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Endocrine Abstracts (2016) 41 EP34 | DOI: 10.1530/endoabs.41.EP34

1Moscow Regional Research and Clinical Institute n.a. Vladimirsky, Moscow, Russia; 2Moscow State University, Moscow, Russia.

Background: Menstrual abnormalities (MA) can be the first sign of the disease.

Aim: To assess the structure of MA before and after treatment of CD.

Material and methods: Twenty-eight women with CD 39 (31.8;43.5) y.o., were investigated initially and 3.5 (2;5.5) years after treatment. Patients were subdivided into three groups: with normal cycles (NC; 26–30 days), oligomenorrhea (31–120 days), amenorrhea (>120 days).

Results: Before treatment of CD, NC had 3 (10.7%), oligomenorrhea 8 (28.6%), amenorrhea 17 (60.7%). UFC were higher in women with MA than in women with NC (993±629 and 536±159 nmol/24 h, P=0.05). 1) 17 women with previous amenorrhea. Remission was achieved in 11: NC restored in 2 (18.2%), oligomenorrhea – 4 (36.4%), amenorrhea – 5 (45.4). Persistence of CD in 6: NC restored in 2 (33.3%), 4 (66.7%) have amenorrhea. 2) three women with initially NC. Remission in 2: 1 NC, 1 amenorrhea. One woman with persistence of CD now has oligomenorrhea. 3) eight women with oligomenorhea initially. In remission-6: NC 1 (16.7%), oligomenorrhea 4 (66.6%), amenorrhea 1 (16.7%). Two have persistence of CD: 1 amenorrhea, 1 oligomenorrhea.

In overall after treatment of CD, NC had 6 (21.4%), oligomenorrhea 10 (35.7%), amenorrhea 12 (42.8%). In 19 with remission, NC have 4 (21.1%), oligomenorrhea 8 (42.1%), amenorrhea 7 (36.8%). In nine with persistence, NC have 2 (22.2%), oligomenorrhea 2 (22.2%), amenorrhea – 5 (55.6%). There were no any differences between those with remission and persistence of CD. Patients with remission and amenorrhea were significantly older and had less weight loss after treatment of CD, than patients with remission and NC. Patients with persistence of CD had no any differences between groups. Pituitary insufficiency did not correlate with MA. Spontaneous pregnancy occurred in two patients with remission of CD and oligomenorrhea.

Conclusion: MA are common both before and after treatment of CD. Women with remission and women with persistence of CD have not any differences in frequencies of MA.

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