Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Pituitary and Neuroendocrinology

Clinical case reports - Pituitary/Adrenal

ea0049ep832 | Clinical case reports - Pituitary/Adrenal | ECE2017

Coexistence of TSH-secreting pituitary adenoma, primary hyperparathyroidism and vitamin D deficiency

Oueslati Ibtissem , Mchirgui Nadia , Khiari Karima , Abdallah Nejib Ben

Introduction: The simultaneous occurrence of central hyperthyroidism and primary hyperparathyroidism is extremely rare. Few cases of TSH pituitary adenoma in the setting of multiple endocrine neoplasia type 1-associated syndrome were reported in literature. Herein, we report a new case of TSH secreting pituitary adenoma particular by the coexisting of primary hyperparathyroidism and vitamin D deficiency.Observation: A 76-year-old woman was referred to ou...

ea0049ep833 | Clinical case reports - Pituitary/Adrenal | ECE2017

Central diabetes insipidus in children: about eight cases

Lassoued Najoua , Ouannes Selmene , Jguirim Afef , Sfar Mohamed Taher

Introduction: Central diabetes insipidus (CDI) is a rare but potentially dangerous dysregulation of the water balance secondary to an arginine vasopressin (AVP) deficiency. Diabetes insipidus may have different manifestations in children compared to adults. CDI is more common in children than nephrogenic diabetes insipidus.Methods: A retrospective study of eight patients collected in the pediatric department of Mahdia.Results: The ...

ea0049ep834 | Clinical case reports - Pituitary/Adrenal | ECE2017

A hpothyroid case with pituitary hyperplasia mimicking TSHoma

Dokmetas H Sebile , Kinikoglu Oguzcan , Altintas Y Emre , Atmaca Murat , Kilicli Fatih

A 36-year-old female patient was referred to endocrinology outpatient clinic due to increased TSH levels. Two years ago, she had been diagnosed and treated as Graves’ disease with propylthiouracil. Total thyroidectomy was performed in another center due to ineffective medical treatment and oral levothyroxine sodium (LT4) was started. During the follow-up her TSH levels were normal. Thirteen months after the last normal TSH value, she consulted the endocrinology outpatient...

ea0049ep835 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pachydermoperiostitis associated with non secrettory pituitary macroadenoma in patient with toxic multinodular goitre

Gen Ramazan

Pseudoacromegaly is associated with acromegalic phenotype but normal insulin like growth factor-1 (IGF-1) levels and suppressed growth hormone levels. The reasons of this condition may be pachydermoperiostitis insulin resistance, drug intake such as minoxidil and hypothyroidism (4). We describe pachydermoperiostitis in a patient with hyperthyroidism and non-secretory pituitary macroadenomas.Clinical case: A 62 year old man presented with palpitation, swe...

ea0049ep836 | Clinical case reports - Pituitary/Adrenal | ECE2017

Successful management of macroprolactinoma with aromatase inhibitor in a patient with hypogonadotropic hypogonadism

Ozturk Feyza Yener , Sen Esra Cil , Erol R Selvinaz , Cakir Sezin Dogan , Basmaz Seda Erem , Saygili Emre Sedar , Batman Adnan , Altuntas Yuksel

Introduction: Hypogonadism persisting in man with macroprolactinoma requires exogenous testosterone replacement therapy (TRT). But TRT may cause secondary elevations of prolactin. We report here a case of macroprolactinoma and hypogonadotropic hypogonadism with persistently high prolactin level after initiating TRT.Case report: A 28 year-old male was admitted to outpatient clinic with complaints of headache, low libido and blurred vision on left eye for ...

ea0049ep837 | Clinical case reports - Pituitary/Adrenal | ECE2017

Multifocal multisystem langerhans cell histiocytosis – a rare cause of panhypopituitarism and diabetes insipidus – a case report

Gabalec Filip , Simkovic Martin , Kasparova Petra , Zak Pavel , Cap Jan

Introduction: Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the evaluation and the treatment of LCH.Case: 39 years old woman has had amenorrhea for 2 years and higher intake of fluids (5–7 l/day) for 6 years. Non-functioning pitu...

