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Endocrine Abstracts (2016) 44 P58 | DOI: 10.1530/endoabs.44.P58

1“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 2Coltea Clinical Hospital, Bucharest, Romania; 3“CI Parhon” National Institute of Endocrinology, Bucharest, Romania; 4“Elias” Emergency Hospital, Bucharest, Romania; 5Dr. Ioan Cantacuzino Clinical Hospital, Bucharest, Romania.


Aim: Somatic growth results from the generation of new support and connective tissue. Since collagen is the major protein constituent of connective tissue, its synthesis must be a prerequisite for the normal growth. The aim of the study was to determine age-related reference intervals for P3NP, a collagen – formation marker in a group of normal height prepubertal children and to compare to IGF1 levels.

Subjects: Forty-three prepubertal children, male (n=26) and female n=(17) participated in this study. Their height and weight were recorded. All the children have normal height.

Methods: For quantitative measurement of P3NP, we used a research kit with sandwich enzyme immunoassay with a detection limit of 62.5 pg/ml. P3NP values were analyzed for normality using Shapiro–Wilk test. Tukey test was used to identify outliers. We divided the prepubertal period into three intervals for each sex: 4 to 5-year old, 6 to 7 year old, and 8 to 9 year old.

Results: Age was determinant for the standard deviation score but not for the mean of P3NP values for each age group. A t-test was used to compare means and SDS for each sex and age-group. There were similar values for P3NP between males and females in the group of age 4 to 5-year old and 6 to7 years old. There was a trend towards significant higher values for P3NP in the girls when compared with the male in the age group of 8 to 9-year-old. No correlation between IGF1 and P3NP was fond.

Conclusion: Higher values for P3NP in girls compared to males in the group of 8 to 9 year old can be explained by an earlier onset of puberty in girls associated with the increase during early puberty of collagen markers.

Volume 44

Society for Endocrinology BES 2016

Brighton, UK
07 Nov 2016 - 09 Nov 2016

Society for Endocrinology 

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