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Endocrine Abstracts (2016) 41 EP361 | DOI: 10.1530/endoabs.41.EP361

1Endocrinology and Nutrition Department, Hospital de Mendaro, Gipuzkoa, Spain; 2Nuclear Medicine Department, Instituto Oncológico de Kutxa, Gipuzkoa, Spain.


Introduction: Radioiodine whole-body scintigraphy (WBS) has been widely used for detection of differentiated thyroid cancer (DTC), based on the marked storage of iodine in functioning thyroid tissue. However, radioiodine uptake is not specific for thyroid gland. Iodine accumulation in lactating breast has been demonstrated, but it is rare in nonlactating breast.

Case report: A 74-year-old-woman who underwent near-total thyroidectomy in 1988 due to a multinodular non-toxic goitre, presented during the surveillance a suspicious left thyroid nodule. Ultrasound (US) guided fine needle aspiration (FNA) was performed and the cytologic examination showed a follicular proliferation with atypia. A total thyroidectomy and selective lymphadenectomy was realised because of macroscopic lymph node affectation. Pathology examination showed a 1.1 cm papillary thyroid carcinoma and regional lymph node metastases. Radioiodine ablation with 100 mCi 131I was realised after the surgery. WBS was negative for extrathyroidal metastases. Patient presented progressive elevation of thyroglobulin (34 ng/ml) and increasing antithyroglobulin antibodies (307 UI/ml). US identified left III cervical compartment lymph node involvement. 150 mCi 131I were administrated after recombinant human thyrotropin injection. Postablative WBS showed focal intense uptake in left cervical region and increase uptake in bilateral breasts. Hyperprolactinemia (serum prolactin 110 μg/ml) was found in biochemical test and a magnetic resonance imaging detected a pituitary microadenoma (6 mm). Medical treatment was rejected due to the postmenopausal condition.

Conclusions: Radioactive iodine uptake in functioning thyroid tissue is mediated by enhanced expression of sodium-iodide symporter (NIS). This case illustrates that not only lactating breast can concentrate iodine, but also in nonlacting mammary gland the presence of prolactin hypersecretor pituitary gland tumour can induce increased NIS expression and therefore prominent accumulation of iodine.

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