Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 S21.1 | DOI: 10.1530/endoabs.41.S21.1

ECE2016 Symposia An update on hyperparathyroidism (3 abstracts)

Primary hyperparathyroidism: what is new?

Camilla Schalin-Jäntti



Primary hyperparathyroidism (PHPT) is a common endocrine disorder, with a prevalence of 1–4 per 1000, that increases to 21 per 1000 in age groups 55–75 years. PHPT may be cured in only one way: by surgical excision of the abnormal parathyroid tissue, which in ~85% of patients is due to a parathyroid adenoma. Double adenomas are found in ~4% of cases and parathyroid carcinoma in 1%. There is consensus that patients with markedly increased serum calcium concentrations, symptomatic kidney stones and osteoporosis should undergo surgery. In 5–10% of cases, PHPT is part of a genetic syndrome, such as multiple endocrine neoplasia type 1 or 2, hyperparathyroidism-jaw tumor syndrome (HPT-JT), familial isolated hyperparathyroidism (FIHP), or familial hypocalciuric hypercalcemia (FHH).

To date, exciting topics within PHPT include the evaluation of neurocognitive symptoms and health-related quality of life (HRQoL). Such symptoms are commonly reported in PHPT, and there is a need for a sensitive tool applicable for the assessment of such symptoms in the out-patient clinic. The value of symptoms as prognostic factors regarding who benefits from surgery has so far been poorly studied. Whether HRQoL in PHPT improves after surgery is a matter of debate. I will discuss some of the studies available on HRQoL in PHPT, and the outcome of surgery on HRQoL.

An increasing amount of genetic defects underlying PHPT have been identified over the years, and I will go through some of the recent findings in HPT-JT, FIHP, and familial hypocalcuric hypercalcemia (FHH).

Last but not least, the incidence of parathyroid carcinoma seems to be increasing world-wide. I will shortly review this topic, and also share some novel data from the Finnish Parathyroid Carcinoma Cohort with you.

Other topics discussed in this session include the relationship between primary hyperparathyroidism, hypertension and hyperaldosteronism, and novel data regards available preoperative imaging techniques in PHPT.

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