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18th European Congress of Endocrinology

ea0041ep777 | Obesity | ECE2016

A prostate cancer risk associated polymorphism regulates androgen mediated regulation of a novel long noncoding RNA, IRX4lncRNA

Panchadsaram Janaththani , Tevz Gregor , Stylianou Nataly , Hollier Brett , Nelson Colleen , Williams Elizabeth , Clements Judith , Batra Jyotsna

Prostate cancer (PCa) is the second most common cause of cancer death in developed countries. Our RNAseq analysis identified a novel long non-coding RNA, IRX4lncRNA at chromosome 5p15. The expression of IRX4lncRNA was much higher in prostate tumor samples (n=50) compared to their matched controls. Moreover, knockdown of lncRNA reduced the cell proliferation of LNCaP cells and this lncRNA was down-regulated in the cells undergoing Epithelial ...

ea0041ep778 | Obesity | ECE2016

Is Pentraxin 3 a marker in pathogenesis of central obesity?

Dedeoglu Ozen , Yaylali Guzin , Akin Fulya , Topsakal Senay , Demir Suleyman , Senol Hande

Introduction: Pentraxin 3 (PTX3) is an acute-phase protein that shares structural homology with C-reactive protein (CRP). PTX3 is produced in macrophages, endothelial cells, and adipocytes in response to inflammatory stimuli, whereas hepatocytes are the main source of CRP. Because obesity and metabolic syndrome (MetS) are considered chronic inflammatory states, PTX3 might be involved in the pathogenesis of obesity and MetS as well as CRP. In this study, we aimed to investigate...

ea0041ep779 | Obesity | ECE2016

Skin autofluorescence is associated with the metabolic syndrome and its individual components

van Waateringe Robert , Slagter Sandra , van Vliet-Ostaptchouck Jana , Graaff Reindert , van der Klauw Melanie , Paterson Andrew , Lutgers Helen , Wolffenbuttel Bruce

Background: Skin autofluorescence (SAF) has been demonstrated to be associated with long-term cardiovascular complications in subjects with either diabetes or renal failure. Since the metabolic syndrome (MetS) is a risk factor for cardiovascular disease, the aim of the study was to assess the association between SAF and MetS as well as its individuals components.Materials and methods: For this cross-sectional analysis, we included subjects 18–80 yea...

ea0041ep780 | Obesity | ECE2016

Glucose and insulin up-regulate the cardiovascular biomarker GDF15 in vivo and in vitro: effect of meal content and obesity

Schernthaner-Reiter Marie Helene , Kasses Dominik , Tugendsam Christina , Riedl Michaela , Peric Slobodan , Clodi Martin , Luger Anton , Vila Greisa

Introduction: Growth differentiation factor 15 (GDF15) has recently been characterized as a cardiovascular risk factor. GDF15 correlates with insulin resistance and obesity in cross-sectional studies and exerts anorexigenic effects in interventional rodent studies. GDF15 has been proposed as a possible therapeutic target in the treatment of obesity, however its meal- and nutrient-dependent regulation in humans has not been investigated previously.Methods...

ea0041ep781 | Obesity | ECE2016

Bariatric surgery: a health economic perspective of the prescription costs

Paredes Silvia , Pereira Maria Lopes , Fernandes Aline , Manso Fernando , da Costa Maia , Marques Olinda , Alves Marta

Introduction: The economic burden of obesity on healthcare systems is increasing. Bariatric surgery leads to considerable weight loss and health improvement. However, this surgery is costly and doubts about its affordability have been raised. Few studies have assessed outcomes such as drug use and costs after bariatric surgery. The aim of this study was to evaluate drug consumption and costs before and after bariatric surgery.Methods: Retrospectively, da...

ea0041ep782 | Obesity | ECE2016

Dietary and social factors associated to obesity among greek adolescent girls

Leontaridou Ioanna , Moutsiou Lydia , Iliadou Paschalia K. , Somali Maria , Sakali Anastasia-Konstantina , Papagianni Maria , Mastorakos George , Goulis Dimitrios G. , Mouslech Zadalla

Objectives: To estimate the body mass index (BMI) distribution among Greek female adolescents in 2012 and to compare it with data from 2000, to find associations of obesity with dietary and social factors, as well as to determine the prevalence of acne, hirsutism and menstrual irregularities in the same population.Methods: All female students (n=380) aged 12–18 years of two randomly selected high schools, after obtaining a written consent f...

ea0041ep783 | Obesity | ECE2016

Relationship between lipopolysaccharide levels and the gene expression profile in adipose tissue from morbidly obese patients

Clemente-Postigo Mercedes , Coin-Araguez Leticia , Oliva-Olivera Wilfredo , Alcaide-Torres Juan , Fernandez-Garcia Jose-Carlos , Cardona Fernando , Tinahones Francisco J

Introduction: Obesity is characterized by a low-grade inflammatory state which has been directly related to the development of insulin resistance and diabetes. Circulating lipopolysaccharides (LPS) have been proposed as a triggering factor for this inflammation. Likewise, adipose tissue (AT) capacity for lipid handling and storage is also a key factor for the development of obesity-related metabolic disorders. Animal studies have shown that LPS are able to modify the expressio...

ea0041ep784 | Obesity | ECE2016

The circulating fingerprint revealed by targeted metabolomic as biomarker of metabolic impairment in female overweight/obesity

Mezzullo Marco , Fanelli Flaminia , Fazzini Alessia , Baccini Margherita , Casadio Elena , Ibarra-Gasparini Daniela , Mazza Roberta , Vicennati Valentina , Fontanesi Luca , Pasquali Renato , Pagotto Uberto

The comprehension of the network of metabolic processes may help the understanding of the molecular pathways driving obesity and related complications. However this is a hard task due to the large number of actors and their complex interplay. We aimed at exploring by targeted metabolomic the circulating metabolite profile in lean (NW, n=42; BMI: 18.5–24.9 kg/m2) and age-matched overweight/obese (OB, n=37, BMI≥25.0 kg/m2), drug...

ea0041ep785 | Obesity | ECE2016

Interventional changes of thyroid hormone levels do not affect circulating irisin levels in humans

Panagiotou Grigorios , Pazaitou-Panayiotou Kalliopi , Komninou Despina , Paschou Stavroula A. , Kalogeris Nikolaos , Vryonidou Andromachi , Mantzoros Christos S.

