Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology Endocrine Update 2017

Obesity Update

Poster Presentations

ea0048p1 | Poster Presentations | SFEEU2017

Weight loss and associated improvements in cardiometabolic risk factors with liraglutide 3.0 mg in the SCALE Obesity and Prediabetes randomised, double-blind, placebo-controlled 3-year trial

McGowan Barbara , Fujioka Ken , Greenway Frank , Krempf Michel , Le Roux Carel , Vettor Roberto , Lilleore Soren , Astrup Arne

Aims/objectives: Obesity and prediabetes are risk factors for developing T2D. 5–10% weight-loss can reduce risk of developing T2D by >50%. The 3-year part of this phase 3 trial investigated effects of liraglutide 3.0 mg, as adjunct to diet+exercise, in delaying onset of T2D over 3 years, body-weight and cardiometabolic risk factors in adults with obesity or overweight with comorbidities, and diagnosed with prediabetes at screening.Methods: Indiv...

ea0048p2 | Poster Presentations | SFEEU2017

Effect of increased endogenous glucose levels within Type 2 diabetes on cellular lipid profiles

Churm Rachel , Barry John , Caplin Scott , Davies Jeffrey , Stephens Jeffrey , Prior Sarah

Background & Aims: ATP binding cassette subfamily G1 (ABCG1) is involved in mediating cholesterol efflux and modulating cellular lipid homeostasis. It is influenced by endogenous glucose and our aim was to examine the relationship between ABCG1 expression and lipid profiles within the increased glucose levels of subjects with Type 2 diabetes (ODM).Methods: RNA was extracted from visceral fat collected from subjects undergoing abdominal surgery (baria...

ea0048p3 | Poster Presentations | SFEEU2017

Hyperinsulinemic hypoglycaemia after bariatric surgery: Is it commoner than anticipated?

Al-Sharefi Ahmed , Arutchelvam Vijayaraman

Introduction: With the increasing incidence of obesity worldwide, there is growing demand for bariatric surgery which carries its own risks. Post Bariatric hyperinsulinemic hypoglycaemia is rare but yet challenging condition to manage.Case Presentation: In this paper we are describing the case of a 54 years old female who presented with severe hypoglycaemia symptoms 10 months post her RYGB surgery. She underwent an oral glucose tolerance test through whi...

ea0048p4 | Poster Presentations | SFEEU2017

Night-blindness and neurological sequelae post bariatric surgery

Iftikhar Mawara , Waller Kathryn , Crane James , McGowan Barbara

Background: Bariatric surgery is considered the most effective tool to manage the growing pandemic of obesity related health disorders. Lack of regular surveillance following bariatric procedures can put patients at risk of developing serious micro-nutritional deficiencies and related complications.Case report: A 51-year-old lady presented to the bariatric services in 2015 with long standing neurological symptoms including memory and cognitive impairment...

ea0048p5 | Poster Presentations | SFEEU2017

Oral glucose tolerance test should be selectively performed to confirm reactive hypoglycaemia in post-bariatric surgery patients

Lim Jonathan ZM , Thomas Cecil

Background: Bariatric surgery has contributed to a large spectrum of presentations of hypoglycaemia. Dumping syndrome caused by food reaching the duodenum rapidly is associated with abdominal pain, bloating and diarrhoea as well as vasogenic symptoms of tachycardia and flushing. Hypoglycaemia may occur as a late sign of dumping 1–3 hours after a meal. In contrast, post-gastric bypass reactive hypoglycaemia is thought to result from discordance between blood glucose circul...

ea0048p6 | Poster Presentations | SFEEU2017

Review of process of care for bariatric surgery in a specialist weight management centre

Elkhenini Hanaa , Slater Chris , Ammori Basil , Akhtar Khurshid , Senapati Siba , Summers Lucinda , New John Syed Akheel , Ammori Basil , Summers Lucinda , Syed Akheel , New John

Background: Whilst bariatric surgery is cost effective in the management of severe or complex obesity, successful outcomes necessitate specialist multidisciplinary pre-operative and post-operative care. The report by the National Confidential Enquiry into Patient Outcome and Death (NCEPOD), Too Lean a Service? A review of the care of patients who underwent bariatric surgery (2012) made critical recommendations for the process of care.Aims: To as...

ea0048p7 | Poster Presentations | SFEEU2017

Setting a weight loss or clothes size goal following laparoscopic adjustable gastric banding: Does this impact on outcomes?