ea0049ep838 | Clinical case reports - Pituitary/Adrenal | ECE2017

A rare association of autoimmune diabetes insipidus and hypophysitis with partial pituitary insufficiency

Matei Livia , Stefaroi Corina , Mogos Simona , Branisteanu Dumitru

We present the case of a 40 year old man presenting at first consultation an ‘idiopathic’ fast-onset and severe polyuro-polydipsic syndrome (diuresis of 10 l/24 hours, with urine osmolality of less than 50 mOsm/kg and urine gravity lower than 1001). Clinical examination showed pallor and decreased pilosity at an asthenic patient with limited lesions of vitiligo and loss of libido. Water deprivation test showed the persistence of excretion of highly diluted amounts of...

ea0049ep839 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pituitary apoplexy while treating recurrence of Cushing’s disease with Pasireotide

Zilaitiene Birute , Kondrotiene Aiste , Verkauskiene Rasa , Barsiene Lina , Knispelis Robertas , Sarauskas Valdas , Colao Annamaria

Introduction: ACTH producing macroadenoma and pituitary apoplexy are rare in Cushing’s disease. Somatostatin receptor agonist Pasireotide is indicated for the treatment of patients with Cushing’s disease for whom surgery is not an option or has failed. We present a case of pituitary apoplexy in patient with recurrence of Cushing’s disease treated with Pasireotide.Case: 38 years old female presented with quick weight gain, weakness, irregul...

ea0049ep840 | Clinical case reports - Pituitary/Adrenal | ECE2017

Hemodialysis patient with metastatic renal cell carcinoma to the pituitary stalk presenting as hypopituitarism: an autopsy case

Sugano Hisashi , Ino Riku , Dehara Yuko , Tuchiyama Yoshinori

Introduction: Pituitary metastases occur in 1% to 4% of cancer patients in autopsy studies. The most frequent primary tumors are breast and lung tumors. Renal cell carcinoma (RCC) is a rare cause of pituitary metastases, with only 25 previously reported cases.Case report: A 77-year-old-man was admitted to our hospital because of acute progression of chronic renal failure presenting with appetite and weight loss in August 2014. He underwent hemodialysis. ...

ea0049ep841 | Clinical case reports - Pituitary/Adrenal | ECE2017

Effect of the addition of lanreotide autogel to the treatment of an aggressive prolactinoma – a case report

Vilar Lucio , Vilar Clarice , Albuquerque Jose Luciano , Gadelha Patricia , The Ana Carolina , Trovao Erik , Cardoso Izabela , Cardoso Thaise , Lyra Ruy

Case report: A giant prolactinoma (size=5.2×4.1×3.2 cm; PRL=6 400 ng/mL) was diagnosed in an amenorrheic 19-year old girl who presented to the emergency room complaining of headaches and bilateral decrease in visual acuity for 10 days. The patient was started on cabergoline (CAB) in progressive doses up to 3 mg/week. PRL levels decreased from 6 400 to 4 600 ng/dl within 60 days, with improvement of visual complaints and visual fields defects. The dose was subsequentl...

ea0049ep842 | Clinical case reports - Pituitary/Adrenal | ECE2017

A hypopituitarism case diagnosed after sphenoid sinus mucocele operation

Ekiz-Bilir Betul , Bilir Bulent , Oz Aysel , Gunes-Ciftci Halide , Soysal-Atile Neslihan , Elbuken Gulsah

Introduction: Mucoceles-mucus containing benign cysts of paranasal sinuses- are common with an incidence of 1% but involvement of sphenoid sinus is much less common. In this case report, we reported a patient presented with hypopituitarism after sphenoid mucocele drainage operation.Case report: A 59- year-old woman was admitted to our endocrinology out-patient clinics with a complaint of fatigue over the past 2 months. One month prior to admission, she h...

ea0049ep843 | Clinical case reports - Pituitary/Adrenal | ECE2017

Coexistence of acromegaly and rheumatoid arthritis: presentation of three cases

Ersoy Reyhan , Bestepe Nagihan , Faki Sevgul , Bilginer Cuneyt , Ozdemir Didem , Erten Sukran , Cakir Bekir

