pasireotide in Cushing’s disease: an Italian multicenter experience based on “Real Word Evidence”

Pivonello Rosario , Arnaldi Giorgio , Scaroni Carla Maria , Giordano Carla , Cannavo Salvatore , Iacuaniello Davide , Trementino Laura , Zilio Marialuisa , Guarnotta Valentina , Albani Adriana , Cozzolino Alessia , Michetti Grazia , Boscaro Marco , Colao Annamaria

A recent phase III clinical trial has demonstrated that the treatment with the somatostatin analogue pasireotide normalizes cortisol secretion in 15–28% of patients with Cushing’s disease (CD). The aim of the current study was to evaluate the effectiveness of 6-months pasireotide treatment on clinical and hormonal profiles in a group of CD patients with mild to moderate disease according with the real-word evidence. Thirty-two patients with CD unsuccessfully treated ...

ea0041ep737 | Neuroendocrinology | ECE2016

Sublingual desmopressin is efficient and safe in the therapy of lithiasic renal colic

Branisteanu Dumitru , Pricop Catalin , Orsolya Martha

Background: Antidiuretic analogue desmopressin was tested in its intranasal form in renal colic, with variable effects.Aims: We evaluated the effects of sublingual desmopressin in lithiasic renal colic, alone or combined with a non-steroidal antiinflammatory drug (NSAID).Materials and methods: Our prospective single-blind study included an initial number of 371 patients with lithiasic renal colic randomized as follows: group NSAID ...

ea0041ep738 | Neuroendocrinology | ECE2016

The effects of pituitary replacement therapies on body composition in adult patients with growth hormone deficiency

Frara Stefano , Maffezzoni Filippo , Formenti Anna Maria , Mezzone Monica , Ferreira Caroline Ronchini , Doglietto Francesco , Maroldi Roberto , Mazziotti Gherardo , Giustina Andrea

Growth hormone deficiency (GHD) has become increasingly recognized as a cause of metabolic syndrome, characterized by altered body composition and adverse cardiovascular risk. The effects of other pituitary hormone deficiencies or their replacement therapies on the metabolic profile in this clinical setting are still largely unclear. In this study, we aimed to evaluating the effects of replacement therapies of central hypoadrenalism and hypothyroidism on body composition in a ...

ea0041ep739 | Neuroendocrinology | ECE2016

Nuchal Skinfold Thickness: a novel parameter for assessment of body composition in childhood craniopharyngioma

Sterkenburg Anthe S. , Hoffmann Anika , Reichel Julia , Lohle Kristin , Eveslage Maria , Warmuth-Metz Monika , Muller Hermann L.

Context: Hypothalamic obesity, subsequent cardiovascular disease (CVD), and relapses/progression have major impact on prognosis in childhood-onset craniopharyngioma (CP). We analyzed nuchal skinfold thickness (NST) on magnetic resonance imaging (MRI) performed for follow-up monitoring as a novel parameter for body composition (BC) and CVD in CP.Objective: Identify association of NST with body mass index (BMI), waist-to-height ratio (WHtR), caliper-assess...

ea0041ep740 | Neuroendocrinology | ECE2016

Nonalcoholic fatty liver disease and fatigue in long-term survivors of childhood-onset craniopharyngioma

Hoffmann Anika , Bootsveld Klaus , Gebhardt Ursel , Daubenbuchel Anna M. , Sterkenburg Anthe S. , Muller Hermann L.

Objective: Hypothalamic obesity in childhood craniopharyngioma (CP) patients bares a high risk for development of metabolic syndrome. In metabolic syndrome, the development of nonalcoholic fatty liver disease (NAFLD) is known. The aim of this study is to detect the risk for NAFLD in childhood-onset CP.Design: This cross-sectional study included liver computed tomography (CT); ultrasound analysis of abdomen; measurements of serum parameters, height, weigh...

ea0041ep741 | Neuroendocrinology | ECE2016

Hypothalamic dysfunction revealed by magnetic resonance diffusion tensor imaging in childhood leukemia survivors treated with cranial radiotherapy but not in craniopharyngioma survivors

Follin Cecilia , Fjalldal Sigridur , Svard Daniel , van Westen Danielle , Gabery Sanaz , Petersen AEsa , Latt Jimmy , Rylander Lars , Erfurth Eva Marie

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

ea0041ep742 | Neuroendocrinology | ECE2016

How frequently can we predict failure of fluid restriction in SIAD? Results of a multicenter prospective audit

Cuesta Martin , Ortola Ana , Slattery 2David , Garrahy Aoife , Pascual Alfonso Luis Calle , Tormey William , de la Vega Isabelle Runkle , Thompson Christopher J.