Introduction: Thyroid hormones and irisin increase energy expenditure and induce browning of adipose tissue. However, little is known about irisin physiology and regulation. Here we aim to elucidate whether thyroid hormones alter circulating irisin concentrations in humans.Design and subjects: One cross-sectional (case-control) evaluation and two interventions were performed independently from each other, including previously thyroidectomized patients. C...

ea0041ep786 | Obesity | ECE2016

Chemerin correlates with obesity and metabolic syndrome and decreases after weight loss in children

Tan Xinrui , Li Min , Xiao Yanfeng

Introduction: Chemerin is a pro-inflammatory adipokine, which has been shown as a mediator between obesity and metabolic syndrome (MetS). The aim of this study was to evaluate the associations of chemerin with insulin resistance and the effects of lifestyle interventions on circulating chemerin levels in Chinese obese children.Methods: A cross-sectional study was conducted among 225 obese children (101 with MetS and 124 without MetS) and 119 lean control...

ea0041ep787 | Obesity | ECE2016

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in obese patients

Bekaert Marlies , Margriet Ouwens D , Horbelt Tina , Van de Velde Frederique , Van Nieuwenhove Yves , Calders Patrick , Praet Marleen , Geerts Anja , Verhelst Xavier , Kaufman Jean-Marc , Lapauw Bruno

Aims: Emerging data indicate that an impaired release of adipose tissue-derived adipokines could play a pivotal role in the development of non-alcoholic fatty liver disease (NAFLD). We aimed to evaluate whether circulating levels or visceral adipose tissue (VAT) expression of recently described adipokines associate with the histopathological disease severity and thus may contribute to the progression of pure fatty liver into an inflammatory and insulin resistant NASH status.</...

ea0041ep788 | Obesity | ECE2016

Mean platelet volume in a patient with celiac disease: the relationship between metabolic syndrome, impaired fasting glucose and cardiovascular risk

Cipil Handan , Baydar Idris , Altinkaynak Konca , Ademoglu Esra , Laloglu Esra , Filiz Murat , Sanibas Ahmet Veli , Yildiz Faruk , Sevimli Hakan , Arslan Muttalip , Arikan Senay , Carlioglu Ayse

Celiac Disease (CD) is a chronic inflammatory disorder and requires life-long treatment and follow-up. Mean platelet volume (MPV), determinant of platelet function, is an independent risk factor for cardiovascular disease (CVD). Metabolic syndrome (MS) is a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose deposition and function. It is a risk factor for coronary heart disease, as well as for diabetes, fatty liver, and several cancers....

ea0041ep789 | Obesity | ECE2016

Intergenerational influence of paternal obesity on metabolic and reproductive health of the offspring: male-preferential impact and potential involvement of Kiss1-mediated pathways

Sanchez-Garrido Miguel Angel , Ruiz-Pino Francisco , Barroso Alexia , Velasco Inmaculada , Heras Violeta , Jesus Vazquez Maria , Castellano Juan Manuel , Roa Juan , Pinilla Leonor , Tena-Sempere Manuel

Obesity and its comorbidities are reaching epidemic proportions. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested for paternal obesity during the pre-conception stage, as it appears to have a negative impact on the metabolic and reproductive health of the offspring, likely via epigenetic changes in spermatozoa. However, whether paternal obesity sensiti...

ea0041ep790 | Obesity | ECE2016

Micronutrients status in bariatric patients-middle term follow-up for Sleeve Gastrectomy

Hristov Ioana , Mocanu Veronica , Labusca Luminita , Zugun-Eloae Florin , Ciobanu Delia , Timofte Daniel

Introduction: Sleeve gastrectomy is a highly effective bariatric technique for morbidly obese patients thus nutritional deficiencies resulting need routine screening for proper evaluation.Aim: Little is still known about the nutritional side-effects for this restrictive bariatric procedure and our study aims to evaluate the impact of sleeve gastrectomy on micronutrients status.Methods: Our prospective study included 48 morbidly obe...

ea0041ep791 | Obesity | ECE2016

Menopause and obesity

Nadira Fafa , Djamila Meskine , Saida Fedala , Lamia Kedad

Introduction: Many studies have shown that the transition to menopause or peri menopause that begins with onset of menstrual irregularities and ends with the last menstrual period, was often associated with changes in body composition and specifically central distribution of adipose tissue.The objective is this study is to determine the prevalence of global and android obesity in postmenopausal women compared to premenopausal women in the general populat...

ea0041ep792 | Obesity | ECE2016

Waist-to-hip ratio is the most discriminative parameter detecting OGTT alterations in men

Perez-Pevida Belen , Andrada Patricia , Llavero-Valero Maria , Gala Gutierrez-Buey , Jorge Nunez-Cordoba , Javier Gomez-Ambrosi , Camilo Silva , Juan Carlos Galofre , Javier Salvador , Gema Fruhbeck , Javier Escalada

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

ea0041ep793 | Obesity | ECE2016

Obstructive sleep apnoea syndrome – longitudinal outcomes and improvement predictors after bariatric surgery

Bettencourt-Silva Rita , Magalhaes Daniela , Souteiro Pedro , Sergio Neves Joao , Castro Oliveira Sofia , Manuel Costa Maria , Saavedra Ana , Bettencourt-Silva Marilia , Almeida Leonor , Drummond Marta , Queiros Joana , Varela Ana , Freitas Paula , Correia Flora , Carvalho Davide , AMTCO group Davide

Background: Bariatric surgery has been associated with a decrease in multiple obesity-related comorbidities including obstructive sleep apnoea syndrome (OSA). This study aims to access the OSA evolution in obese patients who underwent bariatric surgery.Methods: Retrospective longitudinal study of a population of obese patients who underwent bariatric surgery between January/2010 and July/2014 in our centre. Only patients who have undergone polysomnograph...

ea0041ep794 | Obesity | ECE2016

Whole body and regional fat and lean mass in Bulgarian women of different ages and body mass index