Introduction: Musculoskeletal system is widely affected in acromegalic patients which might cause difficulties in the diagnosis and treatment of inflammatory rheumatological diseases. Here, we report coexistent rheumatoid arthritis (RA) in three acromegalic patients presenting with continuing joint and back pain although acromegalic state was in remission.Case 1: A 64 years old female patient with acromegaly and macroadenoma had undergone transsphenoidal...

ea0049ep844 | Clinical case reports - Pituitary/Adrenal | ECE2017

Case of TSH secreating pituitary adenoma (TSHOMA) where course was modified by coexistant autoimmune hypothyroidism

Joshi Ameya , Ghagre Rajesh , Varthakavi Premlata , Dalwadi Pradeep , Bhagwat Nikhil

Introduction: TSHOMAs are rare pituitary tumors with prevalence of 1–2 cases per million. We present a case of of TSHoma where the course was complicated by the coexistence of autoimmune hypothyroidism.Case: 41 year old male presented with fatigue, lethargy and palpitations. On screening was found to have raised t3 – 216.30 ng/dl (N-70-204 ng/dl), t4 – 12.10 μg/dl(N-4.2-11.6 μg/dl) and TSH – 27.55 uIU/ml (0.2–5.7 uIU/ml...

ea0049ep845 | Clinical case reports - Pituitary/Adrenal | ECE2017

Cyclic Cushing’s syndrome: a diagnostic challenge

Ghizlane Elmghari , Meryam Elbahi , Sana Rafii , Nawal Elansari

Introduction: Cyclic Cushing’s syndrome is a rare disorder, characterized by repeated episodes of cortisol excess interspersed by periods of normal cortisol secretion ranging from days to years. It remains a difficult diagnostic challenge in endocrinology, we report a case.A case report: The patient was 41 years old woman, she presented in 2012 a period of symptomatic hypercortisolism. Urinary free cortisol was elevated to 113 μg/24, Low-dose d...

ea0049ep846 | Clinical case reports - Pituitary/Adrenal | ECE2017

Breast cancer and newly discovered non-secretor pituitary mass- as risk of metastases?

Valea Ana , Oprisor Iulia , Carsote Mara , Pop Dan Dumitru , Morar Andra , Ghervan Cristina , Georgescu Carmen Emanuela

Introduction: Even if breast cancer is rare cause of pituitary metastases, the diagnosis of a pituitary adenoma, shortly after surgery for breast cancer, raises suspicion of a possible secondary determinations.Material and method: This is a case report revealing the medical history and endocrine profile of a female with breast cancer and pituitary macroadenoma.Case data: A 64-year old non-smoking female (with menopause at age of 52...

ea0049ep847 | Clinical case reports - Pituitary/Adrenal | ECE2017

Meningoencephalitis as the first clinical sign of a pituitary macro adenoma: a case report

Elmghari Ghizlane , Bouizammarne Ilham , Elansari Nawal

Introduction: The classical revealing manifestations of a pituitary adenoma are represented by the combination of a tumor syndrome and endocrine syndrome. The occurrence of meningoencephalitis as a mode of revelation of a macroadenoma is exceptional.Case: Mr. M.O, 36 years old, with no significant medical history, brutally presented severe headaches, vomiting, behavioral disorder with fever and bilateral decreased visual acuity. On examination, the patie...

ea0049ep848 | Clinical case reports - Pituitary/Adrenal | ECE2017

A rare case with acromegaly: increased hypophyseal FDG uptake in PET/CT performed for lung cancer staging

Asoglu Veysi , Celik Ece , Celik Mehmet , Bulbul Buket Yilmaz , Durmus Yusuf , Ayturk Semra , Ustun Funda , Guldiken Sibel

Acromegaly affects 4–6 people in a million and hypophyseal GH releasing adenoma is the most common cause of the disease. It shows its effects on GH and IGF1. Since they grow rapidly, they are usually diagnosed at the stage of macroadenomas. Heart failure, arthritis, OSAS and DM may develop during course of the disease. Although the most common accompanying malignancy is colon cancer, the incidence of malign melanoma, breast, thyroid, gastric and lung cancers is also incre...

