Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 46 P24 | DOI: 10.1530/endoabs.46.P24

UKINETS2016 Poster Presentations (1) (35 abstracts)

Improving outcomes for patients with resectable small bowel NET tumours; 5 year experience from a tertiary centre

Khalil ElGendy 1, , Sarah Johnson 1, , Jeremy French 1, , Steven White 1, , Richard Charnley 1, , Derek Manas 1, & Colin Wilson 1,

1NET Service, Newcastle-upon-Tyne Hospitals Trust, Newcastle-upon-Tyne, UK; 2Hepato-pancreatico-biliary Surgery, The Freeman Hospital, Newcastle-upon-Tyne, UK; 3Histopathology service, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK

Introduction: There remains controversy about which patients benefit from removal of their primary small bowel tumour and whether this should be performed in a specialist tertiary referral hospital as an elective procedure. Part of the decision making and consenting process in patients with metastases will be a shared decision about surgery with the patient in light of symptoms, morbidity from surgery and survival. The aim of this study was to elucidate important institution specific data.

Methods: Retrospective cohort study. Patients were identified from the hospital pathology database having had their primary tumour resected between January 2011 and December 2015 and the specimen reviewed by our specialist NET pathology service. Indications for surgery were either symptomatic primary or attempted curative resection. Patients with encased main SMA or SMV were considered unresectable.

Results: 100 patients were included, of which 49 had small bowel surgery in the tertiary centre; of these 59% (n=29) had metastases (Stage IV) at the time of surgery. Overall mean survival was 182 months with 5 yr survival 87%. There was no postoperative mortality and 26% morbidity; 10.1% Clavien-Dindo ≥Grade3 within our institution. Median overall survival for patients with Stage IV disease having surgery was 156 months. Multivariate analysis of overall survival suggested age at presentation being the only significant factor (P=0.03) with liver metastasis (P=0.07) and surgery within the tertiary centre (P=0.09) not significant.

Conclusions: Small bowel NET surgery in our institution is safe and maybe preferable to surgery in a peripheral hospital. Current indications and acceptance criteria for small bowel surgery yield acceptable surgical morbidity.

Article tools

My recent searches

No recent searches.