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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Diabetes, Obesity and Metabolism

Cardiovascular Endocrinology and Lipid Metabolism

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Calcium & Vitamin D metabolism
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Clinical case reports - Pituitary/Adrenal

ea0049ep355 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Metabolic syndrome in digestive neoplasms

Mrabet Soumaya , Elleuch Nour , Hammami Aya , Jaziri Hanen , Slama Aida Ben , Braham Ahlem , Ajmi Salem , Ksiaa Mehdi , Jmaa Ali

Introduction: The metabolic syndrome (MS) is a real public health problem on a global scale. People with MS are at increased risk not only for cardiovascular diseases but also for neoplasia. The aim of our study is to determine the prevalence of MS in patients with digestive neoplasia and to study the impact of MS on the epidemiological, clinical profile and prognosis of digestive neoplasms.Material and methods: This is a retrospective study including pa...
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ea0049ep356 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Dyslipidemia-associated skin lesions as a short key for etiology unraveling and management of life-threatening acute pancreatitis in young male

Gluvić Zoran , Mitrović Bojan , Samardžić Vladimir , Jevtić Jelena Tica , Vujović Marina , Popović-Radinović Vesna , Stanojević Aleksandar , Isenović Esma R.

Background: After the gall bladder stones and alcohol abuse, dyslipidemia is among most frequent causes of acute pancreatitis, especially in youngsters. Some clinical signs can be useful to alleviate either a medical condition diagnosis confirmation or unraveling of its etiology.Aim: We present a case 30 years old male, presented with nausea, vomiting and diffuse abdominal pain. Three months before hospital admission, patient was unsuccessfully treated f...
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ea0049ep357 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Metformin and changes in blood pressure and heart rate in lean patients with polycystic ovary syndrome (PCOS)- preliminary study

Kialka Marta , Milewicz Tomasz , Klocek Marek , Tomczyk Rita

Introduction: The aim of our study was to assess the value of blood pressure and heart rate using the 24-h blood pressure monitoring (ABPM) before and after treatment with metformin to patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 20 patients received metformin 1500 mg/day in three divided doses. ABPM was performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.<p class="a...
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ea0049ep358 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Screening for type 2 diabetes mellitus as a method of secondary prevention of cardiovascular lesions

Prystupiuk Lev , Naumova Liudmyla , Prystupiuk Maksym , Onofriichuk Iuliia , Naumova Marianna

In patients with type 2 diabetes mellitus (T2DM), cardiovascular lesions are 3–4 times more often than in non-diabetics. Screening for T2DM in 1564 people from all Ukraine revealed that 12% had HbA1c at 6.1–6.4% and 16% had HbA1c above 6.5%. Those with HbA1c above 6.5% were examined for BMI, glycemia, total cholesterol, HDL-C, non-HDL-C. Dyslipidemia was defined as total cholesterol over 5.20 mmol/l, HDL-C – less than 1.02 mmol/l for males and less than 1.29 mmo...
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ea0049ep359 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Soybean phytoestrogens reduce 27-hydroxycholesterol concentration in the liver of middle-aged female rats

Šošić-Jurjević Branka , Janković Snežana , Lutjohann Dieter , Jarić Ivana , Miler Marko , Filipović Branko , Ajdžanović Vladimir , Milošević Verica

Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean phytoestrogens, isoflavones genistein (GEN) and daidzein (DAI), were reported to exert moderate cholesterol-lowering effect. In this research first we studied age-related modifications in hepatic cholesterol metabolism and serum est...
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ea0049ep360 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Awareness and prevalence of metabolic syndrome among high-risk individuals attending internal medicine clinics across Jordan

Efaishat Rania , Farha Rana Abu , Alefishat Eman

Purpose: To examine the prevalence and awareness of metabolic syndrome (MetS) in high-risk individuals attending 30 internal medicine clinics in Amman, Jordan, and also to evaluate the various factors associated with increased risk of MetS among them.Methods: This retrospective cross-sectional study was carried out across Amman, Jordan from October to December 2014. During the study period, 900 high-risk individuals (with hypertension, diabetes, central ...
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ea0049ep361 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Nine months of practice in California - self-referrals in endocrinology

Maletkovic Jelena

Objective: A great number of patients are self-referred to endocrinologist. Most of these patients had some research of their symptoms and have a specific diagnosis that they want to investigate.Methods: A retrospective chart review of 628 new consults conducted in one outpatient endocrine office at University of California, Los Angeles was conducted.Results: Of the 628 new patients 326 were referred by another physician and were e...
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ea0049ep362 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Identifiying underdiagnosed or undertreated patients with familial hypercholesterolemia from the central laboratory registries

