Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Interdisciplinary Endocrinology

Nuclear receptors and Signal transduction

ea0049ep801 | Nuclear receptors and Signal transduction | ECE2017

18β-glycyrrhetinic acid reduces VLDL secretion as a modulator for HNF4α

Liu Qingli , Yang Meng , Zhang Minyi , Guan Min

Glycyrrhizin (GL) is a major bioactive triterpene glycoside of licorice root, a traditional Chinese herbal medicine. GL and primary metabolite 18β-glycyrrhetinic acid (GA) have been developed as anti-inflammatory and antiviral drugs for liver diseases in China and Japan. Hepatic VLDL secretory pathway is not only responsible for lipid homeostasis but also associated with viral particles assembly and secretion. Hepatocyte nuclear factor 4α (HNF4α) together with i...

ea0049ep802 | Nuclear receptors and Signal transduction | ECE2017

5α-THB as a novel anti-inflammatory drug: The roles of the glucocorticoid and mineralocorticoid receptors

Abernethie Amber , Gastaldello A , Morgan RA , Mitchell C , McInnes KJ , Beck K , Odermatt A , Houtman R , Melchars D , Meijer OC , Hadoke PWF , Livingstone DEW , Walker BR , Andrew R

Glucocorticoids (GC) are potent anti-inflammatory compounds, acting mainly through the glucocorticoid receptor (GR). GC therapy, however, has debilitating side-effects, necessitating safer new alternative therapies. The natural GC metabolite 5α-Tetrahydrocorticosterone (5αTHB) is anti-inflammatory in vivo in mice, but with fewer side-effects. Its mechanism of action is unknown, and here we test signalling via GR and the mineralocorticoid receptor (MR). 5&#94...

ea0049ep803 | Nuclear receptors and Signal transduction | ECE2017

Development of novel human stable reporter cell line for the assessment of PPARγ transcriptional activity

Illes Peter , Grycova Aneta , Prichystalova Hana

Endocrine disrupting chemicals (EDCs) are exogenous compounds that affect the endocrine system, disrupt the hormonal balance and consequently cause the adverse health effects in humans. These compounds persist and accumulate in the environment and can easily gain entry to the food chain. Peroxisome proliferator-activated receptor gamma (PPARγ) and its heterodimeric partner retinoid X receptor alpha (RXRα) are very often targets of EDCs. PPARγ play crucial role i...

ea0049ep804 | Nuclear receptors and Signal transduction | ECE2017

Functional characterization of inherited S127F substitution in V2 vasopressin receptor revealed a loss-of-function mutation leading to nephrogenic diabetes insipidus

Erdelyi Laszlo , Balla Andras , Hunyady Laszlo

The V2 vasopressin receptor (V2-R) mediates the effect of vasopressin on the water reabsorption in the kidney and several mutations in the V2-R have been identified causing nephrogenic diabetes insipidus (NDI). In this study, we investigated a previously not characterized mutation of the. We obtained genomic DNA of a young male patient with NDI, the AVPR2 gene was amplified with PCR and a missense mutation (S127F) was identified. We monitored the cellular localization of the S...

ea0049ep805 | Nuclear receptors and Signal transduction | ECE2017

Effects of human interleukins on transcriptional activity of vitamin D receptor in transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24

Bartonkova Iveta , Grycova Aneta , Dvorak Zdenek

Vitamin D receptor (VDR) signalling can be affected with a variety of compounds, both endo- or exogenous. However, any disruption of VDR transcriptional activity can exert severe physiological or pathophysiological outcomes. It is therefore of a great importance to have a reliable in vitro screening technique that would provide a tool for efficient identification of agonists and activators of human VDR. In the current work, we described two novel human reporter cell l...

ea0049ep806 | Nuclear receptors and Signal transduction | ECE2017

3-Iodothyronamine induces transient receptor potential melastatin 8 (TRPM8) channel activation in human corneal endothelial cells and human corneal keratocytes

Ljubojevic Nina , Khajavi Noushafarin , Lohse Katharina , Valtink Monika , Mergler Stefan

3-Iodothyronamine (3-T1AM) is an endogenous metabolite of thyroid hormone (TH) for which was shown to have various effects. One of the effects is body temperature decline, which may be related with menthol receptor TRPM8. Normally, this ion channel is expressed in neuronal tissue, where it has a nociceptive role. Functional TRPM8 expression has also been shown in non-neuronal cells of the eye such as corneal and conjunctival epithelial cells, corneal endothelial cel...

ea0049ep807 | Nuclear receptors and Signal transduction | ECE2017

Cytotoxic activity of plant extracts from Brazilian biome in prostate cancer cell lines

Cardoso Sarah , Andrade Matheus , Cunha Vinicius , Silva Cristian , Rodrigues Patricia , Leao Mayra , Fagg Christopher , Guerra Eliete , Neves Francisco , Simeoni Luiz , Silveira Damaris , Lofrano-Porto Adriana

Introduction: Prostate cancer is a public health problem worldwide. The cure is unlikely and therapeutic alternatives are limited. The Brazilian biodiversity represents a huge source of potential discovery of new drugs derived from plants. We therefore aimed to conduct a biomonitoring chemical study of plant extracts from Pouteria sp. previously shown to be cytotoxic in androgen-sensitive (LNCaP) and androgen-resistant (PC3) human prostate cancer cell lines.<p cla...