ea0049ep850 | Clinical case reports - Pituitary/Adrenal | ECE2017

Temozolomide alone or in combination with bevacizumab and capecitabine in the treatment of atypical pituitary adenomas – own experience

Kurowska Maria , Malicka Joanna , Tarach Jerzy

Introduction: Atypical pituitary adenomas are tumors refractory to conventional therapy and characterized by a tendency to rapid progression and high recurrence rate. The aim of the study was to summarize our experience in treatment of atypical pituitary adenomas with temozolomide (TMZ).Material: 5 patients (3F;2M) aged 44–58 (mean 52.4±5.4) years treated in 2013–2016. We analyzed the results, tolerance and side effects of TMZ.<p class...

ea0049ep851 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pachydermaperiostosis: a rare syndrome presented with acromegaloid changes

Uygur Meliha Melin , Arikan Izzet Hakki , Deyneli Oguzhan , Yavuz Dilek Gogas

Introduction: Pachydermoperiostosis (PDP) is a rare hereditary syndrome with familial and idiopathic forms that is characterized by subperiosteal new bone formation with pain, polyarthritis, cutis vertices grata, seborrhea, hyperhidrosis and digital clubbing. Periostosis and cutaneous thickening along with the absence of any signs of cardiovascular, pulmonary, hepatic, intestinal and mediastinal diseases causing secondary hypertrophic osteoarthropathy suggest PDP. The incidenc...

ea0049ep852 | Clinical case reports - Pituitary/Adrenal | ECE2017

Temozolomide Treatment in Aggressive Pituitary Adenoma

Sisman Pinar , Sahin Ahmet Bilgehan , Gul Ozen Oz , Cander Soner , Erturk Erdinc , Ersoy Canan

Background: Aggressive pituitary adenomas (APAs) take place phenotypically between benign pituitary adenomas and pituitary carcinomas with systemic metastasis. Frequent recurrence and resistance to conventional treatments are characteristic features of APAs in their clinical course. Temozolomide is an alkylating agent that has been used in the treatment of pituitary carcinomas and APAs since 2006. Herein, we report a patient who received temozolomide treatment due to APA.<...

ea0049ep853 | Clinical case reports - Pituitary/Adrenal | ECE2017

Ocult Cushing syndrome: (adicional) difficulties in hypercortisolism approach

Martins Ana Filipa , Martins Joao Martin , Vale Sonia Do

Introduction: Cushing syndrome (CS) result from inappropriate exposure to increased non regulated glucocorticoid levels. It remains challenging regarding diagnosis and management. Pituitary ACTH-secreting adenomas account for most of the cases if exogenous and paraneoplasic forms are excluded.Case report: A 45-year-old women was referred to the endocrine outpatient department because of obesity, muscular weakness, high blood pressure (HBP), diabetes ...

ea0049ep854 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of cystic prolactinoma responsed to medical treatment

Omma Tulay , Gulcelik Nese Ersoz , Karaca Anara , Taskaldiran Isilay

Introduction: Cystic prolactinomas are considered resistant to volume depletion by dopamine agonists (DAs). Because of the effectiveness and tolerability, dopamine agonists (DAs) are the first line therapies in prolactinoma and reduce tumor mass as well as prolactin levels in most of all patients. Rathke’s cleft cysts, craniopharyngiomas and arachnoid cysts are differential diagnoses to keep in mind. DAs resistance or intolerance, psychiatric disorders associated with dop...

ea0049ep855 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of pituitary apoplexy in a patient with Cushing’s disease due to corticotroph macroadenoma

Sava Elisabeta , Leca Bianca , Sirbu Anca , Georgescu Olivia , Cima Luminita , Florea Suzana , Fica Simona

Corticotroph macroadenomas are exceptionally found in Cushing’s disease. Pituitary apoplexy is a rare endocrine emergency condition caused by either hemorrhage or infarction of the pituitary gland. We report a case of a 56-year-old female diagnosed with type 2 diabetes in 2008. One year after, at the periodical follow up, she presented with uncontrolled diabetes (HbA1c=12.26%) and clinical manifestations suggestive for hypercortisolism, therefore insulin therapy was initi...

