Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Cardiovascular Endocrinology

ea0049oc5.1 | Cardiovascular Endocrinology | ECE2017

Polarized epithelial cells release exosomes loaded with miRNAs capable of interacting with HSD11B2 and MR genes

Barros Eric , Ortiz David , Campino Carmen , Valdivia Carolina , Tapia-Castillo Alejandra , Lizama Jaime , Allende Fidel , Solari Sandra , Gonzalez Jose Vicente , Martinez-Aguayo Alejandro , Vecchiola Andrea , Repetto Gabriela , Aglony Marlene , Baudrand Rene , Salomon Carlos F , Fardella Carlos E , Carvajal Cristian

Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). The MR pathway is expressed mainly in placenta, kidney and colon epithelial cells. Current research highlights potential epigenetic regulatory mechanisms for the MR pathway. Here, specific m...

ea0049oc5.2 | Cardiovascular Endocrinology | ECE2017

Association of PPAR gamma gene expression with dietary intake of fat and oil among non-diabetic subjects

Yuzbashian Emad , Zarkesh Maryam , Asghari Golaleh , Zadeh-Vakili Azita , Mahmoodi Behnaz , Hedayati Mehdi , Mirmiran Parvin , Khalaj Alireza

Background and Objective: Several animal studies showed the expression of peroxisome proliferator activated receptor-gamma (PPAR gamma) in adipocytes among rats fed with high-fat diet was higher than those fed with normal diet. However, there are no human studies to support this. The objective of the present study was to investigate the association between the PPAR gamma expression in adipose tissue and intake of hydrogenated and non-hydrogenated vegetable oils and butter....

ea0049oc5.3 | Cardiovascular Endocrinology | ECE2017

Cardio metabolic assessment of lamin A/C mutation carriers according to R482 or Non-R482 mutation

Kwapich Maxime , Benomar Kenza , Espiart Stephanie , Belle Eric Van , Pigny Pascal , Bonne Gisele , Vigouroux Corinne , Lacroix Dominique , Vantyghem Marie-Christine

Background: Lamin A/C mutations show heterogeneous phenotypes expanding from cardiopathies to lipodystrophies. LMNA-related heart disease has recently been shown to be associated with a high incidence of phenotypic progression and adverse arrhythmic and non-arrhythmic events. Anticipatory planning to prevent sudden death has been recommended in a multicentric cardiologic recruitment. Nevertheless the specific cardiac prognosis of R482-LMNA mutated patients, the hot-spot for pa...

ea0049oc5.4 | Cardiovascular Endocrinology | ECE2017

Food history characterization of Portuguese centenarians, nutritional biomarkers and cardiovascular risk: case control study

da Silva Alda Pereira , Chaves Catarina , Matos Andreia , Gil Angela , Santos Carolina , Valente Ana , Bicho Manuel , Clara Joao Gorjao

Introduction: Eating habits may contribute to longevity. Consumption of red meat, source of saturated fatty acids and cholesterol may be associated with increased risks of diabetes, cardiovascular disease (CVD), and mortality risk.Methods: We studied 521 subjects, both genders, 253 centenarians (CENT) (100.26±1.98 age) and 268 controls (67.51±3.25 age), both low (LCR) and high cardiovascular risk (HCR), calculated based on QRISK®2-2016. An...

ea0049oc5.5 | Cardiovascular Endocrinology | ECE2017

Sex dimorphism of renal corticosteroid signaling during development and long term consequence on blood pressure

Dumeige Laurence , Storey Caroline , Decourtye Lyvianne , Nehlich Melanie , Lhadj Christophe , Viengchareun Say , Kappeler Laurent , Lombes Marc , Martinerie Laetitia

Sex differences have been demonstrated in various biological processes such as arterial blood pressure. However, the potential sex dimorphism of the renin-angiotensin-aldosterone system and, by extension, the mineralocorticoid receptor (MR) signaling pathway, major regulators of blood pressure, has only been poorly studied, notably in the kidney. Basal systolic blood pressure (SBP) and heart rate (HR) were measured in adult male and female mice. Renal gene expression studies o...