Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Diabetes, Obesity and Metabolism

Clinical case reports - Thyroid/Others

ea0049ep385 | Clinical case reports - Thyroid/Others | ECE2017

Insulin autoimmune syndrome (Hirata Disease) triggered by a tyrosine kinase inhibitor drug in a Latin American patient

Gil Susana Mallea , Ballarino Carolina , Polesel Daniel Lotero , Kleine Maria Teresa , Batagelj Emilio , Picon Nicolas

Hirata syndrome is a rare cause of spontaneous hypoglycaemia, more prevalent in Japanese population, very infrequent in Caucasian patients. It has been described that it can be triggered by medication with sulfhydryl compounds or α-lipoic acid. A 73-year-old male patient was sent to the Endocrinology Division in December 2015 because he had been presenting with episodes of sweating, palpitations and feeling hungry for 6 months; these symptoms improved when he ate carbohyd...

ea0049ep386 | Clinical case reports - Thyroid/Others | ECE2017

Fulminant diabetic ketoacidosis complicating nivolumab immunotherapy

Tzoulis Ploutarchos , Stebbing Justin , Baker Elly , Heaton Daniel , Corbett Richard

A 56-year-old woman, recently commenced on immunotherapy as second-line treatment for advanced non-small cell lung cancer, presented at the hospital critically unwell with severe diabetic ketoacidosis (DKA) (glucose 47 mmol/l, blood ketones 7.5 mmol/l, pH 6.95, bicarbonate 6.6 mmol/l). One week prior to presentation, she was clinically well with random glucose of 6.1 mmol/l. Following admission to Intensive Care Unit, she responded well to standard treatment for DKA and discha...

ea0049ep387 | Clinical case reports - Thyroid/Others | ECE2017

Dyslipidemia and antiretroviral therapy: a case report

Ghizlane El Meghari , Meryam Elbahi , Sana Rafii , Nawal El Ansari

Introduction: The use of highly active antiretroviral therapy in 1996 helped greatly reduce the morbidity and mortality in patients infected by HIV. Very quickly, secondary metabolic complications to this same treatment have been described. Dyslipidemia occupy a large part of these complications and give the patients an atherogenic profile favouring the occurrence of acute coronary events. We report a case that illustrates the lipid abnormalities associated with anti retrovira...

ea0049ep388 | Clinical case reports - Thyroid/Others | ECE2017

Diabetic patient with suppurative thyroiditis caused by Salmonella enterica complicated with acute kidney injury

Hernik Aleksandra , Szczepanek-Parulska Ewelina , Falkowski Bogusz , Komarowska Hanna , Wejman-Matela Anna , Drews Michal , Ruchala Marek

Incidence of acute thyroiditis is about 0.1% of thyroid gland conditions requiring surgical treatment. Main pathogen causing acute thyroiditis is Staphylococcus aureus while Salmonella enterica is extremely rare.Herewith we report a 61-year-old obese woman with sore throat and fever. She had chronic atrial fibrillation, hypertension, and well-controlled type 2 diabetes mellitus (HbA1C 5.5%) for 3 years (on metformin and gliclazide). Her...

ea0049ep389 | Clinical case reports - Thyroid/Others | ECE2017

Improved xanthomas after leptin replacement short therapy in congenital lipodystrophy patient

Oliveira-Filho Antonio F , Dantas Irla A , Velloso Renata N , de Oliveira Sofia N P , Candido Diego F F , Nunes Adriana

Berardinelli-Seip syndrome is an autosomal recessive disorder characterized by generalized lipoatrophy, extreme insulin resistance with dyslipidaemia in childhood and development of diabetes and hepatic steatosis in adolescence. The metabolic derangements can be severe and lead to substantial comorbidities, including acute pancreatitis, hepatic cirrhosis, and premature cardiovascular disease. Other manifestations can include polycystic ovarian syndrome, acanthosis nigricans, a...

ea0049ep390 | Clinical case reports - Thyroid/Others | ECE2017

Resistant hypertension in an obese type 2 diabetic male with obstructive sleep apnea: resolution with CPAP, weight loss and Dulaglutide

