Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Guided Posters

Adrenal 2

ea0049gp11 | Adrenal 2 | ECE2017

A country comparison of glucocorticoid replacement therapy in patients with primary and secondary adrenal insufficiency: data from the EU-AIR

Ekman Bertil , Quinkler Marcus , Zhang Pinggao , Zelissen Pierre , Murray Robert D.

Introduction: The daily maintenance dose of conventional hydrocortisone currently recommended by international guidelines for the management of primary adrenal insufficiency (PAI) or secondary adrenal insufficiency (SAI) is 15−25 mg/day, in 2−3 divided doses. The aim of this analysis was to investigate inter-country differences in glucocorticoid replacement doses in patients with PAI and SAI.Design: EU-AIR ( identifier: NCT0...

ea0049gp12 | Adrenal 2 | ECE2017

Activation of the cAMP/PKA transduction system triggers abnormal expression of the serotonin signaling pathway in human adrenocortical cells

Mestre Julie Le , Duparc Celine , Bram Zakariae , Reznik Yves , Bertherat Jerome , Touraine Philippe , Young Jacques , Chabre Olivier , Stratakis Constantine A. , Lefebvre Herve , Louiset Estelle

In human adrenals, serotonin (5-HT), released by subcapsular mast cells, increases aldosterone secretion through activation of type 4 serotonin receptors (5-HT4R) but only exerts a modest control on cortisol production. Interestingly, illicit synthesis of 5-HT in adrenocortical cells as well as overexpression of the 5-HT4R and ectopic expression of the type 7 receptor (5-HT7R) have been observed in bilateral macronodular adrenal hyperplasia res...

ea0049gp13 | Adrenal 2 | ECE2017

PRKARIA (Carney complex gene) is a major regulator of the tight link between cell cycle phases and steroidogenesis in the adrenocortical tumor cells H295R

Rizk-Rabin Marthe , Ragazzon Bruno , Bertherat Jerome

The cyclic AMP/PKA signalling cascade is involved in the pathogenesis of cortisol-secreting adrenocortical tumors (ACT). Defects in cell cycle checkpoints play a major role in oncogenesis. The PKA regulatory subunits PRKARIA and PRKARIIb are involved in cell survival and steroidogenesis in the adrenocortical carcinoma H295R cell line. We have previously shown that their inactivation enhances the accumulation of cells in the G2 phase and act...

ea0049gp14 | Adrenal 2 | ECE2017

Simultaneous assays of aldosterone and renin concentrations in just ten minutes could change the clinical assessment for the diagnosis of primary aldosteronism

Satoh Fumitoshi , Ryo Morimoto , Ono Yoshikiyo , Tezuka Yuta , Omata Kei , Nezu Masahiro , Iwakura Yoshitsugu , Igarashi Yoshuhiro , Kudo Masataka , Ito Sadayoshi

Measurement of plasma aldosterone and renin concentration, or activity, is useful for selecting antihypertensive agents as well as detecting hyperaldosteronism in hypertensive patients. However, it takes several days to get results when measured by radioimmunoassay and development of more rapid assays has been long expected. We have developed chemiluminescent enzyme immunoassays enabling the simultaneous measurement of both aldosterone and renin concentrations in ten-minutes b...

ea0049gp15 | Adrenal 2 | ECE2017

Integrated genomic and phenomic analysis reveals key molecular pathways of aldosterone producing adenoma

Fernandes-Rosa Fabio , Boulkroun Sheerazed , Dzib Felipe Golib , Daniil Georgios , Amar Laurence , Rance Bastien , Samson-Couterie Benoit , Jeunemaitre Xavier , Meatchi Tchao , Benecke Arndt , Strom Tim , Zennaro Maria-Christina

Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D have been described in 50% of aldosterone producing adenomas (APA). To identify genetic alterations in new genes, we performed whole exome sequencing in 23 patients with APA negative for recurrent mutations in known driver genes. A low number of somatic variations were identified per patient, ranging from 1 to 22. N...