Boyanov Mihail

Up-to-date dual-energy X-ray absorptiometry (DXA) offers an insight into body composition (fat and lean mass) in different body regions.Objectives: To measure the regional fat and lean mass in women of different age and to describe age-related changes.Material and Methods: One hundred and twenty women referred for DXA participated in the whole body (WB) study – age range was 20–75 yrs. They were subdivided in three age gr...

ea0041ep795 | Obesity | ECE2016

Effect of osteocalcin on fat distrubution in premenopausal obese women

Dedeoglu Ozen , Yaylali Guzin , Yaylali Tolga , Topsakal Senay , Akin Fulya , Herek Duygu , Senol Hande

Introduction: Recent studies suggested that plasma levels of osteocalcin (OC) were negatively associated with both fat mass and plasma glucose. These findings may suggest that endocrine function of the osteoblast-derived osteocalcin on fat mass/glucose homeostasis in mice also might exist in humans. The aim of this study was to determine if osteocalcin has any effect on fat distrubution in different parts of body.Methods: Eighty-six obese premenapousal w...

ea0041ep796 | Obesity | ECE2016

Decrease in arterial stiffness (AS) in morbidly obese (MO) patients after bariatric surgery (BS): Relationship with obstructive sleep apnoea (OSA), anthropometric parameters and low-grade inflammation (LGI)

Caixas Assumpta , Tirado Raquel , Vigil Laura , Jose Masdeu Maria , Villaplana Maria , Luna Alexis , Rebassa Pere , Hurtado Marta , Pareja Rocio , Pons Belen , Rigla Mercedes

Materials and methods: We studied 30 MO patients with OSA without Continuous Positive Airway Pressure (CPAP) treatment, before and one year after surgery. All patients underwent overnight conventional polisomnography (CE-Series Compumedics, Victoria, Australia). Sleeve gastrectomy or Roux-en-Y gastric bypass were performed according to the local protocol. To asses AS, augmentation index adjusted for heart rate (IAx@75) was obtained by applanation tonometry (Sphygmocor&#17...

ea0041ep797 | Obesity | ECE2016

Relationship between the severity of obstructive sleep apnoea (OSA), low-grade-inflammation (LGI) and Heme Oxygenase 1 (HO1) in morbidly obese (MO) patients, before and after bariatric surgery (BS)

Tirado Raquel , Jose Masdeu Maria , Vigil Laura , Rebassa Pere , Luna Alexis , Montmany Sandra , Villaplana Maria , Pons Belen , Rigla Mercedes , Caixas Assumpta

Introduction: HO1 is a new adipokine with a protective role against cellular stress and hypoxia1. MO presents with high low grade inflammation (LGI)2 and high circulating levels or adipose tissue expression of HO13. The effect of bariatric surgery on HO1 and its relationship with OSA and LGI has not yet been studied.Methods: We studied 66 MO patients before and 1 year after BS. All of them presented OSA without Continuous...

ea0041ep798 | Obesity | ECE2016

Serotoninergic influence of the developing of obesity in children

Zagrebaeva Olga , Solntsava Anzhalika , Yemelyantsava Tatsiana , Dashkievich Helena , Aksyonova Elena

Background: It is well known that many nuerohormonal and genetic factors influence on the developing of obesity in children. Serotoninergic system is determined to be one of the most important factors. Serotonin may induce lipogenesis or triacylglycerol synthesis in the liver and/or white adipose tissue.Aim: To establish interactions between serotoninergic system and metabolic parameters in obese children.Methods: We examined 280 c...

ea0041ep799 | Obesity | ECE2016

16p11.2 Microdeletion and Prader Willi syndrome: similarities and differences

Casamitjana Laia , Caixas Assumpta , Berges Irene-Noelia , Albert Lara , Cano Albert , Capel Ismael , Gimenez-Palop Olga , Gabau Elisabet , Corripio Raquel , Rigla Mercedes

Introduction: Prader Willi syndrome (PWS) is the most common syndromic form of obesity, caused by the absence of expression of the paternally active gens on the long arm of chromosome 15.The 16p11.2 microdeletion has recently been recognized as a syndromic condition appearing to be a predisposing factor for overweight, being the second most common genetic cause of obesity. One possible causative gen- SH2B1- involving leptin and insulin signaling, has been identified, although ...

ea0041ep800 | Obesity | ECE2016

Phenylbutyrate inhibits diet induced obesity through inhibition of pyruvate dehydrogenase kinase

kim Dongwook , Min Byung-keol , kang Hyeon-Ji , Choi Byoungjun , Lee In-Kyu

Obesity caused by excess energy intake has been emerging as a major health concern in the world, with increased risk leading to diabetes, hypertension, nephropathy, and cardiovascular disease. A better understanding of the molecular mechanism on how obesity develops is of critically clinical importance. Accumulating data suggest that ER-stress is strongly related with development of obesity, implying that ER stress can be a therapeutically target of obesity. 4-Phenylbutyrate (...

ea0041ep801 | Obesity | ECE2016

Comparison of the effects on comorbidities and the safety of gastric bypass and sleeve gastrectomy in morbid obesity patients

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Ojeda-Schuldt Maria Belen , Mayo-Osorio Maria Angeles , Pacheco-Garcia Jose Manuel , Escobar-Jimenez Luis , Aguilar-Diosdado Manuel

Introduction: Obesity is a multifactorial disease associated with numerous comorbidities. Bariatric surgery is postulated as an effective tool in weight loss and improves associated pathologies. The aim of this study was to evaluate and compare the safety and the effects on major comorbidities associated with morbid obesity of gastric bypass (GBP) and sleeve gastrectomy (SG) 2 years after intervention.Methods: Cohort study with intrasubject measures (bef...

ea0041ep802 | Obesity | ECE2016

A 4-year effects of body weight reduction on arterial function after bariatric surgery in morbidly obese patients

Dzenkeviciute Vilma , Petrulioniene Zaneta , Sapoka Virginijus , Urbanavicius Vaidotas , Brimas Gintautas , Galkine Aiste

Objective: To determine the long-term effect of weight loss on arterial function parameters in morbidly obese patients who underwent laparoscopic adjustable gastric banding (LAGB).Subjects: Forty-eight Caucasian subjects mean age 47.38±10.77 years and 32 (66.67%) were female with morbid obesity who underwent LAGB and completed 4 years follow-up.Measurements: Patients were evaluated at baseline, 1 year and 4 years after LAGB fo...