ea0049ep856 | Clinical case reports - Pituitary/Adrenal | ECE2017

Ectopic ACTH syndrome presenting with partial loss of conciousness and nonconvulsive status epilepticus in a patient with no signs of Cushing syndrome

Mert Eray Onur , Yaman Samet , Ozdemir Didem , Bestepe Nagihan , Saglam Dursun Ali , Ersoy Osman , Ersoy Reyhan , Cakir Bekir

Introduction: Ectopic adrenocorticotrophic hormone (ACTH) syndrome is associated with variable tumor groups most commonly originating from neuroendocrine cells. Here, we reported a patient considered to have nonconvulsive status epilepticus initially due to neurological symptoms and diagnosed as neuroendocrine tumor with ectopic ACTH syndrome.Case: A 85 years old woman with regulated hypertension admitted with partial loss of conciousness. She had cachec...

ea0049ep857 | Clinical case reports - Pituitary/Adrenal | ECE2017

Cushing’s disease management through time- a case report

Borozan Sanja , Boskovic Olivera

Cushing’s disease (CD) is a rare disorder caused by an increased secretion of adrenocorticotropin hormone (ACTH) from the anterior pituitary gland, usually as a result of pituitary adenoma. Transsphenoidal tumour resection is the best first line therapy option for these patients but 10–30% of them fail to achieve remission and need further treatment modalities to eliminate hypercortisolemia. Long-term outcomes and possible impacts on quality of life in these patients...

ea0049ep858 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of extrapontine myelinolysis after surgery for a pituitary tumor

Cayon-Blanco Manuel , Baena-Nieto M Gloria , Marquez-Pardo Rosa , Lopez-Valasco Rosario , Torres-Barea Isabel M , Garcia-Garcia-Doncel Lourdes

Introduction: Rapid correction of hyponatremia is known to cause central pontine myelinolysis. It may concurrently involve other areas of brain as well, referred as extra-pontine myelinolysis (EPM). Isolated EPM however is a very rare occurrence. We present a case of EPM where the hyponatremia was secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgery for a pituitary macroadenoma.Case report: A 36-year-old man underwe...

ea0049ep859 | Clinical case reports - Pituitary/Adrenal | ECE2017

Hypopituitarism caused by an intrasellar meningioma: case report

Gavriilidou Stavroula , Belis Constantinos , Xydiari Kalliopi , Afentoulidi Aikaterini , Athanasiou Vasilios , Malaktari-Skarantavou Sofia , Tournis Symeon , Savvidis Christos

Meningioma is a common, usually benign, tumor of the brain and the spinal cord that originates from any dura surface. Such lesion accounts for 10 to 15% of nonadenomatous sellar masses. Purely intrasellar meningiomas are relatively rare and can mimic a nonfunctioning adenoma. A 33-year-old man with a history of 1.5 year fatigue, anemia and erectile dysfunction referred to our department. The laboratory data revealed low levels of ACTH, Cortisol, FSH, LH and Testosterone, while...

ea0049ep860 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of tuberous sclerosis complex associated with non-functioning pituitary incidentaloma and moderate hyperprolactinaemia

Szanto Zsuzsanna , Tanko Zsuzsa

Tuberous sclerosis complex is characterised by non-malignant tumours in the skin, brain, kidneys, heart, eyes, lung, but sometimes angiomyolipomas may develop in the adrenals, ovaries, thyroid, and rarely neuroendocrine tumours in the pancreas, pituitary gland, parathyroids. The case of a 46-years-old female patient suffering of tuberous sclerosis and endocrine disturbances is presented. She is known with temporal lobe epilepsy since early childhood, and anxious depressive dis...

ea0049ep861 | Clinical case reports - Pituitary/Adrenal | ECE2017

Patient with empty sella and clinical features of acromegaly

Pappa Dimitra , Thoda Pinelopi , Rizoulis Andreas , Gountios Ioannis , Kapsalaki Eftihia , Bargiota Alexandra

Introduction: Acromegaly is a systematic disease with charecteristic clinical features, which is due to GH hypersecretion mainly from pituitary adenomas and in rare cases it can be due to ectopic GHRH and GH hypersecretion. Sometimes localizing the source of hypersecretion is difficult. Here we present a case of a woman with acromegalic phenotype and empty sella.Presentation: A 47 years old woman referred to our department after recent onset of high bloo...

