SFEBES2016 Poster Presentations Obesity and Metabolism (26 abstracts)
Impact of weight gain on long term outcomes in women with turner syndrome: The turner syndrome life course project
Antoinette Pimblett , Thomas J King , Vikram Talaulikar , Melanie Davies & Gerard Conway
University College London Hospitals, London, UK.
Turner syndrome (TS) affects over 15,000 females in the UK and is defined by the loss of X chromosome material. In the setting of an adult clinic we can observe adverse outcomes and determine their risk factors. For instance women with TS have an excess risk of hypertension, diabetes, fatty liver and osteoporosis. The Turner Syndrome Life Course Project at UCLH has collected data from over 750 women with TS over 20 years. Here we report the influence of weight on these outcomes.
Full data sets were available for 659 women with TS who were subdivided by BMI quintiles of 132 women in each group. Comparisons were made using ANOVA (***=P<0.001; **=P<0.01; *=P<0.05. Data in the table are presented for mean (SEM) Diastolic blood pressure (BP), glycated haemoglobin (HbA1c), gamma glutamyl transferase (GGT) and t-score at the lumbar spine measured by DEXA.
| Quintile | 1 | 2 | 3 | 4 | 5 |
| BMI (kg/m2) | <20.6 | 20.6–23.2 | 23.2–26.3 | 26.3–31.0 | >31 |
| Diastolic BP | 71.4 (1.1) | 71.4 (0.9) | 74.2 (1.0) | 76.7 (1.1) | 78.1 (1.1)*** |
| HbA1c % | 5.3 (0.09) | 5.4 (0.10) | 5.4 (0.08) | 5.6 (0.012) | 5.7 (0.09)* |
| GGT mu/L | 60.1 (7.6) | 51.4 (5.7) | 56.2 (7.3) | 97.1 (13.5) | 102 (12.0)*** |
| Spine t-score | −1.10 (0.12) | −1.35 (0.11) | −1.04 (0.11) | −0.83 (0.12) | −0.67 (0.13)** |
The results show that weight has a major influence on health risk factors in women with TS. This information emphasises the need to incorporate weight loss programs as part of routine care in adult clinics.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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