Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Eposter Presentations: Thyroid

Nuclear receptors and Signal transduction

ea0049ep1222 | Nuclear receptors and Signal transduction | ECE2017

The human TRα variants affect the specification of haematopoietic stem cells during zebrafish haematopoiesis

Marelli Federica , Rurale Giuditta , Carra Silvia , Persani Luca

Anaemia in RTHα patients correlates with documented abnormal erythropoiesis and reduced haematocrit in TRα-null or mutant mice, but the underlying mechanisms and characterization of the defect remain elusive. In a previous work, we described that the injection of several hTRα variants in zebrafish eggs caused a marked reduction of circulating erythrocytes at later stages of the erythropoiesis. To characterise the involvement of TRα during erythrocyte develo...