ECE2016 Guided Posters Receptors & Signalling (10 abstracts)
Salivary testosterone to androstenedione (T/A4) ratio is significantly higher in PCOS patients and accompanied with an adverse metabolic phenotype
Julia Muenzker 1 , Lisa Lindheim 1 , Jo Adaway 2 , Elisabeth Lerchbaum 1 , Thomas Pieber 1 , Brian Keevil 2 & Barbara Obermayer-Pietsch 1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Australia; 2Manchester Academic Health Science Centre, Department of Clinical Chemistry, University Hospital South Manchester, Manchester, UK.
Background: The aim of this study was to evaluate salivary androgen measurements via liquid chromatography-mass spectrometry as a non-invasive tool for the diagnosis of polycystic ovary syndrome (PCOS) and the assessment of metabolic health.
Methods: Saliva and serum samples of 274 patients with PCOS fulfilling Rotterdam criteria and 51 BMI-matched, premenopausal, healthy controls were analysed for steroid hormones using liquid chromatography/mass spectrometry. The ratio of testosterone to androstenedione (T/A4 ratio) in saliva and serum was assessed and correlated with parameters of metabolic health.
Results: Serum and saliva levels of testosterone and androstenedione are significantly higher in PCOS patients (P<0.001 each). PCOS patients also show significantly higher free testosterone and free dihydrotestosterone levels in serum, as well as a higher free androgen index (P<0.001 each). Testosterone to androstenedione ratio is significantly higher in saliva from PCOS patients compared to saliva from healthy, BMI-matched controls (P<0.001), whereas no significant difference for the T/A4 ratio in serum was found. Only in PCOS patients, salivary T/A4 ratio is significantly higher in patients with obesity (P=0.001), metabolic syndrome (P=0.004), insulin resistance (P=0.016) and glucose intolerance (P=0.038) compared to PCOS women without the respective metabolic alterations.
Conclusions: Assessing salivary androgens and calculating the salivary T/A4 ratio could be a novel, non-invasive tool for the diagnosis of PCOS. Further, a higher T/A4 ratio is linked with an adverse metabolic phenotype in PCOS patients.
Volume 41
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Endocrine Abstracts
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