ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2016) 43 OC16 | DOI: 10.1530/endoabs.43.OC16

Effects of hesperidin supplementation on glycemic control, lipid profile and inflammatory factors in patients with type 2 diabetes: a randomized, double-blind and placebo-controlled clinical trial

Shahryar Eghtesadi1, Mohammad Mohammadi1, Mohammadreza Vafa1, Iraj Heidari2, Masoud Salehi3, Hossein Khadem Haghighian4, Fatemehsadat Amiri1, Rooya Alipour1 & Maryam Eghtesadi5


1Nutrition, Iran University of Medical Sciences, Tehran, Iran; 2Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran; 3Biostatistics, Iran University of Medical Sciences, Tehran, Iran; 4Nutrition, Ahwaz Judishapur University of Medical Sciences, Ahwaz, Iran; 5Research, Azad University, Tehran Medical Branch, Tehran, Iran.


Background: Diabetes mellitus is a common chronic disease and a major public health problem globally. The management of this disease through antioxidative and anti-inflammatory agents specially flavonoids, as an adjuct therapy, is of interest and attention.

Objectives: This study was conducted to investigate the effects of hesperidin (a common constituent of citrus fruits) supplementation on indices of glycemic control, insulin resistance, lipid profile, and inflammatory markers in patients with type 2 diabetes.

Methods: Following approval by Ethics Committee of Iran University of Medical Sciences for Human Studies 45 patients with type 2 diabetes were recruited in a randomized double-blind controlled clinical trial design. Subjects consumed 500 mg/d hesperidin supplement in the intervention group (n=23) and 500 mg/d placebo in the control group (n=22), for 8 weeks. 10 cc blood samples and three days dietary Information were obtained at the baseline and the end of the study. The levels of fasting blood glucose (FBG), insulin, hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, insulin resistance, inflammatory factors IL6 and hs- CRP were measured and compared within and between treatment group. Statistical analyses were conducted with SPSS software by using independent t and paired t test.

Results: Hesperidin supplementation led to significant decrease in FBG and glycated hemoglobin (HbA1c) (P=0.041 and 0.028, respectively). A significant increase in serum insulin (P=0.018) and decrease in TC (P=0.049) were also observed in the hesperidin group, whereas no significant changes occurred in the placebo group. Inflammatory factors, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) were not significantly changed in the hesperidin group compared to the control group.

Conclusions: Hesperidin supplementation lowered the plasma level of TC and improved glycemic control and insulin resistance in patients with type 2 diabetes.

Keywords: Hesperidin, glycemic control, insulin resistance, lipid profile, inflammatory markers, type 2 diabetes