ea0041ep803 | Obesity | ECE2016

Msr1 and Cxcl16 scavenger receptors in adipose tissue are positively associated with BMI and insulin resistance

Santiago-Fernandez Concepcion , Garcia-Almeida JM , Gutierrez-Repiso Carolina , Alcaide Juan , Ocana-Wilhelmi Luis , Tome Monica , Rodriguez-Morata Alejandro , Tinahones Francisco J , Tatzber Franz , Pursch Edith , Garcia-Fuentes Eduardo , Garrido-Sanchez Lourdes

Introduction: Obesity is associated with an increasing risk of diabetes and atherosclerosis. Previous studies in animals show that oxidized low-density lipoprotein (Ox-LDL) can be captured by the adipocyte through different scavenger receptors (SR) and thus contribute to the worsening of insulin resistance (IR). We analyze the association between Ox-LDL levels and different SR present in adipose tissue and their relationship with the presence of obesity and insulin resistance ...

ea0041ep804 | Obesity | ECE2016

Medium-term evolution of ghrelin levels according to three types of bariatric surgeries and its relation with HDL and insulin resistance

Santiago-Fernandez Concepcion , Garcia-Serrano Sara , Tome Monica , Valdes Sergio , Ocana-Wilhelmi Luis , Rodriguez-Canete Alberto , Tinahones Francisco J. , Garcia-Fuentes Eduardo , Garrido-Sanchez Lourdes

Introduction: Ghrelin is a gastrointestinal peptide involved in the regulation of body weight and energy balance. However, its behavior after bariatric surgery and its relationship with other biochemical variables is still under discussion. We aim to undertake a simultaneous evaluation of the changes in ghrelin levels after three types of bariatric surgery and its relationship with different variables.Design: The study included 21 non-obese and 103 morbi...

ea0041ep805 | Obesity | ECE2016

Aripiprazole effects on triglyceride content of in vitro differentiating adipocytes

Kolcsar Melinda , Gall Zsolt , Tabi Tamas , Baba Laszlo Istvan , Koncz Szabolcs , Kun Imre Zoltan

Introduction: In vitro adipogenesis is a two-step developmental process in which an undifferentiated mesenchymal cell differentiates into a preadipocyte, which then undergoes a secondary differentiation step to become a lipid-filled adipocyte. The triglyceride accumulation is influenced by various endogenous and exogenous factors.Methods: In an attempt to understand the antipsychotics effects on lipid accumulation duri...

ea0041ep806 | Obesity | ECE2016

Copeptin, a marker of vasopressin, decreases significantly in early state after bariatric surgery

Aktimur Recep , Mete Turkan , Cetinkunar Suleyman , Yaman Mehmet , Beton Osman , Avci Emre , Erdem Hasan , Yildirim Kadir

Introduction: Copeptin, the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development. The aim of our study is to evaluate preoperative and postoperative alterations of copeptin in patients who underwent obesity surgery and evaluate any differences between sleeve gastrectomy (SG) and mini gastric bypass (MGB) in terms of copeptin levels.Subjects and Methods: Twenty ...

ea0041ep807 | Obesity | ECE2016

Changes in SCD1 promoter DNA methylation after bariatric surgery in morbid obese patients are associated with free fatty acids levels

Morcillo Sonsoles , Martin-Nunez Gracia Ma , Garcia-Serrano Sara , Gutierrez-Repiso Carolina , Rodriguez-Pacheco Francisca , Ho-Plagaro Ailec , Alaminos-Castillo Miguel A , Valdes Sergio , Gonzalo Motserrat , Moreno-Ruiz Francisco J. , Montiel-Casado Custodia , Rodriguez-Canete Alberto , Garcia-Fuentes Eduardo

Introduction: Epigenetic is acquiring great importance in complex diseases, providing mechanisms whereby environmental factors can influence complex diseases such as obesity and type 2 diabetes. Experimental animal and human studies have revealed the association between SCD1 and obesity and insulin resistance. The aim of this study was to evaluate whether metabolic changes after intervention are associated with DNA methylation pattern and if these changes are related to weigh ...

ea0041ep808 | Obesity | ECE2016

Increased Urocortin 3 blood levels in morbidly obese subjects are reduced after excess body weight reduction with laparoscopic sleeve gastrectomy

Bargiota Alexandra , Papamargaritis Dimitris , Sioka Eleni , Zacharoulis Dimitris , Tzovaras George , Koukoulis George

Aim: To measure Urocortin3 (Ucn3) blood levels in morbidly obese (MO) non diabetic patients before and after laparoscopic sleeve gastrectomy (LSG) for excess body weight reduction and explore its relationship with b-cell function. Ucn3 is involved in insulin secretion in the presence of nutrient excess, a key feature of obesity, and may be an integral part of the compensation of β-cells function.Methods: Nine MO patients who underwent LSG and 11 hea...

ea0041ep809 | Obesity | ECE2016

Glucose transporter 1 suppresses melanocortin 4 receptor activity

Muller Anne , Niederstadt Lars , Jyrch Sabine , Jonas Wenke , Meyer Franziska , Grotzinger Carsten , Schurmann Annette , Kleinau Gunnar , Gruters Annette , Krude Heiko , Biebermann Heike

The melanocortin 4 receptor (MC4R) represents the major hypothalamic G-protein coupled receptor (GPCR) controlling feeding behavior and therefore body weight regulation. MC4R is highly expressed in the paraventricular nucleus (PVN) where hormonal and neuroendocrine signals from periphery and arcuate nucleus (ARC) are allocated. MC4R knockout in mice or natural occurring loss-of function variants result in hyperphagia and early-onset obesity. MC4R mutations represent the most f...

ea0041ep810 | Obesity | ECE2016

A body-wide transcriptome screen reveals high ghrelin gene (GHRL) expression in monocytes and supports a hypothesis of monocyte GHRL-derived hormones as critical mediators of the brain-gut axis and monocyte-adipocyte cross-talk in health and obesity

