Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep738 | Endocrine Disruptors | ECE2017

Endocrine disrupting chemicals exacerbate type 1 diabetes mellitus model

Ahn Changhwan , An Jin Yong , Tran Dinh Nam , Park Seon Young , Jeung Eui-Bae

It has been proposed that cellular Ca2+ signals activate hormone secretion. In pancreatic β cells, which produce insulin, Ca2+ signals have been known to contribute to insulin secretion. In previous study, demonstrated that endocrine disrupting chemicals (EDCs) such as bisphenol A (BPA) and Octylphenol (OP) could cause increase in insulin level and insulin transcription factors. But in regulations of plasma glucose level were not decreased as much as...

ea0049ep739 | Endocrine Disruptors | ECE2017

Stimulating effect of 17β-estradiol and TCDD and on the protein expression of cytochrome P450 1A1 gene in cellular and xenografted models of breast cancer

Go Ryeo-Eun , Hwang Kyung-A , Choi Kyung-Chul

Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. Especially, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known as an agonist of AhR. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and ...

ea0049ep740 | Endocrine Disruptors | ECE2017

Abstract withdrawn....

ea0049ep741 | Endocrine Disruptors | ECE2017

24 hrs chronomics of BP/HR in terms of double amplitude, acrophase, hyperbaric index and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift nursing professionals: A Case-control study

Anjum B , Verma Narsingh , Tiwari Sandeep , Singh Ranjana , Mahdi Abbas

The present study was aimed to investigate the 24 hours chronomics of BP/HR in terms of Double amplitude, Acrophase and Hyperbaric index and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift nurses and actual day workers. 56 night shift nurses, aged 20–40 years, performing day and night shift duties were recruited from the Trauma Center, KGMU, India, and 56 age sex matched actual day workers were also enrolled as controls. BP and HR were recorded ...

ea0049ep742 | Endocrine Disruptors | ECE2017

The effects of halogenated-hydrocarbon uron herbicides, as endocrine disruptor compounds on the oxytocin (OT) hormone regulation in vitro

Sepp Krisztian , Valkusz Zsuzsanna , Molnar Zsolt , Laszlo Anna , Alapi Tunde , Radacs Marianna , Galfi Marta

The biological organisms are complex systems regulated by the homeostatic back-end network. In these days the growing environmental loads (from industry, household, etc.) contain chemical exposure eg. halogenated hydrocarbons (monuron: MU (C9H11ClN2O), diuron: DU (C9H10Cl2N2O)), which can be endocrine disruptor compounds (EDCs). Synthesis, release of hormones and cell processes of endocrine cells, and...

ea0049ep743 | Endocrine Disruptors | ECE2017

The protective role of Zingiber officinale extract against methyl thiophanate induced toxicity in male rats

Mosbah Rachid , Bahri Malika , Azzoug Said , Djerrou Zouhir , Mantovani Alberto

In this study, we attempted to assess the toxicity of Methyl Thiophanate (MT) on the biochemical and reproductive parameters in male Wistar rats as well as the possible protective role of Zingiber officinale (Ginger, Ging) extract against MT-induced toxicity. Hence, forty adult Wistar rats were allocated into four groups of 10 rats for each; the first group served as control, groups 2, 3 and 4 were treated orally (5/week) for 8 weeks by MT (150 mg/kg bw), Ging (100 mg...

ea0049ep744 | Endocrine Disruptors | ECE2017

Systematic screening for environmental and behavioral determinants identifies factors detrimental to skeletal health

Oei Ling , Wu Joy , Oei Edwin , Rivadeneira Fernando , Uitterlinden Andre , Ioannidis John , Snyder Michael , Patel Chirag

Background: An increasing amount of biomedical data is becoming available, and methods are needed to tackle these “big data”.Methods: We performed a systematic evaluation of 138 environmental and behavioral factors in relation to bone mineral density (BMD) in the National Health and Nutrition Examination Survey (NHANES). Dual energy X-ray absorptiometry (DXA) scans were available for total body, head, pelvis and lumbar spine for 27,259 particip...

ea0049ep745 | Endocrine Disruptors | ECE2017

Quantitative image based analysis of endocrine disruptor effects on mitochondria morphology-function in prostate cancer cells

Charazac Aurelie , Deconde Le Butor Celia , Gueye Mamadou , Gilleron Jerome , Giulietti Kevin , Fenichel Patrick , Descombes Xavier , Bost Frederic , Clavel Stephan , Chevalier Nicolas

Persistent organic pollutants (POPs) are environmental contaminants that interfere with normal hormonal homeostasis and act as endocrine disrupting compounds (EDC). These molecules can mimic hormone effects on metabolism. The links between metabolism and cancer are now well established. Metabolism generates reactive oxygen species (ROS), which contribute to mutations and induces oncogenic transformation. In turn, cancer cells display high metabolic flexibility allowing them to...