Endocrine Abstracts

The known functions of the thyroid hormones in the liver have expanded from their well-known roles in regulating metabolism to also participate in liver regeneration, senescence and hepatocarcinogenesis. The transcription factors STAT3 and NF-κB play a key role in liver homeostasis, in the response to infection and inflammation and in hepatocarcinoma development. Interleukin 6 (IL-6) and Tumour Necrosis α (TNFα) are the best-known cytokines responsible for hepat...

Introduction: Although the protective effects of 1,25(OH)2D3 on the early stages of atheromatosis process have been investigated, data on its influence on factors implicated in plaque vulnerability are limited. During these stages metalloproteinases MMP-2, MMP-9, their inhibitors TIMP-1,TIMP-2, the RANKL-RANK-OPG system and MCP-1 play a critical role. We aimed to investigate the effect of vitamin D on the expression of the above factors on endothelial cel...

Background: Child obesity has become a global health problem. The younger treatment starts the better outcome, but few treatment modalities are efficient. Whether obese children have an increased risk of neurodevelopmental disorders with worse treatment outcome is not studied. Objectives: To investigate the prevalence of ADHD, autism spectrum disorder (ASD) and other neurodevelopmental disorders in obese children. As a second objective gender differences were evaluated.<p ...

Statins are drugs used for the treatment of hypercholesterolemia. Statins have two chiral centers in their molecules, thus they form four enantiomers (3R5R-, 3R5S-, 3S5R- and 3S5S-). Regarding the most frequently prescribed statins, following enantiopure formulations are used in the clinics: 3R5R-atorvastatin, 3R5S-rosuvastatin and 3R5S-fluvastatin. Individual enantiomers of one drug can qualitatively and quantitatively differ in their biological activities. In some cases, onl...

Mycophenolate mofetil (MYC) is widely used in transplant medicine as an immunosuppressant drug to prevent rejection in organ transplantation. In this work we investigated the effect of MYC on the activity of androgen receptor (AR) by employing gene reporter assay (GRA) and PCR in prostate cancer cell line 22Rv1.Slight but significant activation of AR was observed for cells treated with MYC in stably transfected 22Rv1 cells (AIZ-AR). Moreover, significant...

Anthocyanidins are aglycons of anthocyanins, which are plant pigments responsible for floral and fruits color. Anthocyanidins possess beneficial pharmacological properties such as antioxidant, anti-inflammatory, anti-tumor and anti-diabetic. Anthocyanidins are contained in normal diet and might play role in food-drug interactions.The aim of current study was to evaluate the effects of cyanidin, delphinidin, malvidin, pelargonidin and peonidin on the tran...