Seim Inge , Crisp Gabrielle , Jeffery Penelope , Chopin Lisa

Introduction: It is now appreciated that peptide hormones encoded by the ghrelin gene, GHRL, have roles in many biological systems and cell types. In particular, the hormone ghrelin is a therapeutic target and clinical marker for a range of pathologies, including diet-induced and genetic obesity. High-quality transcriptome (RNA-seq) data sets generated by consortia, such as the Human Protein Atlas (HPA) and Encyclopedia of DNA Elements (ENCODE), now offer an opportuni...

ea0041ep811 | Obesity | ECE2016

Positive association between blood natural killer T cells and liver enzymes ALT, AST and GGT levels

Lopez Soledad , Pozo David , Garcia-Serrano Sara , Gutierrez-Repiso Carolina , Rodriguez-Pacheco Francisca , Ho-Plagaro Ailec , Alaminos-Castillo Miguel A , Valdes Sergio , Gonzalo Montserrat , Andrade Raul J. , Garcia-Fuentes Eduardo

Introduction: Obesity is associated to a pro-inflammatory state with a different pattern of response from the classical response. Also, obesity is associated to non-alcoholic fatty liver disease (NAFLD). In this sense, natural killer T (NKT) cells are a subset of innate immune cells that abundantly reside within the liver and are readily activated by lipid antigens. However, the phenotype and functional characteristics of these cells are no clear in the immune homeostasis in o...

ea0041ep812 | Obesity | ECE2016

The effect of urbanization on adiposity and insulin resistance among Indonesian

Tahapary Dicky , Kurniawan Farid , de Ruiter Karin , Sartono Erliyani , Djuardi Yenny , Supali Taniawati , Yazdanbakhsh Maria , Soewondo Pradana , Harbuwono Dante

Background: The prevalence of obesity and type 2 diabetes (T2DM) in Indonesia is increasing. One of the major socio-environmental factors that might contribute to this is urbanization, which is associated with changes into more sedentary lifestyle and unhealthy diet. These changes can lead to obesity. The metabolic risks of obesity are mainly determined by the body fat content. The higher the body fat content the higher insulin resistance and hence susceptibility of T2DM. The ...

ea0041ep813 | Obesity | ECE2016

Continuous glucose monitoring for evaluation of glycemic variability after bariatric surgery

Martins Diana , Cardoso Luis , Baptista Carla , Rodrigues Dircea , Barros Luisa , Vicente Nuno , Oliveira Diana , Lages Adriana , Ventura Mara , Carrilho Francisco

Introduction: Neuroglucopenic hypoglycaemia might be an underestimated threat of bariatric surgery, as Roux-en-Y gastric bypass (RYBG) or gastric sleeve. We aimed to evaluate glucose variability after bariatric surgery by continuous glucose monitoring (CGM) in a real-life setting.Methods: CGM was used in twelve patients with clinical suspicion of hypoglycaemia after undergoing bariatric surgery (RYBG or sleeve), during seven days. CGM was through using i...

ea0041ep814 | Obesity | ECE2016

Extra virgin olive oil and red wine polyphenols modulate fecal microbiota and reduce metabolic risk factors in high insulin resistant obese patients

Moreno-Indias Isabel , Sanchez-Alcoholado Lidia , Fernandez-Garcia Jose Carlos , Castellano-Castillo Daniel , Cardona-Diaz Fernando , Queipo-Ortuno Maria Isabel

Objectives: This study evaluated the prebiotic effect of a moderate intake of extra virgin olive oil (Evoo) and red wine (Rw) polyphenols on modulating the gut microbiota composition and the improvement of metabolic risk factors in obese subjects with high insulin resistance (HIR).Methodology: 10 obese patients with HIR (HOMA-IR>5.5) and 10 lean subject with low insulin resistance (HOMA-IR< 3.3) were included in a randomized and controlled interv...

ea0041ep815 | Obesity | ECE2016

Prevalence of obesity in an Algerian adult population

Nadira Fafa , Djamila Meskine , Aicha Bouzid , Saida Fedala , Lamia Kedad

Introduction: The epidemiological transition has resulted in a major increase in the prevalence of obesity in our country. Obesity is closely associated with chronic diseases such as type 2 diabetes, hypertension and dyslipidemia.The aim of our study is assessing the prevalence of general obesity, central obesity (OA), associated risk factors (type2 diabetes, hypertension and dyslipidemia) and try to provide information on determinants of obesity in Alge...

ea0041ep816 | Obesity | ECE2016

Obesity may influence on measurements of choroid thickness in optical coherence tomography

Yumusak Erhan , Durmaz Senay Arikan , Guler Hatice Ayhan , Bacanli Zehra , Carlioglu Ayse

Introduction and aims: It is known that obesity is associated with retinal microvascular changes. Optical coherence tomography (OCT), a new imaging technique, is used to visualize the choroid. In addition, OCT can also give more beneficial information about systemic and eye diseases. We aim to investigate whether or not obesity may impact on choroid and macula thickness.Material and methods: Forty-four subjects who were apply for obesity in our Endocrino...

ea0041ep817 | Obesity | ECE2016

Effects of bariatric surgery on blood pressure of non-hypertensive obese patients

Neves Joao Sergio , Oliveira Sofia Castro , Souteiro Pedro , Bettencourt-Silva Rita , Magalhaes Daniela , Costa Maria Manuel , Saavedra Ana , Oliveira Joana , Cunha Filipe , Lau Eva , Esteves Cesar , Belo Sandra , Santos Ana Cristina , Freitas Paula , Varela Ana , Queiros Joana , Correia Flora , Carvalho Davide , Amtco Grupo

Introduction: Increased blood pressure (BP) above >115/75 mmHg presents an independent association with cardiovascular events. Although there is a clear benefit of bariatric surgery on BP of hypertensive patients, the impact in non-hypertensive patients remains largely unknown. Therefore, the aim of our work was to evaluate the impact of bariatric surgery on BP of non-hypertensive obese patients.Methods: We evaluated a cohort of 224 non-hypertensive ...

ea0041ep818 | Obesity | ECE2016

Metabolically healthy obesity: exploring the paradox

Ventura Mara , Lages Adriana , Rodrigues Dircea , Oliveira Patricia , Melo Miguel , Martins Diana , Oliveira Diana , Carrilho Francisco