Context: Fluid restriction (FR) is recommended as first line therapy for SIAD by both the European1 and the American guidelines2 for management of SIAD. Not all patients respond to FR however, and the American guidelines have identified clinical predictors of failure to respond to FR. These include 1.Urine osmolality (UOsm) >500 mOsm/Kg 2. Furst formula (ratio UNa+UK/pNa) > 1, and 3. 24 hour-urine volume<1500 mlObjective...

ea0041ep743 | Neuroendocrinology | ECE2016

Liraglutide restores the endocrine function of islet’s β-cells and the altered lipid profile in early stages of life induced by food restriction in pregnancy

Diz-Chaves Yolanda , Toba Laura , Fandino Juan , Ogando Hugo , Gonzalez-Nunez Maria , Romani Marina , Vigo Eva , Gonzalez-Matias Lucas , Mallo Federico

Maternal food restriction during late pregnancy and lactation, increases the risk of glucose intolerance and metabolic diseases such as diabetes & obesity in rats. Liraglutide is a GLP-1 receptor agonists administered for treating DM2. The aim of this study was to elucidate if liraglutide given to pregnant rats may prevent the deleterious effects of malnourishment in male pups analyzed at 21 days of age.Twenty eight Sprague-Dawley pregnant rats were ...

ea0041ep744 | Neuroendocrinology | ECE2016

Assessment of bilateral inferior petrosal sinus sampling in the differential diagnosis of the ACTH-Dependent cushing’s syndrome

Moreno-Moreno Paloma , Prior-Sanchez Inmaculada , Jimenez-Gomez Elvira , Padillo-Cuenca Jose Carlos , Delgado-Acosta Fernando , Oteros-Fernandez Rafael , Corpas-Jimenez Maria Sierra , Galvez-Moreno Maria Angeles

Objective: The aim of this study was to assess the diagnostic accuracy of BIPSS with desmopressin stimulation in the differential diagnosis of ACTH-dependent Cushing’s syndrome.Patients and methods: Retrospective study of patients studied to our hospital for diagnosis of ACTH-dependent Cushing’s syndrome (2000–2015). The histopathological results in patients who underwent a surgical procedure was considered the reference for statistical st...

ea0041ep745 | Neuroendocrinology | ECE2016

Hormonal characteristics of recurrent ACTH-secreting pituitary adenomas

Marova Evgenia , Arapova Svetlana , Lapshina Anastasia , Kolesnikova Galina , Grigoriev Andrey , Voroncov Alexsandor

Cushing’s disease (CD) remission after primary surgical treatment is achieved in 70–90%, but recurrence ranges 18–25% after.The aim of this work was to study clinical, hormonal and MRI indicators before and after surgical treatment in patients with recurrent CD to identify possible predictors of recurrence. We examined 49 patients with recurrent CD in the active stage (disease duration up to 3 years). Before neurosurgery blood ACTH (median...

ea0041ep746 | Neuroendocrinology | ECE2016

Quality of sleep and salivary cortisol

Painold Annamaria , Braunsteiner Teresa , Tripolt Norbert , Warnkross Helga , Kapfhammer Hans-Peter , Pieber Thomas , Obermayer-Pietsch Barbara

Introduction: Contradictory associations between sleep disturbances and changes in cortisol levels or unfavourable metabolic conditions like obesity and diabetes mellitus have been observed.The aim of the present study was to examine salivary cortisol in persons with reduced sleep quality and to evaluate the relationship between sleep quality and metabolic parameters.Methods: The Pittsburgh Sleep Quality Index (PQ8I) was used in 15...

ea0041ep747 | Neuroendocrinology | ECE2016

Limited value of the standard 8-hour water deprivation test in the diagnostic work-up of patients with suspected diabetes insipidus

