Searchable abstracts of presentations at key conferences in endocrinology
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World Congress on Clinical Trials in Diabetes

Abstract Topics

Cardiovascular Outcome Studies

ea0043oc1 | Cardiovascular Outcome Studies | WCTD2016

Evolution of the magnitude of stroke at the teaching hospital of Bobo-Dioulasso

Samadoulougou Delwende Rene Severin , Kpoda Herve , Traore Isidore , Savadogo Leon , Sombie Issiaka , Millogo Athanase

Background: Strokes are more and more frequent in the world, particularly in Africa. The evolution of their magnitude remains still poorly documented in the context of Burkina Faso, particularly in Bobo-Dioulasso. That is why this study was conducted to clarify the epidemiology of stroke and its risk factors in order to raise the alarm.Objective: Investigate the evolution of the magnitude of stroke and its risk factors at the Teaching Hospital of Bobo-Di...

ea0043oc2 | Cardiovascular Outcome Studies | WCTD2016

HyperapoB and dysfunctional white adipose tissue; relation to risk factors for type 2 diabetes in humans

Lamantia Valerie , Bissonnette Simon , Wassef Hanny , Cyr Yannick , Baass Alexis , Dufour Robert , Rabasa-Lhoret Remi , Faraj May

Background: Elevated plasma concentrations of apoB-lipoproteins (i.e. hyperapoB) is an independent predictor of type 2 diabetes (T2D) in humans; however underlying mechanisms remain unclear. Chronic reduction in the function of white adipose tissue (WAT) promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL, the most common form of apoB-lipoproteins, induce their dysfunction, measured as decreased hydrolysis and storage of t...

ea0043oc3 | Cardiovascular Outcome Studies | WCTD2016

Effects of combined acute versus chronic aerobic and resistance exercises on HbA1c, cardiovascular and immune functions in type 2 diabetic condition

Ibeneme Sam , Azubuike Obed , Ibeneme Georgian , Okoye Ifeoma , Fortwengel Gerhard , Limaye Dnyanesh , Ezuma Amara

Background: Elevated HbA1c, cardio-vascular and immune dysfunctions are common complications of poorly controlled type 2 diabetes (T2D), which can be improved by aerobic and resistance exercises, respectively. Therefore, effects of combined aerobic and resistance exercises in acute and chronic conditions might also have beneficial health outcomes and was investigated.Objective: Determine the effects of combined aerobic and resistance exercises on serum n...

ea0043oc4 | Cardiovascular Outcome Studies | WCTD2016

Antihyperglycermic drugs use and new-onset atrial fibrillation in elderly patients: a popuation-based longitudinal cohort study

Jong Gwo-Ping , Liou Yi-Sheng , Ma Tsochiang , Chen Hung-Yi

Background: Antihyperglycermic drugs have been linked to new-onset atrial fibrillation (NAF); however, the effect of different class antihyperglycermic drugs on the development of NAF in elderly patients with diabetes millitus (DM) has not been well studied.Objectives: We investigated the association between different class antihyperglycermic drugs and NAF in elderly patients.Methods: This was a retrospective cohort study performed...

ea0043oc5 | Cardiovascular Outcome Studies | WCTD2016

Diabetes and blood pressure rhythm abnormalities

Klaric Dragan , Artukovic Kristina

Background: The absence of blood pressure dip during sleep is a common disorder in patients on dialysis, especially those with diabetes. Non-dipping is clinically significant as a predictor of cardiovascular events and an overview of the situation is possible only during ambulatory blood pressure monitoring (AMP), especially during sleep.Objective: Inversion of nighttime blood pressure is an indication of worse outcomes.Methods: Du...

ea0043oc6 | Cardiovascular Outcome Studies | WCTD2016

Nootkatone from Cyperus rotundus Protects Against Ischemia-reperfusion Mediated Acute Myocardial Injury in the Rat