Introduction: Obesity is a chronic disease associated with multiple comorbidities, defined by BMI, without considering the metabolic state of the patient. There are few data on the proportion of obese patients without metabolic syndrome (MS).Objective: To characterize patients considered to be metabolically healthy (MH) followed at the obesity outpatient clinic of one University Hospital, and to compare this group with a group of obese patients with MS.<...

ea0041ep819 | Obesity | ECE2016

Changes in testosterone levels and sex hormone-binding globulin levels in extremely obese men after bariatric surgery

Boonchaya-anant Patchaya , Laichuthai Nitchakarn , Suwannasrisuk Preaw , Snabboon Thiti

Objective: Obesity is a risk factor for hypogonadotrophic hypogonadism in men. Increase in body weight was found to be associated with decrease testosterone level and sex hormone-binding globulin (SHBG) level. The aim of this study was to evaluate the change in testosterone levels in extremely obese men after bariatric surgery.Methods: This is a prospective study including 29 morbidly obese men undergoing bariatric surgery. Main outcomes were changes in ...

ea0041ep820 | Obesity | ECE2016

Neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity

Karakaya Serdar , Altay Mustafa , Kaplan Efe Fatma , Karadag Ibrahim , Unsal Oktay

Aim: In our study we aimed to investigate neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes and relationship between N/L ratio and insulin resistance (IR) in obesity.Material and methods: In this study 250 obese patients data were scanned retrospectively and 96 patients that are convenient to inclusion criteria and has complete file information were included in the study. Forty healthy individual with similar age and sex ...

ea0041ep821 | Obesity | ECE2016

Association of body fat distribution and carotid intima media thicknesss with Vitamin D in obese premenopausal women

Dedeoglu Ozen , Fidan Yaylalı Guzin , Herek Duygu , Topsakal Senay , Akin Fulya , Senol Hande

Introduction: It has been demonstrated that there are differences in the effect of body mass index (BMI) on the serum 25-hydroxyvitamin D levels (25-OH D); differences appeared stronger in subjects with higher BMI. In this study we aimed to assess the association between 25-OH D status and body fat distribution and caratid intima medai thickness.Methods: 86 obese premenapousal women (aged 17–55 years) and 56 women with normal BMI took part in this s...

ea0041ep822 | Obesity | ECE2016

Visceral adiposity index as a marker of hepatic steatosis in overweight and obese premenopausal women

Vassilatou Evangeline , Vassiliadi Dimitra , Lazaridou Helen , Koutsomitopoulos Nikitas , Kelekis Nikolaos , Hadjidakis Dimitrios , Dimitriadis George

Introduction: Visceral adiposity index (VAI), initially developed as an indicator of visceral adipose function for the assessment of cardiometabolic risk, has been also proposed for the detection of nonalcoholic fatty liver disease (NAFLD). However, the diagnostic performance of VAI as a marker of hepatic steatosis (HS) is still under investigation.Objective: To evaluate the accuracy of VAI as a marker of HS in a cohort of overweight and obese premenopau...

ea0041ep823 | Obesity | ECE2016

Hif-1α is positively associated with scavenger receptors Lox-1, Cxcl16 and Msr1 in adipose tissue

Santiago-Fernandez Concepcion , Garcia-Almeida Jose M. , Ocana-Wilhelmi Luis , Rodriguez-Morata Alejandro , Gutierrez-Repiso Carolina , Tome Monica , Alcaide Juan , Tinahones Francisco J , Tatzber Franz , Pursch Edith , Garcia-Fuentes Eduardo , Garrido-Sanchez Lourdes

Introduction: HIF-1α, a hypoxia marker, is an important factor for transcriptional regulation of cell metabolism and the adaptation to cellular stress. It modulates the function of phagocytic cells by stimulating surface receptors such as scavenger receptors. But little is known on their relationship in adipose tissue, whose increase has been associated with an increased risk of atherosclerosis. The aim of this study is to analyze in adipose tissue the association between...

ea0041ep824 | Obesity | ECE2016

Pro-inflammatory cytokines responses to acute exercise in athletes and sedentary controls: association with body composition and insulin sensitivity

Djelic Marina , Trajkovic Vladimir , Dumanovic Mirjana Sumarac , Mazic Sanja , Durmic Tijana , Jeremic Rada , Bjelic Ankica , Micic Dragan

Balance between pro- and anti- inflammatory cytokines is necessary for the physiological functioning of the immune system. A chronic systemic inflammation is one of the causes of insulin resistance in obesity.The aim of this study was to investigate the pro-inflammatory cytokines and visfatin response to an single bout acute exercise in athletes and non-athletes, as well as the possible relationship pro-inflammatory cytokines with body composition and in...

ea0041ep825 | Obesity | ECE2016

Physical function, quality of life and energy expenditure during activities of daily living in post-bariatric surgery patients and obese individuals

Monteiro Fabiane , Ponce Diego Augusto Nascimento , Silva Humberto , Pitta Fabio , Carrilho Alexandre JF

Introduction: Bariatric surgery (BS) is an effective method to weight loss, however, some patients experience persistence of physical inactivity or even weight gain over the years. Furthermore, It is not clear if some surgical techniques, mainly those with disabsortive components, could be involved in the low physical performance through interfering with nutritional status This study aimed to evaluate physical function (PF), quality of life (QOL) and energy expenditure (EE) du...

ea0041ep826 | Obesity | ECE2016

The effect of gastric bypass surgery on lipid profile in obese patients with type 2 diabetes mellitus

Cetin Sedat , Sumer Fatih , Sahin Ibrahim , Kayaalp Cuneyt

Introduction: Few studies have investigated the effect of gastric bypass surgery on lipid profile in obese patients with type 2 diabetes mellitus. We aimed to evaluate changes in lipid profile in obese diabetic patients undergoing Roux-en-Y gastric bypass (RYGB) surgery.Method: We retrospectively analysed 71 obese type 2 diabetic patients (46 women, 25 men) who underwent RYGB surgery. Weight, body mass index (BMI), total cholesterol (TC), high-density-li...