Trimpou Penelope , Olsson Daniel S. , Ragnarsson Oskar

Background: Diabetes insipidus (DI) is characterized by polyuria and consequently thirst and polydipsia. Excessive water intake can also cause polyuria, i.e. primary polydipsia. It is of utmost importance to differentiate between the two disorders since the treatment is different.Aims: To study the clinical value of the standard 8-hour as well as an extended water deprivation test in patients with polyuria and polydipsia.P...

ea0041ep748 | Neuroendocrinology | ECE2016

Severe carcinoid cardiac disease in a young patient with neuroendocrine tumor of unknown origin

Poiana Catalina , Nitu Ileana , Baciu Ionela

Carcinoid cardiac disease is a rare cause of intrinsic right heart valve disease with significant impact on mortality. We present the case of a young male patient (38 yrs old) complaining in the last 5 yrs of abdominal pain associated with flushing of the face that progressively worsened (up to 15 episodes/day) accompanied by diarrhoea and, in the last 2 months, by night sweats, distension of the abdomen, bilateral ankle swelling and progressive limitation in effort. Endocrine...

ea0041ep749 | Neuroendocrinology | ECE2016

Molecular genetic analysis in familial isolated pituitary adenoma patients

Pigarova Ekaterina , Tarasova Tatiana , Mamedova Elizaveta , Dalantaeva Nadezhda , Tulpakov Anatoliy , Dzeranova Larisa

Introduction: FIPA- is a syndrome which includes pituitary adenomas with any kind of secretion in two or more members in a family in the absence of MEN or Carney complex; it also includes isolated family somatotropin syndrome (IFS).Aim: Molecular genetic study of a gene panel in FIPA patient.Materials and methods: Study included 1 family (2 men, 24 and 58 years) with pituitary adenomas with homogeneous secretion type — somatot...

ea0041ep750 | Neuroendocrinology | ECE2016

Nonfunctioning pituitary adenoma: a clinical and pathological study

Arcano Karina , Trivino Vanessa , Garcia Paula , Diez Juan Jose , Cordido Fernando , Villabona Carles , Iglesias Pedro

Objective: To assess clinical outcome after pituitary surgery in patients nonfunctioning pituitary adenomas (NFPA) surgically treated in the past 3 decades in three tertiary referral hospitals.Methods: A multicenter retrospective study on clinical and pathological characteristics, treatment patterns, and outcome in patients with NFPA periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1982–2015 was pe...

ea0041ep751 | Neuroendocrinology | ECE2016

Pressure pain threshold and β-endorphins plasma level are higher in lean polycystic ovary syndrome women

Kialka Marta , Milewicz Tomasz , Mrozinska Sandra , Sztefko Krystyna , Rogatko Iwona , Majewska Renata

Aim: Evaluation of pressure pain threshold and β-endorphin plasma level in lean women with polycystic ovary syndrome (PCOS) and healthy controls. The associations between β- endorphins and pressure pain threshold were also investigated.Materials and methods: In 48 lean women with polycystic ovary syndrome and 38 lean women without this disorder plasma β-endorphins and pressure pain thresholds were measured.Results: T...

ea0041ep752 | Neuroendocrinology | ECE2016

The hypotalamic-pituitary-adrenal axis changes in non-pituitary brain tumors survives and the best method of its diagnostic

Yudina Alla , Tselovalnikova Tatiana , Pavlova Maria , Mazerkina Nadezhda , Gheludcova Olga , Arefeva Irina , Martynova Evgenia , Koklina Anastasia

The number of the non-pituitary brain tumors survives increases and will be growing up in the future. Although the prevalence of secondary adrenal insufficiency (SAI) vary depending on the methods of diagnostic, we have a few data about their ACTH and DHAE-S status. The aim of our study was to describe the hypotalamic-pituitary-adrenal axis (HPAA) changes after craniospinal irradiation (CRT) and diagnostic utility basal cortisol (BC), DHAE-S, glucagon stimulation test (GST) in...

ea0041ep753 | Neuroendocrinology | ECE2016

Prognostic factors of pituitary growth hormone-secreting tumors

Alhambra Exposito Maria Rosa , Ibanez Costa Alejandro , Moreno Paloma Moreno , Galvez Moreno Maria Angeles

