Introduction: Previous studies suggest close relationship between thyroid morphology and the danger of thyroid hormones (THs) disturbances after high single dose of iodine-containing contrast agent. The aim of the study was to assess the prognostic risk factors which influence on THs after the cardiac catheterization at patient with coronary artery disease (CAD).
Methods: One hundred twenty patient (F/M=40/80, 59±11 years old) without recognized previous thyroid dysfunction and CAD were enrolled between March and October 2015 into the study group I (N=70) with acute coronary syndrome (ACS) and II group (N=50) with stable angina pectoris, matching to the age. Thyroid function serum parameters (TSH, fT3, fT4), serum concentration of thyroid antibodies (TPO-Ab, Tg-Ab) and thyroid ultrasound were performed before conventional angiography. Hormone status was also evaluated 48 h and 50 days after catheterization.
Results: At the admission, the subclinical hypothyroidism was recognize at five (4%) patients, low T3 syndrome in two percents, thyroid antibodies at 8% and thyroid gland nodules at 44 (37%) participants. Two days after angiography the significant decrease of fT3 occurred (mean differences −0.32 pg/ml, P<0.01) and it was more significant in the group II (time×group interaction P<0.01). After adjusting for thyroid morphology and thyroid antibodies the differences between groups was still significant (P=0.04), but not after adjusting for the peak value of hs troponin T and hs CRP (P=0.23). The concentration of fT3 normalized after 50 days in the whole group.
The TSH serum concentration was stable after 2 and 50 days after catheterization.
Conclusion: The iodine-containing contrast agent administration during coronary angiography is safe in the aspect of the thyroid function. It was not thyroid morphology but the presence of ACS which influenced THs levels.