Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

ea0049ep889 | Neuroendocrinology | ECE2017

Empagliflozin increases urinary volume output in healthy volunteers with artificial SIADH – a placebo-controlled double blind crossover study

Refardt Julie , Winzeler Bettina , Meienberg Fabian , Vogt Deborah , Christ-Crain Mirjam

Introduction: The Syndrome of inappropriate antidiuresis (SIADH) is the predominant cause of hyponatremia and its therapy options are unsatisfying. SGLT2-inhibitors have become a valuable treatment option for type 2 diabetes by increasing glucose excretion in the urine with concomitant osmotic diuresis. We therefore hypothesized that SGLT2-inhibitors could be a novel treatment option for SIADH.Material and methods: We included 14 healthy volunteers in th...

ea0049ep890 | Neuroendocrinology | ECE2017

Metformin increases pressure pain threshold in lean PCOS women

Kialka Marta , Milewicz Tomasz , Sztefko Krystyna , Rogatko Iwona , Majewska Renata

Background: Despite the strong preclinical rationale, there are only very few data considered the utility of metformin, as a potential pain therapeutic in humans. The aim of this study was to determine, the association between metformin therapy and pressure pain threshold (PPT) in lean polycystic ovary syndrome (PCOS) women. We hypothesized that metformin therapy in lean PCOS women increases pressure pain threshold.Materials and methods: Twenty-seven lea...

ea0049ep891 | Neuroendocrinology | ECE2017

Clinical features and natural history of clinically non-functioning pituitary incidentalomas

Iglesias Pedro , Arcano Karina , Trivino Vanessa , Garcia-Sancho Paula , Diez Juan Jose , Cordido Fernando , Villabona Carles

Objetive: To assess the clinical features of incidental clinically non-functioning pituitary adenoma (NFPA) and to analyze its natural history.Methods: A multicenter retrospective study in patients with NFPA followed-up from 1992 to 2015 was performed.Results: Fifty-seven patients were studied (29 women (50.9%); age 55.8±16.7 years. 43.9% were older than 60 years, 40.3% belonged to the age group of 40–60 years and 15.8% w...

ea0049ep892 | Neuroendocrinology | ECE2017

Pituitary stalk lesions - experience of single center

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Petakov Milan

Introduction: Lesions of the pituitary stalk (PSL) are a challenging diagnostic problem for clinicians. Because of the critical location and role of the pituitary stalk, mass lesions in this area are not often biopsied, and the diagnosis may be based on clinical evaluation and imaging. Due to biopsy risk, about 40% PSL diagnosis are ‘probable’ or ‘unknown’.The main clinical symptoms of PSL are visual field defect, DI and hypopituitarism.<p class="abstex...

ea0049ep893 | Neuroendocrinology | ECE2017

First pediatric case of successfully treated Cushing’s disease in Armenia

Bayburdyan Gayane , Arakelyan Lusine , Aghajanova Yelena

Introduction: Cushing’s disease (CD) is the most common albeit rare in paediatric and adolescent population form of ACTH-dependent Cushing’s syndrome, with potentially serious morbidity. Thus, it presents diagnostic and therapeutic challenges for the clinician. Early diagnosis and treatment of Cushing’s disease is vital for long-term outcome. Paediatric pituitary-dependent Cushing’s disease, caused by an ACTH-secreting corticotroph adenoma, accounts for 75&...

ea0049ep894 | Neuroendocrinology | ECE2017

SCTR/AT1aR heteromer related osmoregulation in hypothalamus

Mak Oi Kwan , Chow Billy K.C.

Emerging studies suggest that GPCR oligomerization could confer functional advantages to receptors and even constitute clinical applications. Recent study found that angiotensin II 1a receptors (AT1aR) and secretin receptors (SCTR) can form heteromer and participate in osmoregulation. Studying GPCR dimerization faces many technical challenges, including selectivity and specificity. Since transmembrane (TM) peptides can act as competitors against the interacting surfaces betwee...

ea0049ep895 | Neuroendocrinology | ECE2017

The hyponatremia in neurosurgical patients

Astaf'eva Liudmila , Kutin Maxim , Sidneva Yuliya , Kalinin Pavel

Background: Hyponatremia is a relatively frequent and serious complication developed in patients with different neurosurgical pathology. The aim of the study was to identify the frequency of occurrence of hyponatremia in neurosurgical patients.Materials and methods: A retrospective analysis included 39479 patients operated in the Institute of Neurosurgery from January 2008 to December 2014.Results: 785 patients (2% of all operated ...