ea0041ep827 | Obesity | ECE2016

Evaluation of the use of parenteral nutrition premixed bags vs individualized nutrition in our hospital

Gonzalez-Molero Inmaculada , Torralvo Francisco Sanchez , Mora Rosario Vallejo , Gonzalo-Marin Monserrat , Bolivar Victoria Contreras , Fernandez C Gallego , Olveira Gabriel , Tinahones Francisco

Introduction: Parenteral nutrition (PN) is indicated in patients in which gastrointestinal tract is inaccessible or is severely affected. In our hospital, specialists often use commercial three-compartment bags of PN that provide standard nutritional requirements regardless a total parenteral nutrition (TPN) with macro and micronutrients adjusted to each patient by Endocrinology and Nutrition Service.Objectives: To assess the use of commercial premixed P...

ea0041ep828 | Obesity | ECE2016

Hormonal response to physical exercise

Lencu Codruta , Alexescu Teodora , Lencu Monica , Georgescu Carmen

Aims: The effects of physical exercise on the endocrine system were monitored.Material and method: The study included 60 young and healthy subjects.The subjects were divided into two groups:– group A (30) performed anaerobic exercise for 50 minutes: running on the treadmill at a speed of 8 km/hour, walking on the treadmill at a speed of 5 km/hour, and running on the treadmill at a speed of 8 km/hour;...

ea0041ep829 | Obesity | ECE2016

Predicting the risk of colonic adenomatous polyps in obese patients by TANITA: a new and practical method

Yonem Ozlem , Dokmetas Hatice Sebile , Ataseven Hilmi , Ozer Hatice , Kilicli Fatih

Background/aim: Visceral obesity rather than generalized obesity has been recognized as a risk factor for development of colonic adenomatous polyps. We aimed to to find out whether there is association between the obesity parameters determined by TANITA such as fat percent, body mass index (BMI) and visceral fat rating and prevalence of colonic adenomatous polyps.Material and methods: We conducted a cross-sectional study using a consecutive series of 231...

ea0041ep830 | Obesity | ECE2016

Identification of adipogenesis specific microRNAs

Lisa Cherradi M. , Perwitz Nina , Werner Ralf , Brabant Georg E.

Introduction: Obesity associated with the risks of metabolic syndrome is a rising problem in Western societies but shows a wide depot- and sex-specific variation. A better understanding of the regulatory mechanisms underlying this different depot- and sex-specific role is crucial to identify potential diagnostic and therapeutic targets. MicroRNAs are recently recognized important players in adipogenesis and fat metabolism. They post-transcriptionally regulate diverse biologica...

ea0041ep831 | Obesity | ECE2016

Level of fitness among overweight medical students in Uzbekistan

Gulyamova Khilola , Muminova Sitora , Ismailov S.I.

Actuality: According to the World Health Organization, the escalating international epidemic of obesity is now the most significant contributor to ill health. More than 30% of US adults are obese, i.e. body mass index (BMI) 30 kg/m2, and it is feared that one in three children born in the early 21st century will develop diabetes with a consequent reduction in lifetime expectancy. In Uzbekistan 20.2% of population is obese.Aims of study: Examin...

ea0041ep832 | Obesity | ECE2016

Comparison of Framingham and REGICOR scales for calculating cardiovascular risk in a cohort of patients with morbid obesity

Vilchez-Lopez Francisco Javier , Mateo-Gavira Isabel , Ojeda-Schuldt Maria Belen , Escobar-Jimenez Luis , Aguilar-Diosdado Manuel

Introduction: The prevalence of obesity has increased, reaching epidemic proportions. Framingham and REGICOR scales predict the likelihood of developing a coronary event in the next 10 years. The aim of this study was to assess the concordance of these scales in the stratification of cardiovascular risk (CVR) in a cohort of patients with morbid obesity.Methods: We designed a cross-sectional study in a sample of patients with morbid obesity evaluated from...

ea0041ep833 | Obesity | ECE2016

Lipodystrophia ın a pregnant women wıth unregulated glycemıa

Doğan Bercem Aycicek , Arıkan Tuğba , Donmez Emre

Introduction: Many endocrinopathies such as acromegaly, Cushing’s syndrome (CS), pheomochromocytom and lipodystrophia can be associated with insülin resistance and unregulated diabetes mellitus (DM).Case report: A 37 –year- and 2 months pregnant women admitted to our out patient clinic for regulation of hyperglycemia. On physical examination; Blood Pressure: 140/95 mmHg, Body Mass Index: 31 kg/m2, central obesity, acanthosis nig...

ea0041ep834 | Obesity | ECE2016

The level of SCD1 in subcutaneous adipose tissue is associated with the presence of metabolic syndrome in morbidly obese patients

Garcia-Serrano Sara , Gutierrez-Repiso Carolina , Rodriguez-Pacheco Francisca , Ho-Plagaro Ailec , Garcia-Escobar Eva , Alaminos-Castillo Miguel A , Garrido-Sanchez Lourdes , Valdes Sergio , Gonzalo Montserrat , Rodriguez-Canete Alberto , Montiel-Casado Custodia , Moreno-Ruiz Javier , Garcia-Fuentes Eduardo

Introduction: The stearoyl-CoA desaturase 1 (SCD1) is an enzyme involved in the metabolism of fatty acids, and seems to be involved in the regulation of atherosclerosis development. In this study we want to check the expression of SCD1 in visceral and subcutaneous adipose tissue and its relationship with the metabolic syndrome.Methods: We measured SCD1 mRNA and protein expression in visceral and subcutaneous adipose tissue from 25 morbidly obese patients...

ea0041ep835 | Obesity | ECE2016

Correlation between selected anthropometric, biochemical parameters and CRP- reactive protein concentration among patients with endocrine disorders

Kulpok Agata , Nowak Justyna , Kulik-Kupka Karolina , Bronczyk-Puzon Anna , Koszowska Aneta , Zubelewicz-Szkodzinska Barbara

Introduction: Anthropometric studies are one of the methods, by means of which it is possible to assess patient’s nutritional status.Aim: The aim of this study was to assess the relationship between the selected anthropometric as well as biochemical parameters and CRP- reactive protein concentration among patients with endocrine disorders.Materials and methods: The studied group involved all patients hospitalized at the Endocr...