Haymana Cem , Berlik Hamza , Gunes Yalcin , Tuncez Orhan Enes , Aytekin Cihat , Tapikara Zafer , Guzel Huseyin , Ozturk Ozlem , Barcin Cem , Ozgurtas Taner , Azal Omer , Sonmez Alper

Objective: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is globally underdiagnosed and undertreated. This study aimed to search for the demographical characteristics, awareness and treatment adherence of underdiagnosed or undertreated FH patients from the records of the central biochemistry laboratory.Methods: Patient...
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ea0049ep363 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The effect of admission hyperglycemia on clinical outcome of ischaemic stroke patients

Susanti Vina Yanti , Darwis Iswandi , Rahmayani Fidha

Background and objective: Hyperglycemia exacerbates multiple deleterious derangements and this process would influence the clinical outcome in diabetic patient. The objective of this study is to know the effect of admission hyperglycemia on clinical outcome of ischamic stroke patients admitted in Sardjito General Hospital.Method: Observational cohort study over 5 months’ period from August 1-2016 to December 31-2016 was done. All patients 18 years o...
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ea0049ep364 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Deleting genomic region of Hsd17b1 in mice results into a hypomorphic Naglu allele, and consequently to a phenotype mimicking a lysosomal storage disease

Jokela Heli , Hakkarainen Janne , Pakarinen Pirjo , Ruohonen Suvi , Zhang Fuping , Poutanen Matti

Hydroxysteroid 17-beta dehydrogenase 1 (HSD17B1) is an enzyme catalyzing the reduction of estrone (E1) to estradiol (E2), as well as androstenedione (Adione) to testosterone (T). To elucidate the physiological function of HSD17B1, we generated knockout mice with disrupted Hsd17b1 gene using targeted ES cells (clone 10231) obtained from KOMP repository (www.komp.org). In these ES cells the whole coding region of Hsd17b1 was replaced with LacZ/Neo cass...
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ea0049ep365 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Salivary lactate levels during anaerobic threshold (AT) training

Berea Hugo Ogando , Estevez Laura Toba , Gomez Juan Fandino , Chaves Yolanda Diz , Soidan Jose Luis Garcia , Matias Lucas Gonzalez , Ferrer Federico Mallo

Anaerobic threshold (AT) is defined as the point of maximum intensity at which lactate is being produced but does not accumulate in blood during exercise. Training at this intensity is common in athletes. Lactate is currently regard as indicator of effort intensity. It is usually quantified by reflectometry of capillary blood. This procedure although not very invasive, may be annoying during repeated measurements. Saliva is proposed as an alternative sample.<p class="abste...
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ea0049ep366 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The effect of tocilizumab – an interleukin-6 receptor antagonist – on lipid levels in rheumatoid arthritis

Kostoglou-Athanassiou Ifigenia , Athanassiou Lambros , Tzanavari Aikaterini , Katsavouni Charoula , Kostopoulos Markos , Pantelidis Dimitrios , Athanassiou Panagiotis

Tocilizumab is an interleukin-6 receptor antagonist used in the treatment of rheumatoid arthritis (RA). It is known to induce remission and inhibit radiographic progression in RA. Tocilizumab may be administered either intravenously or subcutaneously. Its effect on lipid levels and the cardiovascular risk has not been fully investigated. The aim was to study the effect of tocilizumab i.v. on disease activity, lipid levels and cardiovascular risk in RA patients.<p class="ab...
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ea0049ep367 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Homocystein-significant marker of metabolic syndrome and atherosclerosis risk

Sreckovic Branko , Dimitrijevic-Sreckovic Vesna , Soldatovic Ivan , Janeski Hristina , Janeski Nenad , Gacic Jasna , Sumarac-Dumanovic Mirjana , Mrdovic Igor

Background: Obesity is followed by insulin resistance (IR) and low grade inflammation. In patients with metabolic syndrome (MS) and clinicaly evident vascular complications homocystein values are higher. Hyperhomocysteinemia correlates with hyperinsulinemia and IR, resulting in oxidative stress, which causes endothelial lesions and dysfunction, promoting atherosclerosis and hypertension.Objectives: To examine homocystein levels in patients with and witho...
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ea0049ep368 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Graft vs host disease and insulin resistance after bone marrow transplantation

Athanassiou Panagiotis , Kostoglou-Athanassiou Ifigenia

Graft vs host disease is a disorder in which the graft, i.e. bone marrow, attacks the host after bone marrow transplantation. It has various manifestations, one being skin and muscle involvement with cutaneous sclerosis and diffuse muscle pain. The aim was to describe the case of a patient with graft vs host disease complicated by insulin resistance and metabolic syndrome, after bone marrow transplantation for the treatment of acute lymphoblastic leukemia.<p class="abstext...
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ea0049ep369 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Coronary artery calcium score in prediabetes – preliminary results