ea0049gp16 | Adrenal 2 | ECE2017

Cardiovascular features of autonomous cortisol secretion in patients with adrenal incidentalomas

Sbardella Emilia , Minnetti Marianna , Rizza Laura , Giorgio Maria Rosaria Di , Hasenmajer Valeria , D'Aluisio Denise , Morelli Sergio , Lenzi Andrea , Isidori Andrea M

Background: Possible Autonomous Cortisol Secretion (pACS) is a condition found in 1–29% of patients with adrenal incidentalomas. The diagnosis of pACS has been variably associated with an increased risk of cardiovascular events and mortality. However, dedicated studies describing the morphologic and functional cardiac alterations in these patients are lacking.Aim: To compare the cardiovascular features of patients with pACS to those with nonfunction...

ea0049gp17 | Adrenal 2 | ECE2017

Hypercortisolism is prevalent in newly diagnosed type 2 diabetes: a prospective study of 384 consecutive patients

Steffensen Charlotte , Dekkers Olaf M , Lyhne Johanne , Poulsen Per L , Rungby Jorgen , Sorensen Henrik T , Jorgensen Jens Otto L

Background: Cross-sectional studies in small and selected populations indicate a relatively high prevalence of incipient and/or subclinical Cushing’s syndrome (CS) in patients with type 2 diabetes (T2D), which could have therapeutic implications.Aim: To estimate the prevalence of CS in a large, unselected cohort of recently diagnosed T2D patients.Methods: A total of 384 consecutive out – patients with T2D diagnosed after ...

ea0049gp18 | Adrenal 2 | ECE2017

Effects of two mineralocorticoid receptor antagonists on the morphology of the adrenal cortex

Pereira Sofia S , Costa Madalena M , Moreira Angela , Carvalho Liliana , Monteiro Mariana , Vinson Gavin , Pignatelli Duarte

Arterial hypertension usually results from the deregulation and hyperactivity of the renin angiotensin-aldosterone system. One of the available therapeutic approaches for its treatment is the use of mineralocorticoid receptor (MR) antagonists, thus blocking aldosterone action.The aim of this study was to characterize the effects of spironolactone and eplerenone, on the morphology of the adrenal gland of spontaneously hypertensive (SHR) and normotensive (...

ea0049gp19 | Adrenal 2 | ECE2017

Plasma cortisol and aldosterone responses to insulin tolerance test and sodium depletion in women with non classic 21-hydroxylase deficiency caused by bi-allelic CYP21A2 mutations (NC-CAH)

Kamenicky Peter , Blanchard Anne , Lamaziere Antonin , Donadille Bruno , Duranteau Lise , Salenave Sylvie , Pietri Laurence , Raffin-Sanson Marie Laure , Gautier Jean-Francois , Chanson Philippe , Maitre Sophie Christin , Tardy Veronique , Bouc Yves Le , Brailly-Tabard Sylvie , Young Jacques

NC-CAH is diagnosed in pubertal/post-pubertal women because of androgen excess however, the risk of potential adrenal insufficiency is not known, and indication of systematic glucocorticoid replacement therapy is controversial.Design: Prospective controlled clinical study in a tertiary referral center. 20 women with NC-CAH (serum stimulated 17-OHP >10 ng/ml/250 μg, Synacthen) comparatively to matched healthy women, were included if they had not ...

ea0049gp20 | Adrenal 2 | ECE2017

Which are the factors and causes of death in patients with adrenal insufficiency? Mortality data from EU-AIR

Quinkler Marcus , Ekman Bertil , Zhang Pinggao , Zelissen Pierre , Murray Robert D

Introduction: If untreated, adrenal insufficiency (AI) leads to premature death. Hospital record data suggest mortality associated with primary (PAI) and secondary AI (SAI) to be 2–3-fold higher than in the general population. Major causes of death include cardiovascular disease, Addisonian crises, brain tumours and infections; however, there is little further characterization of patients who died.Design: We analysed real-world data from the Europea...