Background: Acromegaly is the consequence of excessive growth hormone (GH) secretion, usually produced by a pituitary adenoma. Transphenoidal surgery is the first-choice treatment; however, the development of new drug therapies in the last years, specially the somatostatin analogues (SSA), has open new and promising avenues for the treatment of pituitary tumors.Objective: To determine whether a detailed knowledge of the clinico-pathological and radiologi...

ea0041ep754 | Neuroendocrinology | ECE2016

The use of a specific protocol for initiation of tolvaptan therapy in mild/moderate euvolemic hyponatremia secondary to SIADH: not a single case of overcorrection

Amengual Angela , Ortola Ana , Crespo Irene , Penso Rona , Ruiz-Gracia Teresa , Gomez-Hoyos Emilia , Cuesta-Hernandez Martin , Santiago Alejandro , Calle Alfonso , Runkle Isabelle

Introduction: ESE guidelines state a risk for overcorrection of serum sodium levels (SNa) with vaptans. We present the results of our protocol for initiation of tolvaptan(TV) therapy in SIADH.Methods: Retrospective (2011–15). 86 patients with SIADH-induced mild/moderate hyponatremia received TV:7.5 mg day 1, ad-libitum liquids, no other Na-raising therapies. Conventional hospitalization (CH):66/86, day hospital (DH):20/86. Glycemia-corrected SNa det...

ea0041ep755 | Neuroendocrinology | ECE2016

Peripheral neuropathy and depressive symptoms in patients with diabetes.

Umarov Azamatjon , Prokhorova Anna , Mamatkulov Elbek

Objective: To examine the association between severity of diabetic peripheral neuropathy and depressive symptoms and investigated the potential mediators of this association.Materials and methods: The Hospital Anxiety and Depression Scale (HADS) was used to assess depressive symptoms in 492 patients (mean age 62 years; 70% male; 72% type 2 diabetic) with diabetic neuropathy diagnosed by the Neuropathy Disability Score (NDS) and the Vibration Perception T...

ea0041ep756 | Neuroendocrinology | ECE2016

Pharmacological effects of urocortin (Ucn) on nicotine-induced oxidative stress to cardiomyocytes

Ikeda Keiichi , Manome Yoshinobu , Tojo Katsuyoshi

Based on the known oxidative stress of nicotine, we examined the effects of Ucn I on nicotine-induced oxidative stress in HL-1 cardiomyocytes. HL-1 cardiomyocytes is plated on 96-well plate at a density of 2.0×104 cells/well with Claycomb medium containing 10% fetal bovine serum (FBS) and 0.1 mmol/L epinephrine. After starvation of FBS and epinephrine with Claycomb medium, cells were stimulated with or without (+/−)-nicotine, Ucn I and Ucn II. Cells were ...

ea0041ep757 | Neuroendocrinology | ECE2016

Persistence of obesity and overweight in patients with Cushing disease in remission

Moreno-Moreno Paloma , Rebollo-Roman Angel , Ibanez-Costa Alejandro , Alhambra-Exposito Maria Rosa , Munoz-Jimenez Concepcion , Galvez-Moreno Maria Angeles

Objective: Obesity and overweight persist in patients with Cushing’s disease (CD) in remission, its persistence seems to be related to the duration of the disease. The aim of this study was to describe the persistence of overweight/obesity in patients with CD in remission and their relation to the duration of the disease.Patients and methods: Descriptive study of patients with CD (1995-2015). Variables analyzed: age, sex, body mass index (BMI), time...

ea0041ep758 | Neuroendocrinology | ECE2016

Treatment of mild-moderate hyponatraemic encephalopathy with intravenous bolus therapy of 3% hypertonic saline solution: a case series

Luis Guillermo Ropero , Fernandez Jose Abuin , Torralvo Francisco Sanchez , Sanchez Beatriz Rivas , Masa Estibaliz Romero , Doulatram Gamgaram Viyey Kishore , Fernandez Sonia Santamaria , Huelgas Ricardo Gomez

Introduction: Hyponatraemia is the most common electrolytic disorder in clinical practice. We designed a protocol, based on the latest consensus statements and adapted to our Hospital, for the use of 3% hypertonic saline solution (HSS) in patients with hyponatraemia.Material and methods: Unicentric observational study of a case series. We collected data from 14 adult patients with severe hyponatraemia (serum sodium [SNa] <125 mmol/l) and mild-moderat...