Petkovic Milica Marjanovic , Sasic Ivana , Vuksanovic Miljanka , Zivkovic Teodora Beljic

Introduction: Coronary artery calcium (CAC) is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. An association exists between CAC with coronary vascular disease (CVD), Agatston score being an independent predictor of CVD. Including CAC may improve CV risk prediction in addition to conventional risk factors. The AIM of our study was to assess CAC in subjects with prediabetes (preDM) at the beginning of the long term follow...
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ea0049ep370 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Cardiometabolic risk and female sexuality: focus on clitoral vascular resistance

Maseroli Elisa , Fanni Egidia , Cipriani Sarah , Scavello Irene , Pampaloni Francesca , Battaglia Cesare , Fambrini Massimiliano , Mannucci Edoardo , Jannini Emmanuele A , Maggi Mario , Vignozzi Linda

The relation between sexual and cardiovascular health in women is not well defined. Clitoral colour Doppler ultrasound (CDU) with assessment of the pulsatility index (PI), reflecting resistance to blood flow, has been proposed as an objective measurement of sexual functioning. We aimed to investigate the associations between clitoral PI and cardiometabolic risk factors. Seventy-one adult heterosexual women attending our clinic for sexual dysfunction were consecutively recruite...
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ea0049ep371 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Metformin and changes in serum lipid profile in lean patients with polycystic ovary syndrome (PCOS)

Kialka Marta , Milewicz Tomasz , Wajda Anna , Czekanska Patrycja , Zdzierak Barbara , Mrozinska Sandra

Introduction: The aim of our study was to assess the values of total cholesterol, HDL-C, LDL-C and triglycerides before and after treatment with metformin in patients with polycystic ovary syndrome (PCOS) and normal lean.Material and methods: 32 patients received metformin 1500 mg/day in three divided doses. Lipids measurements were performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.Res...
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ea0049ep372 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Prevalence of major cardiovascular risk factors among people living with HIV in a low risk country for cardiovascular disease

Mateos Carolina Garcia-Figueras , Cayon-Blanco Manuel

Introduction: It is well known that the prevalence of major cardiovascular risk factors has increased in HIV-infected people since improvement of antiretroviral therapy. Currently, Spain is defined as a ‘low risk country’ for cardiovascular diseases (CVD) by 2016 European Guidelines on cardiovascular disease prevention. The objective of this study is to assess the prevalence and characteristics of CVD risk factors and risk for CVD in a cohort of HIV-infected adults l...
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ea0049ep373 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The role of leptin signalling in the development of cardiovascular diseases in obesity

Simonds Stephanie , Cowley Michael

Cardiovascular diseases are the greatest cause of death globally. Obesity significantly increases the risk for the development of cardiovascular diseases. However research does not under stand the physiological and molecular connections of these diseases. We have identified that the hormone leptin in obesity plays a key role in elevating blood pressure in obesity. However recent findings in humans treated with leptin in the disease state of lipodystrophy, did not result in the...
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ea0049ep374 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Influence factors on lipid profile among patients with rheumatoid arthritis

Cayon-Blanco Manuel , Mateos Carolina Garcia-Figueras , Menor-Almagro Raul , Rios Mario H Cardiel

Introduction: Patients with rheumatoid arthritis (RA) face an increased risk of developing premature cardiovascular disease and limited ability to modify risk factors such exercise or dietetic habits. Influence of exercise, dietetic habits or treatment on lipid profile has been little studied in patients with RA. Here we aim to determine differences in lipid profile between two cohorts of patients with RA with different habits and patterns of treatment.M...
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ea0049ep375 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Abstract withdrawn....
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ea0049ep376 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Oxidative stress and metabolic profiles assessment after melatonin and irbesartan co-administration in a novel pharmaceutical formulation

Dragoi Cristina Manuela , Nicolae Alina Crenguta , Popa Daniela Elena , Dumitrescu Ion-Bogdan , Arsene Andreea Letitia , Grigore Corina , Dinu-Pirvu Cristina Elena

The concurrence of glucose intolerance, hypertension, dyslipidemia and obesity has been termed metabolic syndrome. Each component of the metabolic syndrome is an independent risk factor for cardiovascular disease and diabetes type 2, the combination of these risk factors elevating the rates and severity of cardiac pathology.The therapeutic use of irbesartan, a selective blocker of the AT1 receptors, administered in arterial hypertension, coronary heart d...
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ea0049ep377 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