ea0049ep896 | Neuroendocrinology | ECE2017

Bilateral inferior petrosal sinus sampling and the outcome of transsphenoidal surgery in patients with Cushing’s disease: experience of a Tertiary Portuguese Hospital

Gomes Ana Coelho , Neto Lia Lucas , Tortosa Francisco , Carvalho Maria Raquel , Barreiros Eduardo , Barreiros Luis , Miguens Jose , Bugalho Maria Joao

Introduction: Bilateral inferior petrosal sinus sampling (BIPSS) is the gold-standard for the differential diagnosis of ACTH-dependent Cushing Syndrome when the pituitary adenoma on MRI is doubtful or absent. This study aimed to analyze whether BIPSS can influence the outcome in patients with Cushing disease (CD).Methods: Retrospective, descriptive study. Forty-two patients with CD submitted to transsphenoidal surgery (TS) between 2005 and 2016 were divi...

ea0049ep897 | Neuroendocrinology | ECE2017

The prevalence of colorectal cancer and colon polyps in acromegaly: thirty years’ experience of a tertiary referral center

Gomes Vania , Barreiros Luis , Barreiros Eduardo , Ferreira Florbela , Gomes Ana , Martins Ana Filipa , Osorio Ana Sofia , Wessling Ana , Silvestre Catarina , Reis Dinis , Nobre Ema , Carvalho Maria Raquel , Mascarenhas Mario , Vale Sonia do , Miguens Jose , Bugalho Maria Joao

Introduction: Several studies suggest a higher risk of colorectal cancer (CRC) and colon polyps (CP) in acromegaly, however there is still controversy regarding associated factors (AF) able to contribute for its development. Data on the prevalence of CRC and CP in Portuguese patients with acromegaly are limited.Objectives: To assess the prevalence of CRC and CP in acromegalic patients and compare to the normal Portuguese population. To determine the rele...

ea0049ep898 | Neuroendocrinology | ECE2017

Acromegaly and malignant neoplasms

Gomes Vania , Barreiros Eduardo , Barreiros Luis , Ferreira Florbela , Gomes Ana , Martins Ana Filipa , Osorio Ana Sofia , Wessling Ana , Silvestre Catarina , Reis Dinis , Nobre Ema , Carvalho Maria Raquel , Mascarenhas Mario , do Vale Sonia , Miguens Jose , Bugalho Maria Joao

Introduction: Acromegaly is a rare disease resulting from pathological oversecretion of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). The clinical spectrum includes cardiovascular and respiratory diseases but also increased risk of benign and malignant neoplasms.Objectives: Evaluate the prevalence of cancer and seek for associated factors in acromegaly.Methods: Retrospective study of 94 patients with acromegaly trea...

ea0049ep899 | Neuroendocrinology | ECE2017

Endogenous Cushing’s syndrome ( clinical and biochemical features in a large cohort of patients

Vilar Lucio , Vilar Clarice , Albuquerque Jose Luciano , Trovao Erik , The Ana Carolina , Gadelha Patricia , Melo Maira , Gomes Barbara , Borges Thaise , Cardoso Izabela , Lyra Ruy

Patients and methods: We retrospectively analysed the clinical and biochemical characteristics of a cohort of 150 patients with endogenous Cushing’s syndrome (CS). Cushing’s disease (CD) accounted for 61.3% of cases (n=92), ectopic ACTH secretion (EAS) 7.3% (n=11), and adrenal diseases 31.3% (n=47). Among CD cases, there were 19 macroadenomas (20.6%), a female predominance (60.5%) and a median age of 33 years old (range 14–55). Bronchi...

ea0049ep900 | Neuroendocrinology | ECE2017

Hyponatremia predating the diagnosis of malignancy in oncological/hematological patients with SIADH

Crespo-Hernandez Irene , Cuesta-Hernandez Martin , Santiago-Perez Alejandro , Gomez-Hoyos Emilia , Ortola-Buigues Ana , Miguel-Novoa Paz de , Chafer-Vilaplana Joan , Calle-Pascual Alfonso , Runkle Isabelle

Introduction: Euvolemic hyponatremia (HN) caused by the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) can predate a diagnosis of malignancy. It is thus essential to accurately diagnose the etiology of HN/SIADH when detected.Methods: Retrospective, descriptive study of all 52 oncological/hematological malignancy patients diagnosed with SIADH in our Department between January 2011 and December 2016. HN was detected via computerized Prima...