Lee Dong-Ung , Chang Ki Churl

Background: Myocardial infarction is a common type of ischemic heart disease, which is the leading cause of disease-related death worldwide. In the ischemic heart, cardiac damage is initiated by a diminished blood supply, and swift restoration of blood supply is imperative to minimize cardiac injury. However, reperfusion itself can induce additional injury in the form of cardiac dysfunction, reperfusion arrhythmia, and by exacerbating myocardial infarction.<p class="abstex...

ea0043oc7 | Cardiovascular Outcome Studies | WCTD2016

The effect of eye mask on sleep quality in patients of coronary care unit

Mashayekhi Fatemeh , Barzin Zahra

Objectives: Patients in coronary care unit (CCU) are at risk of sleep deprivation. This study investigated effects of eye mask on sleep quality in patients of CCU in Southeast of Iran by a crossover design.Methods: Using Verran and Snyder-Halpern Sleep Scale (VSH Sleep Scale), quality sleep of 60 patients with and without usage of eye mask were evaluated. This tool consists of 16 items that includes three main sleep sub scales: disturbance, effectiveness...

ea0043oc8 | Cardiovascular Outcome Studies | WCTD2016

Bromocriptine shifts the blood pressure circadian rhythm in type 2 DM and stage 4 of chronic kidney disease patients: A post hoc study

Mejia-Rodriguez Oliva , Ruiz-Vega Humberto , Alvarez-Aguilar Cleto , Ceballos-Reyes Guillermo , Galvan-Plata Maria Eugenia , Paniagua Ramon

Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 ...

ea0043oc9 | Cardiovascular Outcome Studies | WCTD2016

Years of Life Gained by Multifactorial Intervention in Patients with Type 2 Diabetes and Microalbuminuria – 21 Years Follow-Up on the Steno-2 Study

Ollgaard Jens , Gaede Peter , Carstensen Bendix , Rossing Peter , Lund-Andersen Henrik , Parving Hans-Henrik , Pedersen Oluf

Aims: To study the potential long-term impact of a 7.8 years intensified, multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria in terms of gained years of life and years free from incident cardiovascular disease.Methods: The original intervention (mean treatment duration 7.8 years) involved 160 patients with type 2 diabetes and microalbuminuria that were randomly assigned to either conventional therapy or intensified...

ea0043oc10 | Cardiovascular Outcome Studies | WCTD2016

Efficacy, outcome and safety of SGLT2-I in patients with type II diabetes meta analysis review

Singh Mukunda , Pham Thuy , Dao Marvin

Background: SGLT2-I is a promising new class of diabetes pharmacotherapy, it targets blood glucose lowering in both postprandial and fasting states. It offers minimal risk of hypoglycemic events and demonstrates modest effects on blood pressure and weight.Objective: Meta-analysis review of SGLT2-I outcome, safety and efficacy RCT.Methods: Medline, EMBASE & CENTRAL were searched until August 2015, double blind RCT in T2DM with a...

ea0043oc11 | Cardiovascular Outcome Studies | WCTD2016

Managing cardiometabolic risk in type 2 diabetes care

Terkes Nurten , Bektas Hicran

Background: Cardiometabolic risk (CMR) refers to risk factors that increase the likelihood of experiencing vascular events or developing diabetes. This concept encompasses traditional risk factors, such as hypertension, dyslipidemia, smoking. Abnormal glucose metabolism is a risk factor for cardiovascular disease (CVD) and, in some individuals, may progress to meet the threshold for the diagnosis of diabetes. CVD is the leading cause of death in the worldwide, and nearly one q...

ea0043oc12 | Cardiovascular Outcome Studies | WCTD2016

Interleukins 6 and 8 and abdominal fat depots are distinct correlates of lipid moieties in healthy pre- and postmenopausal women

Veldhuis Johannes , Dyer Roy , Trushin Sergey , Bondar Olga , Singh Ravinder , Klee George

Purpose: Available data associate lipids concentrations in men with BMI, anabolic steroids, age, and certain cytokines. Data are less clear in women, especially across the full adult lifespan, and when segmented by pre- and postmenopausal status.Methods: Subjects: 120 healthy women in Olmsted County, MN, USA, a stable well studied clinical population. Dependent variables: measurements of 10-hr fasting high-density lipoprotein cholesterol (HDL-C), total c...