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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Pituitary and Neuroendocrinology

Pituitary - Basic

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Paediatric endocrinology
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Pituitary - Clinical

ea0049ep924 | Pituitary - Basic | ECE2017

SSTR2 inhibits GH-secreting pituitary tumoral cells migration and invasion by increasing cofilin phosphorylation

Peverelli Erika , Giardino Elena , Treppiedi Donatella , Locatelli Marco , Lania Andrea G , Arosio Maura , Spada Anna , Mantovani Giovanna

Although generally benign, pituitary tumors frequently present local invasiveness that strongly reduces neurosurgery success. We recently demonstrated a role for the actin binding protein cofilin in promoting non functioning pituitary tumors invasiveness and an inhibitory effect of dopamine receptor type 2. Somatostatin (SS) receptor type 2 (SSTR2) is the main target of pharmacological therapy of GH-secreting pituitary tumors, reducing both GH secretion and cell proliferation,...
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ea0049ep925 | Pituitary - Basic | ECE2017

Anti-proliferative effect of sodium metaarsenite (KML001) on ACTH-secreting pituitary adenoma cells

Kim Dong Sun , Park Jung Hwan , Sung Yeon-Ah

KML001 is an orally bioavailable and water soluble trivalent arsenic compound having anti-cancer activity via controlling the numerous signaling pathways including phosphoinositide 3-kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK) signaling pathways. PI3K/Akt and ERK signaling pathways are overactivated in adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. In this study, we evaluated the effects of KML001 on cell viability, cell cycle, apoptosis,...
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ea0049ep926 | Pituitary - Basic | ECE2017

Angiogenesis-related proteins in pituitary adenomas

Karabid Ninelia Minaskan , Atkinson Michael , Pellegata Natalia

Pituitary adenomas are frequent intracranial tumors that often associate with the hypersecretion of pituitary hormones or may be non-secreting (nonfunctioning pituitary adenomas, NFPA). Tumors resembling human NFPAs develop with complete penetrance in rats affected by the multiple endocrine neoplasia syndrome, MENX. This syndrome is caused by a germline loss of function mutation in p27Kip1. Gene expression array analysis performed in our group identified a considera...
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ea0049ep927 | Pituitary - Basic | ECE2017

Ketoconazole induces inhibition of cell viability and apoptosis in an ACTH-secreting tumour cell line model

Patalano Roberta , Pivonello Claudia , Solari Domenico , Vitulli Francesca , Iacuaniello Davide , Leo Monica De , Negri Mariarosaria , Provvisiero Donatella Paola , Cavallo Luigi Maria , Cappabianca Paolo , Colpo Annamaria , Pivonello Rosario

Chronic cortisol excess as a consequence of ACTH overproduction from a pituitary tumour is responsible for the development of Cushing’s disease (CD). The first-line treatment for CD is pituitary surgery, but medical treatment is an alternative second-line approach to control cortisol excess. Among pharmacological agents, the adrenal-blocking drug ketoconazole (KT), is able to control cortisol excess in the majority of patients with CD. During KT treatment, the adrenal blo...
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ea0049ep928 | Pituitary - Basic | ECE2017

GPR101 orphan receptor: a novel cause of growth hormone deregulation

Abboud Dayana , Daly Adrian , Dupuis Nadine , Laschet Celine , Pirotte Bernard , Beckers Albert , Hanson Julien

GPR101 is an orphan G-protein coupled receptor with unknown ligand. In 2014, an international study clearly pointed to a strong association between this receptor and the X-linked acrogigantism (X-LAG) syndrome, which begins in childhood and causes the “tallest giants”. The children (carriers of the GPR101 duplication on the X chromosome) grow abnormally even before they are one year old, secrete phenomenal quantities of growth hormone, and develop pituitary adenomas ...
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ea0049ep929 | Pituitary - Basic | ECE2017

Potential role of biguanides and statins in the treatment of pituitary adenomas

Vazquez-Borrego Mari C. , Fuentes-Fayos Antonio C , Ibanez-Costa Alejandro , Blanco-Acevedo Cristobal , Venegas-Moreno Eva , Galvez-Moreno Maria A , Soto-Moreno Alfonso , Castano Justo P. , Luque Raul M.

