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Endocrine Abstracts (2016) 41 GP224 | DOI: 10.1530/endoabs.41.GP224

1Department of Endocrinology and Metabolism, Ataturk Education and Research Hospital, Ankara, Turkey; 2Faculty of Medicine, Department of Endocrinology and Metabolism, Yildirim Beyazit University, Ankara, Turkey; 3Faculty of Medicine, Department of Surgery, Yildirim Beyazit University, Ankara, Turkey; 4Faculty of Medicine, Department of Pathology, Yildirim Beyazit University, Ankara, Turkey.

Introduction: Incidental thyroid carcinoma (ITC) in patients operated on for a benign disease is frequent. ITC characteristics in patients operated for malign disease, but not sampled by fine needle aspiration (FNA) or seen in ultrasonography, is unknown. We aimed to compare ITC with nonincidental ITC (NITC) in this study.

Material and method: Retrospective analyses of 918 individual patients who were operated for benign and malign thyroid disease in our hospital between December 2006 and September 2014 and had a final histologic diagnosis of thyroid carcinoma were enrolled in this study. All patients underwent ultrasonographic examination and FNA biopsy was performed for all nodules >1 cm and nodules ≤1 cm with at least one of the suspicious ultrasonographic findings as irregular margins, hypoechoism, increased internal vascularity and presence of microcalcifications. The lesions in thyroidectomy specimens that did not represent the FNA or ultrasonographic nodule target were classified as ITC. The lesions that match with FNA results or ultrasonographic features were classified as NITC. Characteristics of ITC and NITC were compared in this study.

Results: There were 1231 cancer foci in histopathology specimens. Among all these cancer foci, 687 were detected incidentally while 635 were detected non-incidentally. Mean age was 51.6±11.01 in ITC group and 48.1±13.1 in NITC group (P<0.001). Mean size was 12 mm (1–90 mm) in NITC group while it was 3 mm (0.1–25 mm) in ITC group and differed significantly between the groups (P<0.001). Frequency of capsular invasion (37%/7.9%), extrathyroidal extension (16.2%/4.1%), non-complete resection (11.9%/2%) and lymph node metastasis (9.1%/2.6%) were significantly higher in the NITC group (P<0.001).

Conclusion: ITC is often encountered in older patients and frequently determined in early stages that can relieve the clinicians.

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