Searchable abstracts of presentations at key conferences in endocrinology
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19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

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20-23 May 2017, Lisbon, Portugal Further information

Oral Communications

Neuroendocrinology

ea0049oc8.1 | Neuroendocrinology | ECE2017

Elucidating the molecular mechanisms underlying AIP dependent tumorigenesis

Bogner Eva-Maria , Daly Adrian F. , Beckers Albert , Atkinson Michael J. , Pellegata Natalia S.

Pituitary adenomas (PAs) are benign neoplasms that comprise 10–20% of all intracranial tumors. Mutations in the aryl hydrocarbon receptor interacting protein (AIP) have been identified to cause a small subset of hereditary PAs. To study the mechanisms of tumor formation in patients with AIP-mutated PAs we conducted a miRNA array analysis comparing AIP-mutated PAs with AIP-wild type PAs. We found a novel and specific set of miRNAs differentially expressed between the two g...

ea0049oc8.2 | Neuroendocrinology | ECE2017

Knocking down/out the prokineticin pathway during zebrafish development results in the GnRH neurons axons misguiding

Bassi Ivan , Marelli Federica , Vezzoli Valeria , Persani Luca , Gothilf Yoav , Bonomi Marco

Studies conducted using knockout mouse model revealed that defects of PROKR2 affect the correct ontogeny of GnRH neurons and, by consequence, neuroendocrine control of reproduction. Nevertheless its exact role during these processes and in the pathogenesis of congenital hypogonadotropic hypogonadism (CHH) remains elusive due to the phenotypic differences observed between mouse and human. Zebrafish (ZF) has emerged in the last ten years as a reliable model organism for studying...

ea0049oc8.3 | Neuroendocrinology | ECE2017

RNA sequencing and RT-qPCR identify different gene expression profiles in fast- vs. slow-growing non-functioning pituitary adenomas

Falch Camilla Maria , Sundaram Arvind Y.M. , Oystese Kristin Astrid Berland , Normann Kjersti Ringvoll , Silamikelis Ivars , Andersen Marianne , Bollerslev Jens , Olarescu Nicoleta Cristina

Background: Non-functioning pituitary adenomas (NFPAs) necessitate prolonged clinical, biochemical and radiological observation, constituting a significant burden in terms of medical resources and societal costs. Reliable biomarkers associated with aggressiveness and recurrence of NFPAs are lacking. As the growth of tumor remnants is highly variable, molecular markers that can predict growth potential and tumor behavior are necessary.Aim: To identify tar...

ea0049oc8.4 | Neuroendocrinology | ECE2017

Cerebrovascular stroke incidence in GH-treated adults: experience from KIMS (Pfizer International Metabolic Database)

Camacho-Hubner Cecilia , Cara Jose , Mattsson Anders

Background and aim: Patients with GH deficiency (GHD) have increased risk of cerebrovascular events. The aim of this study was to evaluate the rate and factors associated with the occurrence of stroke, a major cause of death and disability, in adults with GHD.Patients and methods: Data from 15,188 GHD patients treated with GH replacement therapy (GHRT) enrolled in KIMS were analyzed. Stroke incidence rates were compared to rates from the Oxford Vascular ...

ea0049oc8.5 | Neuroendocrinology | ECE2017

Ephrin-B2 is required for pituitary development

Jimenez Fernando , Gualtieri Angelica , Scagliotti Valeria , Gaston-Massuet Carles

The pituitary progenitors are responsible for generating a fully functional endocrine organ during embryonic development. They also preserve potency, to maintain the homoeostasis in the adult pituitary, being able to respond to endocrine challenges, such as pregnancy or obesity. But the main players of this complex process remain elusive. Eph-Ephrins have been implicated in an increasing number of physiological functions such as axon-guidance, eye field segregation from neural...