Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Interdisciplinary Endocrinology

Cardiovascular Endocrinology and Lipid Metabolism

ea0049ep753 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Resveratrol increases hepatic SHBG expression through human constitutive androstane receptor: a new Contribution to the French Paradox

Saez-Lopez Cristina , Brianso-Llort Laura , Torres-Torrenteras Javier , Simo Rafael , Hammond Geoffrey , Selva David

Sex hormone-binding globulin (SHBG) carries sex steroids in blood regulating their bioavailability. Red wine consumption increases plasma SHBG levels, and we have discovered that resveratrol, a polyphenol enriched in red wine, acts specifically through the human constitutive androstane receptor (CAR), a drug/xenobiotic detoxification gene regulator, to increase hepatic SHBG production. Chromatin immunoprecipitation and luciferase reporter gene assays show that human CAR binds ...

ea0049ep754 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Therapeutic potentials of small molecular weight allosteric agonist of relaxin receptor

Agoulnik Alexander , Agoulnik Irina , Hu Xin , Kaftanovskaya Elena , Huang Zaohua , Myhr Courtney , Xiao Jingbo , Soula Mariluz , Ho Brian , Barnaeva Elena , Southall Noel , Ferrer Marc , Marugan Juan

The anti-fibrotic, vasodilatory, and angiogenic therapeutic properties of relaxin peptide have been shown in several animal models of human diseases and in clinical trials. Using high-throughput screening of small molecule library, structure-activity relationship (SAR) studies, ligand-receptor interaction modeling, site-specific mutagenesis, and transgenic animal studies we discovered the first series of small molecule agonists of relaxin GPCR, RXFP1. The lead compound ML290 i...

ea0049ep755 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

PCSK9 inhibitors effects on lipid profile in familial hypercholesterolemia in a specific Lipid Unit: experience in first year commercialization

Gonzalez-Molero Inmaculada , Doulatram Viyu , Marin Monserrat Gonzalo , Abuin Jose , Morillas Virginia , Olveira Gabriel , Tinahones Francisco

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

ea0049ep756 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Non-lipidic effects of PCSK9 inhibitors in real life

Gonzalez-Molero Inmaculada , Doulatram Viyu , Dominguez Marta , Torralvo Francisco Sanchez , Garcia Ignacio Ruiz , Olveira Gabriel , Tinahones Francisco

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

ea0049ep757 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Renal function preservation with Manidipine vs Amlodipine in type 2 diabetic hypertensive patients with persistent microalbuminuria

Quintana-Arroyo Sara , Arnas-Leon Claudia , Santana-Suarez Ana Delia , Nivelo-Rivadeneira Manuel , Kuzior Agnieszka , Acosta-Calero Carmen , Saiz-Satjes Margarita , Martinez-Martin Francisco Javier

Objectives: The AMANDHA randomized study (PROBE design) showed that the addition of Manidipine 20 mg vs Amlodipine 10 mg for 2 years in 91 hypertensive type 2 diabetic patients with persistent microalbuminuria, uncontrolled with a renin-angiotensin system inhibitor (given full-dose for at least the 6 previous months) was more effective in reducing albuminuria in spite of similar blood pressure control. Patients with significant renal impairment (PlCr >1.4 mg/dl in women an...

ea0049ep758 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Effects of calcineurin inhibitors on abdominal obesity in kidney transplant recipients

Sayilar Emel Isiktas , Ersoy Alparslan , Ersoy Canan

Calcineurin inhibitors (CNI, cyclosporine A: CsA and tacrolimus: Tac) cause posttransplant diabetes mellitus, hypercholesterolemia and hypertension. Post-transplant weight gain can be related to the type of CNIs. Distribution of obesity is one of the major predictors of cardiovascular diseases. Several indices assessed upper body obesity such as waist circumference (WC) and waist to hip ratio (WHR) are more accurate than whole body obesity (body mass index: BMI). This study ai...

ea0049ep759 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Anthropometric measurements, nutrition and exercise habits in kidney transplant recipients

Ersoy Alparslan , Koca Nizameddin , Koca Tuba Gullu , Ersoy Canan

After a successful kidney transplant, the nutrition of patients is improved and they gain weight. Increased appetite due to medication, age of transplant, gender, race, pre-transplant obesity story and dialysis type increase the obesity frequency. We aimed to evaluate the effect of gender on nutrition and exercise habits on transplant recipients.Methods: Stable patients were divided into two groups according to gender: 29 males and 33 females. Their nutr...

ea0049ep760 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Hyperglycemia as a factor changing the level of the patient’s rehabilitation after ischemic stroke

Dzherieva Irina , Volkova Natalia , Maslova Natalia , Krivonosov Nikolay

The aim of the study was to defined the level of rehabilitation after the stroke depending on the type of hyperglycemia.Materials and methods: The retrospective analysis of 122 (54 female and 68 men) cases of ischemic stroke (IS) has been done. The diagnosis of IS was confirmed by computer tomography. According to the level of hyperglycemia at the debut of IS the patients were divided into three groups. Group 1 (60 patients) – with normoglycemia, gr...

ea0049ep761 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

An investigation into role of circulating concentrations of vitamin D and calcium in the development of hypertension and related cardiovascular diseases

Nazir Saba , Afzal Nadia , Akram Maleeha , Iqbal Zubaria , Raza Abida , Qayyum Mazhar , Naseem Afzaal Ahmed , Kazmi Syed Ali Raza , Tahir Faheem , Afshan Kiran , Jahan Sarwat , Rizvi Syed Shakeel Raza

Vitamin D plays a key role in the control of cardiovascular diseases (CVDs), acting as negative regulator of renin-angiotensin-aldosterone-system (RAAS), whereas calcium directly affects central blood pressure (BP) control center, nucleus tractus solitarus. We investigated associations between plasma concentrations of vitamin D and calcium and BP in 100 hypertensive CVDs patients and 100 normotensive subjects of 21–60 years. Vitamin D concentrations were measured using EC...