ea0049ep862 | Clinical case reports - Pituitary/Adrenal | ECE2017

Esthesioneuroblastoma causing ectopic ACTH Syndrome

Gonzalez Cristina Lorenzo , Melo Estefania Gonzalez , Mesa Elena Marquez , Marquez Pilar Olvera , Arranz Maria Teresa Herrera , Bray Bruno Francisco Garcia , Huerta Yolanda Zambrano , Abizanda Enrique Palacio

Introduction: Esthesioneuroblastoma is an uncommon malignant neoplasm with an average 5-year survival rate of about 45%. Ectopic ACTH syndrome due to esthesioneuroblastoma is extremely rare and there have been very few cases reported.Case report: A 54-year-old woman was admitted to our hospital with symptoms of leg edema and general fatigue of one month’s duration. Physical examination showed moon facies and edema on her lower extremities bilaterall...

ea0049ep863 | Clinical case reports - Pituitary/Adrenal | ECE2017

Lymphocytic hypophysitis which underwent surgery despite the absence of compression of nearby structures. A case report

Gonzalez Javier , Diez Alberto , Prieto Alma , Fernandez Marta

Introduction: Lymphocytic hypophysitis is a strange cause of hypopituitarism which can represent a difficult diagnostic and therapeutic challenge.Objectives and methods: Describe the diagnosis, evolution and treatment of a case of lymphocytic hypophysitis in a patient who began with hypopituitarism and a year after the diagnosis had local symptoms. We reviewed the medical history of the patient from the moment the patient contacted with us to the months ...

ea0049ep864 | Clinical case reports - Pituitary/Adrenal | ECE2017

Title: IgG4 related hypophysitis

Thoda Pinelopi , Pappa Dimitra , Sakali Anastasia-Konstantina , Georgiou Eleni , Gountios Ioannis , Bargiota Alexandra

Introduction: IgG4 Related Hypophysitis (IgG4-RH) is a newly recognized form of hypophysitis. It usually appears as part of IgG4-Related Disease (IgG4-RD), an immune mediated disease, with manifestations in many organs. Isolated hypophysitis without other IgG4-RD manifestations is rare.Presentation: A 64 years old female referred to our department for further investigation of a 9 month history of fatigue, muscle weakness, recurrent episodes of right temp...

ea0049ep865 | Clinical case reports - Pituitary/Adrenal | ECE2017

Pituitary apoplexy as the first manifestation of silent somatotropinoma

Obel Ewa , Lewicki Marcin , Urbanczuk Magdalena , Smolen Agata , Matyjaszek-Matuszek Beata , Tarach Jerzy

Introduction: Pituitary apoplexy is a rare endocrine disorder which can occur due to haemorrhage into pituitary gland. It is often associated with the presence of pituitary adenoma, uncommonly being the first clinical manifestation of an underlying tumour. It can cause hypopituitarism and diabetes insipidus. Pituitary adenomas are classified by their secretion properties as functional and clinically non-functioning, the latter, however, can exhibit positive immunostaining for ...

ea0049ep866 | Clinical case reports - Pituitary/Adrenal | ECE2017

Unprogrammed pregnancy in women with active Acromegaly: a case report

Luque-Fernandez Ines , Olivar-Azuara Monica , Llamazares-Iglesias Ofelia , Vicente Almudena

Introduction: Reports of pregnancy occurring in acromegalic patients are uncommon. Nevertheless, it appears that women are usually able to carry their pregnancy to full termCase: 39 year old woman referred to endocrinology for secondary amenorrhea and hyperprolactinemia (PRL 55.54 mg/dl). As she mentioned typical symptoms of Acromegaly, we extended the study, finding high levels of IGF1 and a pituitary macroadenoma (25×16 mm) in MRI. Presurgical tre...