Arnas-Leon Claudia , Santana-Suarez Ana Delia , Rodriguez-Perez Alba , Nivelo-Rivadaneira Manuel , Kuzior Agnieszka , Quintana-Arroyo Sara , Acosta-Calero Carmen , Martinez-Martin Francisco Javier

A 49-year-old male was referred to our Hypertension Clinic with uncontrolled hypertension, treatment Valsartan/Amlodipine/Hydrochlorothiazide 80/10/25 mg + Doxazosine 4 mg. Mean home BP was 156/103 mmHg. Personal history: dyslipidaemia, central obesity and type 2 diabetes, with mild diabetic retinopathy, persistent microalbuminuria and preserved renal function. Treatment: Metformin/Sitagliptin 1000/50 mg BID; Pravastatin/Fenofibrate 40/160 mg. Height 172 cm, weight 112 kg, BMI...

ea0049ep391 | Clinical case reports - Thyroid/Others | ECE2017

Morgagni-Stewart-Morel Syndrome in a 61-years patient: case report

Stanciu Mihaela

Introduction: Morgagni-Stewart-Morel syndrome is a disorder defined by the presence of internal frontal hyperostosis, variably associated with metabolic disorders, endocrine and neuropsychiatric disorders. Hyperostosis frontalis interna (HFI) is a morphological change of the frontal bone like a single or multiple bilateral nodules on the inner lamina, characteristically sparing the diploë and the midline calvaria.Case presentation: We present a 61-y...

ea0049ep392 | Clinical case reports - Thyroid/Others | ECE2017

Continuous glucose monitoring in glycogen storage disease type Ia – a major improvement for patients

Martins Diana , Oliveira Diana , Baptista Carla , Paiva Sandra , Vicente Nuno , Cardoso Luis , Lages Adriana , Ventura Mara , Cunha Nelson , Moreira Sonia , Clemente Hugo , Esperto Helder , Carrilho Francisco

Introduction: Glycogen storage disease (GSD) type Ia (von Gierke’s disease) is an inherited metabolic disorder of glycogen metabolism, caused by defects in the glucose-6-phosphatase complex, with associated risk of severe hypoglycemia within 3–4 h after a meal.The aim of the present study was to evaluate the efficacy of continuous glucose monitoring (CGM) system in determining the magnitude of hypoglycemia in patients with GSD type Ia.<p cl...

ea0049ep393 | Clinical case reports - Thyroid/Others | ECE2017

Diabetes mellitus: one train may hide another

Vandewalle Sara , Van Doninck Nike , Coremans Peter

A 26-year-old Chinese male with autism spectrum disorder and mental retardation, was referred to start insulin therapy for uncontrolled diabetes mellitus (DM) (HbA1c: 9%; C-peptide: 1.75 ng/ml; anti-GAD AB: negative) treated with oral antidiabetic drugs since 2012.Clinical examination revealed a tall man with overweight and truncal obesity in light of his ethnicity. We withheld facial dysmorphism with hypertelorism, scarce facial hair, and clinodactyly. ...

ea0049ep394 | Clinical case reports - Thyroid/Others | ECE2017

Endocrine manifestations of Woodhouse-Sakati Syndrome – a Portuguese case

Oliveira Diana , Paiva Sandra , Louro Pedro , Macario M Carmo , Duraes Joao , Martins Diana , Ventura Mara , Lages Adriana , Cunha Nelson , Carrilho Francisco

Introduction: Woodhouse-Sakati Syndrome (WSS) is a very rare autossomic recessive disorder caused by mutations in DCAF17 gene that primarily affects the endocrine and the nervous systems. It is associated with hypogonadism, diabetes mellitus, hypothyroidism, sensorineural hearing loss, alopecia and extrapyramidal findings. Treatment is symptomatic and managed by multidisciplinary teams. Less than 80 cases are reported to date.Case repor...

ea0049ep395 | Clinical case reports - Thyroid/Others | ECE2017

Hypoglycaemia due to hydroxychloroquine in a patient who underwent Roux-en-Y gastric bypass surgery