The dual FXR/TGR5 agonist INT-767 counteracts nonalcoholic steatohepatitis and visceral adipose tissue dysfunction in a rabbit model of high fat diet-induced metabolic syndrome

Comeglio Paolo , Cellai Ilaria , Filippi Sandra , Morelli Annamaria , Sarchielli Erica , Adorini Luciano , Maggi Mario , Vignozzi Linda

The nuclear Farnesoid X receptor (FXR) and the G protein-coupled bile acid receptor 1 (TGR5) are bile acids receptors that play a key role in energy metabolism. In an animal model of non-genomic metabolic syndrome (MetS), obtained with a high fat diet (HFD), treatment with the dual FXR/TGR5 agonist INT767 reduced visceral adipose tissue (VAT) accumulation, insulin resistance, hypercholesterolemia and nonalcoholic steatohepatitis (NASH). In liver, INT767 reduced the high macrop...
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ea0049ep378 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Prevalence of metabolic syndrome and its relation to physical activity and nutrition in Azerbaijan

Mammadova Afruz , İşikhan Selen Yilmaz , Acikgoz Aylin , Yildiz Okan Bulent

Aim: Metabolic syndrome is a major public health challenge associated with an increased risk for cardiovascular disease and type 2 diabetes. The prevalence of metabolic syndrome in Azerbaijan is unknown. The purpose of this study was to examine the prevalence of metabolic syndrome and its relation to physical activity and nutrition in a representative sample of adult population in Azerbaijan.Methods: The study population consisted of 288 adults, 20 years...
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ea0049ep379 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Isolated low HDL-Cholesterol in patients with type 2 diabetes about 168 cases

Nawal El Ansari , Bahia Habra , Ghizlane El Mghari

Introduction: Lipid abnormalities in diabetics both quantitative and qualitative contribute to the increased cardiovascular risk.Aim: The aim of this study is to determine the prevalence of isolated hyoHDLémie in type 2 diabetics and assess cardiovascular risk in two populations of type 2 diabetes with and without Low HDL-Cholesterol isolated.Patients and methods: Prospective study started in diabetic patients seen in diab&#23...
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ea0049ep380 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Can hypoglycemic episodes in type 1 diabetics trigger cardiac arrhythmias?

Lainetti Kelly Regina , Pimenta Joao , Vendramini Marcio Faleiros , Cassiolato Jose Luiz B.

Type 1 diabetes mellitus (DM1) accounts for 5 to 10% of DM cases, and can occur both in childhood and adults. Studies show an association between severe hypoglycemia and increased vulnerability to cardiac arrhythmias due to conduction disorders, interval ST-segment changes, and even sudden death. The aim of this study is to evaluate the occurrence of cardiac arrhythmias during episodes of hypoglycemia. A prospective study with DM1 patients under insulin therapy for at least 5 ...
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ea0049ep381 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Family hypercholesterolemia: about 4 cases

Bouzid Aicha , Mineesk Djamila

Familial hypercholesterolemia (HF) is a rare hereditary dyslipidemia characterized by a major elevation of LDLc, cutaneo-tendinous xanthomas and atheromatous manifestations. This anomaly exposes a high vascular risk, more than 50% for men and 30% for women, occurring early.Observations: We report four cases of HF from the same family, three girls and one boy and whose parents are affected by hypercholesterolemia. The average age of patients is 11 years. ...
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ea0049ep382 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Description of an educational intervention lifestyle program in reducing cardiovascular risk factors

Oliveira Eduardo

Goals: The purpose of this article is to describe an educational program of lifestyle intervention rather successful, taught for 25 groups of customers of a private hospital in Amazon, for a total of 2,215 individuals between 2008 and 2014, 1448 being female and male 767 and briefly assess its results in relation to some of the main risk factors.Methods: The PVS - Programa Vida Saudável, promotes evaluations and individual and group counselling, con...
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ea0049ep383 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Role of lactate dehydrogenase-A (LDH-A) in atherosclerosis

Park Keun Gyu , Choi Yeon Kyung , Bae Kwi Hyun , Seo Jung Beom

Pathological proliferation and migration of vascular smooth muscle cells (VSMCs) has been implicated in the pathogenesis of accelerated atherosclerosis in patients with diabetes mellitus. Increased aerobic glycolysis is a key feature of cellular phenotypes including cancer and immune cells. However, it remains largely unknown about the role of aerobic glycolysis in atherogenic phenotype of VSMCs. Here, we investigated the role of lactate dehydrogenase-A (LDH-A), which is a key...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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