Hancock Jude , Jackson Sue , Johnson Andrew

Background: Setting a goal helps individuals achieve their long-term aims. A goal that challenges an individual, but at the same time is achievable, is likely to be attained. Candidates for laparoscopic adjustable gastric banding (LAGB) may have different long-term goals, which may include achieving a particular weight loss or clothes size.Methods: 39 individuals undergoing LAGB were prospectively monitored for 5 years. Participants were weighed, had a 1...

ea0048p8 | Poster Presentations | SFEEU2017

Perioperative nutritional status, supplementation and monitoring in patients referred for bariatric surgery: Closing the audit loop

Prankerd-Smith Olivia , Shotliff Matthew , Zalin Anjali , Morganstein Daniel , Shotliff Kevin , Edmiston Kelli , Davison Nuala , Ashrafian Hutan , Efthimiou Evangelos , Greener Veronica

Background: Nutritional deficiencies are frequently seen in bariatric patients, and typically become increasingly common and resistant following bariatric surgery. Local, national and international guidelines recommend routine blood tests and lifelong supplementation protocols after surgery. Local practice was initially audited for 2013. The purpose of this re-audit was to assess the impact of changes made in the department and to assess concordance with current recommendation...

ea0048p9 | Poster Presentations | SFEEU2017

Comparison of the impact of Roux-en-Y gastric bypass and sleeve gastrectomy on 2-year post-operative glycaemic outcomes in people with type 2 diabetes: the role of weight-loss

Pucci Andrea , Makaronidis Janine , Cheung Wui-Hang , Jenkinson Andrew , Adamo Marco , Elkalaawy Mohamed , Tymoszuk Urszula , Hashemi Majid , Finer Nicholas , Batterham Rachel

Background & aims: Data comparing the effect of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) on type-2 diabetes (T2D) outcomes and the relationship between weight-loss (WL) and T2D remission are limited. Thus, we undertook a retrospective study of patients with obesity and T2D who underwent RYGB or SG and examined the relationship between 2-year (2y) post-surgery T2D and WL outcomes.Material & methods: Patients who underwent RYGB (...

ea0048p10 | Poster Presentations | SFEEU2017

Change in body mass index (BMI) after highly active antiretroviral therapy among hiv patients in kano, Northwestern Nigeria

Muhammad Fakhraddeen , Ramalan Mansur , Enikuomehin Adenike

Background: Highly Active Antiretroviral Therapy (HAART) has improved the health and wellbeing of people living with HIV, but at the same time, it causes excessive weight gain through abnormal fat distribution (lipodystrophy). Overweight and obesity have implications on the cardiovascular status of these patients. We aimed to determine the change in BMI after the commencement of HAART and the factors associated with this change.Methodology: It was a long...

ea0048p11 | Poster Presentations | SFEEU2017

Reduction in the risk of developing type 2 diabetes (T2D) with liraglutide 3.0 mg in people with prediabetes from the SCALE Obesity and Prediabetes randomised, double-blind, placebo-controlled trial

McGowan Barbara , Roux Carel Le , Astrup Arne , Fujioka Ken , Greenway Frank , Lau David , Van Gaal Luc , Ortiz Rafael Violante , Wilding John , Skjoth Trine , Pi-Sunyer Xavier

Background: The 3-year part of this trial investigated the effect of liraglutide 3.0 mg, as an adjunct to diet+exercise, in delaying onset of T2D (primary endpoint) in adults with prediabetes and obesity (BMI ≥30 kg/m2) or overweight (≥27 kg/m2) with comorbidities.Methods: Participants were randomised 2:1 to once-daily subcutaneous liraglutide 3.0 mg or placebo plus 500 kcal/day deficit diet and 150...

ea0048p12 | Poster Presentations | SFEEU2017

Role of peri-operative psychiatric assessment and intervention in managing the obese patient presenting for bariatric surgery: A complex case of post-bariatric surgery addiction transfer

Mohamed Isra Ahmed , Waller Kathryn , McGowan Barbara

Objective: A case study that demonstrates the importance of thorough psychiatric assessment, intervention and follow-up in morbidly obese patients presenting for Bariatric surgery and risk of addiction transfer.Background: Positive correlation between psychiatric disorders and obesity is documented. Cases of addiction transfer have been reported complicating outcome post Bariatric Surgery.Case description: A 29 year old Caucasian f...

ea0048p13 | Poster Presentations | SFEEU2017

Insulin and glucose homeostasis 5 years after bariatric surgery

Min Thinzar , Barry Jonathan , Caplin Scott , Stephens Jeffrey

Background: Literature suggests that whole glucose excursion, rather than plasma glucose concentration at a point, provides more information about glucose tolerance. The glucose area under the curve (AUC) is an index of whole glucose excursion after glucose load. We sought to investigate changes in insulin and glucose homeostasis, including the glucose AUC, 5 years after bariatric surgery.Method: A non-randomised prospective study of 18 participants with...

ea0048p14 | Poster Presentations | SFEEU2017

Clinical outcomes of bariatric surgery in a specialist centre

Elkhenini Hanaa , Slater Chris , Ammori Basil , Ammori Basil , Akhtar Khurshid , Senapati Siba , Summers Lucinda , Summers Lucinda , New John , New John , Syed Akheel Syed Akheel

Background: Bariatric surgery is the most successful treatment for patients with severe and complex obesity.Aims: To assess clinical outcomes after bariatric surgery in a specialist centre.Setting: Specialist weight management service in a university teaching hospital.Methods: We performed an observational analysis of clinical outcomes for patients who underwent bariatric surgery during the period 31st</...