ea0049ep867 | Clinical case reports - Pituitary/Adrenal | ECE2017

Acromegaly and pregnancy: case report

Khatib Maria

Introduction: Pregnancy in patients with acromegaly is a rare and challenging medical situation. Here in, we report a patient with acromegaly who presented to us in the 3rdtrimester of pregnancy after endoscopic transnasaltranssphenoidal radical excision of the tumor.Observation: A 36-year-old lady (Gravida 3 Parity 2 Live Birth 2), presented to our outpatient clinic on May 2007 forsuspicion of acromegaly. Clinical examination revealed acromeg...

ea0049ep868 | Clinical case reports - Pituitary/Adrenal | ECE2017

Clinical case report: MEN-1 syndrome with coincident AIP gen mutation and MEN-1 gen deletion

Gonzalez-Molero Inmaculada , Arnes Juan Antonio Garcia , Oriola Josep , Romero Stella Gonzalez , Almaraz Maria Cruz , Maraver Silvia , Olveira Gabriel , Tinahones Francisco

We present the clinical case of a family with an initial diagnosis of AIP syndrome with AIP mutation and a secondary diagnosis of MEN syndrome associated because of a large MEN-1 gen deletion. A male patient 16 years old was evaluated because of delayed growth and pubertal development. He had headaches, nausea and vomits since seven years old. MRI showed: Large pituitary mass of 47.6×22×47.2 mm that erode the floor of the sella, extending into the left prepontine cis...

ea0049ep869 | Clinical case reports - Pituitary/Adrenal | ECE2017

Coexistence of thyrotropinoma and chronic autoimmune thyroiditis, a diagnostic challenge

Olaizola Izaskun , Egana Nerea , Bilbao Ismene , de Ciriza Maite Perez , Antunano Maria Luisa , Elias Estela , Garcia Cristina , Aranburu Maite , Yoldi Alfredo , Goena Miguel Maria

Introduction: TSHomas are rare TSH producing tumors, whereas chronic autoimmune thyroiditis is a frequent condition. Patients with TSHoma are characterized by increased circulating levels of peripheral thyroid hormones, but when a chronic autoimmune thyroiditis is associated, they may be normal or low, making the diagnosis challenging.Case report: A 55 year-old woman, with previous medical history of obesity and impaired fasting glucose, was diagnosed of...

ea0049ep870 | Clinical case reports - Pituitary/Adrenal | ECE2017

Central diabetes insipidus and cerebral salt wasting syndrome: a challenging coexistence

Costa Maria Manuel , Esteves Cesar , Castedo Jose Luis , Pereira Josue , Carvalho Davide

Introduction: Combined central diabetes insipidus (DI) and cerebral salt wasting syndrome (CSW) is a rare clinical finding. However, when this happens, mortality is high due to delayed diagnosis and/or inadequate treatment.Case report: 42-year-old man referred to neurosurgery due to a non functional pituitary macroadenoma with bitemporal hemianopsia. He underwent partial ressection of the tumour on July 2nd 2015. On the following day of surgery he presen...

ea0049ep871 | Clinical case reports - Pituitary/Adrenal | ECE2017

Adipsic diabetes insipidus – a diagnostic and therapeutic challenge

Magalhaes Daniela , Esteves Cesar , Costa Maria Manuel , Rodrigues Pedro , Carvalho Davide

Introduction: In diabetes insipidus (DI) the serum sodium is often in the high normal range, required to provide the ongoing stimulation of thirst to replace the urinary losses. Marked hypernatremia can occur if a central lesion impairs both ADH release and thirst.Case report: A 57-year-old woman presented with dysuria, polyuria and fever. She was medicated with ciprofloxacin, however, she maintained symptoms, accompanied in the next day by nausea, vomit...

ea0049ep872 | Clinical case reports - Pituitary/Adrenal | ECE2017

Endosalpingiosis – re-thinking risk tumours in acromegaly

Magalhaes Daniela , Bettencourt-Silva Rita , Leitao Patricia , Morgado Paulo , Souto-Moura Conceicao , Carvalho Davide

Introduction: There is circumstantial evidence supporting a role of growth hormone and insulin-like growth factor 1 in the development and progression of tumors. Endosalpingiosis is characterized by the presence of non-neoplastic fallopion tube-like epithelium in ectopic anatomical locations.Case report: A 45-year-old woman presented with a constant moderate to intense perianal pain limiting basic daily life activities. She also complained about pain at ...