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Endocrine Abstracts

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World Congress on Clinical Trials in Diabetes

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Translational and Preclinical Trend in Diabetes

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Regulatory Trends in Diabetes
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ea0043oc53 | Translational and Preclinical Trend in Diabetes | WCTD2016

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ea0043oc54 | Translational and Preclinical Trend in Diabetes | WCTD2016

Insomnia in adults with Type 2 diabetes: Baseline data from the Diabetes Sleep Treatment Trial

Chasens Eileen R. , Burke Lora E. , Baniak Lynn M. , Sereika Susan M. , Atwood Charles , Strollo Patrick J. , Korytkowski Mary

Purpose: Previous studies have established that obstructive sleep apnea (OSA) frequently co-exists in persons with type 2 diabetes (T2DM) with negative effects on glycemic control and functional outcomes. However, there is limited data about the effect of insomnia or co-morbid OSA and insomnia among those with T2DM. We compared glucose control, functional outcomes, sleep quality, and daytime sleepiness among 4 groups of participants with T2DM: (i) OSA, (ii) insomnia, (iii) OSA...
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ea0043oc55 | Translational and Preclinical Trend in Diabetes | WCTD2016

“Energetic balance” appreciation as a complementary feedback for insulin delivery monitoring in glucose metabolism disorders

Coulic Very , Novikov VK , Iu Anisimov , Devriendt J , Dmitriev T

Background: Hoping to avoid repeated hypoglycaemia and yo-yo phenomena, alternative feedback was proposed based on the body “energetic balance” evolution checking. A device (ADD-CIT – Apparatus for Diagnosis of Diabetes and Complex Insulin Therapy) measuring the differences between core and superficial temperatures (Dt) evolution and programming insulin delivery was proposed and first-tested (PDT, 2015).Objective: The present work aims at ...
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ea0043oc56 | Translational and Preclinical Trend in Diabetes | WCTD2016

The use of modified hyperinsulinemic hypoglycaemic glucose clamp to evaluate the accuracy of blood glucose monitoring systems in T1DM patients

Fawkes Neil , Fawkes Neil , Bell David , Bell Patrick

Background and aims: The ISO guideline 15197 lays out the system accuracy (SA) and user performance (UP) evaluation requirements for BGMS for self-testing in managing diabetes mellitus. They require the measurement of blood glucose to be tested across a spectrum of glucose ranges to demonstrate accuracy, including within the hypoglycemic range. Fulfilling the requirements for accuracy evaluations at the hypoglycaemic range can be challenging. The aim of the study was to show t...
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ea0043oc57 | Translational and Preclinical Trend in Diabetes | WCTD2016

Variation in arch index and subtalar joint range of motion in diabetic and non-diabetic conditions with and without neuropathy

Ibeneme Sam , Onyeje Uche , Ibeneme Georgian , Okoye Ifeoma , Fortwengel Gerhard

Background: Non-enzymatic glycosylation of tissues damage the innervation of intrinsic foot muscles leading to diabetic neuropathy (DN), and an imbalance between flexors and extensors of the foot. This might derange the arches of the foot and predispose to foot deformity, prior to foot ulceration, and was investigated.Objective: To determine the variation in arch index (AI) and subtalar joint (STJ) range of motion in diabetic and non-diabetic conditions ...
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ea0043oc58 | Translational and Preclinical Trend in Diabetes | WCTD2016

ALMS1 acts as a critical molecular switch that controls Insulin-stimulated glucose transport in adipocytes

Licona Cynthia , Obringer Cathy , Rajapaksha Harinda , Dollfus Helene , Petrovsky Nikolai , Marion Vincent

Background: ALMS1 is a 461kDa protein that, when mutated, causes Alström syndrome (AS). AS is a rare autosomal recessive disorder characterized by childhood obesity and early-onset insulin-resistant diabetes, amongst other features. Studies using primary human adipocytes revealed that ALMS1 is critical for insulin-regulated glucose transport. The predilection for insulin resistance and T2DM in AS children seems to reflect a hitherto uncharacterized role of ALMS1 in the in...
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ea0043oc59 | Translational and Preclinical Trend in Diabetes | WCTD2016

Human cartilage glycoprotein39 (HC-gp39) stands up for “Madam Diabetes”-a peasant French Woman: An update

Ofodile Okom

Diabetes remains a major public health burden worldwide. The causes of Diabetes have not been fully understood and there is to date no cure for Diabetes. Accumulating evidence, however, supports the notion that interplay between HC-gp39 and adipocytes could be fundamental in understanding the pathobiology of type 2 Diabetes and help to develop novel therapeutic strategies to arrest metabolic dysfunction. HC-gp39 is an inflammation-associated chitinase-like protein, found in ve...
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ea0043oc60 | Translational and Preclinical Trend in Diabetes | WCTD2016

Glucose transporters and C peptide role in diabetes control a preclinical review of literature

Pham Thuy , Dao Marvin , Singh Mukunda

Background: C-peptide therapy ameliorates sensory nerve function in T1DM neuropathy. Prolonged GLUT-4 translocation and delayed counter regulation can induce hypoglycemia. GLUT-2 protein is the primary hepatic liver transporter related to hepatic glucose regulation it also plays a role on glucose sensing by pancreatic beta cells, via hepatoportal sensors controlling the autonomic nervous system and stimulates glucagon secretion.Objective: To discuss the ...
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ea0043oc61 | Translational and Preclinical Trend in Diabetes | WCTD2016

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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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