ea0041ep759 | Neuroendocrinology | ECE2016

Review of neonatal hypoglycaemia and adverse neurological outcomes

Begley Roisin , Rafique Bushra , Davies Olajumoke , Abdul Salam Ahmed Mohamed

Introduction: Neonatal hypoglycaemia (NH) is a well-recognized cause of adverse neurological outcomes. While hypoglycaemic brain injury is well reported in the literature there is limited data on the effect of neonatal hypoglycaemia solely with other risk factors for brain injury excluded. The aim of study was to evaluate the long-term outcome in patients with a history of symptomatic NH and no other risk factors of brain injury.Methodology: This retrosp...

ea0041ep760 | Neuroendocrinology | ECE2016

Morbimortality of hospitalized patients receiving parenteral nutrition and presenting hyponatremia

Gomez Hoyos Emilia , Matia Martin Pilar , Ortola Buigues Ana , Crespo Hernandez Irene , Cuesta Hernandez Martin , Perez Ferre Natalia , Angel Rubio Herrera Miguel , De Luis Roman Daniel , Calle Pascual Alfonso , Runkle de la Vega Isabelle

Introduction: Hyponatremia is the most frequent electrolyte disorder found in clinical practice, and has been associated with increased morbimortalty. Hyponatremia is even more common among patients receiving parenteral nutricion(PN), a therapy increasingly in use. However, the morbimortality of hyponatremic patients on PN is unknown.Methods: Retrospective study, selecting all patients receiving PN in a teaching hospital from 01/11/11 to 01/06/12. We eva...

ea0041ep761 | Neuroendocrinology | ECE2016

The quality of life of patients with nonfunctional pituitary adenomas and growth hormone deficiency

Urmanova Yulduz , Saidnazirkhanova Mushtary

Aim: To assess the quality of life of patients with nonfunctional pituitary adenomas (NFPA) and growth hormone deficiency (GHD).Materials and methods: Eighteen GHD patients with non-functional pituitary adenomas (NFPA), (12 F/6 M), aged 35.5±14.4 yr (mean±SD; range 23–58), body mass index (BMI) 28.6±0.6, with a history of adult-onset hypothalamic-pituitary disease, were recruited for the study. The examination included hormonal assess...

ea0041ep762 | Neuroendocrinology | ECE2016

The histological structure of nonfunctional pituitary giant adenomas (NFPA)

Urmanova Yulduz , Alimova Kamola

Aim of the research: To study the histological structure of nonfunctional pituitary giant adenomas (NFPA)Materials and methods: We observed 11 patients with giant NFPA, among them 5 male and 6 female, mean age 37.8. All patients were undergone surgical treatment by transsphenoidal access in Center of Endocrinology of MoH RU in neurosurgery department during 2014–2015 year.All patients were undergone the spectrum of analyses, i...

ea0041ep763 | Neuroendocrinology | ECE2016

The comparison between neurological symptoms and histological structure in chiasm and sellar region giant tumors

Urmanova Yulduz , Alimova Kamola

Aim of the research: To study special features of pituitary adenoma (PA) clinical manifestation depending on hormonal characteristic and histological structure, and reveal correlation between clinical manifestation and tumor pathology.Materials and methods: Outcomes of surgery in 66 patients with PA were analyzed. Age of patients at surgery was from 18 to 71 years. Mean age of patients – 44 years.According to K. Thapar classif...

ea0041ep764 | Neuroendocrinology | ECE2016

Presence of adrenal lesions at diagnosis of cushing’s disease

Moreno-Moreno Paloma , Rosa Alhambra-Exposito Maria , Munoz-Jimenez Concepcion , Prior-Sanchez Inmaculada , Angeles Galvez-Moreno Maria

Objective: Patients with Cushing’s disease (CD) may have adrenal nodules or hyperplasia related chronic hyperstimulation by adrenocorticotropic hormone (ACTH). The aim of this study was to describe the prevalence of adrenal nodules or hyperplasia in patients with CD and their relation with ACTH levels at diagnosis.Patients and methods: Descriptive study of patients with CD (1995–2015). Variables analyzed: age, sex, body mass in...