Pituitary adenomas (PA) comprise a commonly underestimated pathology in terms of incidence and associated morbimortality. To date, somatostatin and dopamine analogs represent the main medical treatment, but an appreciable subset of patients are resistant or poorly responsive to these drugs. Therefore, the search for new approaches to control tumor growth and/or hormone secretion is crucial. Biguanides such as metformin (MF; commonly used to treat type-2 diabetes), phenformin (...
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ea0049ep930 | Pituitary - Basic | ECE2017

Abstract withdrawn....
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ea0049ep931 | Pituitary - Basic | ECE2017

Whole exome sequencing of two non-secreting pituitary adenoma tumors from the same patient

Rovite Vita , Peculis Raitis , Balcere Inga , Stukens Janis , Konrade Ilze , Valtere Andra , Nazarovs Jurijs , Caune Olivija , Pirags Valdis , Klovins Janis

Pituitary adenomas (PA) are benign tumors that develop in pituitary gland. Hormone secreting PA can cause overproduction of pituitary hormones leading to different systemic endocrine disorders (acromegaly, Cushing’s disease and others). Non-secreting PA can promote headaches (stretching of the dural sheath) and visual field defects (chiasma compression). We managed to obtain resected tumor samples from the patient having non-secreting PA, first tumor was resected in 2010,...
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ea0049ep932 | Pituitary - Basic | ECE2017

Ubiquitin specific peptidase 8 (USP8) in human corticotroph pituitary tumors- possible targets and mode of action

Weigand Isabel , Knobloch Lisanne , Vanselow Jens T. , Flitsch Jorg , Monoranu Carmelia M , Saeger Wolfgang , Hagel Christian , Herterich Sabine , Ronchi Cristina , Schlosser Andreas , Fassnacht Martin , Deutschbein Timo , Sbiera Silviu

Recently, somatic, heterozygous mutations in the gene encoding the deubiquitinase USP8 have been identified in 30–60% of corticotroph tumors. These mutations were found to hinder binding of 14-3-3 proteins, increasing its deubiquitinating activity. One substrate is Epidermal Growth Factor Receptor (EGFR), USP8 triggering EGFR recycling and increased EGFR signaling. However, tumors harboring mutations in USP8 are smaller than WT tumors, raising the debate if EGFR, as a pot...
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ea0049ep933 | Pituitary - Basic | ECE2017

Acquired temozolomide resistance in ACTH-secreting pituitary tumour cells

Silva Ticiana , Van Koetsveld Peter , Dogan Fadime , Feelders Richard , Hofland Leo

Introduction: Temozolomide (TMZ) treatment has been used for aggressive pituitary tumours with positive results, but has proven ineffective in controlling tumour regrowth in cases of disease recurrence. TMZ resistance has been linked to the expression of O6-methyl-guanine-DNA-methyltransferase (MGMT) protein and mismatch repair components (MMR). In the present study, we describe the development of an in vitro model of acquired resistance to TMZ and the mechanisms invo...
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ea0049ep934 | Pituitary - Basic | ECE2017

PP4C restrains dopamine D2 receptor expression in rat pituitary MMQ cells

Yi Na , Lu Bin

Objective: Decline in the number of D2 receptor (D2R) is considered as the reason of resistance to dopamine agonists (DA). PP4R2 gene was observed up-regulated in prolactinoma patients according to our previous genechip study. In this study, we demonstrated that PP4C was crucial for D2R expression and PRL secretion in rat pituitary MMQ cells.Methods: In this study, we used rat pituitary MMQ cells which could secrete abundant prolactin and express functio...
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ea0049ep935 | Pituitary - Basic | ECE2017

HER2, EGFR and PDGF family members as potential prognostic markers and their therapeutic implications

Corlan Ana Silvia , Cimpean Anca , Raica Marius , Melnic Eugen , Ceausu Raluca Amalia

Background: The role of EGFR, HER2, PDGF-A and the axis PDGF-B/ PDGFR-β in the pathogenesis of pituitary adenomas and their correlation with the tumoral immunoprofile are poorly understood.Materials and methods: The study included 92 cases. We used morphological stains, immunohistochemistry and molecular methods to characterize the tumors.Results: 33.33% of adenomas showed a positive immunohistochemical reaction for HER2- with...
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ea0049ep936 | Pituitary - Basic | ECE2017

Carbohydrate metabolism disturbances at different types of acromegaly treatment

Dreval' Alexandr , Vinogradova Anna

Purpose: To investigate the carbohydrate metabolism in depend on acromegaly treatment.Material and methods: 23 patients with newly diagnosed acromegaly (NA) were observed. Carbohydrate metabolism were investigated after somatostatine analogues treatment (SSA) (14 patients) or after surgery (TSA) (9 patients). Groups were comparable on age, BMI, acromegaly duration. Were researched HbA1c, fasting plasma glucose level (FPG), indexes of insulin resistance (...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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