Endocrine Abstracts

Background: Skeletal muscle is known to be a target of THs, regulating oxygen consumption, fiber composition, calcium mobilization and glucose uptake. However, a possible role for THs in muscle homeostasis and cellular metabolism under pathological has never been investigated. Food deprivation induces skeletal muscle atrophy, causing metabolic changes, and forcing the tissue to utilize fatty acid as the main oxidation substrate. Aim of this project was to understand whether T3...

Introduction: The phenomenon of false memory is quite prevalent among people with cognitive impairment. Cognitive dysfunction and its relationship with the thyroid gland has been described. In contrast, little is known about the phenomenon of false memory in patients with thyroid diseases. That is why we want to introduce our preliminary observation.Method: Patients aged 64 to 90 years (average 77) with endocrine disorders were subjected to tests for typ...

Background: TAO is a rare disease, seriously involving 5% of patients with autoimmune thyroid disease. The clinical presentation may be difficult to distinguish from other orbital conditions.Case 1: A 63-year-old woman was admitted to the Neurology Service for worsening diplopia over the previous six months, with a working diagnosis of myasthenia gravis or multiple sclerosis. The Endocrine Service was consulted because of a long history of Hashimoto&#146...

Introduction: Although Graves’ orbitopathy (GO) is common in the course of Graves’ disease, dysthyroid optic neuropathy and corneal breakdown are rare. We describe two cases of severe GO treated successfully with rituximab.Case 1: A 50-year-old female smoker with Graves’disease, presented with disfiguring eyelid edema, exophthalmos and diplopia, preserved visual acuity and clinical activity score (CAS) ≥ 5. She received pulsed medrox...

Introduction: Anti-TSH receptors (TRAb) are an important marker in the differential diagnosis of the etiologies of hyperthyroidism. They detect serum TSH receptor immunoglobulins that interact with the TSH receptor without the functional discrimination of stimulating from blocking antibodies. A new assay has recently been released, that utilizes recombinant human TSH receptors (hTSHR) for the specific detection and quantification of thyroid stimulating autoantibodies (TSI).</p...