Searchable abstracts of presentations at key conferences in endocrinology
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44th Meeting of the British Society for Paediatric Endocrinology and Diabetes

ea0045p6 | Bone | BSPED2016

Awareness of Vitamin D supplementation guidelines among the junior doctors at University Hospital of Wales, Cardiff

Sakamudi Jayabharathi , Abdulkader Huda , Vander voort Judith

Background: The prevalence of childhood vitamin D deficient rickets in the UK is rising due to lack of sun exposure. The Department of Health, Royal College of Paediatrics and Child Health (RCPCH) and the National Institute for Health and Care Excellence (NICE) have devised guidelines on vitamin D supplementation during pregnancy, breastfeeding and childhood. A recent Government initiative, Healthy Start vitamins allow access to free vitamin D for women and children from low-i...

ea0045p7 | Bone | BSPED2016

Craniosynostosis in a case of nutritional rickets

Mohamed Zainaba , Law James , Benson Joanna , Sachdev Pooja , Randell Tabitha , Denvir Louise

Background: Nutritional rickets (NR), due to poor dietary calcium intake or vitamin D deficiency is still the most common form of growing bone disease despite the efforts of health care providers to reduce its incidence. Clinical history, physical examination and laboratory evaluation are mainstay of diagnosis.Aim: We report a case of NR where the radiological report was misleading causing significant parental anxiety and delay in diagnosis.<p class=...

ea0045p8 | Bone | BSPED2016

Denosumab therapy for hypercalcaemia of malignancy in a young child

Saravanamuthu Abiramy , Katugampola Harshini , Collard Grace , Matei Cristina , Peters Catherine

Introduction: Hypercalcaemia secondary to malignancy is rare in childhood. Bisphosphonates have previously been shown to be effective in managing such cases in adults, however caution must be exercised in patients with renal failure or respiratory compromise. Denosumab, a RANKL monoclonal antibody is a very potent inhibitor of osteoclasts and can induce hypocalcaemia. It is not excreted by the kidney. Limited trials in adults have shown denosumab to have greater efficacy compa...

ea0045p9 | Bone | BSPED2016

The use of Bone Health Index standard deviation score (BHI-SDS) in the analysis of cohorts with constitutional delay of growth (CGP), Growth Hormone deficiency (GHD), Turners syndrome (TS) and congenital adrenal hyperplasia (CAH)

Park Julie , Alsaffar Hussain , Frerichs Carley , Parvatti Prashant , Dharmaraj Poonam , Das Urmi , Didi Mohamed , Ramakrishnan Renuka , Senniappan Senthil , Abernethy Laurence , Blair Jo

Background: BoneXpert software calculates bone health index (BHI) from 100 measurements of cortical thickness and mineralisation of three metacarpals. BHI-SDS is derived from 3,121 X-rays from 231 healthy Caucasian children, corrected for bone age (BA), estimated from the same x-ray.BHI-SDS is new with relatively unknown clinical utility. Strong correlations between BHI and dual-energy x-ray (DXA) absorptiometry and peripheral quantitative computed CT me...

ea0045p10 | Bone | BSPED2016

Chubby cheeks: could it be cherubism?

Farnan Sheila , Kumar Yadlapalli

Background: A 5 year old boy who had been born at 29 weeks gestation presented to the paediatrics clinic with abnormally chubby cheeks. Our patientÂ’s great-grandmother had had a similar appearance and his uncle had recently been diagnosed with giant cell granuloma of the jaw. After extensive imaging and genetic work-up, our patient was diagnosed with cherubism: a condition so named because of the resemblance to cherubic putti in Italian art.Cherubis...