ea0041ep765 | Neuroendocrinology | ECE2016

History before diagnosis in childhood craniopharyngioma: associations with initial presentation and long-term prognosis

Hoffmann Anika , Boekhoff Svenja , Gebhardt Ursel , Sterkenburg Anthe S , Daubenbuchel Anna M , Eveslage Maria , Muller Hermann L

Objective: Childhood craniopharyngiomas (CP) are often diagnosed after long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC). The effect of DOH and specific symptoms in history on presentation at initial diagnosis and long-term prognosis are unknown.Design: Retrospective analysis of patients’ records and prospective longitudinal follow-up....

ea0041ep766 | Neuroendocrinology | ECE2016

Hydrocephalus and hypothalamic involvement in pediatric patients with craniopharyngioma or cysts of Rathke’s pouch: impact on long-term prognosis

Daubenbuchel Anna M , Hoffmann Anika , Gebhardt Ursel , Warmuth-Metz Monika , Sterkenburg Anthe S , Muller Hermann L

Objective: Pediatric patients with sellar masses such as craniopharyngioma (CP) or cyst of Rathke’s pouch (CRP) frequently suffer disease- and treatment-related sequelae. We analyzed the impact and prognostic relevance of initial hydrocephalus (HY) and hypothalamic involvement (HI) on long-term survival and functional capacity (FC) in children with CP or CRP.Subjects and methods: Using retrospective analysis of patient records, presence of initial H...

ea0041ep767 | Neuroendocrinology | ECE2016

Emotional behavior is modulated by liragutide in an age and gender manner in rats from food restriction mothers

Toba Laura , Fandino Juan , Gonzalez-Nunez Maria , Gonzalez-Matias Lucas , Diz-Chaves Yolanda , Mallo Federico

Food restriction (FR) of mothers during the perinatal period, can lead to disorders in emotional behaviors at offspring. GLP-1 may play a role in the regulation of anxiety-like behavior in rodents. The aim of this study was to asses if Liraglutide (a GLP-1 receptor agonist; LIR) given to pregnant rats may prevent the deleterious effects of FR in the anxiety-like behavior in pups at 21 days and two months of age males.Twenty-five pregnant Sprague-Dawley r...

ea0041ep768 | Neuroendocrinology | ECE2016

Characteristics and management of hospitalized patients with hyponatremia in an endocrinology department

Sanz Revert Pablo , Carlos Ferrer Garcia Juan , Sanchez Juan Carlos , Garcia Blasco Lourdes

Hyponatremia is the electrolyte disorder most commonly encountered in hospitalized patients. The prevalence and characteristics of patients admitted with hyponatremia are analyzed in this study.Description of methods/design: cross sectional study is carried out at the University General Hospital of Valencia, comprising a population of 350,000. 681 of the 30676 patients admitted during the period from January 2014 to December 2015 had hyponatremia include...

ea0041ep769 | Neuroendocrinology | ECE2016

Factors influencing health-related quality of life in chronic endocrine diseases: results from a focus group discussion (qualitative research)

Stieg Mareike , Gebert Dorothea , Kopczak Anna , Muller Marion , Sievers Caroline

Introduction: Improvement of health related quality of life (QoL) is one of the main goals defined by the WHO and besides reduction of mortality and morbidity an important objective for health outcomes. In chronic endocrine diseases, QoL often remains impaired despite cure or remission of the disease. In quantitative analyses, factors such as age, gender, BMI and depression, are associated with reduced QoL. However, aspects of social interaction and more complex individual con...

ea0041ep770 | Neuroendocrinology | ECE2016

Study protocol: ‘Health outcomes in pituitary adenoma’s: focus on hormone deficiencies’

Stalla Gunter , Sievers Caroline , Geraedts Victor

Background: Acromegaly is characterized by hormonal excess of GH and IGF-1, however many patients suffer from hypopituitarism as a result from either disease or treatment. Quality of Life (QoL) is known to be reduced both in acromegaly, with mixed results on the role of biochemical control herein, and hypopituitarism. Studies report the level of surgery-induced hypopituitarism after acromegaly at 12.79% (CI 9.88–16.00%). Treatment of acromegaly aimed at normalization of h...