ea0049ep901 | Neuroendocrinology | ECE2017

Hyperprolactinemia as a manifestation of hormonally inactive pituitary adenoma

Khalimova Zamira , Safarova Mijgona

Aim: The work was initiated to study prolactin levels in hormonally inactive pituitary adenoma by the size of the tumor.Material and methods: We examined 85 patients with hormonally inactive pituitary adenomas, 45 women and 40 men among them aged from 18 to 50 years (mean age 44.5±3.85 years). The disease duration from the onset to diagnosis based on the medical history and MRI ranged from 1 to 15 years.Results and discussion:...

ea0049ep902 | Neuroendocrinology | ECE2017

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ea0049ep903 | Neuroendocrinology | ECE2017

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ea0049ep904 | Neuroendocrinology | ECE2017

Study of CHD7 gene in KAL 1-negative patients previously diagnosed with congenital hypogonadotropic hypogonadism that develop new pituitary deficiencies

Lecumberri Beatriz , Rodriguez Francisco Javier , Moreno Oscar , Santiago Manuel de , Nistal Manuel , Vallespin Elena , Campos Angel , Heath Karen

Introduction: Recent studies suggest that some patients initially diagnosed with congenital hypogonadotropic hypogonadism (CHH), may evolve towards a combined pituitary hormonal deficiency (CPHD). Heterozygous pathogenic CHD7 variants impair neural cell crest guidance causing CHARGE syndrome and have been associated with abnormal pituitary development/function/structure and isolated CHARGE features, including HH. We aimed to genotype CHD7 and phenotype thoroughly those adult p...

ea0049ep905 | Neuroendocrinology | ECE2017

MR-characteristics as predictors of pituitary adenomas hormonal and proliferal activity

Krivosheeva Yulya , Dreval Alexander , Panteleeva Evgenia , Stashuk Galina , Ilovayskaya Irena

Introduction: Previous studies demonstrated a relationship between T1- and T2-weighted signal intensity and tumor growth pattern in pituitary somatotropinomas. The goal of this retrospective study was to analyze the MRI characteristics of pituitary macroadenomas with different hormonal activity in newly diagnosed patients.Material and methods: Pre-treatment T1- and T2-weighted MR-images (Intera Achieva, PHILIPS, 3.0T) of patients with 42 non-functional a...

ea0049ep906 | Neuroendocrinology | ECE2017

Cholinergic modulation of the hypothalamic-pituitary-adrenal activity and somatotroph function in smokers and non-smokers

Perez-Luis Jesus , Lopez-Fernandez Judith , Mascareno Isabel , Salvador Javier

Introduction and objectives: The inhalation of tobacco smoke leads to an acute increase in cortisol, ACTH and GH concentration, both in chronic smokers as in non-smokers. However, most studies have failed to demonstrate differences between both groups in basal levels of these hormones in plasma or urine. Additionally, cholinergic pathways have been shown to play an inhibitory role in ACTH secretion in non-smokers. UFC and circulating levels of cortisol, ACTH and GH were evalua...

ea0049ep907 | Neuroendocrinology | ECE2017

Diagnosis, treatment and follow-up of non-functioning pituitary adenomas

Barrera-Martin Ana , Moreno-Moreno Paloma , Alhambra-Exposito Maria-Rosa , Herrera-Martinez Aura-Dulcinea , Rebollo-Roman Angel , Garcia-Jurado Pedro-Blas , Galvez-Moreno Maria-Angeles

Introduction: Non-functioning pituitary adenomas (NFPAs) represent the most common pituitary tumour. They usually appear in the middle age of life, without differences between genders. Mass growth produces the first symptoms so the diagnosis is usually late. Surgery is the first-line treatment with variable success (19-83%). The objective of this study is to evaluate the symptoms, diagnosis, treatment and final state of patients with NFPAs.Methods: Obser...

ea0049ep908 | Neuroendocrinology | ECE2017

Decreased prolactin levels in plasma and cerebrospinal fluid in naïve to treatment patients with multiple sclerosis

Baranowska-Bik Agnieszka , Uchman Dorota , Martynska Lidia , Kalisz Malgorzata , Litwiniuk Anna , Bik Wojciech , Baranowska Boguslawa , Kochanowski Jan

Background: Data from the literature has documented a remarkable immune-modulating role of prolactin. Previous evaluations of prolactin levels in patients with multiple sclerosis (MS), disease of autoimmune origin, showed conflicting results. Thus, to clarify the impact of prolactin on MS pathology we decided to assess prolactin levels in plasma and cerebrospinal fluid in naïve to treatment subjects with newly diagnosed MS.Material and methods: A to...

