Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 GP51 | DOI: 10.1530/endoabs.41.GP51

ECE2016 Guided Posters Cardiovascular endocrinology (9 abstracts)

Pericardial rather than intramyocardial fat is independently associated with systolic and diastolic left ventricular heart function in metabolically healthy humans

Peter Wolf 1 , Yvonne Winhofer 1 , Sabina Smajis 1 , Drazenka Jankovic 2 , Christian-Heinz Anderwald 1 , Siegfried Trattnig 1 , Anton Luger 1 , Michael Krebs 1 & Martin Krssak 1

1University of Vienna, Vienna, Austria; 2Wilhelminenspital, Vienna, Austria.

Background: Obesity is a major risk factor to develop heart failure, in part due to possible lipotoxic effects of increased intramyocardial (MYCL) and/or pericardial (PERI) lipid accumulation. Recent evidence suggests that MYCL is highly dynamic and might rather be a surrogate marker for disturbed energy metabolism than the underlying cause of cardiac dysfunction. On the other hand, PERI might contribute directly by mechanic and paracrine effects. Therefore, we hypothesized that PERI rather than MYCL is associated with myocardial function.

Methods: To avoid potential confounding of metabolic disease 38 metabolically healthy, but slightly overweight subjects (age: 33±15 years; BMI: 25±4 kg/m2) were investigated using 1H-magnetic resonance spectroscopy and imaging. MYCL and PERI, as well as systolic and diastolic left ventricular heart function were assessed.

Results: Correlation analysis with parameters of systolic heart function revealed significant associations for PERI (Ejection fraction: R=0.404 P=0.016; Cardiac index: R=−0.482 P=0.003), but not for MYCL. With regard to diastolic heart function MYCL (R=−0.349 P=0.034) and PERI (R=−0.472 P=0.004) were negatively correlated with the E/A ratio. In multiple regression analysis CI and E/A ratio were negatively predicted by PERI, whereas no impact of MYCL could be found in direct comparison.

Discussion: Cardiac fat depots impact heart function in slightly overweight subjects. Moreover, direct comparison of different lipid stores revealed that PERI is a more important predictor than MYCL for altered systolic and diastolic function in a metabolically healthy population.

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