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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep878 | Growth hormone IGF axis - basic | ECE2017

Initial response to octreotide LAR in Mexican patients with acromegaly

Velarde Arturo Pena , Lopez Alma Vergara

Introduction: In Mexico there is scant literature about medical management and its response in patients with acromegaly. Octreotide LAR at a dosage of 20 mg weekly is considered as first line treatment in patients who failed to surgery or who are not candidates to surgical treatment. The goal of this initial dosage is to reach GH levels below 1.0 ng/ml and insuline like factor type 1 (IGF1) levels within range for age and gender. The objective of this study is to determine the...

ea0049ep879 | Growth hormone IGF axis - basic | ECE2017

Pasireotide: an effective treatment for resistant acromegaly

Amarawardena Wickrama Kankanamge Maheshi Gihani , Liyanarachchi Kamani Dhanushka , Newell-Price John David Charles , Ross Richard John Martin , Debono Miguel

The granulation pattern of somatotroph adenoma is well known to be associated with differing clinical and biochemical characteristics and it has been shown that sparsely granulated tumors respond poorly to commonly used somatostatin analogs. We report a challenging case of acromegaly with a sparsely granulated tumor, resistant to multiple modalities of treatment given over several years and ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented...

ea0049ep880 | Growth hormone IGF axis - basic | ECE2017

The disorder of secretion of somatotropic hormone in women with the polycystic ovaries syndrome (PCOS) by comparison to patients with the non-functional pituitary adenomas (NFPA)

Urmanova Yulduz , Saidnazirkhanova Mushtary

Tashkent Pediatric Medical Institute, department of endocrinology, department of dietology, Center of the Scientific and Clinical Study of Endocrinology, department of neuroendocrinoloy, Ministry of Health of the Republic of Uzbekistan. Republic of Uzbekistan, 100125, Tashkent, Mirzo Ulugbek str. 56. The aim to study the disorder of secretion of growth hormone for women with PCOS by comparison to patients with NFPA.Material and methods: Under our supervi...

ea0049ep881 | Growth hormone IGF axis - basic | ECE2017

The levels of decorin in patients with Cushing’s disease and acromegaly

Tsoriev Timur , Belaya Zhanna , Rozhinskaya Lyudmila , Ilyin Alexandr , Nikankina Larisa , Mel'nichenko Galina , Dedov Ivan

Decorin is myokine expressed and released in response to muscle contractions. It induces growth and hypertrophy of skeletal muscles in different ways including myostatin inhibition. It is still not clear whether decorin takes part in development of muscle atrophy in endocrine pathologies.Objective: To evaluate decorin levels in patients with endogenous hypercortisolism and GH oversecretion.Materials and methods: Three groups were i...

ea0049ep882 | Growth hormone IGF axis - basic | ECE2017

Could statin modify molecular phenotype of pituitary growth hormone-secreting tumors?

Exposito Maria Rosa Alhambra , Moreno Paloma Moreno , Jimenez Concepcion Munoz , Moreno Maria Angeles Galvez , Huertas Raul Luque

Background: Acromegaly is the consequence of excessive growth hormone (GH) secretion, usually produced by a pituitary adenoma. In the last years, statins have been implicated in the response to treatment of patients with acromegaly. Although this fact is not very clear.Objective: To analyze whether pretreatment with statins modifies the adenoma molecular phenotype of the acromegalic patients and how this changes could help to influence the response to tr...

ea0049ep883 | Growth hormone IGF axis - basic | ECE2017

A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH)

Farhat Khalil , Bodart Gwennaelle , Renard Chantal , Desmet Christophe , Moutschen Michel , Baron Frederic , Beguin Yves , Salvatori Roberto , Matens Henri , Geenen Vincent

In the framework of close interactions between the immune and neuroendocrine systems, Growth Hormone (GH) has been proposed to exert significant effects on the immune system, but there is not yet a consensus about GH immunomodulatory properties. These studies investigated the immune and anti-infectious response of dwarf Ghrh−/− mice presenting a severe deficiency of the GHRH/GH/IGF-1 axis. In basal conditions, thymic parameters and T-cell respon...

ea0049ep884 | Growth hormone IGF axis - basic | ECE2017

Safety of growth hormone replacement therapy (GHRT) in adult patients with GH deficiency: data from kims

Camacho-Hubner Cecilia , Jonsson Peter , Aydin Ferah , Rajicic Natasa , Cara Jose , Abs Roger , Hey-Hadavi Judith

Background: The efficacy of recombinant human growth hormone replacement therapy (GHRT) has been demonstrated, in part, through clinical trials conducted worldwide. KIMS (Pfizer International Metabolic Database), established in 1994 and active until 2012, includes treatment outcome data and real world safety from 15 809 patients from 31 countries.Objective: The main objective of this analysis was to evaluate the long-term safety of patients with hypopitu...

ea0049ep885 | Growth hormone IGF axis - basic | ECE2017

Effect of GH treatment on coagulation and fibrinolysis parameters in prepubertal children with growth hormone deficiency

Karachaliou Feneli , Pergadou Helen , Dettoraki Anastasia , Boudouvi Evangelia , Kafetzi Maria , Fotinou Aspasia , Platokouki Helen , Papaevangelou Vassiliki

Background: Increased fibrinogen levels have been reported in prepubertal children and adolescents with growth hormone deficiency (GHD), which were reduced after rhGH treatment. rhGH treatment has also been shown to exert a beneficial effect on the amount of aPAI-1 in children with GHD. Aim of the study was to evaluate whether prepubertal GH deficient (GHD) children showed any impairment in coagulation- and fibrinolysis-related parameters and the effect of GH therapy on these ...

ea0049ep886 | Growth hormone IGF axis - basic | ECE2017

Nodular thyroid disease in acromegaly: cohort of 69 patients at a single institution

Alvarez-Escola Cristina , Gonzalez Diego Meneses , Dominguez Oscar Moreno , de la Morena Lucrecia Herranz

Materials and methods: The aims were to evaluate the frequency of nodular thyroid disease (NTD) in acromegalic patients and to correlate clinical and metabolic features with disease activity and other. We conducted a cross-sectional study including retrospectively 69 acromegalic patients attending to an University Hospital in Madrid, Spain between 1980 and 2016. Mean age was 63 (32–92) years, 63.8% of patients were female. Mean age at diagnosis of acromegaly was 48 (11&#1...

ea0049ep887 | Growth hormone IGF axis - basic | ECE2017

Somatropin treatment Supported by NHS: characterization of submitted patients – 2006 to 2016

Bastos Margarida , Mirante Alice , Afonso Caldas , Vasconcelos Carlos , Bacelar Conceicao , Pereira Conceicao , Lopes Lurdes , Fonseca Marcelo , Serra-Caetano Joana , Patricio Miguel , Esteves Cesar Marques , Ferreira Florbela , Braganca Graciete , Raimundo Luisa , Matos Lurdes , Sampaio Lurdes , Fontoura Manuel , Borges Teresa

Introduction: In our country somatropin treatment is supported by the National Health Service. A National Committee (CNNHC) rules and analysis the submission papers of patients with: isolated/multiple somatotropin deficiency (STD), short stature in: renal chronic disease (DRC), small for gestational age (SGA), Turner syndrome (TS) and Prader Willi syndrome (PWS). In adults only isolated somatropin deficiency diagnosed in childhood.Aims: To analyze the ch...