ea0049ep909 | Neuroendocrinology | ECE2017

Cholinergic modulation of the hypothalamic–pituitary–adrenal activity and somatotroph function in DM-1

Perez-Luis Jesus , Lopez-Fernandez Judith , Mascareno Isabel , Salvador Javier

Introductions: Alterations of the somatotrophic and hypothalamic–pituitary–adrenal (HPA) axes occur frequently in patients with poorly controlled DM-1. These disorders could be related to abnormalities in the cholinergic tone regulating both hormonal axes.Subjects and Methods: UFC (urinary free cortisol) on 24 h urine samples and the effects of placebo and pyridostigmine on ACTH, cortisol, GH and glucose circulating levels were studied in 16 yo...

ea0049ep910 | Neuroendocrinology | ECE2017

Increased GH response to GHRH plus pyridostigmine unrelated to augmented glomerular filtration rate in DM-1

Perez-Luis Jesus , Lopez-Fernandez Judith , Mascareno Isabel , Salvador Javier

Introduction and Objectives: In patients with poorly controlled DM-1, the frequently observed alterations of somatotrophic axis seem to be related to abnormalities in the hypothalamic cholinergic tone regulating this axis. The effects of cholinergic stimulation on GH responses to GHRH were evaluated in patients with poorly controlled DM-1 and the relationship of these responses to metabolic control and kidney function tests.Subjects and Methods: Microalb...

ea0049ep911 | Neuroendocrinology | ECE2017

Increased morbidity associated with the treatment of craniopharyngioma

Capatina Cristina , Dumitrascu Anda , Caragheorgheopol Andra , Poiana Catalina

Background: Craniopharyngioma is a rare epithelial tumor of the central nervous system, affecting both children and adults and associated with significant morbidity.Objective: To study the posttreatment evolution of craniopharyngioma in children and adults in a large mixed cohort.Material and Methods: We performed a retrospective review of craniopharyngioma patients evaluated in the National Institute of Endocrinology in Bucharest ...

ea0049ep912 | Neuroendocrinology | ECE2017

The PATRO adults study of Omnitrope for the treatment of adult patients with growth hormone deficiency: latest results

Beck-Peccoz Paolo , Hoybye Charlotte , Murray Robert , Simsek Suat , Zabransky Markus , Stalla Gunter

Introduction: The ongoing, international, open, longitudinal, non-interventional study, PATRO Adults, aims to determine the long-term safety and efficacy of Omnitrope® (Sandoz), a recombinant human growth hormone (rhGH). Safety data from an interim analysis are presented here.Methods: Eligible patients are male or female adults who are receiving treatment with Omnitrope® and who have provided informed consent. Patients tre...

ea0049ep913 | Neuroendocrinology | ECE2017

Clinical case description of family with hereditary pituitary adenoma

Tarasova Tatiana , Pigarova Ekaterina , Dzeranova Larisa , Tulpakov Anatoly , Dedov Ivan

Introduction: In recent years, more attention is driven to the cause of hereditary forms of pituitary adenomas. Although for most cases causal genes are not discovered yet, AIP mutations are the most prevalent.Materials and Methods: Case descriptions, high-parallel sequencing using a gene panel (MEN1, CDKN1B, PRKAR1A, GNAS, AIP, SDHA, SDHB, SDHS, SDHD, PRKCA, CDKN2C, CDKN2A, POU1F1, PTTG2).Case description: Index ...

ea0049ep914 | Neuroendocrinology | ECE2017

Molecular and genetic basis of the disease in families with pituitary adenomas

Tarasova Tatiana , Pigarova Ekaterina , Dzeranova Larisa , Tulpakov Anatoly , Dedov Ivan

Introduction: Most of the work on the analysis of molecular genetic defects in pituitary adenomas devoted to the study of 1–2 candidate genes. The high-performance parallel sequencing is more promising.Materials and Methods: There were a total of 26 families (58 patients, 36 (62.1%) men and 22 (37.9%) women) with pituitary adenomas secretion of various types. The number of families with homogenous type was 17 (somatotropinomas 13, prolactinomas 2, c...

ea0049ep915 | Neuroendocrinology | ECE2017

Pituitary adenoma with gigantism and TSH-induced hyperthyroidism: a case report

Baena-Nieto M Gloria , Marquez-Pardo Rosa , Cayon-Blanco Manuel , Garcia-Garcia-Doncel Lourdes , Lopez-Velasco Rosario , Torres-Barea Isabel M

