Endocrine Abstracts

Long-term diabetes is associated with accelerated ageing of the brain as evidence by impairment of cognitive function as well as motor performance. The aim of this study was to investigate the effects of voluntary daily exercise and environmental enrichment on spatial memory and learning as well as motor coordination and learning, in diabetic mice. Briefly, BALB/C mice (20–25 g) received 55 mg/kg streptozotocin i.p. daily for 5 days. Diabetes was confirmed by measurement ...

Background: Monogenic diabetes is a rare form of diabetes which accounts for 5% of all diabetes cases. This is caused by a single gene mutation mostly inherited from an autosomal dominant pattern. The two types of monogenic diabetes are Neonatal monogenic diabetes (NMD) and Maturity-onset diabetes of the young (MODY). Accurate diagnosis of monogenic diabetes remains to be a great challenge for most clinicians due to its overlapping clinical features from other forms of diabete...

Background: There is a complex interaction between psychosocial factors and type 1 diabetes (T1D) resulting in compromised diabetes management and suboptimal glycemic control. Individuals with T1D are at increased risk of developing depression and anxiety. Screening for psychosocial risk factors from diagnosis of T1D has been recommended. International standard is integrated care by a multidisciplinary team.Objective: We performed a systematic review and...

Background: Diabetes mellitus is a common chronic disease and a major public health problem globally. The management of this disease through antioxidative and anti-inflammatory agents specially flavonoids, as an adjuct therapy, is of interest and attention.Objectives: This study was conducted to investigate the effects of hesperidin (a common constituent of citrus fruits) supplementation on indices of glycemic control, insulin resistance, lipid profile, ...

Background: Hypocaloric diets reduce the risk for type 2 diabetes (T2D) in obese subjects. However, there is a large inter-subject variability in the response to these interventions. The factors affecting this variability remain poorly understood. We and others reported that high plasma apoB-lipoproteins predict risk factors for, and incidence of, T2D in obese subjects independent of adiposity or fat distribution.Objective: To test the hypothesis that pl...

Background: A feasibility trial was conducted to determine the potential for telemedicine to replace alternate diabetes review appointments in the care of those with gestational diabetes (GDM). One of the aims of this study was to access concordance of clinical decision making between diabetes clinic visits and telemedicine review sessions.Methods: 50 women with GDM were randomised to usual care (n=26) or usual care plus telemedicine (n=24). Telemedicine...

Background: Diabetes and hypertension are among leading causes of premature adult deaths in India. Innovative approaches such as electronic clinical decision support systems (DSS) could play major role in improving quality and access to diabetes and hypertension care at primary care settings.Objective: The main objective of this study is to develop an innovative tablet-computer based DSS namely “m-WELLCARE”, and other essential support healthca...

Introduction: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP9) and allograft inflammatory factor-1 (AIF-1) belong to the proteins produced by adipocyte tissue, which differently contribute to oxidative stress, chronic inflammation, insulin resistance and endothelial damage. The aim of this pilot study was to compare their levels in patients with diabetes and in healthy individuals and determine ...

Background: Patient engagement and adherence are critical to the success of clinical trials. Electronic patient-reported outcomes (ePROs) are increasingly used to evaluate diabetes clinical trial endpoints. This study characterized how subjects prefer to use various types of technology to report ePROs in a clinical trial. Considering patient preference during diabetes trial design may reduce patient burden and improve patient engagement.Methods: 102 subj...

Background: Electronic patient-reported outcomes (ePROs) are a reliable method for collecting patient data in diabetes clinical trials and offer many advantages over paper collection; however, it is essential to consider patient preference and ease of use when employing this technology. Improving the usability of ePRO in clinical trials could ultimately reduce subject burden and improve subject engagement.Methods: 102 subjects with type 2 diabetes were s...

Background: People with intellectual disability (ID) are living longer and more likely to develop Type 2 diabetes (T2D). It is recognised in many westernised countries that better self-management of T2D can improve the persons’ health and quality of life: one such programme is DESMOND. However, such programmes have not been adapted for adults with ID.Objective: This poster focuses upon adapting DESMOND. There were two objectives, firstly, to explore...

A comprehensive pregestational prenatal monitoring and early detection of diabetes amongst pregnant patients is the cornerstone of the updated ADA recommendation 2016 in Diabetes Care.It is our main objective to lay out an attainable management plan for early diagnosis, and management of gestational diabetic in a community clinic.The plan includes implementation of family planning and effective contraception for known women with pr...

Background: By using new treatment modalities in DM1 patients (glucose sensors, insulin pumps) we quite often do not reach optimal results.Objective: As a part of the project developing software for smartphones (a self-learning diabetes management advisory tool) we provided in insulin pump users detail diet and RT-CGM records analysis. As the main cause of postprandial hyperglycaemia in our DM1 patients we identified dietary mistakes. Moreover diet of ou...

Background: Plantar pressure and pressure-time integral are two important factors for creating foot ulcer in diabetic patients. Increasing foot contact area with a metatarsal pad has been reported as one of the best strategies to decrease the risk of ulcer; but there is no clear guideline to determine optimal length of metatarsal pad.Objective: The purpose of present study was to determine the effects of metatarsal pad length on peak plantar pressure and...

Background: Carpal Tunnel syndrome (CTS) was reported in 2.6 to 20% in diabetic patient’s population that may be as results of repeated undetected trauma, metabolic changes, and accumulation of fluid or edema within the confined space of the carpal tunnel and/or diabetic Cheiroarthropathy. Manual therapy is prescribed as a conservative treatment for CTS.Objective: The aim of this study was to compare the effects of two manual therapy methods includi...

Background: Transition of diabetes care from adolescents to adulthood remains a challenging field due to many social, demographic, and economic factors. During the transition phase, strong emphasis should be placed on encouraging teens to assume self-care and self-management of their diabetes through guided practice of physical and practical skills needed once they transition to adult care.Objectives: Through the Medicaid 1115 Waiver-Delivery System Refo...

Background: Pediatric patients with diabetes are required to adhere to strict regimens including blood glucose testing, insulin therapy, and dietary restrictions. Adequate glucose control is necessary to prevent acute and chronic complications. Testing Hemoglobin A1c (HgbA1c) provides a simple evaluation of diabetes control and compliance with therapy. Psychological factors (depression, anxiety) play a major role in pediatric diabetes compliance. Access to psychological suppor...