Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Calcium and Bone

Steroid metabolism + action

ea0049ep353 | Steroid metabolism + action | ECE2017

Genetic variations in the HSD11B1 gene in patients treated with glucocorticoids show associations with bone mineral density

Siggelkow Heide , Blaschke Martina , Armbrecht Gabriele , Thomasius Friederike , Bock Oliver , Tzvetkov Mladen , Gluer Claus-C , Felsenberg Dieter

Introduction: Physiological glucocorticoids play an essential role in bone formation but can cause osteoporosis if present in excess. The key enzyme converting inactive cortisone into the active cortisol and vice versa is 11-beta-hydroxy-steroid-dehydrogenase (11β-HSD1). We have reported that genetic variations in the HSD11B1 gene correlate with increased cortisol levels in dexamethasone suppression and with changes in bone mineral density (BMD) suggesting indivi...