Abstract: A 14-yr-old male patient with acromegaly and TSH-induced hyperthyroidism is reported. He was referred for hormonal study due to clinical suspicion of acromegaly. Physical examination showed acromegalic/gigantism features (high stature: 194.5 cm (P>90), such as: abnormal growth of the hands and feet, furrowed forehead and pronounced brow ridge). No goiter was found. GH levels were high and were not suppressed after oral glucose (GH: 12.50 ng/ml, GH after ...

ea0049ep916 | Neuroendocrinology | ECE2017

Secretin protects from apoptosis by activation of ERK1/2 and CREB

Wang Lei , Chow Billy

Abstract: There are a growing number of studies identifying secretin as a neuroprotective factor. Consistently, our previous data showed that neuronal apoptosis considerably increased in the developing cerebellum from secretin knockout (Sct-/-) mice. However, the underlying mechanisms remained poorly understood. Extracellular signal-regulated protein kinase (ERK) and AKT signalling pathways are known for the regulation of apoptosis. Additionally, these two pathways could activ...

ea0049ep917 | Neuroendocrinology | ECE2017

Predictors of remission after transsphenoidal adenomectomy in patients with Cushing’s disease

Marova Eugenia , Kolesnicova Galina , Arapova Svetlana , Grigoriev Andrey , Lapshina Anasteysa

Abstract: Cushing’s disease (CD) is the heavy disease of the hypothalamic–pituitary–adrenal axis. The cause of the disease is pituitary adenoma (corticotropinoma). Hypersecretion of ACTH by a pituitary adenoma leads to increased secretion of cortisol by the adrenal cortex and the development of total endogenous hypercortisolism. The gold standard treatment for this disease is surgical removal of corticotropinoma. However, adenomectomy is not effective in all cas...

ea0049ep918 | Neuroendocrinology | ECE2017

Copeptin after arginine infusion for the differential diagnosis of the polyuria–polydipsia syndrome “The CARGO-Study”

Winzeler Bettina , Nigro Nicole , Refardt Julie , Christ-Crain Mirjam

Background: The spectrum of polyuria-polydipsia syndrome (PPS) includes diabetes insipidus (central or nephrogenic) and primary polydipsia. In clinical practice the differential diagnosis particularly of central diabetes insipidus (cDI) and primary polydipsia (PP) is often difficult. The current gold standard – the water deprivation test (WDT) with or without vasopressin (AVP) measurements – lacks reliable diagnostic accuracy. Arginine infusion is known to stimulate ...

ea0049ep919 | Neuroendocrinology | ECE2017

Diabetes mellitus in Cushing’ syndrome: a systematic review

Londero Thiza , Moreira Ana Marina , Leitao Cristiane , Rodrigues Ticiana , Czepielewski Mauro

Introduction: Diabetes mellitus (DM) is an expected condition in Cushing syndrome (CS) but there are few data about prevalence and factors associated to occurrence of DM in these patients.Objective: To determine the main aspects of DM in CS through a systematic review (SR) of the literature.Methods: MEDLINE and LILACS were searched for studies published until March, 2016. Search strategy comprised the terms “Diabetes Mellitus&...

ea0049ep920 | Neuroendocrinology | ECE2017

Thyroiditis and hypophysitis caused by nivolumab

Fernandez Leticia Perez , Monreal Isabel Azcona , Garcia Maria Martinez , Alaminos Maria Elena Lopez , Aznar Pablo Trincado , Carceller Diana Boj , Ballano Diego Alvarez , Garcia Patricia de Diego

Introduction: Nivolumab is an anti-programmed cell death-1 monoclonal antibody approved for the treatment of metastatic malignant melanoma. Several endocrine disorders have been reported as immune-related adverse effects. However, nivolumab-induced hypophysitis has a lower incidence than ipililumab.Case report: A 69-years old man with metastatic melanoma started to receive nivolumab. Ten weeks after the first cycle of nivolumab he presented hyperthyroidi...

ea0049ep921 | Neuroendocrinology | ECE2017

Kallmann syndrome: about eleven clinical cases

Fonseca Liliana , Amaral Claudia , Dores Jorge , Palma Isabel , Carvalho Rui , Cardoso Helena , Vilaverde Joana , Borges Fatima

Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotrophin-realising hormone (GnRH) deficiency. When CHH is associated with hyposmia or anosmia is designated by Kallmann Syndrome (KS). This syndrome is a genetic disorder with significant genetic heterogeneity that may present as a sporadic or familial case, following autosomal dominant, autosomal recessive, or X – linked recessive modes of inherita...