Mohammed Kamrudeen , Abdalaziz Altayeb

A 45-year-old female presented with recurrent episodes of neuroglycopaenic symptoms 6 years after Roux-en-Y gastric bypass surgery. Her symptoms occurred during both the fasting and postprandial state. She had a history of Rheumatoid Arthritis. Her symptoms did not response to a complex carbohydrate diet or Acarbose use.Whipple’s triad was demonstrated during a 72 h fast; symptomatic hypoglycaemia (1.8 mmol/l) occurred which resolved with glucose ad...

ea0049ep396 | Clinical case reports - Thyroid/Others | ECE2017

A case report of insulin autoimmune syndrome in a Caucasian

Jendrzejewski Jaroslaw , Obolonczyk Lukasz , Leczycka Martina , Sworczak Krzysztof

The Insulin Autoimmune Syndrome (IAS) also called Hirata’s disease consists of hypoglycemia, high insulin concentration and presence of anti-insulin antibodies. IAS is the third leading cause of spontaneous hypoglycemia among Japanese population. The syndrome is exceptionally rare among Caucasians, with <50 cases described in literature.In this report we showcase a 67 year-old female patient. She presented with paroxysmal sweating, daily fatigue...

ea0049ep397 | Clinical case reports - Thyroid/Others | ECE2017

Acquired generalized lipodystrophy associated with latent autoimmune diabetes mellitus in adults: a new metabolic phenotype

Ferrari Federica , Maranghi Marianna , Ceccarini Giovanni , Magno Silvia , Pelosini Caterina , Maffei Margherita , Vitti Paolo , Arca Marcello , Santini Feruccio

Introduction: Acquired generalized lipodystrophies (AGL) are rare syndromes characterized by complete loss of subcutaneous adipose tissue and very low serum leptin levels. AGL are complicated by severe insulin resistance, diabetes mellitus, dyslipidemia and fatty liver. In most patients evidence exists of an autoimmune etiology.Case report: We herein describe the case of a Caucasian woman who was diagnosed with lipodistrophy at 5 years of age, when she b...

ea0049ep398 | Clinical case reports - Thyroid/Others | ECE2017

Humalog Mix50® massive overdose for suicidal purpose: a case report

Cosma Daniel-Tudor , Silaghi Cristina Alina , Silaghi Horatiu , Mocan Mihaela , Veresiu Ioan Andrei

Intentional insulin overdose in diabetic patients is a rare critical situation. The severity is due to numerous neurological complications, electrolyte disturbances, liver and lung damage or death.A 76-years old female, with significant cardiac pathology, diagnosed with type 2 diabetes and treated with Humalog Mix50® 0-0-24 U/day, is admitted to our center via ER (emergency room) after an episode of severe hypoglycemia after administratio...

ea0049ep399 | Clinical case reports - Thyroid/Others | ECE2017

Extensive venous thrombosis of the upper extremity in a newly diagnosed type 2 diabetic female

Cosma Daniel-Tudor , Silaghi Cristina Alina , Bontea Vlad Florin , Homorodean Calin , Silaghi Horatiu , Veresiu Ioan Andrei

Upper extremity deep vein thrombosis (UEDVT) is not infrequent and accounts for approximately 14% of deep vein thrombosis. The risk of pulmonary embolism is lower than in lower extremity DVT and prompt diagnosis is essential to select those patients who deserve anticoagulant treatment. Previous studies indicated that type 2 diabetes (DM) patients carried greater risk of DVT development or recurrence than the general population.A 49-years old female, with...

ea0049ep400 | Clinical case reports - Thyroid/Others | ECE2017

Early association of three autoimmune disorders in a young male with polyglandular autoimmune syndrome type IIIA

Cosma Daniel-Tudor , Silaghi Cristina Alina , Mocan Mihaela , Silaghi Horatiu , Veresiu Ioan Andrei

Polyglandular autoimmune syndromes (PAS) are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. In PAS III, autoimmune thyroiditis occurs with another organ-specific autoimmune disease, but the syndrome cannot be classified as PAS I or II.A 29-years old man was refer to our center for diagnostic confirmation with the following complaint...