Endocrine Abstracts

Background: Strokes are more and more frequent in the world, particularly in Africa. The evolution of their magnitude remains still poorly documented in the context of Burkina Faso, particularly in Bobo-Dioulasso. That is why this study was conducted to clarify the epidemiology of stroke and its risk factors in order to raise the alarm.Objective: Investigate the evolution of the magnitude of stroke and its risk factors at the Teaching Hospital of Bobo-Di...

Background: Elevated plasma concentrations of apoB-lipoproteins (i.e. hyperapoB) is an independent predictor of type 2 diabetes (T2D) in humans; however underlying mechanisms remain unclear. Chronic reduction in the function of white adipose tissue (WAT) promotes T2D. We reported that differentiation of preadipocytes and acute incubation of human WAT with LDL, the most common form of apoB-lipoproteins, induce their dysfunction, measured as decreased hydrolysis and storage of t...

Background: Elevated HbA1c, cardio-vascular and immune dysfunctions are common complications of poorly controlled type 2 diabetes (T2D), which can be improved by aerobic and resistance exercises, respectively. Therefore, effects of combined aerobic and resistance exercises in acute and chronic conditions might also have beneficial health outcomes and was investigated.Objective: Determine the effects of combined aerobic and resistance exercises on serum n...

Background: Antihyperglycermic drugs have been linked to new-onset atrial fibrillation (NAF); however, the effect of different class antihyperglycermic drugs on the development of NAF in elderly patients with diabetes millitus (DM) has not been well studied.Objectives: We investigated the association between different class antihyperglycermic drugs and NAF in elderly patients.Methods: This was a retrospective cohort study performed...

Background: The absence of blood pressure dip during sleep is a common disorder in patients on dialysis, especially those with diabetes. Non-dipping is clinically significant as a predictor of cardiovascular events and an overview of the situation is possible only during ambulatory blood pressure monitoring (AMP), especially during sleep.Objective: Inversion of nighttime blood pressure is an indication of worse outcomes.Methods: Du...

Background: Myocardial infarction is a common type of ischemic heart disease, which is the leading cause of disease-related death worldwide. In the ischemic heart, cardiac damage is initiated by a diminished blood supply, and swift restoration of blood supply is imperative to minimize cardiac injury. However, reperfusion itself can induce additional injury in the form of cardiac dysfunction, reperfusion arrhythmia, and by exacerbating myocardial infarction.<p class="abstex...

Objectives: Patients in coronary care unit (CCU) are at risk of sleep deprivation. This study investigated effects of eye mask on sleep quality in patients of CCU in Southeast of Iran by a crossover design.Methods: Using Verran and Snyder-Halpern Sleep Scale (VSH Sleep Scale), quality sleep of 60 patients with and without usage of eye mask were evaluated. This tool consists of 16 items that includes three main sleep sub scales: disturbance, effectiveness...

Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 ...

Aims: To study the potential long-term impact of a 7.8 years intensified, multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria in terms of gained years of life and years free from incident cardiovascular disease.Methods: The original intervention (mean treatment duration 7.8 years) involved 160 patients with type 2 diabetes and microalbuminuria that were randomly assigned to either conventional therapy or intensified...

Background: SGLT2-I is a promising new class of diabetes pharmacotherapy, it targets blood glucose lowering in both postprandial and fasting states. It offers minimal risk of hypoglycemic events and demonstrates modest effects on blood pressure and weight.Objective: Meta-analysis review of SGLT2-I outcome, safety and efficacy RCT.Methods: Medline, EMBASE & CENTRAL were searched until August 2015, double blind RCT in T2DM with a...

Background: Cardiometabolic risk (CMR) refers to risk factors that increase the likelihood of experiencing vascular events or developing diabetes. This concept encompasses traditional risk factors, such as hypertension, dyslipidemia, smoking. Abnormal glucose metabolism is a risk factor for cardiovascular disease (CVD) and, in some individuals, may progress to meet the threshold for the diagnosis of diabetes. CVD is the leading cause of death in the worldwide, and nearly one q...

Purpose: Available data associate lipids concentrations in men with BMI, anabolic steroids, age, and certain cytokines. Data are less clear in women, especially across the full adult lifespan, and when segmented by pre- and postmenopausal status.Methods: Subjects: 120 healthy women in Olmsted County, MN, USA, a stable well studied clinical population. Dependent variables: measurements of 10-hr fasting high-density lipoprotein cholesterol (HDL-C), total c...