ea0041ep836 | Obesity | ECE2016

Retinol-binding protein 4 expression in subcutaneous neck adipose tissue and serum in patients with and without metabolic syndrome

Jaksic Vlatka Pandzic , Livun Ana , Grizelj Danijela , Boscic Drago , Ajduk Marko , Kusec Rajko , Jaksic Ozren

Retinol-binding protein 4 (RBP4) is considered as an important mediator of insulin resistance and metabolic syndrome (MS). In adipose tissue (AT)) it is mainly secreted from visceral depots. The residual metabolic risk which remains beyond that caused by visceral AT seems to be hold by upper body subcutaneous AT. This large pathogenic depot might be representative by subcutaneous neck AT.The aim of this study was to examine and to compare RBP4 gene expre...

ea0041ep837 | Obesity | ECE2016

Metabolic syndrome and insulin resistance: can they be predicted by clinical indicators in obese prepubertal children?

Vlachopapadopoulou Elpis , Dikaiakou Eirini , Petrou Vasilis , Anagnostou Elli , Karachaliou Feneli , Patinioti Ioanna , Fotinou Aspasia , Michalacos Stefanos

Aim: To evaluate whether anthropometric indices and acanthosis nigricans can be useful markers for early detection of Insulin Resistance and Metabolic Syndrome (MetS) in overweight and obese children.Methods: Data from 510 prepubertal children (40% boys), 12.9% overweight and 87.1% obese with mean age 9.7±2.5 years were analyzed. Logistic regression analysis was used to investigate which factors were associated with HOMA-IR >3 and metabolic synd...

ea0041ep838 | Obesity | ECE2016

Association of sex hormones with metabolic syndrome among Egyptian males

Mahdy Maram , Eloraby Hussein , Zaky Eman

Metabolic Syndrome (Met S), is associated with increased risk of cardiovascular disease (CVD) and mortality, the presence of 1 or 2 components of the (MetS) increases overall mortality compared with the absence of any component of the (MetS). Epidemiological studies have shown that low testosterone is associated with MetS. While testosterone levels decline with age, Estradiol (E2) levels remain relatively stable resulting in a decreased testosterone: E2 ratio (T:E), Whether th...

ea0041ep839 | Obesity | ECE2016

Bad eating habits among type II diabetic patients at tertiary hospital: a case-control study

Alwan Ali , Saeedi Pouya , Farhood Hadeel , Alhusuny Ameer

Background: There is a strong association between type II diabetes mellitus (DM) and gaining weight. Lifestyle modification is an important factor for weight management to overcome the obesity as well as DM epidemics.Aim of study: To find the differences of eating habits and Rosenberg Self-Esteem between DM patients and control and to find the strongest contributor of risk factors by study groups.Methods: A hospital-based matched c...

ea0041ep840 | Obesity | ECE2016

“The menstrual disorders in women with obesity in fertile age”

Shakhnoza Akhmedova , Dildora Sadikova

The aim: To examine menstrual disorders in women with obesity in fertile age.Material and methods: We observed the reproductive health of 25 women with obesity and infertility (1 st group). Second group of patients consisted from 25 healthy women without obesity. The age of patients of 1 st group was from 20 to 39 years old, in average 28.3±0.64. The age of patients of 1 st group was from 22 to 37 years old, in average 30.4±0.51/<p class="a...

ea0041ep841 | Obesity | ECE2016

“The ultrasound data of gonads in women with obesity in fertile age”

Dildora Sadikova , Shakhnoza Akhmedova

The aim: To examine the ultrasound data of gonads in women with obesity in fertile age.Material and methods: We observed the reproductive health of 25 women with obesity and infertility (1 st group). Second group of patients consisted from 25 healthy women without obesity. The age of patients of 1 st group was from 20 to 39 years old, in average 28.3±0.64. The age of patients of 1 st group was from 22 to 37 years old, in average 30.4±0.51/<...

ea0041ep842 | Obesity | ECE2016

Using on-line program of good nutrition and right diet helps to fight against obesity

Krylov Vadim , Levine Evgeny

Introduction: It is too much easier and cheaper to obesity, than in the future to treat diabetes mellitus and its complications.Materials and methods: We used an online system for patient education based on the video lessons, full of humor, pictures, and cartoons to convey the necessary information on good nutrition, necessary to do exercises and the need for exposure to the sun to our patients.Study results: Watching the short mov...

ea0041ep843 | Obesity | ECE2016

Hypogonadotropic hypogonadism and obesity, what came first?

Serbanescu Cristina , Nila Alexandra , Sirbu Anca , Fica Simona

Introduction: Morbidly obese patients raise many problems in therapeutic attitude, sometimes associating a cluster of obesity-related abnormalities: hypogonadotropic hypogonadism, metabolic syndrome, respiratory insufficiency, and high risk for cardiovascular disease. These afflictions can be reversed through weight loss, especially in young patients.Case presentation: We present the case of a 41 year old male patient, smoker, with morbid obesity (BMI =6...

ea0041ep844 | Obesity | ECE2016

The role of smoking in endothelial dysfunction in patients with obesity

Lyndina Maria , Shishkin Alex

Introduction and aims: Numerous studies in recent years have confirmed the existence of a link between endothelial dysfunction and vascular diseases, and lifestyle factors such as obesity, sedentary lifestyle and smoking.Methods: We examined 108 patients with obesity (90 women and 18 men, mean age 54.62±0.4 years). All patients underwent clinical and laboratory examination. Vasomotor endothelial function was evaluated by reactive hyperemia using ult...

ea0041ep844b | Obesity | ECE2016

Effect of supplementation with chitosan on food intake, weight gain, and cardiometabolic risk indices in Wistar rats fed normal diet ad libitum

Bahijri Suhad , Alsheikh Lubna , Ajabnoor Ghada , Borai Anwar

Introduction: Prevalence of obesity is increasing globally and in Saudi Arabia in particular. Obesity is associated with increased risk of diabetes and cardiovascular diseases. Therefore, studies to control obesity and its effect on health are important. Chitosan has been recommended as a suitable functional supplement for controlling obesity; and consequently; its associated complications. However, results were inconclusive.Aim: To investigate the effec...